Infectious Disease Case Studies

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Leishmania donovani

A protozoan parasite that is transmitted by sandflies. It is the causative agent of visceral leishmaniasis (kala-azar), a potentially fatal disease.

Crimean-Congo hemorrhagic fever

A viral hemorrhagic fever that is transmitted by ticks. It is endemic to parts of Africa, Asia, and the Middle East.

Yellow Fever

A viral hemorrhagic fever that is transmitted by mosquitoes. The virus infects the liver and can cause jaundice. It is endemic to Africa and South America.

Dengue Fever

A viral hemorrhagic disease that is transmitted by mosquitoes. It is endemic to tropical regions of the world.

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Ebola Virus Disease

A viral hemorrhagic fever that is transmitted through contact with infected animals, especially bats. It is endemic to Africa and is often fatal.

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Hantavirus Pulmonary Syndrome

A viral hemorrhagic fever that is transmitted through contact with infected rodents, especially mice.

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Giardia lamblia

A protozoan parasite that is found in the intestines of humans and other animals. It is an important cause of diarrhea, particularly in children.

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Entamoeba histolytica

A protozoan parasite that is found in the intestines of humans. It is the causative agent of amoebic dysentery, a severe form of diarrhea.

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Plasmodium spp.

A parasite that causes malaria. It is transmitted by mosquitos. There are several species of Plasmodium, each with different characteristics and disease severity.

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Rocky Mountain Spotted Fever

A bacterial infection that is transmitted by ticks. The bacteria infect the blood vessels and can cause a rash, fever, and headache.

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Endemic Typhus

A bacterial infection that is transmitted by fleas. The bacteria infect the lymphatic system and can cause a rash, fever, and headache.

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Epidemic Typhus

A bacterial infection that is transmitted by lice. The bacteria infect the blood vessels and can cause a rash, fever, and headache.

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Scrub Typhus

A bacterial infection that is transmitted by mites. The bacteria infect the blood vessels and can cause a rash, fever, and headache. It is endemic to Southeast Asia.

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Q Fever

A bacterial infection that is transmitted by a variety of animals. It is often associated with livestock, especially cattle. The bacteria can cause a range of symptoms, including fever, headache, and muscle aches.

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Leptospirosis

A bacterial infection that is transmitted by rodents, especially rats. It is endemic to parts of Africa and Asia. The bacteria can cause a range of symptoms, including fever, headache, and muscle aches.

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Visceral Leishmaniasis

A parasitic infection that commonly affects the liver and spleen. It is caused by a protozoan parasite that is transmitted by sandflies.

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Cutaneous Leishmaniasis

A parasitic infection that commonly affects the skin. It is caused by a protozoan parasite that is transmitted by sandflies.

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African Trypanosomiasis

A parasitic infection that is transmitted by tsetse flies, which are found in parts of Africa. It is a potentially fatal disease that can affect the brain and spinal cord.

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Ascariasis

A parasitic infection that is caused by a worm that lives in the small intestine of humans. It is often asymptomatic but can cause abdominal pain, diarrhea, and weight loss.

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Enterobiasis

A parasitic infection that is caused by a worm that lives in the intestines of humans. It is often asymptomatic, but can cause itching around the anus, particularly at night. It's also known as 'pinworm'.

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Opisthorchiasis

A parasitic infection that commonly affects the liver, bile ducts, and lungs. It is caused by a worm that is transmitted by eating raw or undercooked freshwater fish. Also known as 'liver fluke'.

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Hookworm Infection

A parasitic infection that is caused by a worm that lives in the small intestine of humans. It is often asymptomatic but can cause abdominal pain, diarrhea, and weight loss.

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Trichuriasis

A parasitic infection that is caused by a worm that lives in the intestines of humans. It is often asymptomatic but can cause abdominal pain, diarrhea, and weight loss. It is also known as 'whipworm'.

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Taeniasis

A parasitic infection that is caused by a worm that lives in the intestines of humans. It is often asymptomatic but can cause abdominal pain, diarrhea, and weight loss. It is also known as 'tapeworm'.

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Echinococcosis

A parasitic infection that is caused by the worm Echinococcus granulosus. The worm's larvae form cysts in the liver, lungs, and brain. They cause a range of symptoms, including abdominal pain, coughing, and seizures.

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Schistosomiasis

A parasitic infection that is caused by a worm that lives in the blood vessels of humans. It is transmitted by snails. It can cause a range of symptoms, including fever, abdominal pain, and bloody diarrhea.

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Trichinosis

A parasitic infection that is caused by a worm that lives in the muscles of humans. It is transmitted by eating raw or undercooked pork. It can cause muscle pain, fever, and swelling.

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Filariasis

A parasitic infection that is caused by a worm that lives in the lymphatic system of humans. It is transmitted by mosquitoes. It can cause a range of symptoms, including swelling of the limbs, genitals, and breasts. Also known as 'elephantiasis'.

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Onchocerciasis

A parasitic infection that is caused by a worm that lives in the subcutaneous tissues of humans. It is transmitted by blackflies. It can cause a range of symptoms, including itching, skin nodules, and blindness. Also known as 'river blindness'.

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Dracunculiasis

A parasitic infection that is caused by a worm that lives in the subcutaneous tissues of humans. It is transmitted by drinking contaminated water. It can cause a range of symptoms, including pain, swelling, and blisters. Also known as 'Guinea worm disease'.

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Recrudescence

Occurs when a patient experiences a return of symptoms after an initial period of improvement. It is often seen in people infected with Malaria.

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Study Notes

Case Studies

  • Case 185 (â„–=200097): A 40-year-old man with HIV infection presented with fever, loss of appetite, weight loss, enlarged spleen (7cm below the left costal margin), and liver (6cm below the right costal margin).  Complete blood count showed pancytopenia and spleen aspiration identified Leishmania Donovan bodies. Indicates Leishmaniasis.

  • Case 184 (â„–=200096): A 35-year-old patient presented with symptoms including fever, vomiting, abdominal pain, back pain, pale face, and nosebleeds.  Diagnosed with hemorrhagic fever with renal syndrome (HFRS). The case specifies the oliguric phase.

  • Case 183(â„–=200095): Patient with HFRS. Laboratory results demonstrate moderate leukocytosis, elevated erythrocyte sedimentation rate (ESR), elevated protein in the urine, and increased number of white blood cells and red blood cells in urine sample. Suggests the oliguric period of the disease in HFRS.

  • Case 182 (â„–=200094): A 36-year-old patient with HFRS experiencing deterioration to acute kidney injury.  Symptoms include headache, back pain, anorexia, pale skin, dry mouth, swelling, nosebleeding, vomiting, hemorrhagic rash, elevated blood pressure, bradycardia, and anuria.  Needs protein and bilirubin levels.

Other Information

  • Case 181 (â„–=200093): A 37-year-old patient presented with fever, headache, nasal bleeding, and skin rash. History indicates tick bite. Diagnosed with suspected Crimean-Congo hemorrhagic fever and needs a laboratory test to confirm.

  • Case 180 (â„–=200092): A 27-year-old patient with HFRS experiencing complications. Symptoms include headache, back pain, anorexia, pale skin, dry mouth, swelling, nosebleeding, vomiting, hemorrhagic rash and anuria. Acute kidney injury is a potential complication.

  • Case 179 (â„–=200091): A 37-year-old presented with fever, nasal bleeding and skin rash. Exposure to ticks and history of livestock breeding risk. Diagnosed with possible tick-borne encephalitis or Crimean-Congo Hemorrhagic Fever

  • Case 178 (â„–=200090): A 47-year-old experiencing high fever, headache, insomnia, skin rashes, jaundice, vomiting and abdominal pain. History indicates eating raw fish two weeks prior. Laboratory results show eosinophilia, leukocytosis, increased conjugated bilirubin, ALT, AST, and alkaline phosphatase. Ultrasound reveals hepatitis signs.. Possible helminthiasis (opisthorciasis) is suspected

  • Case 177, 175, and 174 (â„–=200089, 200087, and 200086): These cases share a common theme of patients presenting with fever, cough, chest pain, headache, and rash. All diagnoses involve allergic pneumonitis, and are caused by helminthic infections.

  • Case 176 (â„–=200088): A 47-year-old with fever, headache, jaundice, vomiting, and abdominal pain. History indicates eating raw fish. Symptoms include jaundice and hepatomegaly, elevated eosinophilia, and liver function test abnormalities. Diagnosis involves possible helminthic (opisthorchiasis) infection

  • Many other cases involve a variety of ailments and suspected infections, including helminth infections, malaria, and viral infections. Additional cases involve complications that affect the kidney, liver, or other organs, all of which need specific diagnoses and further investigation.

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