In Vivo Studies in Biological Research

Play an AI-generated podcast conversation about this lesson

What are the two major alternatives to in vivo animal testing?

In vitro cell culture techniques, in vivo animal testing, and in silico computer simulation

In silico computer simulation and in vivo animal testing

In vitro cell culture techniques and computer simulation (correct)

In vitro cell culture techniques and in vivo animal testing

What does the term 'in silico' mean?

Within a computer simulation (correct)

Within a silicon chip

Within a cell culture

Within an animal model

What is an example of an 'in silico' model mentioned in the text?

Computer-aided molecular drug design

Quantitative structure activity relationships (QSAR)

Computer assisted learning (CAL)

All of the above (correct)

What is the purpose of the graph shown in the text?

To show the number of animal experiments in implant dentistry over time Signup and view all the answers

What is the significance of the 3Rs mentioned in the text?

They are now widely embedded in legislation and regulations on the use of animals in scientific procedures Signup and view all the answers

What is a logical extension of controlled in vitro experimentation?

In silico computer modeling Signup and view all the answers

What is the main objective of in vivo studies?

To study biological processes within a living organism Signup and view all the answers

What advantage of in vivo studies is mentioned in the text?

Can address the complexity of organ systems Signup and view all the answers

What is a disadvantage of animal studies mentioned in the text?

Involve considerable physiological differences between humans and animals Signup and view all the answers

What does 'in vitro' mean in Latin?

In glass Signup and view all the answers

Which statement accurately describes the main disadvantages of animal tests?

They involve significant ethical concerns and oversight Signup and view all the answers

What term is used in Latin for 'within the living'?

In vivo Signup and view all the answers

What is essential for implant development in implantology before conducting an in vivo test?

In vitro analysis Signup and view all the answers

What are some drawbacks of in vivo studies according to the text?

Time-consuming Signup and view all the answers

What concept is used to redefine animal usage in research?

3Rs concept Signup and view all the answers

For testing the biocompatibility of materials for bone tissue regeneration, what kind of test would you choose?

Implantation tests Signup and view all the answers

What should be considered before conducting an in vivo test in relation to animal usage?

Avoid using animals entirely Signup and view all the answers

What is the primary objective of in vivo studies according to the text?

Monitor biological responses Signup and view all the answers

What is a key limitation of using animal models in research, as mentioned in the text?

They do not interact with the body material. Signup and view all the answers

What is the purpose of in vivo tests for biocompatibility?

To assess how materials interact with the body. Signup and view all the answers

What dynamic interactions occur at the interface between a material and the body?

Interactions altering the material or the body Signup and view all the answers

What is a common feature of animal tests for biocompatibility?

They usually involve mammals like mice, rats, or guinea pigs. Signup and view all the answers

Why is it necessary to validate results from animal studies with human studies?

To confirm that findings are applicable to humans. Signup and view all the answers

What is one of the four levels of testing mentioned in ISO 7405 for evaluating new dental materials?

Initial cytotoxicity and secondary tissue screening tests Signup and view all the answers

Why might a dental material manufacturer choose one cytotoxicity test over another according to ISO 7405 guidelines?

Based on intended use of the material Signup and view all the answers

What is the significance of following strict guidelines and humane animal use ethics in in vivo testing as per the text?

It ensures data collection is accurate Signup and view all the answers

According to ISO 7405 and ISO 10993, what should always be considered when evaluating test results for dental materials?

Manufacturers' stated use for the material Signup and view all the answers

What are three ethical concerns raised when animal research is not conducted with high standards?

The misuse of animals, The waste of resources, The misuse of data Signup and view all the answers

What is the ultimate goal of developing approved treatments for humans as mentioned in the text?

To improve quality of life Signup and view all the answers