Inflammation and Tissue Response Quiz

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Questions and Answers

Which of the following is NOT a cardinal sign of acute inflammation?

  • Calor
  • Odor (correct)
  • Rubor
  • Tumor

In a gas gangrene infection, the bacteria thrive in anaerobic conditions and produce toxins that spread the infection.

True (A)

What is the main characteristic of living tissue that allows for an acute inflammatory response?

Blood vessels

A ______ is an area of tissue death caused by a lack of blood supply.

<p>infarct</p> Signup and view all the answers

Match the type of inflammatory process with its associated characteristic:

<p>Pyogenic = Formation of pus Granulomatous = Collection of immune cells Necrosis = Tissue death Vasodilation = Increased blood flow</p> Signup and view all the answers

A surgical intervention to separate loops of bowel during peritonitis can help control the spread of infection by disrupting the adherence of the bowel surfaces.

<p>True (A)</p> Signup and view all the answers

Why is it difficult to treat bacterial infections in tissues with few blood vessels?

<p>Antibiotics are delivered through the bloodstream, making it challenging to reach the site of infection in tissues with limited blood supply.</p> Signup and view all the answers

Neutrophils can survive for up to 48 hours while circulating in the blood.

<p>True (A)</p> Signup and view all the answers

What is the name of the enzyme released by dying neutrophils that can damage lung tissue?

<p>Elastase</p> Signup and view all the answers

What is the primary function of Alpha-1-antitrypsin (A1A)?

<p>To destroy harmful enzymes released by neutrophils (C)</p> Signup and view all the answers

The presence of myeloperoxidase in pus gives it a ______ color.

<p>green</p> Signup and view all the answers

Match the following terms with their definitions:

<p>Exudate = Fluid rich in proteins Pus = Yellow/green fluid collection containing dead and dying cells, polymorphs + organisms Bacteraemia = Bacteria circulating in blood stream, dividing, may be ingested by polymorphs + is not life threatening Septicaemia = Bacteria circulating in the blood, actively dividing, have overcome host defences (present where neutrophils are most present) \ Not localized \ life-threatening</p> Signup and view all the answers

Which of the following is NOT a characteristic of pyogenic bacteria?

<p>They are often associated with tuberculosis or syphilis (A)</p> Signup and view all the answers

Passive hyperaemia is a condition where blood flow to an area is decreased due to a blockage in an artery.

<p>False (B)</p> Signup and view all the answers

What is the difference between bacteraemia and septicaemia?

<p>Bacteraemia is the presence of bacteria in the bloodstream without causing symptoms. Septicaemia is a more serious condition where bacteria are actively dividing and spreading in the blood, overwhelming the host's immune system.</p> Signup and view all the answers

Antibodies against antigens in the cytoplasm of neutrophils are called ______.

<p>Anti-neutrophilic-cytoplasmic-antibodies</p> Signup and view all the answers

What is a primary cause of endarteritis obliterans?

<p>Chronic inflammation (D)</p> Signup and view all the answers

Granulomatous inflammation is characterized by the presence of mononuclear cells.

<p>True (A)</p> Signup and view all the answers

Name two common causes of granulomatous infections.

<p>Tuberculosis and leprosy</p> Signup and view all the answers

The primary cell type responsible for secreting substances that stimulate the formation of fibrous tissue in chronic inflammation is the ________.

<p>macrophages</p> Signup and view all the answers

Match the following cellular components with their roles in chronic inflammation:

<p>Lymphocytes = Associated with immune response Plasma cells = Produce antibodies Neutrophils = Present in small numbers Eosinophils = Associated with parasites</p> Signup and view all the answers

What is a characteristic of chronic inflammation?

<p>It involves both inflammation and attempts at healing. (C)</p> Signup and view all the answers

Chronic inflammation can be caused by an autoimmune response.

<p>True (A)</p> Signup and view all the answers

What type of immunity involves the production of antibodies?

<p>Humoral immunity</p> Signup and view all the answers

___ are proteins produced by B-lymphocytes in response to molecular weight antigens.

<p>Antibodies</p> Signup and view all the answers

Which of the following can contribute to chronic inflammation persistence?

<p>Poor circulation (B)</p> Signup and view all the answers

Chronic inflammation responses are always highly specific to the injurious agent.

<p>False (B)</p> Signup and view all the answers

Chronic inflammation often involves the infiltration of ___ cells, including lymphocytes and plasma cells.

<p>immune</p> Signup and view all the answers

Match the immune concepts with their descriptions:

<p>B-lymphocytes = Produce antibodies Phagocytosis = Process of engulfing pathogens Granulomatous inflammation = Chronic inflammatory response Autoimmune response = Body fails to recognize self molecules</p> Signup and view all the answers

Which condition may allow an injurious agent to evade the immune system?

<p>Frustrated acute inflammatory response (C)</p> Signup and view all the answers

What type of cellular activity is primarily involved in phagocytosis during chronic inflammation?

<p>Macrophages</p> Signup and view all the answers

What type of cytokines are secreted by T-helper lymphocytes?

<p>Lymphokines (A)</p> Signup and view all the answers

Macrophages are derived from bone marrow monocytes.

<p>True (A)</p> Signup and view all the answers

What is the primary function of cytotoxic T-cells?

<p>Destroy cells</p> Signup and view all the answers

Cytokines are produced by many cells, most prominently by _____ and _____.

<p>macrophages, T-lymphocytes</p> Signup and view all the answers

What is one of the main activities of the complement system?

<p>Facilitating the effects of antibodies (B)</p> Signup and view all the answers

Memory cells can produce the same antibodies upon future challenges.

<p>True (A)</p> Signup and view all the answers

What happens to the complement proteins upon contact with microorganisms or antigen-antibody complexes?

<p>They become activated and cleave into fragments.</p> Signup and view all the answers

Helper T-cells produce _____ that mediate local reactions between leukocytes.

<p>cytokines</p> Signup and view all the answers

Which cells are predominantly associated with cellular immunity?

<p>Mononuclear leukocytes (A)</p> Signup and view all the answers

Flashcards

Pyogenic Inflammation

An inflammatory response that leads to pus formation.

Granulomatous Inflammation

A type of inflammation with a collection of immune cells, forming granulomas.

Fibrin Precipitation

Process where fibrin forms a sticky layer that helps contain an infection in the peritoneal cavity.

Gas Gangrene

A bacterial infection in anaerobic conditions leading to tissue necrosis from toxin diffusion.

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Dead Tissue and Infections

Dead tissue lacks blood flow, allowing bacteria to thrive and cause infection.

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Cardinal Signs of Acute Inflammation

The five signs are redness, heat, swelling, pain, and loss of function.

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Tissue Response Variation

Different tissues respond uniquely to acute inflammation based on their anatomy and physiology.

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Multinucleated Giant Cells

Cells formed by the fusion of several macrophages, often seen in chronic inflammation.

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Fibroblasts

Cells that develop from stem cells and produce connective tissues including bone and cartilage.

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Chronic Inflammation

A prolonged inflammatory response that can lead to tissue damage and fibrosis.

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Epithelioid Cells

Macrophages that resemble epithelial cells, often found in granulomas during chronic inflammation.

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Neutrophils lifespan

Neutrophils live 24-48 hours in blood, 9 hours outside.

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Bone Marrow Replacement

Neutrophils must be continuously replaced by bone marrow.

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Alpha-1-antitrypsin function

Alpha-1-antitrypsin destroys elastase and prevents lung damage.

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Emphysema cause

Lack of A1A leads to elastase damage, causing emphysema.

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Anti-neutrophilic cytoplasmic antibodies

Antibodies targeting neutrophil cytoplasmic antigens, linked to vasculitis.

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Pus composition

Pus is a fluid containing dead cells, polymorphs, and bacteria.

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Pyogenic bacteria

Bacteria causing pus formation, such as Streptococcus and Staphylococcus.

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Abscess

A localized collection of pus resulting from tissue necrosis.

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Septicemia

Life-threatening condition with actively dividing bacteria in the blood.

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Cytokines

Signaling molecules that mediate communication between cells in immune responses.

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Lymphokines

Cytokines produced by T-helper lymphocytes after sensitization by antibodies.

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Interleukins

A type of cytokine that facilitates interactions between leukocytes.

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Chemokines

A class of cytokines that attract other immune cells to sites of infection.

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Growth Factors

Cytokines that promote growth of specific cell populations.

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Interferons

Cytokines that activate macrophages and fibroblasts, providing antiviral action.

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Tumor Necrosis Factor (TNF)

A cytokine involved in stimulating blood vessel growth and inhibiting tumors.

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Complement Proteins

Proteins that enhance immune response through a cascading activation effect.

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B Lymphocytes

Cells that mature in the bone marrow and can produce antibodies upon antigen presentation.

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T Lymphocytes

Cells that mature in the thymus, with roles in immunity including helper and cytotoxic functions.

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Injurious Agents

Substances perceived as foreign or harmful by the body, leading to inflammation.

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Autoimmune Response

Misguided immune response where the body attacks its own cells as if they were foreign.

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Phagocytosis

Process where cells, like macrophages, engulf and digest harmful particles or pathogens.

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Humoral Immunity

Immune response involving antibodies produced by B-lymphocytes against specific antigens.

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Antibodies

Proteins generated by B-lymphocytes that neutralize specific antigens.

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Ag-Ab Complex

Combination of an antigen and its corresponding antibody, leading to neutralization.

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Complement Activation

Process where antibodies form complexes that trigger further immune responses.

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