Indomethacin

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Questions and Answers

Which term describes a drug that selectively relieves pain by acting in the central nervous system (CNS) or on the peripheral pain mechanism, without significantly altering consciousness?

  • NSAID
  • Pharmacokinetics
  • Inflammation
  • Analgesic (correct)

What is the most common type of pain experienced by adults?

  • Toothache (correct)
  • Chronic pain
  • Orofacial pain
  • Acute pain

Which term describes pain that extends beyond 3 or 6 months beyond onset or beyond the expected period of healing?

  • Acute pain
  • Inflammation
  • Pharmacodynamics
  • Chronic pain (correct)

Which of the following is a potential use of ibuprofen according to the text?

<p>All of the above (D)</p> Signup and view all the answers

What is the recommended dose of ibuprofen according to the text?

<p>400-600 mg three times daily (C)</p> Signup and view all the answers

Which medication has greater potency against COX-2 compared to indomethacin according to the text?

<p>Diclofenac (B)</p> Signup and view all the answers

Which of the following is a contraindication for the use of salicylates in children with fever associated with viral infection?

<p>Chickenpox (A)</p> Signup and view all the answers

What is the maximum total daily dose of salicylates for children?

<p>3.6 g (B)</p> Signup and view all the answers

Which condition is aspirin commonly used to treat?

<p>Headache (A)</p> Signup and view all the answers

What is the pregnancy category of aspirin according to FDA?

<p>Category C (C)</p> Signup and view all the answers

Which of the following is a side effect of salicylates at anti-inflammatory doses?

<p>Dizziness and tinnitus (C)</p> Signup and view all the answers

What is the mechanism of action of aspirin?

<p>It irreversibly acetylates cyclooxygenase (D)</p> Signup and view all the answers

Which of the following is a potential complication of traditional NSAID use?

<p>Renal failure (B)</p> Signup and view all the answers

What is the recommended antipyretic dose of salicylate for adults?

<p>325 mg (D)</p> Signup and view all the answers

Which of the following NSAIDs is contraindicated in pregnant women and children?

<p>Ketorolac (A)</p> Signup and view all the answers

What is the usual oral dose of Ketorolac?

<p>15-30mg (A)</p> Signup and view all the answers

Which NSAID has been rated superior to aspirin and equivalent to ibuprofen in dental pain relief?

<p>Ketorolac (B)</p> Signup and view all the answers

Which NSAID is equivalent to 4g of aspirin in anti-inflammatory effect when taken in a dose of 2.4g daily?

<p>Ibuprofen (D)</p> Signup and view all the answers

Which enzyme is inhibited by NSAIDs to inhibit prostaglandin synthesis?

<p>Cyclooxygenase-2 (COX-2) (B)</p> Signup and view all the answers

Which of the following is NOT a potential side effect of NSAIDs?

<p>Closure of ductus arteriosus (B)</p> Signup and view all the answers

Which class of drugs irreversibly inactivates both COX-1 and COX-2?

<p>Salicylates (C)</p> Signup and view all the answers

What is the main mechanism of action for the analgesic effect of NSAIDs?

<p>Inhibition of prostaglandin production (B)</p> Signup and view all the answers

Which of the following is the definition of neuropathic pain according to the IASP Task Force?

<p>Pain caused by a primary lesion or dysfunction in the nervous system (D)</p> Signup and view all the answers

Which of the following is NOT a cause of nociceptive pain?

<p>Peripheral nociceptor activation (C)</p> Signup and view all the answers

Which of the following is involved in the analgesia system that can block pain signals at the initial entry point to the spinal cord?

<p>Beta-endorphin (A)</p> Signup and view all the answers

Which of the following is NOT a characteristic of NSAIDs?

<p>They raise pain threshold in the CNS (D)</p> Signup and view all the answers

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