Podcast
Questions and Answers
Which disease is caused by the bacterium Mycobacterium leprae?
Which disease is caused by the bacterium Mycobacterium leprae?
- Tuberculosis
- Leprosy (correct)
- Cholera
- Gonorrhea
What does the term 'virulence' refer to in the context of infectious diseases?
What does the term 'virulence' refer to in the context of infectious diseases?
- The rate of transmission from one host to another
- The ability of a microorganism to remain dormant in a host
- The speed at which symptoms appear in the infected individual
- The degree of pathogenicity and extent of damage caused to the host (correct)
Which causative agent is associated with stomach ulcers?
Which causative agent is associated with stomach ulcers?
- Ebola virus
- Bartonella henselae
- Helicobacter pylori (correct)
- Clostridium tetani
Which disease listed originated in 1976 and is classified under infectious diseases caused by viruses?
Which disease listed originated in 1976 and is classified under infectious diseases caused by viruses?
What defines a carrier in the context of infectious diseases?
What defines a carrier in the context of infectious diseases?
What is a key requirement for an organism to establish an infectious disease?
What is a key requirement for an organism to establish an infectious disease?
Which of the following microbial factors is responsible for evading the immune response?
Which of the following microbial factors is responsible for evading the immune response?
What is the role of hyaluronidase in microbial pathogenesis?
What is the role of hyaluronidase in microbial pathogenesis?
Which enzyme is NOT mentioned as a microbial factor leading to disease?
Which enzyme is NOT mentioned as a microbial factor leading to disease?
Which factor can inhibit the processes of chemotaxis and phagocytosis?
Which factor can inhibit the processes of chemotaxis and phagocytosis?
Which of the following is not one of Koch's postulates?
Which of the following is not one of Koch's postulates?
What defines a primary pathogen?
What defines a primary pathogen?
Which of the following best describes a parasite?
Which of the following best describes a parasite?
Which statement about opportunistic pathogens is accurate?
Which statement about opportunistic pathogens is accurate?
What role does the microbiome play in host defenses?
What role does the microbiome play in host defenses?
Which of the following statements is TRUE regarding disease transmission?
Which of the following statements is TRUE regarding disease transmission?
What does Koch’s second postulate entail?
What does Koch’s second postulate entail?
What is the definition of a host in the context of host-parasite interactions?
What is the definition of a host in the context of host-parasite interactions?
Which of the following is NOT considered an anatomic barrier in host defenses?
Which of the following is NOT considered an anatomic barrier in host defenses?
What role does the microbiome play in host defense against infections?
What role does the microbiome play in host defense against infections?
Which of the following is an example of innate defense mechanisms?
Which of the following is an example of innate defense mechanisms?
Which factor can lead to increased susceptibility to disease?
Which factor can lead to increased susceptibility to disease?
Which component of the microbiome is NOT part of its structure?
Which component of the microbiome is NOT part of its structure?
What physiological functions do microbes in the microbiome impact?
What physiological functions do microbes in the microbiome impact?
Which of the following is a consequence of a splenectomy?
Which of the following is a consequence of a splenectomy?
Which type of immune response involves the production of antibodies?
Which type of immune response involves the production of antibodies?
How does whaling impact the ecosystem involving orcas?
How does whaling impact the ecosystem involving orcas?
What is one potential consequence of antibiotic-induced dysbiosis in the gut microbiome?
What is one potential consequence of antibiotic-induced dysbiosis in the gut microbiome?
Which fish is not primarily affected by commercial fishing and global warming according to the content?
Which fish is not primarily affected by commercial fishing and global warming according to the content?
What is a common effect of dysbiosis on human health?
What is a common effect of dysbiosis on human health?
Which species compete with nutritious fish like herring and ocean perch, impacting the food chain?
Which species compete with nutritious fish like herring and ocean perch, impacting the food chain?
Which of the following is an exogenous source of infectious disease transmission?
Which of the following is an exogenous source of infectious disease transmission?
What is primarily responsible for the transmission of 80% of infectious diseases?
What is primarily responsible for the transmission of 80% of infectious diseases?
Which type of reservoir is associated with zoonoses?
Which type of reservoir is associated with zoonoses?
What is the proper order for removing personal protective equipment (PPE)?
What is the proper order for removing personal protective equipment (PPE)?
Which route is associated with fecal-oral transmission?
Which route is associated with fecal-oral transmission?
Which of the following transmission methods involves a puncture wound?
Which of the following transmission methods involves a puncture wound?
Which statement about environmental reservoirs is true?
Which statement about environmental reservoirs is true?
What is the primary concern when removing PPE in a healthcare setting?
What is the primary concern when removing PPE in a healthcare setting?
Flashcards
Infection
Infection
The invasion and multiplication of microorganisms in or on a host. May or may not cause disease, but can trigger an immune response. Symptoms may be mild or undetectable.
Virulence
Virulence
The ability of a microorganism to cause disease. This ability varies depending on the host's individual immune system, the amount of the microbe, and how it entered the body.
Carrier
Carrier
An infected individual who doesn't show symptoms but can still spread the disease.
Anthrax
Anthrax
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Tuberculosis
Tuberculosis
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Microbial Factors Leading to Disease
Microbial Factors Leading to Disease
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Virulence Factors
Virulence Factors
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Tissue Tropism
Tissue Tropism
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Excrete Enzymes
Excrete Enzymes
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Exotoxins
Exotoxins
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Koch's Postulates
Koch's Postulates
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Parasite
Parasite
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Host
Host
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Pathogen
Pathogen
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Primary pathogen
Primary pathogen
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Opportunistic pathogen
Opportunistic pathogen
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Microbiome
Microbiome
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Disease transmission
Disease transmission
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Proliferation
Proliferation
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Food Web Impact
Food Web Impact
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Microbiota Dysbiosis
Microbiota Dysbiosis
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Antibiotic-Induced Microbiota Alterations
Antibiotic-Induced Microbiota Alterations
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Endogenous Source
Endogenous Source
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Exogenous Source
Exogenous Source
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Route of Transmission
Route of Transmission
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Reservoir
Reservoir
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Anatomic Barriers: First Line of Defense
Anatomic Barriers: First Line of Defense
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Droplet Nuclei
Droplet Nuclei
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Phagocytes: Neutrophils & Macrophages
Phagocytes: Neutrophils & Macrophages
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Lysozymes: Natural Antibacterials
Lysozymes: Natural Antibacterials
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Zoonosis
Zoonosis
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PPE Removal Order
PPE Removal Order
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Complement and Opsonins: Immune System Helpers
Complement and Opsonins: Immune System Helpers
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Contact Transmission
Contact Transmission
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Adaptive Immunity: Targeted Defense
Adaptive Immunity: Targeted Defense
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Microbiome: Our Inner Ecosystem
Microbiome: Our Inner Ecosystem
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Host Factors Affecting Immunity
Host Factors Affecting Immunity
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Microbiome: Key to Host Defense
Microbiome: Key to Host Defense
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Study Notes
Host-Parasite Interaction
- Host-parasite interactions are a significant factor in disease
- Koch's postulates are a set of criteria for determining if a particular bacterium causes a specific disease
- Koch's postulates include:
- The microorganism must be present in every case of the infectious disease
- The microorganism can be isolated in pure culture
- Inoculation of the pure culture into animals produces a similar disease
- The same species of microorganism must be recovered from the diseased animal
- Host: an animal (human) or plant on or in which a parasite or commensal organism lives
- Parasite: an organism that lives in or on an organism of another species and benefits by deriving nutrients at the other's expense
- Pathogen: a microorganism capable of causing an infectious disease
- Primary pathogen: microorganism that regularly causes infection and disease when it enters a healthy host
- Opportunistic pathogen: microorganism that rarely causes disease in healthy humans but may in a host whose defense mechanisms have been compromised or weakened
- Infectious disease: a disease caused by microorganisms
- Infections: invasion and multiplication of microorganisms in or on a host
- Virulence: the degree of pathogenicity and extent to which a microorganism can cause damage to the infected host
- Carrier: an infectious host that, because of inherited genetic traits, either does not develop symptoms or carries an organism in a latent state (symptoms may develop later, such as Herpes reactivation following stress)
- Examples of known carriers include Mary Mallon, known as "Typhoid Mary"
- To establish an infectious disease, an organism must: reach the host, overcome host defenses, invade and proliferate in the host tissues, produce toxins or other virulence factors, and be capable of resisting host defenses
- Microbial factors leading to disease include evading immune response, antibiotic cleaving, ability to attach, inhibiting chemotaxis and phagocytosis, exotoxins, endotoxins, enterotoxin, tissue tropism, excreting enzymes, hyaluronidase splitting hyaluronic acid, collagenase, hemolysins lysing red blood cells, fibrinolysin, ketatinase, lecithinase, IgA proteases and slime layers / biofilms
- Host defenses include anatomic barriers such as skin, sweat, lactic acid, free fatty acids, respiratory tract, mucus and ciliated epithelium, Gl tract with stomach acid, mucus, peristalsis, villi and microvilli, and the microbiome throughout the body
- Host defenses also include innate defenses such as neutrophils and macrophages, the complement system, the adaptive immune response with antibodies, and T cell mediated responses
- Host factors leading to disease include behaviors, occupation, age/genetics/sex, prior viral infections, splenectomy, diabetes, hematoproliferative disorders, burns, steroid therapy, prior course of antibiotics, and immunosuppressive drugs
- The microbiome plays a critical role in host defense against microbial infections
- The human microbiome is made up of bacteria, archaea, viruses and eukaryotic microbes that reside in and on our bodies
- Microbes impact our physiology by affecting metabolic functions, protecting against pathogens, and educating the immune system
- The human body is an ecosystem
- The decline in sea otters is caused by multiple factors: whaling, plankton proliferation, competition with other fish, commercial fishing, and global warming
- Disease burden has decreased over time for communicable, maternal, neonatal and nutritional diseases
- Exogenous sources of infectious disease include inhalation, ingestion, direct contact, inoculation, congenital (transplacental, birth canal), fomites, animal contact, and arthropod vectors
- Routes of transmission include oral and mucous membrane, percutaneous, and respiratory
- Reservoirs for infectious disease include humans, animals, and the environment (e.g. soil, water, or plants)
- Droplet spread and droplet nuclei are methods of infection
- Direct contact is another method of infection
Additional Information
- 80% of infectious diseases are transmitted by touch
- Correct PPE removal procedure is essential to prevent disease transmission
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