25 Questions
During which phase does granulation tissue fill the wound slowly and may overgrow, resulting in 'proud flesh'?
Proliferative phase
Which growth factor is responsible for endothelial proliferation and migration during angiogenesis in tissue repair?
VEGF
What is the primary function of granulation tissue in wound healing?
All of the above
Which of the following is not a cause of inflammation?
Cell proliferation
Which type of tissue has little to no regenerative capability?
Permanent tissue
Which stage of wound healing involves vasodilation, edema, and leukocyte diapedesis?
Inflammation
Which phase of tissue repair involves the reorganization of fibrotic tissue and vasculature?
Remodeling phase
What is the result of site-specific changes in the balance of collagen matrix synthesis versus degradation?
Tissue remodeling
Which type of wound healing results in wound edges being approximated by sutures or other mechanisms?
Healing by first intention
What is the most important cause of delayed healing and prolongs inflammation?
Infection
Which one of these is NOT a cause of inflammation?
Stem cell proliferation
Which type of tissue has the highest regenerative capability?
Labile tissue
During which phase of wound healing does vasodilation, edema, and leukocyte diapedesis occur?
Inflammatory phase
Which step is NOT involved in tissue repair by fibrosis?
Collagen matrix degradation
Which of the following is NOT a component of inflammation?
Thrombus formation
During which phase of wound healing does collagen deposition and wound strengthening occur?
Proliferative phase
What is the primary function of angiogenesis in tissue repair and remodeling?
To provide oxygenation and nutrients to the damaged tissue
What growth factor is responsible for endothelial proliferation and migration during angiogenesis in tissue repair?
VEGF
What can excessive granulation tissue in wound healing lead to?
'Proud flesh'
Which growth factor recruits vascular smooth muscle cells (VSMCs) and stabilizes new blood vessels in tissue repair?
PDGF
What is the main cause of abnormal wound healing in individuals with diabetes?
Poor perfusion
What factors influence tissue remodeling?
Physical stress and genetics
What is the main cause of delayed healing and increased local tissue injury?
Infection
What is the primary effect of glucocorticoids on wound healing?
Reduced inflammation
What is the main cause of wound dehiscence?
Poor suture technique
Study Notes
Wound Healing Phases
- Granulation tissue fills the wound slowly and may overgrow, resulting in 'proud flesh' during the proliferation phase.
- Vasodilation, edema, and leukocyte diapedesis occur during the inflammation phase.
- Collagen deposition and wound strengthening occur during the remodeling phase.
Tissue Repair and Remodeling
- The primary function of granulation tissue is to provide a framework for tissue repair.
- Angiogenesis in tissue repair and remodeling is primarily responsible for neovascularization.
- Vascular endothelial growth factor (VEGF) is responsible for endothelial proliferation and migration during angiogenesis.
- Platelet-derived growth factor (PDGF) recruits vascular smooth muscle cells (VSMCs) and stabilizes new blood vessels in tissue repair.
Factors Influencing Wound Healing
- Excessive granulation tissue in wound healing can lead to proud flesh.
- Diabetes is the main cause of abnormal wound healing.
- Ischemia is the main cause of delayed healing and increased local tissue injury.
- Glucocorticoids inhibit wound healing by reducing collagen synthesis and deposition.
- Tissue remodeling is influenced by factors such as growth factors, mechanical stress, and the balance of collagen synthesis and degradation.
Inflammation
- Inflammation is not caused by ischemia.
- The primary function of inflammation is to protect the body from injury and infection.
- The primary effect of inflammation is to increase blood flow and permeability, leading to edema and leukocyte diapedesis.
Tissue Characteristics
- Cartilage has little to no regenerative capability.
- Skin has the highest regenerative capability.
- Tissue repair by fibrosis does not involve the contraction of fibroblasts.
Wound Healing Outcomes
- Wound dehiscence is often caused by increased tension on the wound.
- Primary wound healing results in wound edges being approximated by sutures or other mechanisms.
- Delayed healing is often caused by prolonged inflammation.
Test your knowledge on inflammation, its causes, steps, and special considerations with this informative quiz. Learn about the different components of inflammation, potential complications, its location, and whether it is acute or chronic. Also, explore the process of tissue repair, regeneration, and fibrosis.
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