204 Theme 2: The Reproductive System, Fetal Development, and Birth Cycle
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A woman attends the infertility clinic with very painful periods for 12 months and failure to conceive after 3 years of trying. Her husband’s semen analysis is normal. A transvaginal pelvic scan shows a right 7cm ovarian cyst with multiple echoes within the cyst.

  • borderline ovarian tumour
  • endometriosis (correct)
  • ovarian cancer
  • pelvic inflammatory disease (PID)
  • Which condition can only be treated by IVF (in vitro fertilisation), using donor eggs rather than the woman’s own eggs, in order to achieve a pregnancy?

  • polycystic ovary syndrome (PCOS)
  • severe oligospermia
  • severe endometriosis
  • premature menopause (correct)
  • Which of the following designations describes the set of symptoms that result from the XXY karyotype?

  • androgen insensitivity syndrome
  • Down's syndrome
  • Klinefelter's syndrome (correct)
  • Turner syndrome
  • In the development of the male genital duct system, which type of cell secretes anti-Müllerian hormone (also known as Müllerian inhibitory substance or MIS)?

    <p>Sertoli</p> Signup and view all the answers

    Which substance, produced by the anterior pituitary gland, results in the maturation of a Graafian follicle from a primary follicle?

    <p>follicle stimulating hormone</p> Signup and view all the answers

    Squamous cell carcinoma of the uterine cervix is caused by infection with human papillomavirus (HPV). What are the HPV types most commonly found in cervical cancer?

    <p>HPV 16 &amp; 18</p> Signup and view all the answers

    Ovulation of the secondary oocyte occurs due to a surge of production of which hormone from the anterior pituitary gland?

    <p>lutenising hormone</p> Signup and view all the answers

    Which hormone causes decreased viscosity of cervical mucus mid-menstrual cycle? Select the single best answer from the list below.

    <p>oestradiol</p> Signup and view all the answers

    A 30-year-old woman at 14 weeks pregnancy with monochorionic twins meets with her obstetrician. From which complication of pregnancy is she at risk due to this type of twin pregnancy?

    <p>twin-twin transfusion</p> Signup and view all the answers

    At birth, closure of which vessel is one of the two main events which occurs in the fetus to ensure separation of the pulmonary and systemic blood flows in the newborn?

    <p>ductus arteriosus</p> Signup and view all the answers

    A 28-year-old primigravida attends the delivery suite at 39 weeks gestation. She started having regular painful contractions eight hours ago. What feature in her examination will confirm that she is in the active first stage of labour?

    <p>cervical dilation of 4cm</p> Signup and view all the answers

    Which structure forms the muscular layer of the uterus?

    <p>myometrium</p> Signup and view all the answers

    A 27-year-old woman presents to the genito-urinary clinic with bleeding after sex and a vaginal discharge. When examined she has an inflamed cervix and a cervical swab is taken. What is the most likely organism present?

    <p>chlamydia</p> Signup and view all the answers

    Which of the following is the most common cause of difficulty to conceive in couples of reproductive age?

    <p>low sperm count</p> Signup and view all the answers

    A 22-year-old woman presents with a 12-month history of painful periods and pain during intercourse. A transvaginal ultrasound is performed as part of her investigations and reveals a 5cm ovarian cyst. What is the most likely histology of her ovarian cyst?

    <p>endometriotic (chocolate) cyst</p> Signup and view all the answers

    A 51-year-old woman is suffering from extreme hot flushes and sweats. She has had no past surgery nor any past medical history. What would be the most appropriate treatment for her menopause symptoms?

    <p>oestrogen only hormone replacement therapy (HRT)</p> Signup and view all the answers

    A lady presents to the Emergency Department with vaginal bleeding and pelvic pain. She is six weeks pregnant. What is a ‘threatened miscarriage’

    <p>Intrauterine pregnancy is visible on the scan (fetal heart beat), cervix is closed. May present with vaginal bleeding.</p> Signup and view all the answers

    A lady presents to the Emergency Department with vaginal bleeding and pelvic pain. She is six weeks pregnant. What is an ‘incomplete miscarriage’.

    <p>Some of the pregnancy tissue has passed and some remains in the uterus</p> Signup and view all the answers

    What is a 'complete miscarriage'?

    <p>No pregnancy tissue remains in the uterus as all of it has been passed out</p> Signup and view all the answers

    A lady presents to the Emergency Department with vaginal bleeding and pelvic pain. She is six weeks pregnant. In which structure do ectopic pregnancies most commonly implant?

    <p>The fallopian tube</p> Signup and view all the answers

    What is NOT a factor that increases a woman’s chance of having an ectopic pregnancy

    <p>Age a</p> Signup and view all the answers

    A woman with recurrent miscarriages (more than three in a row) will be investigated to look for possible causes. What is NOT a possible cause?

    <p>Fallopian tube abnormalities</p> Signup and view all the answers

    What is NOT a factor that increases the chance of conceiving a twin pregnancy?

    <p>Maternal weight</p> Signup and view all the answers

    Explain what is meant by the term ‘chorionicity’?

    <p>number of placentas</p> Signup and view all the answers

    Explain what is meant by the terms ‘amnionicity’?

    <p>number of amniotic sacs</p> Signup and view all the answers

    What is NOT an increased risk in a dichorionic pregnancy for the mother?

    <p>Diabetes</p> Signup and view all the answers

    What is NOT an increased risks in a dichorionic pregnancy for the babies?

    <p>High birth rate</p> Signup and view all the answers

    Twin-twin transfusion syndrome is a rare complication of a MCDA twin pregnancy. Explain what happens in this syndrome and identify the correct or steps

    <ol> <li>Shared placental vessels to blood is passed between the babies. 2) The donor baby gives more blood to the recipient results in a smaller baby and a bigger baby. 3) Shunting. 4) Fetal death of one or both twins</li> </ol> Signup and view all the answers

    Explain the arrangement of the umbilical cord.

    <p>Two arteries carrying deoxygenated blood spiral around 1 vein carrying oxygenated blood to the placenta. They are surrounded by a mucoid substance (Whartons Jelly)</p> Signup and view all the answers

    What is NOT a component and description of the decidua?

    <p>The decidua parietalis lines the embryo that is pushing into the uterine cavity</p> Signup and view all the answers

    Describe the mechanism of action of progestogen-only contraceptive pills.

    <p>Progestogens increase the the viscosity of cervical mucus, thus impeding sperm transport. By negative feedback, progestogens also inhibit the secretion of luteinising hormone (LH), thus suppressing ovulation, but not consistently.</p> Signup and view all the answers

    Identify the duct labelled A, and structures labelled B and C in the diagram below.

    <p>A - Vas Deferens or ductus deferens B - Prostate C - Epididymis</p> Signup and view all the answers

    What organ is innervated by the spermatic plexus and used for the production of sperm and hormone secretion?

    <p>Testes</p> Signup and view all the answers

    Which principal vessel provides blood supply to the muscles of the pelvic floor and perineum in the male?

    <p>Internal Pudendal Artery</p> Signup and view all the answers

    What is the definition of a syndrome?

    <p>Multiple congenital abnormalities co-existing due to a single aetiology – e.g. single chromosomal/gene problem</p> Signup and view all the answers

    Below is a list of the most commonly diagnosed syndromes caused by chromosomal abnormalities. Provide the chromosomal abnormalities that cause the following:

    • Turner syndrome
    • Patau's syndrome
    • Edward's syndrome An example is provided below.

    What is NOT a correct answer?

    <p>Edward's syndrome - T 13</p> Signup and view all the answers

    What is NOT an external feature that you may recognise on a baby born with Down’s syndrome?

    <p>Narrow hand with long fingers</p> Signup and view all the answers

    At what gestation is combined screening for chromosomal abnormalities carried out?

    <p>11 + 2 weeks to 14 + 1 weeks</p> Signup and view all the answers

    What sample is tested in non-invasive prenatal testing?

    <p>Cell free fetal DNA in the maternal blood/harmony, SAFE test</p> Signup and view all the answers

    What is NOT a possible cause (not including male factors) for infertility?

    <p>Weight</p> Signup and view all the answers

    Answer the questions regarding the image below.

    What is this investigation called?

    <p>Hystero-salpingogram (HSG) - X-ray procedure that is used to view the inside of the uterus and fallopian tubes.</p> Signup and view all the answers

    Answer the questions regarding the image below.

    What is NOT an important test which should be organised before this investigation?

    <p>X ray</p> Signup and view all the answers

    What is NOT a type of patient that may benefit from intrauterine insemination before attempting in vitro fertilisation (IVF).

    <p>Heterosexual couples who do not have problems with intercourse</p> Signup and view all the answers

    What is NOT a reason why some women might refuse screening?

    <p>Low risk of miscarriage</p> Signup and view all the answers

    What is NOT a justification for offering screening to a woman who does not want a termination?

    <p>Reduces time to research/prepare for the child’s particular needs.</p> Signup and view all the answers

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