Podcast
Questions and Answers
What is the primary mechanism of analgesia of paracetamol?
What is the primary mechanism of analgesia of paracetamol?
- Activation of descending serotonergic pathways (correct)
- Stimulation of cannabinoid receptors
- Inhibition of COX-2 in peripheral tissues
- Inhibition of COX-1 in the CNS
What is a common side effect of paracetamol?
What is a common side effect of paracetamol?
- Bleeding disorders
- Reye's syndrome
- Skin rash (correct)
- Gastric ulcer
What is the maximum daily dose of paracetamol?
What is the maximum daily dose of paracetamol?
- 3g
- 5g
- 4g (correct)
- 2g
Why is paracetamol safe in patients with bleeding disorders?
Why is paracetamol safe in patients with bleeding disorders?
What is an advantage of paracetamol over other NSAIDs?
What is an advantage of paracetamol over other NSAIDs?
What is the effect of aspirin on labour?
What is the effect of aspirin on labour?
Why are NSAIDs avoided in late pregnancy?
Why are NSAIDs avoided in late pregnancy?
What is the analgesic action of selective COX-2 inhibitors?
What is the analgesic action of selective COX-2 inhibitors?
What is a side effect of selective COX-2 inhibitors?
What is a side effect of selective COX-2 inhibitors?
Why are selective COX-2 inhibitors preferred for elderly patients with osteoarthritis?
Why are selective COX-2 inhibitors preferred for elderly patients with osteoarthritis?
Why are selective COX-2 inhibitors contraindicated in patients with cardiovascular disease?
Why are selective COX-2 inhibitors contraindicated in patients with cardiovascular disease?
What is the primary mechanism by which paracetamol is metabolized in the liver?
What is the primary mechanism by which paracetamol is metabolized in the liver?
What is the highly reactive intermediate formed during paracetamol metabolism?
What is the highly reactive intermediate formed during paracetamol metabolism?
What is the consequence of paracetamol poisoning in the liver?
What is the consequence of paracetamol poisoning in the liver?
Why is paracetamol not effective at the site of inflammation?
Why is paracetamol not effective at the site of inflammation?
What is the typical dose of paracetamol that can lead to poisoning?
What is the typical dose of paracetamol that can lead to poisoning?
What is the consequence of paracetamol poisoning in the kidneys?
What is the consequence of paracetamol poisoning in the kidneys?
What is Indomethacin contraindicated in?
What is Indomethacin contraindicated in?
What is the route of administration for Indomethacin?
What is the route of administration for Indomethacin?
What is Ketorolac used for?
What is Ketorolac used for?
What is a unique characteristic of Piroxicam and Tenoxicam?
What is a unique characteristic of Piroxicam and Tenoxicam?
What is the mechanism of action of Mefenamic acid?
What is the mechanism of action of Mefenamic acid?
What is Mefenamic acid used to treat in children?
What is Mefenamic acid used to treat in children?
What happens when the amount of paracetamol metabolite exceeds the available glutathione?
What happens when the amount of paracetamol metabolite exceeds the available glutathione?
Why is it important to start treatment of paracetamol poisoning early?
Why is it important to start treatment of paracetamol poisoning early?
What is the role of N-acetyl cysteine and oral methionine in treating paracetamol poisoning?
What is the role of N-acetyl cysteine and oral methionine in treating paracetamol poisoning?
What group is present in glutathione, N-acetyl cysteine, and oral methionine?
What group is present in glutathione, N-acetyl cysteine, and oral methionine?
Who are more susceptible to paracetamol poisoning?
Who are more susceptible to paracetamol poisoning?
