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Questions and Answers
Which cell type is directly involved in wound healing?
Which cell type is directly involved in wound healing?
Which of the following is NOT a cardinal sign of inflammation?
Which of the following is NOT a cardinal sign of inflammation?
Which of the following causes the redness (rubor) associated with inflammation?
Which of the following causes the redness (rubor) associated with inflammation?
What is the primary cause of swelling (tumor) during acute inflammation?
What is the primary cause of swelling (tumor) during acute inflammation?
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What is the main reason for the heat (calor) observed during inflammation?
What is the main reason for the heat (calor) observed during inflammation?
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Which cell type is MOST LIKELY responsible for the release of histamine that causes increased vascular permeability during acute inflammation?
Which cell type is MOST LIKELY responsible for the release of histamine that causes increased vascular permeability during acute inflammation?
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Which of the following correctly describes the role of lymphocytes in inflammation?
Which of the following correctly describes the role of lymphocytes in inflammation?
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Which of these cell types is NOT involved in wound healing?
Which of these cell types is NOT involved in wound healing?
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Which type of necrosis is most characteristic of a myocardial infarction?
Which type of necrosis is most characteristic of a myocardial infarction?
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What type of necrosis is specifically associated with the tubercle bacillus?
What type of necrosis is specifically associated with the tubercle bacillus?
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Which of these options is considered the most commonly affected organ by fatty degeneration?
Which of these options is considered the most commonly affected organ by fatty degeneration?
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Which cytological class is generally considered to have a cytological picture that is suggestive but not conclusive of malignancy?
Which cytological class is generally considered to have a cytological picture that is suggestive but not conclusive of malignancy?
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Which cytological class is strongly suggestive of malignancy?
Which cytological class is strongly suggestive of malignancy?
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Which type of necrosis is characterized by the breakdown of tissue into a thick, creamy, yellowish substance?
Which type of necrosis is characterized by the breakdown of tissue into a thick, creamy, yellowish substance?
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Which type of necrosis is characterized by the formation of soap-like deposits?
Which type of necrosis is characterized by the formation of soap-like deposits?
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Which type of tumor is characterized by a lack of supporting tissue or stroma?
Which type of tumor is characterized by a lack of supporting tissue or stroma?
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Which of the following cells is NOT a component of a typical inflammatory response?
Which of the following cells is NOT a component of a typical inflammatory response?
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What type of inflammation is characterized by the presence of large amounts of pus?
What type of inflammation is characterized by the presence of large amounts of pus?
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Which type of inflammation is characterized by an extensive outpouring of a watery, low-protein fluid from the blood?
Which type of inflammation is characterized by an extensive outpouring of a watery, low-protein fluid from the blood?
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Which type of inflammation is marked by the accumulation of fibrin within the exudate?
Which type of inflammation is marked by the accumulation of fibrin within the exudate?
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Which type of inflammation is characterized by the presence of blood within the exudate?
Which type of inflammation is characterized by the presence of blood within the exudate?
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Which of the following is NOT a type of hypertrophy?
Which of the following is NOT a type of hypertrophy?
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In which of the following situations is true hypertrophy MOST likely to occur?
In which of the following situations is true hypertrophy MOST likely to occur?
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Which type of hypertrophy is characterized by an increase in cell size due to increased workload and endocrine stimulation?
Which type of hypertrophy is characterized by an increase in cell size due to increased workload and endocrine stimulation?
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What is the term for an irreversible change where one cell type transforms into another?
What is the term for an irreversible change where one cell type transforms into another?
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Which of the following best describes 'true hypertrophy'?
Which of the following best describes 'true hypertrophy'?
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Which type of necrosis involves conversion of normal cells into 'tombstones'?
Which type of necrosis involves conversion of normal cells into 'tombstones'?
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What is the difference between hyperplasia and hypertrophy?
What is the difference between hyperplasia and hypertrophy?
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Which of the following is NOT a characteristic of anaplasia?
Which of the following is NOT a characteristic of anaplasia?
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Which of the following is a type of necrosis characterized by the formation of a cheesy, yellow material?
Which of the following is a type of necrosis characterized by the formation of a cheesy, yellow material?
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What is a major characteristic of dysplasia?
What is a major characteristic of dysplasia?
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What is the term for a decrease in cell size, due to a decrease in the size of individual cells?
What is the term for a decrease in cell size, due to a decrease in the size of individual cells?
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Which of the following is a characteristic feature of herpes simplex virus (HSV) infection in a smear obtained from a vesicle?
Which of the following is a characteristic feature of herpes simplex virus (HSV) infection in a smear obtained from a vesicle?
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What is the medical term for the process of programmed cell death?
What is the medical term for the process of programmed cell death?
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What is the name given to the physiologic death of cells followed by immediate regeneration of cells of the same type?
What is the name given to the physiologic death of cells followed by immediate regeneration of cells of the same type?
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Which of the following viral infections is NOT typically associated with the formation of multinucleated giant cells with intranuclear inclusions?
Which of the following viral infections is NOT typically associated with the formation of multinucleated giant cells with intranuclear inclusions?
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A 23-year-old female presents with multiple clear vesicles on her vulva and vagina. Which of the following is the most likely cause of these lesions?
A 23-year-old female presents with multiple clear vesicles on her vulva and vagina. Which of the following is the most likely cause of these lesions?
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What is the specific term for the intranuclear inclusions seen in HSV-infected cells?
What is the specific term for the intranuclear inclusions seen in HSV-infected cells?
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In what situation would you expect to see 'ground-glass nuclei' in a histological examination?
In what situation would you expect to see 'ground-glass nuclei' in a histological examination?
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What is the primary difference between necrosis and apoptosis?
What is the primary difference between necrosis and apoptosis?
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What is the optimal temperature for sublimation in the given scenario?
What is the optimal temperature for sublimation in the given scenario?
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What is the primary purpose of "quenching" in this context?
What is the primary purpose of "quenching" in this context?
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Which of the following is the correct sequence of steps in histotechnology, based on the given information?
Which of the following is the correct sequence of steps in histotechnology, based on the given information?
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Why is it important to fix the brain before sectioning?
Why is it important to fix the brain before sectioning?
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Which of the following is NOT a primary aim of fixation?
Which of the following is NOT a primary aim of fixation?
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Which of the following is a secondary goal of fixation?
Which of the following is a secondary goal of fixation?
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Which of the following statements is TRUE about the volume of fixative used?
Which of the following statements is TRUE about the volume of fixative used?
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What is the main reason why the volume of fixative used is greater than the volume of tissue?
What is the main reason why the volume of fixative used is greater than the volume of tissue?
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Flashcards
Cells in Wound Healing
Cells in Wound Healing
Cells such as basophils, fibroblasts, lymphocytes, monocytes, and macrophages play key roles in skin structure and wound repair.
Rubor
Rubor
Rubor refers to redness, one of the cardinal signs of inflammation caused by increased blood flow.
Cardinal Signs of Inflammation
Cardinal Signs of Inflammation
The four original signs of inflammation: rubor (redness), tumor (swelling), calor (heat), and dolor (pain), with loss of function added later.
Vasodilation
Vasodilation
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Acute Inflammation Process
Acute Inflammation Process
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Exudates
Exudates
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Histamine Function
Histamine Function
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Source of Histamine
Source of Histamine
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Endothelial cells
Endothelial cells
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Fibroblast
Fibroblast
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Lymphocytes
Lymphocytes
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Mast cells
Mast cells
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Neutrophils
Neutrophils
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Suppurative inflammation
Suppurative inflammation
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Serous inflammation
Serous inflammation
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True hypertrophy
True hypertrophy
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False hypertrophy
False hypertrophy
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Compensatory hypertrophy
Compensatory hypertrophy
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Hypertrophy
Hypertrophy
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Metaplasia
Metaplasia
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Caseous necrosis
Caseous necrosis
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Coagulation necrosis
Coagulation necrosis
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Dysplasia
Dysplasia
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Fatty degeneration
Fatty degeneration
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Cytological Class III
Cytological Class III
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Cytological Class IV
Cytological Class IV
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Cytological Class II
Cytological Class II
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Malignant tumors
Malignant tumors
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Liquefactive necrosis
Liquefactive necrosis
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Herpes simplex virus (HSV)
Herpes simplex virus (HSV)
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Multinucleated giant cells
Multinucleated giant cells
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Ground-glass nuclei
Ground-glass nuclei
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Intranuclear inclusions
Intranuclear inclusions
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Apoptosis
Apoptosis
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Necrosis
Necrosis
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Cellular senescence
Cellular senescence
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Terminal differentiation
Terminal differentiation
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Quenching
Quenching
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Sublimation
Sublimation
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Correct Quenching Procedure
Correct Quenching Procedure
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Histotechnology Step 1
Histotechnology Step 1
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Organ Fixation
Organ Fixation
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Primary Aim of Fixation
Primary Aim of Fixation
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Secondary Goal of Fixation
Secondary Goal of Fixation
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Fixative Volume Ratio
Fixative Volume Ratio
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Study Notes
Online Assessment Examination: Histopathology Part 1
- The respondent's email address ([email protected]) was recorded during submission.
- The exam had a total of 96 out of 120 possible points.
- The student's name is JAN CHRISTIAN SIENES.
- The student's school is SILLIMAN UNIVERSITY.
- The exam appears to be for a Histology course, possibly Remote Medical Technology (RMT).
- Sections A, B, C1, C2, D1, D2, and E were part of the examination.
Epithelial Tissue
- The respiratory tract is mainly lined by pseudostratified ciliated columnar epithelium.
- Thyroid follicles are lined by simple cuboidal epithelium.
- The urinary bladder, ureters, and parts of the urethra are lined by stratified squamous epithelium.
Muscle Tissue
- Skeletal muscle is long, cylindrical, multinucleated, and has obvious striations, which enable voluntary control.
- Cardiac muscle comprises uninucleate, branching cells tightly connected at intercalated disks.
- Visceral muscle (smooth muscle) contains uninucleate cells without striations.
Connective Tissue Stem Cells
- Mesenchymal cells are the stem cell precursors of most connective tissues.
Types of Cartilage
- Elastic cartilage is found in the external ear and the walls of the Eustachian tubes, but not in the intervertebral discs.
Abscess Definition
- An abscess is a localized accumulation of neutrophils and necrotic tissue debris, and it's a form of suppurative inflammation often linked to pyogenic bacteria.
Cell Functions and Healing
- Cells provide a structural framework for the skin and are crucial in wound healing.
Cardinal Signs of Inflammation
- Rubor (redness) is primarily due to vasodilation of arterioles, increasing blood flow.
Histamine and Vascular Permeability
- Mast cells are the most likely source of histamine that causes increased vascular permeability during inflammation..
Types of Inflammation
- Serous inflammation is characterized by a watery, low-protein fluid leakage from blood vessels.
- Suppurative/purulent inflammation is characterized by pus formation.
Hypertrophy
- True hypertrophy involves an increase in cell size leading to an increased tissue/organ size.
- False hypertrophy refers to an increase in tissue size due to edema and connective tissue, not cell growth.
- Compensatory hypertrophy is an increase in organ size due to increased workload.
Cell Type Changes
- Metaplasia is a reversible cell change, transforming one cell type into another.
- Anaplasia is an irreversible change where cells lose their organizational properties.
Types of Necrosis
- Caseous necrosis involves the "conversion of normal cells into tombstones". This is a hallmark of caseous necrosis.
- Coagulative necrosis, liquefactive necrosis, and fat necrosis are also types of cell death.
Myocardial Infarction and Necrosis
- Coagulative necrosis is the most suitable description of the necrosis in the heart, caused by a blockage of the left anterior descending coronary artery.
Fatty Tissue Affected by Fatty Degeneration
- The liver is the primary organ affected by fatty degeneration (steatosis).
Cytological Picture
- A cytological picture that is strongly suggestive of malignancy is categorized as Class V.
- A cytological picture that is suggestive but not conclusive for malignancy is categorized as Class III.
Tumour Types
- Carcinoma is cancer originating from epithelial tissues.
- Sarcoma originates from connective tissue.
Tumor Markers
- Carcinoembryonic antigen (CEA) is a useful marker for monitoring colon cancer recurrence and metastases.
Genital Infections
- Herpes simplex virus (HSV) is the most likely cause of the vesicles, characterized by intranuclear inclusions and multinucleated giant cells.
Cell Death Mechanisms
- Apoptosis is a programmed form of cell death distinct from necrosis.
- Necrobiosis represents death of a group of cells with immediate regeneration of the same kind.
Postmortem Clot
- A postmortem clot is a gelatinous mass characterized by the lack of fibrin attachments to blood vessel walls.
Autopsy Consent
- It is the next of kin or nearest relative who is authorized to give consent to autopsy.
Cytopathology Founder
- George Nicholas Papanicolaou is considered the Father of Cytopathology.
- Rudolf Carl Virchow is often called the Father of Pathology.
Histological Preservation : Freezing Agent
- Liquid nitrogen is commonly used as it is exceptionally quick and effective for freezing when used in histochemistry and during operative procedures.
Fixation Process
- Fixation is the primary step (the most pivotal stage) in histotechnology. It preserves tissue integrity during handling and processing.
- The secondary goal in fixation is to inhibit bacterial decomposition to preserve tissue structure.
- The typical ratio of fixative to tissue volume is generally 10 – 25 times the volume of tissue.
- Immersion fixation refers to placing the tissue being evaluated in a fixative fluid.
- Perfusion fixation is a method to fix tissue by immersing some sort of whole organ, and is typically used with small animals or some organs such as the lungs.
Fixative Selection Guidelines
- Bouin's solution contains picric acid, formalin, and acetic acid.
- Carnoy's method is a fast and effective fixative, but it lacks the inclusion of picric acid.
- Zenker's solution is a mix of formalin, potassium dichromate, and mercuric chloride.
- Formaldehyde solutions typically are between 4 – 10, 37, or even 98%.
- Formalin discoloration can be removed by adding alcoholic picric acid.
- An increase in temperature enhances the speed of fixation.
Additional Methods
- Paraformaldehyde is a chemical used to prevent polymerization of formalin.
- Sodium thiosulfate and saturated solutions of picric acid help dissolve out mercuric chloride which is a necessary step in processing tissues with mercury content in histological preparations.
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Description
Test your knowledge on the cellular processes involved in inflammation and wound healing. This quiz covers topics such as the signs of inflammation, types of necrosis, and the roles of different cell types. Challenge yourself with questions related to the mechanisms and biology behind these essential physiological responses.