29 Questions
What are the two major alternatives to in vivo animal testing?
In vitro cell culture techniques and computer simulation
What does the term 'in silico' mean?
Within a computer simulation
What is an example of an 'in silico' model mentioned in the text?
All of the above
What is the purpose of the graph shown in the text?
To show the number of animal experiments in implant dentistry over time
What is the significance of the 3Rs mentioned in the text?
They are now widely embedded in legislation and regulations on the use of animals in scientific procedures
What is a logical extension of controlled in vitro experimentation?
In silico computer modeling
What is the main objective of in vivo studies?
To study biological processes within a living organism
What advantage of in vivo studies is mentioned in the text?
Can address the complexity of organ systems
What is a disadvantage of animal studies mentioned in the text?
Involve considerable physiological differences between humans and animals
What does 'in vitro' mean in Latin?
In glass
Which statement accurately describes the main disadvantages of animal tests?
They involve significant ethical concerns and oversight
What term is used in Latin for 'within the living'?
In vivo
What is essential for implant development in implantology before conducting an in vivo test?
In vitro analysis
What are some drawbacks of in vivo studies according to the text?
Time-consuming
What concept is used to redefine animal usage in research?
3Rs concept
For testing the biocompatibility of materials for bone tissue regeneration, what kind of test would you choose?
Implantation tests
What should be considered before conducting an in vivo test in relation to animal usage?
Avoid using animals entirely
What is the primary objective of in vivo studies according to the text?
Monitor biological responses
What is a key limitation of using animal models in research, as mentioned in the text?
They do not interact with the body material.
What is the purpose of in vivo tests for biocompatibility?
To assess how materials interact with the body.
What dynamic interactions occur at the interface between a material and the body?
Interactions altering the material or the body
What is a common feature of animal tests for biocompatibility?
They usually involve mammals like mice, rats, or guinea pigs.
Why is it necessary to validate results from animal studies with human studies?
To confirm that findings are applicable to humans.
What is one of the four levels of testing mentioned in ISO 7405 for evaluating new dental materials?
Initial cytotoxicity and secondary tissue screening tests
Why might a dental material manufacturer choose one cytotoxicity test over another according to ISO 7405 guidelines?
Based on intended use of the material
What is the significance of following strict guidelines and humane animal use ethics in in vivo testing as per the text?
It ensures data collection is accurate
According to ISO 7405 and ISO 10993, what should always be considered when evaluating test results for dental materials?
Manufacturers' stated use for the material
What are three ethical concerns raised when animal research is not conducted with high standards?
The misuse of animals, The waste of resources, The misuse of data
What is the ultimate goal of developing approved treatments for humans as mentioned in the text?
To improve quality of life
Explore the importance and advantages of in vivo studies for investigating biological processes, treatment efficacy, and mechanisms within living organisms. Learn about the benefits of using complex models to evaluate drug candidates and address ethical concerns regarding the use of animals in laboratory research.
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