Indomethacin
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Questions and Answers

Which term describes a drug that selectively relieves pain by acting in the central nervous system (CNS) or on the peripheral pain mechanism, without significantly altering consciousness?

  • NSAID
  • Pharmacokinetics
  • Inflammation
  • Analgesic (correct)
  • What is the most common type of pain experienced by adults?

  • Toothache (correct)
  • Chronic pain
  • Orofacial pain
  • Acute pain
  • Which term describes pain that extends beyond 3 or 6 months beyond onset or beyond the expected period of healing?

  • Acute pain
  • Inflammation
  • Pharmacodynamics
  • Chronic pain (correct)
  • Which of the following is a potential use of ibuprofen according to the text?

    <p>All of the above</p> Signup and view all the answers

    What is the recommended dose of ibuprofen according to the text?

    <p>400-600 mg three times daily</p> Signup and view all the answers

    Which medication has greater potency against COX-2 compared to indomethacin according to the text?

    <p>Diclofenac</p> Signup and view all the answers

    Which of the following is a contraindication for the use of salicylates in children with fever associated with viral infection?

    <p>Chickenpox</p> Signup and view all the answers

    What is the maximum total daily dose of salicylates for children?

    <p>3.6 g</p> Signup and view all the answers

    Which condition is aspirin commonly used to treat?

    <p>Headache</p> Signup and view all the answers

    What is the pregnancy category of aspirin according to FDA?

    <p>Category C</p> Signup and view all the answers

    Which of the following is a side effect of salicylates at anti-inflammatory doses?

    <p>Dizziness and tinnitus</p> Signup and view all the answers

    What is the mechanism of action of aspirin?

    <p>It irreversibly acetylates cyclooxygenase</p> Signup and view all the answers

    Which of the following is a potential complication of traditional NSAID use?

    <p>Renal failure</p> Signup and view all the answers

    What is the recommended antipyretic dose of salicylate for adults?

    <p>325 mg</p> Signup and view all the answers

    Which of the following NSAIDs is contraindicated in pregnant women and children?

    <p>Ketorolac</p> Signup and view all the answers

    What is the usual oral dose of Ketorolac?

    <p>15-30mg</p> Signup and view all the answers

    Which NSAID has been rated superior to aspirin and equivalent to ibuprofen in dental pain relief?

    <p>Ketorolac</p> Signup and view all the answers

    Which NSAID is equivalent to 4g of aspirin in anti-inflammatory effect when taken in a dose of 2.4g daily?

    <p>Ibuprofen</p> Signup and view all the answers

    Which enzyme is inhibited by NSAIDs to inhibit prostaglandin synthesis?

    <p>Cyclooxygenase-2 (COX-2)</p> Signup and view all the answers

    Which of the following is NOT a potential side effect of NSAIDs?

    <p>Closure of ductus arteriosus</p> Signup and view all the answers

    Which class of drugs irreversibly inactivates both COX-1 and COX-2?

    <p>Salicylates</p> Signup and view all the answers

    What is the main mechanism of action for the analgesic effect of NSAIDs?

    <p>Inhibition of prostaglandin production</p> Signup and view all the answers

    Which of the following is the definition of neuropathic pain according to the IASP Task Force?

    <p>Pain caused by a primary lesion or dysfunction in the nervous system</p> Signup and view all the answers

    Which of the following is NOT a cause of nociceptive pain?

    <p>Peripheral nociceptor activation</p> Signup and view all the answers

    Which of the following is involved in the analgesia system that can block pain signals at the initial entry point to the spinal cord?

    <p>Beta-endorphin</p> Signup and view all the answers

    Which of the following is NOT a characteristic of NSAIDs?

    <p>They raise pain threshold in the CNS</p> Signup and view all the answers

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