Inflammation and Wound Healing Quiz
48 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which cell type is directly involved in wound healing?

  • Basophils
  • Fibroblasts (correct)
  • Monocytes and macrophages
  • Lymphocytes
  • Which of the following is NOT a cardinal sign of inflammation?

  • Tumor
  • Diapedesis (correct)
  • Rubor
  • Calor
  • Which of the following causes the redness (rubor) associated with inflammation?

  • Decreased interstitial hydrostatic pressure
  • Decreased vascular permeability of capillaries
  • Vasodilation of arterioles (correct)
  • Increased vascular permeability of venules
  • What is the primary cause of swelling (tumor) during acute inflammation?

    <p>Increased interstitial fluid pressure due to increased vascular permeability. (C)</p> Signup and view all the answers

    What is the main reason for the heat (calor) observed during inflammation?

    <p>Increased blood flow (B)</p> Signup and view all the answers

    Which cell type is MOST LIKELY responsible for the release of histamine that causes increased vascular permeability during acute inflammation?

    <p>Mast cells (A)</p> Signup and view all the answers

    Which of the following correctly describes the role of lymphocytes in inflammation?

    <p>Lymphocytes are primarily involved in adaptive immune responses, targeting specific antigens. (A)</p> Signup and view all the answers

    Which of these cell types is NOT involved in wound healing?

    <p>Eosinophils (B)</p> Signup and view all the answers

    Which type of necrosis is most characteristic of a myocardial infarction?

    <p>Coagulative necrosis (C)</p> Signup and view all the answers

    What type of necrosis is specifically associated with the tubercle bacillus?

    <p>Caseous necrosis (C)</p> Signup and view all the answers

    Which of these options is considered the most commonly affected organ by fatty degeneration?

    <p>Liver (B)</p> Signup and view all the answers

    Which cytological class is generally considered to have a cytological picture that is suggestive but not conclusive of malignancy?

    <p>Class II (D)</p> Signup and view all the answers

    Which cytological class is strongly suggestive of malignancy?

    <p>Class IV (D)</p> Signup and view all the answers

    Which type of necrosis is characterized by the breakdown of tissue into a thick, creamy, yellowish substance?

    <p>Caseous necrosis (C)</p> Signup and view all the answers

    Which type of necrosis is characterized by the formation of soap-like deposits?

    <p>Fat necrosis (D)</p> Signup and view all the answers

    Which type of tumor is characterized by a lack of supporting tissue or stroma?

    <p>Epithelial tumors (A)</p> Signup and view all the answers

    Which of the following cells is NOT a component of a typical inflammatory response?

    <p>Endothelial cells (C)</p> Signup and view all the answers

    What type of inflammation is characterized by the presence of large amounts of pus?

    <p>Suppurative or purulent (C)</p> Signup and view all the answers

    Which type of inflammation is characterized by an extensive outpouring of a watery, low-protein fluid from the blood?

    <p>Serous (D)</p> Signup and view all the answers

    Which type of inflammation is marked by the accumulation of fibrin within the exudate?

    <p>Fibrinous (A)</p> Signup and view all the answers

    Which type of inflammation is characterized by the presence of blood within the exudate?

    <p>Hemorrhagic (D)</p> Signup and view all the answers

    Which of the following is NOT a type of hypertrophy?

    <p>Paralytic hypertrophy (C)</p> Signup and view all the answers

    In which of the following situations is true hypertrophy MOST likely to occur?

    <p>A muscle being repeatedly stimulated with exercise (D)</p> Signup and view all the answers

    Which type of hypertrophy is characterized by an increase in cell size due to increased workload and endocrine stimulation?

    <p>True hypertrophy (C)</p> Signup and view all the answers

    What is the term for an irreversible change where one cell type transforms into another?

    <p>Metaplasia (A)</p> Signup and view all the answers

    Which of the following best describes 'true hypertrophy'?

    <p>An increase in the size of individual cells due to an increase in the amount of cellular components (B)</p> Signup and view all the answers

    Which type of necrosis involves conversion of normal cells into 'tombstones'?

    <p>Coagulation necrosis (B)</p> Signup and view all the answers

    What is the difference between hyperplasia and hypertrophy?

    <p>Hypertrophy involves cell enlargement, while hyperplasia increases cell number. (A)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of anaplasia?

    <p>Anaplasia is a reversible change. (A)</p> Signup and view all the answers

    Which of the following is a type of necrosis characterized by the formation of a cheesy, yellow material?

    <p>Caseous necrosis (A)</p> Signup and view all the answers

    What is a major characteristic of dysplasia?

    <p>Dysplasia involves a loss of normal cell differentiation. (D)</p> Signup and view all the answers

    What is the term for a decrease in cell size, due to a decrease in the size of individual cells?

    <p>Atrophy (C)</p> Signup and view all the answers

    Which of the following is a characteristic feature of herpes simplex virus (HSV) infection in a smear obtained from a vesicle?

    <p>Presence of multinucleated giant cells with intranuclear inclusions and ground-glass nuclei (D)</p> Signup and view all the answers

    What is the medical term for the process of programmed cell death?

    <p>Apoptosis (B)</p> Signup and view all the answers

    What is the name given to the physiologic death of cells followed by immediate regeneration of cells of the same type?

    <p>Regenerative cell death (D)</p> Signup and view all the answers

    Which of the following viral infections is NOT typically associated with the formation of multinucleated giant cells with intranuclear inclusions?

    <p>Human papillomavirus (HPV) (A)</p> Signup and view all the answers

    A 23-year-old female presents with multiple clear vesicles on her vulva and vagina. Which of the following is the most likely cause of these lesions?

    <p>Herpes simplex virus (HSV) (A)</p> Signup and view all the answers

    What is the specific term for the intranuclear inclusions seen in HSV-infected cells?

    <p>Cowdry type A bodies (B)</p> Signup and view all the answers

    In what situation would you expect to see 'ground-glass nuclei' in a histological examination?

    <p>Viral infection (C)</p> Signup and view all the answers

    What is the primary difference between necrosis and apoptosis?

    <p>Necrosis is an uncontrolled cell death, while apoptosis is a programmed cell death. (C)</p> Signup and view all the answers

    What is the optimal temperature for sublimation in the given scenario?

    <p>-160C (A)</p> Signup and view all the answers

    What is the primary purpose of "quenching" in this context?

    <p>To fix the tissue by stopping cellular activity (A)</p> Signup and view all the answers

    Which of the following is the correct sequence of steps in histotechnology, based on the given information?

    <p>Fixation, Quenching, Sublimation, Clearing, Embedding (C)</p> Signup and view all the answers

    Why is it important to fix the brain before sectioning?

    <p>The brain is very fragile and needs to be hardened. (B)</p> Signup and view all the answers

    Which of the following is NOT a primary aim of fixation?

    <p>To make the tissue more resistant to staining (B)</p> Signup and view all the answers

    Which of the following is a secondary goal of fixation?

    <p>To allow the tissue to be cut more easily (C)</p> Signup and view all the answers

    Which of the following statements is TRUE about the volume of fixative used?

    <p>The volume of fixative should be determined by the tissue type. (B)</p> Signup and view all the answers

    What is the main reason why the volume of fixative used is greater than the volume of tissue?

    <p>To ensure proper fixation of the tissue from all sides. (B)</p> Signup and view all the answers

    Flashcards

    Cells in Wound Healing

    Cells such as basophils, fibroblasts, lymphocytes, monocytes, and macrophages play key roles in skin structure and wound repair.

    Rubor

    Rubor refers to redness, one of the cardinal signs of inflammation caused by increased blood flow.

    Cardinal Signs of Inflammation

    The four original signs of inflammation: rubor (redness), tumor (swelling), calor (heat), and dolor (pain), with loss of function added later.

    Vasodilation

    Vasodilation is the widening of blood vessels, leading to increased blood flow and contributing to redness and heat in inflammation.

    Signup and view all the flashcards

    Acute Inflammation Process

    Acute inflammation involves the body's immediate response to harmful stimuli, characterized by increased blood flow and permeability.

    Signup and view all the flashcards

    Exudates

    Exudates are fluid containing proteins, immune cells, and debris that leaks into tissues during inflammation due to increased vascular permeability.

    Signup and view all the flashcards

    Histamine Function

    Histamine increases vascular permeability, allowing immune cells to access injured sites, playing a crucial role in inflammatory response.

    Signup and view all the flashcards

    Source of Histamine

    Mast cells are the most likely source of histamine in the body, leading to increased vascular permeability during inflammation.

    Signup and view all the flashcards

    Endothelial cells

    Cells lining blood vessels involved in inflammation.

    Signup and view all the flashcards

    Fibroblast

    A cell that produces collagen and other fibers in connective tissue.

    Signup and view all the flashcards

    Lymphocytes

    A type of white blood cell pivotal in immune response.

    Signup and view all the flashcards

    Mast cells

    Cells that release chemicals like histamine during inflammation.

    Signup and view all the flashcards

    Neutrophils

    White blood cells that are first responders to sites of infection.

    Signup and view all the flashcards

    Suppurative inflammation

    Inflammation characterized by the presence of pus.

    Signup and view all the flashcards

    Serous inflammation

    Inflammation with a watery, low-protein fluid outpouring.

    Signup and view all the flashcards

    True hypertrophy

    Increase in cell size due to increased workload or stimulation.

    Signup and view all the flashcards

    False hypertrophy

    An apparent increase in size without actual increase in cell size.

    Signup and view all the flashcards

    Compensatory hypertrophy

    Increase in size of an organ due to increased workload or loss of another organ.

    Signup and view all the flashcards

    Hypertrophy

    An increase in the size of individual cells leading to tissue growth.

    Signup and view all the flashcards

    Metaplasia

    Reversible change where one cell type transforms into another.

    Signup and view all the flashcards

    Caseous necrosis

    A type of necrosis characterized by cheese-like appearance of dead tissue.

    Signup and view all the flashcards

    Coagulation necrosis

    Necrosis where cell outlines remain, but internal details are lost.

    Signup and view all the flashcards

    Dysplasia

    Abnormal growth or development of cells, often pre-cancerous.

    Signup and view all the flashcards

    Fatty degeneration

    A condition where fat accumulates within cells, particularly seen in the liver due to injury or toxins.

    Signup and view all the flashcards

    Cytological Class III

    A classification indicating a cytological picture suggestive but not conclusive of malignancy.

    Signup and view all the flashcards

    Cytological Class IV

    A classification indicating a cytological picture strongly suggestive of malignancy.

    Signup and view all the flashcards

    Cytological Class II

    A classification which indicates a cytological picture that is benign and unlikely to show malignancy.

    Signup and view all the flashcards

    Malignant tumors

    Cancers that originate from epithelial tissues and usually have a lesser tendency to produce stroma compared to benign tumors.

    Signup and view all the flashcards

    Liquefactive necrosis

    A type of necrosis characterized by a transformation of tissue into a liquid viscous mass, often due to bacterial infection.

    Signup and view all the flashcards

    Herpes simplex virus (HSV)

    A virus causing clear vesicles and multinucleated giant cells with intranuclear inclusions.

    Signup and view all the flashcards

    Multinucleated giant cells

    Large cells containing multiple nuclei, often seen in infections.

    Signup and view all the flashcards

    Ground-glass nuclei

    A term describing the appearance of the nuclei in certain viral infections, indicating viral effects.

    Signup and view all the flashcards

    Intranuclear inclusions

    Abnormal structures within the nucleus caused by viral infections, such as HSV.

    Signup and view all the flashcards

    Apoptosis

    Programmed cell death, a normal process for cellular turnover.

    Signup and view all the flashcards

    Necrosis

    Uncontrolled cell death due to injury or disease, often causing inflammation.

    Signup and view all the flashcards

    Cellular senescence

    The biological aging of cells where they no longer divide.

    Signup and view all the flashcards

    Terminal differentiation

    The final stage of cell specialization where cells can no longer divide.

    Signup and view all the flashcards

    Quenching

    A process of rapidly cooling a substance.

    Signup and view all the flashcards

    Sublimation

    Transition from solid to gas without becoming liquid.

    Signup and view all the flashcards

    Correct Quenching Procedure

    Quenching at –160C, sublimation at –40C.

    Signup and view all the flashcards

    Histotechnology Step 1

    Fixation is the first critical step.

    Signup and view all the flashcards

    Organ Fixation

    The brain must be fixed before sectioning.

    Signup and view all the flashcards

    Primary Aim of Fixation

    To preserve the morphologic and chemical integrity of the cell.

    Signup and view all the flashcards

    Secondary Goal of Fixation

    To harden and protect tissue from trauma.

    Signup and view all the flashcards

    Fixative Volume Ratio

    Traditionally, 10 to 25 times the volume of tissue.

    Signup and view all the flashcards

    Study Notes

    Online Assessment Examination: Histopathology Part 1

    • The respondent's email address ([email protected]) was recorded during submission.
    • The exam had a total of 96 out of 120 possible points.
    • The student's name is JAN CHRISTIAN SIENES.
    • The student's school is SILLIMAN UNIVERSITY.
    • The exam appears to be for a Histology course, possibly Remote Medical Technology (RMT).
    • Sections A, B, C1, C2, D1, D2, and E were part of the examination.

    Epithelial Tissue

    • The respiratory tract is mainly lined by pseudostratified ciliated columnar epithelium.
    • Thyroid follicles are lined by simple cuboidal epithelium.
    • The urinary bladder, ureters, and parts of the urethra are lined by stratified squamous epithelium.

    Muscle Tissue

    • Skeletal muscle is long, cylindrical, multinucleated, and has obvious striations, which enable voluntary control.
    • Cardiac muscle comprises uninucleate, branching cells tightly connected at intercalated disks.
    • Visceral muscle (smooth muscle) contains uninucleate cells without striations.

    Connective Tissue Stem Cells

    • Mesenchymal cells are the stem cell precursors of most connective tissues.

    Types of Cartilage

    • Elastic cartilage is found in the external ear and the walls of the Eustachian tubes, but not in the intervertebral discs.

    Abscess Definition

    • An abscess is a localized accumulation of neutrophils and necrotic tissue debris, and it's a form of suppurative inflammation often linked to pyogenic bacteria.

    Cell Functions and Healing

    • Cells provide a structural framework for the skin and are crucial in wound healing.

    Cardinal Signs of Inflammation

    • Rubor (redness) is primarily due to vasodilation of arterioles, increasing blood flow.

    Histamine and Vascular Permeability

    • Mast cells are the most likely source of histamine that causes increased vascular permeability during inflammation..

    Types of Inflammation

    • Serous inflammation is characterized by a watery, low-protein fluid leakage from blood vessels.
    • Suppurative/purulent inflammation is characterized by pus formation.

    Hypertrophy

    • True hypertrophy involves an increase in cell size leading to an increased tissue/organ size.
    • False hypertrophy refers to an increase in tissue size due to edema and connective tissue, not cell growth.
    • Compensatory hypertrophy is an increase in organ size due to increased workload.

    Cell Type Changes

    • Metaplasia is a reversible cell change, transforming one cell type into another.
    • Anaplasia is an irreversible change where cells lose their organizational properties.

    Types of Necrosis

    • Caseous necrosis involves the "conversion of normal cells into tombstones". This is a hallmark of caseous necrosis.
    • Coagulative necrosis, liquefactive necrosis, and fat necrosis are also types of cell death.

    Myocardial Infarction and Necrosis

    • Coagulative necrosis is the most suitable description of the necrosis in the heart, caused by a blockage of the left anterior descending coronary artery.

    Fatty Tissue Affected by Fatty Degeneration

    • The liver is the primary organ affected by fatty degeneration (steatosis).

    Cytological Picture

    • A cytological picture that is strongly suggestive of malignancy is categorized as Class V.
    • A cytological picture that is suggestive but not conclusive for malignancy is categorized as Class III.

    Tumour Types

    • Carcinoma is cancer originating from epithelial tissues.
    • Sarcoma originates from connective tissue.

    Tumor Markers

    • Carcinoembryonic antigen (CEA) is a useful marker for monitoring colon cancer recurrence and metastases.

    Genital Infections

    • Herpes simplex virus (HSV) is the most likely cause of the vesicles, characterized by intranuclear inclusions and multinucleated giant cells.

    Cell Death Mechanisms

    • Apoptosis is a programmed form of cell death distinct from necrosis.
    • Necrobiosis represents death of a group of cells with immediate regeneration of the same kind.

    Postmortem Clot

    • A postmortem clot is a gelatinous mass characterized by the lack of fibrin attachments to blood vessel walls.
    • It is the next of kin or nearest relative who is authorized to give consent to autopsy.

    Cytopathology Founder

    • George Nicholas Papanicolaou is considered the Father of Cytopathology.
    • Rudolf Carl Virchow is often called the Father of Pathology.

    Histological Preservation : Freezing Agent

    • Liquid nitrogen is commonly used as it is exceptionally quick and effective for freezing when used in histochemistry and during operative procedures.

    Fixation Process

    • Fixation is the primary step (the most pivotal stage) in histotechnology. It preserves tissue integrity during handling and processing.
    • The secondary goal in fixation is to inhibit bacterial decomposition to preserve tissue structure.
    • The typical ratio of fixative to tissue volume is generally 10 – 25 times the volume of tissue.
    • Immersion fixation refers to placing the tissue being evaluated in a fixative fluid.
    • Perfusion fixation is a method to fix tissue by immersing some sort of whole organ, and is typically used with small animals or some organs such as the lungs.

    Fixative Selection Guidelines

    • Bouin's solution contains picric acid, formalin, and acetic acid.
    • Carnoy's method is a fast and effective fixative, but it lacks the inclusion of picric acid.
    • Zenker's solution is a mix of formalin, potassium dichromate, and mercuric chloride.
    • Formaldehyde solutions typically are between 4 – 10, 37, or even 98%.
    • Formalin discoloration can be removed by adding alcoholic picric acid.
    • An increase in temperature enhances the speed of fixation.

    Additional Methods

    • Paraformaldehyde is a chemical used to prevent polymerization of formalin.
    • Sodium thiosulfate and saturated solutions of picric acid help dissolve out mercuric chloride which is a necessary step in processing tissues with mercury content in histological preparations.

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Related Documents

    Description

    Test your knowledge on the cellular processes involved in inflammation and wound healing. This quiz covers topics such as the signs of inflammation, types of necrosis, and the roles of different cell types. Challenge yourself with questions related to the mechanisms and biology behind these essential physiological responses.

    More Like This

    Early Stages of Skin Wound Healing Quiz
    8 questions
    Inflammation and Wound Healing Quiz
    24 questions
    Inflammation and Wound Healing Quiz
    29 questions

    Inflammation and Wound Healing Quiz

    FineLookingAquamarine248 avatar
    FineLookingAquamarine248
    Inflammation and Wound Healing Concepts
    57 questions
    Use Quizgecko on...
    Browser
    Browser