Industrial Pharmacy: Compressibility Measurement in Solid Dosage Forms

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Bulk density is a characteristic of a volume of divided material such as powders, grains, and ______.

granules

The bulk density of a powder is determined by measuring the volume of a known mass of powder sample that may have been passed through a sieve into a graduated ______.

cylinder

Compressibility can be determined by measuring bulk volume (Bulk density) and tapped volume (tapped ______).

density

The tapped density is an increased bulk density attained after mechanically tapping a container containing the powder ______.

sample

This is of particular relevance during powder mixing, filling of capsules with powders or granules, and filling of dies during ______ operation.

tableting

After observing the initial powder volume or mass, the measuring cylinder or vessel is mechanically tapped, and volume or mass readings are taken until little further volume or mass change is observed. The mechanical tapping is achieved by raising the cylinder or vessel and allowing it to drop. __________ calculation can be calculated by the following equation.

Tap density

__________ can be calculated by the following equation: carr index calculations. Compressibility index values.

Carr index

The Hausner ratio is defined as the ratio of a powder’s tapped bulk density to its poured (loose) bulk density. This ratio can be applied to provide an index of the flow character of a powder. The rationale is that more cohesive powders have greater surface attractive forces that help them overcome gravity, so that particles can support themselves around void spaces. The Hausner ratio This creates greater voids within the bulk when first poured producing a greater poured volume (or lower poured bulk density). The action of tapping adds additional force that overcomes these cohesive attractions and causes particles to fall into voids space, thus reducing the powder volume or increasing its bulk density. The Hausner ratio __________

values

The mechanical tapping is achieved by raising the cylinder or vessel and allowing it to drop. Tap density calculation. __________ index or Carr´s index can be calculated by the following equation.

Compressibility

The Hausner ratio is defined as the ratio of a powder’s tapped bulk density to its poured (loose) bulk density. This ratio can be applied to provide an index of the flow character of a powder. The rationale is that more cohesive powders have greater surface attractive forces that help them overcome gravity, so that particles can support themselves around void spaces. The Hausner ratio This creates greater voids within the bulk when first poured producing a greater poured volume (or lower poured bulk density). The action of tapping adds additional force that overcomes these cohesive attractions and causes particles to fall into voids space, thus reducing the powder volume or increasing its bulk density. The Hausner ratio __________

The

Learn about the importance of compressibility measurement in the production of solid dosage forms such as powders, tablets, and capsules. Explore how bulk volume and tapped volume are measured to determine compressibility.

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