Host - Parasite Interaction

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Questions and Answers

Which disease is caused by the bacterium Mycobacterium leprae?

  • Tuberculosis
  • Leprosy (correct)
  • Cholera
  • Gonorrhea

What does the term 'virulence' refer to in the context of infectious diseases?

  • The rate of transmission from one host to another
  • The ability of a microorganism to remain dormant in a host
  • The speed at which symptoms appear in the infected individual
  • The degree of pathogenicity and extent of damage caused to the host (correct)

Which causative agent is associated with stomach ulcers?

  • Ebola virus
  • Bartonella henselae
  • Helicobacter pylori (correct)
  • Clostridium tetani

Which disease listed originated in 1976 and is classified under infectious diseases caused by viruses?

<p>Ebola (C)</p> Signup and view all the answers

What defines a carrier in the context of infectious diseases?

<p>A host that shows no signs but can transmit the infection (D)</p> Signup and view all the answers

What is a key requirement for an organism to establish an infectious disease?

<p>It must reach the host, overcome defenses, and produce toxins. (D)</p> Signup and view all the answers

Which of the following microbial factors is responsible for evading the immune response?

<p>Antibiotic cleaving (B)</p> Signup and view all the answers

What is the role of hyaluronidase in microbial pathogenesis?

<p>It splits hyaluronic acid in connective tissues. (D)</p> Signup and view all the answers

Which enzyme is NOT mentioned as a microbial factor leading to disease?

<p>Amylase (B)</p> Signup and view all the answers

Which factor can inhibit the processes of chemotaxis and phagocytosis?

<p>Exotoxins (B)</p> Signup and view all the answers

Which of the following is not one of Koch's postulates?

<p>The microorganism must cause disease in healthy hosts. (B)</p> Signup and view all the answers

What defines a primary pathogen?

<p>A microorganism that regularly causes infection and disease in healthy hosts. (A)</p> Signup and view all the answers

Which of the following best describes a parasite?

<p>An organism that lives in or on another organism and benefits at the host's expense. (C)</p> Signup and view all the answers

Which statement about opportunistic pathogens is accurate?

<p>They cause infections only in individuals with weakened defense mechanisms. (D)</p> Signup and view all the answers

What role does the microbiome play in host defenses?

<p>It helps to maintain health and protect against pathogens. (C)</p> Signup and view all the answers

Which of the following statements is TRUE regarding disease transmission?

<p>Microorganisms can be transmitted by vectors and contaminated surfaces. (C)</p> Signup and view all the answers

What does Koch’s second postulate entail?

<p>The microorganism can be isolated in pure culture. (B)</p> Signup and view all the answers

What is the definition of a host in the context of host-parasite interactions?

<p>An organism in or on which a parasite lives. (A)</p> Signup and view all the answers

Which of the following is NOT considered an anatomic barrier in host defenses?

<p>T cells (C)</p> Signup and view all the answers

What role does the microbiome play in host defense against infections?

<p>It helps educate the immune system. (B)</p> Signup and view all the answers

Which of the following is an example of innate defense mechanisms?

<p>Complement activation (D)</p> Signup and view all the answers

Which factor can lead to increased susceptibility to disease?

<p>Prior course of antibiotics (A)</p> Signup and view all the answers

Which component of the microbiome is NOT part of its structure?

<p>Insect cells (A)</p> Signup and view all the answers

What physiological functions do microbes in the microbiome impact?

<p>Metabolic functions and pathogen protection (C)</p> Signup and view all the answers

Which of the following is a consequence of a splenectomy?

<p>Decreased immunity due to loss of filtering blood (C)</p> Signup and view all the answers

Which type of immune response involves the production of antibodies?

<p>B cell-mediated immunity (C)</p> Signup and view all the answers

How does whaling impact the ecosystem involving orcas?

<p>It causes a decline in the sea lion and seal populations, affecting orca food sources. (C)</p> Signup and view all the answers

What is one potential consequence of antibiotic-induced dysbiosis in the gut microbiome?

<p>Increased susceptibility to infections. (B)</p> Signup and view all the answers

Which fish is not primarily affected by commercial fishing and global warming according to the content?

<p>Otters (B)</p> Signup and view all the answers

What is a common effect of dysbiosis on human health?

<p>Compromised immune homeostasis. (B)</p> Signup and view all the answers

Which species compete with nutritious fish like herring and ocean perch, impacting the food chain?

<p>Pollock (A)</p> Signup and view all the answers

Which of the following is an exogenous source of infectious disease transmission?

<p>Inhalation (C)</p> Signup and view all the answers

What is primarily responsible for the transmission of 80% of infectious diseases?

<p>Direct contact (D)</p> Signup and view all the answers

Which type of reservoir is associated with zoonoses?

<p>Animal reservoirs (C)</p> Signup and view all the answers

What is the proper order for removing personal protective equipment (PPE)?

<p>Gloves, eye protection, apron or gown, surgical mask (B)</p> Signup and view all the answers

Which route is associated with fecal-oral transmission?

<p>Oral and mucous membrane contact (A)</p> Signup and view all the answers

Which of the following transmission methods involves a puncture wound?

<p>Percutaneous (C)</p> Signup and view all the answers

Which statement about environmental reservoirs is true?

<p>They consist of soil, water, and plants. (D)</p> Signup and view all the answers

What is the primary concern when removing PPE in a healthcare setting?

<p>Avoiding contamination by following the specific removal sequence (B)</p> Signup and view all the answers

Flashcards

Infection

The invasion and multiplication of microorganisms in or on a host. May or may not cause disease, but can trigger an immune response. Symptoms may be mild or undetectable.

Virulence

The ability of a microorganism to cause disease. This ability varies depending on the host's individual immune system, the amount of the microbe, and how it entered the body.

Carrier

An infected individual who doesn't show symptoms but can still spread the disease.

Anthrax

A disease caused by the bacterium Bacillus anthracis. Symptoms include fever, chills, and skin lesions that can become ulcerated.

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Tuberculosis

A disease caused by the bacterium Mycobacterium tuberculosis. Symptoms include coughing, fever, and weight loss.

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Microbial Factors Leading to Disease

The ability of a microorganism to evade the host's immune defenses, survive antibiotic treatment, attach to host cells, and produce harmful substances.

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Virulence Factors

The ability of a microorganism to produce toxins or other harmful substances that damage the host's tissues.

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Tissue Tropism

A microorganism's preference for a specific type of tissue in the body. For example, the influenza virus targets the respiratory system.

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Excrete Enzymes

Enzymes produced by microorganisms that can break down tissues and promote infection. For example, hyaluronidase breaks down connective tissue, allowing the pathogen to spread.

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Exotoxins

Proteins released by bacteria that can cause various harmful effects on the host, including cell lysis, inflammation, and tissue damage.

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Koch's Postulates

A set of criteria used to establish a causal relationship between a microorganism and a specific disease.

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Parasite

An organism that lives in or on another organism (the host) and benefits by obtaining nutrients at the host's expense.

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Host

Any living organism, such as an animal (including humans) or a plant, that supports a parasite.

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Pathogen

A microorganism capable of causing an infectious disease.

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Primary pathogen

A kind of pathogen that can cause disease in a healthy host.

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Opportunistic pathogen

A microorganism that normally doesn't cause disease in healthy people, but can cause disease in a host with weakened defenses.

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Microbiome

The collection of microorganisms, including bacteria, fungi, and viruses, that live on and in the human body.

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Disease transmission

The way a disease is spread from one person or organism to another.

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Proliferation

A situation where a type of organism dramatically increases in population size, potentially disrupting the balance of an ecosystem.

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Food Web Impact

A chain of events where the decrease in one population causes a ripple effect through the food web, impacting other species.

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Microbiota Dysbiosis

An imbalance or disruption in the composition and function of the microbiome. It can be caused by factors like antibiotics.

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Antibiotic-Induced Microbiota Alterations

A change in the microbiome that can lead to various health problems, including infections, weakened immunity, and metabolic issues.

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Endogenous Source

Infectious diseases can start from within the body, like when natural barriers break down or the immune system weakens.

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Exogenous Source

Infectious diseases can be acquired from external sources like air, water, or contact with animals or contaminated objects.

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Route of Transmission

The way a pathogen travels from one person or animal to another. Examples include direct contact, airborne droplets, or contaminated surfaces.

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Reservoir

A living organism that carries a pathogen and can spread it to others. Humans, animals, or even the environment itself can be reservoirs.

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Anatomic Barriers: First Line of Defense

Anatomic barriers, such as skin, mucus membranes, and stomach acid, act as the first line of defense against pathogens. These barriers prevent pathogens from entering the body.

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Droplet Nuclei

Tiny particles of liquid expelled from the nose or mouth during coughing or sneezing, containing infectious agents.

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Phagocytes: Neutrophils & Macrophages

Neutrophils and macrophages are white blood cells that engulf and destroy pathogens. This is a crucial part of the innate immune system.

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Lysozymes: Natural Antibacterials

Lysozymes, found in saliva and tears, are enzymes that break down bacterial cell walls. They help to prevent infection in the eyes and mouth.

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Zoonosis

A disease that can naturally spread from animals to humans.

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PPE Removal Order

The order for removing personal protective equipment (PPE) to prevent spreading infection. Gloves, eye protection, gown/apron, mask.

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Complement and Opsonins: Immune System Helpers

The complement system is a cascade of proteins that enhance inflammation, attract phagocytes, and directly kill bacteria. Opsonins are molecules that coat pathogens, making them easier to be engulfed by phagocytes.

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Contact Transmission

A disease that can be spread through touch.

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Adaptive Immunity: Targeted Defense

Adaptive immunity is a targeted response to specific pathogens, involving antibodies (proteins that bind to pathogens) and T cells (which kill infected cells). These responses require exposure to the pathogen and are more effective at fighting off subsequent infections.

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Microbiome: Our Inner Ecosystem

The microbiome is the community of microorganisms living in and on our bodies. It plays a key role in protecting us from pathogens, aiding in digestion, and influencing our immune system.

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Host Factors Affecting Immunity

Factors like age, genetics, prior infections, and certain medical treatments can influence the immune system's ability to fight off infections.

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Microbiome: Key to Host Defense

A balanced microbiome is essential for resisting infections. When the microbiome is disrupted, the risk of disease increases.

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Study Notes

Host-Parasite Interaction

  • Host-parasite interactions are a significant factor in disease
  • Koch's postulates are a set of criteria for determining if a particular bacterium causes a specific disease
  • Koch's postulates include:
    • The microorganism must be present in every case of the infectious disease
    • The microorganism can be isolated in pure culture
    • Inoculation of the pure culture into animals produces a similar disease
    • The same species of microorganism must be recovered from the diseased animal
  • Host: an animal (human) or plant on or in which a parasite or commensal organism lives
  • Parasite: an organism that lives in or on an organism of another species and benefits by deriving nutrients at the other's expense
  • Pathogen: a microorganism capable of causing an infectious disease
  • Primary pathogen: microorganism that regularly causes infection and disease when it enters a healthy host
  • Opportunistic pathogen: microorganism that rarely causes disease in healthy humans but may in a host whose defense mechanisms have been compromised or weakened
  • Infectious disease: a disease caused by microorganisms
  • Infections: invasion and multiplication of microorganisms in or on a host
  • Virulence: the degree of pathogenicity and extent to which a microorganism can cause damage to the infected host
  • Carrier: an infectious host that, because of inherited genetic traits, either does not develop symptoms or carries an organism in a latent state (symptoms may develop later, such as Herpes reactivation following stress)
  • Examples of known carriers include Mary Mallon, known as "Typhoid Mary"
  • To establish an infectious disease, an organism must: reach the host, overcome host defenses, invade and proliferate in the host tissues, produce toxins or other virulence factors, and be capable of resisting host defenses
  • Microbial factors leading to disease include evading immune response, antibiotic cleaving, ability to attach, inhibiting chemotaxis and phagocytosis, exotoxins, endotoxins, enterotoxin, tissue tropism, excreting enzymes, hyaluronidase splitting hyaluronic acid, collagenase, hemolysins lysing red blood cells, fibrinolysin, ketatinase, lecithinase, IgA proteases and slime layers / biofilms
  • Host defenses include anatomic barriers such as skin, sweat, lactic acid, free fatty acids, respiratory tract, mucus and ciliated epithelium, Gl tract with stomach acid, mucus, peristalsis, villi and microvilli, and the microbiome throughout the body
  • Host defenses also include innate defenses such as neutrophils and macrophages, the complement system, the adaptive immune response with antibodies, and T cell mediated responses
  • Host factors leading to disease include behaviors, occupation, age/genetics/sex, prior viral infections, splenectomy, diabetes, hematoproliferative disorders, burns, steroid therapy, prior course of antibiotics, and immunosuppressive drugs
  • The microbiome plays a critical role in host defense against microbial infections
  • The human microbiome is made up of bacteria, archaea, viruses and eukaryotic microbes that reside in and on our bodies
  • Microbes impact our physiology by affecting metabolic functions, protecting against pathogens, and educating the immune system
  • The human body is an ecosystem
  • The decline in sea otters is caused by multiple factors: whaling, plankton proliferation, competition with other fish, commercial fishing, and global warming
  • Disease burden has decreased over time for communicable, maternal, neonatal and nutritional diseases
  • Exogenous sources of infectious disease include inhalation, ingestion, direct contact, inoculation, congenital (transplacental, birth canal), fomites, animal contact, and arthropod vectors
  • Routes of transmission include oral and mucous membrane, percutaneous, and respiratory
  • Reservoirs for infectious disease include humans, animals, and the environment (e.g. soil, water, or plants)
  • Droplet spread and droplet nuclei are methods of infection
  • Direct contact is another method of infection

Additional Information

  • 80% of infectious diseases are transmitted by touch
  • Correct PPE removal procedure is essential to prevent disease transmission

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