10 Questions
How can mutations inside the coding sequence impact gene expression?
By resulting in structurally abnormal proteins
What can mutations in regulatory elements alter?
The abundance of the mRNA
Where do most random breakpoints lie?
In intergenic DNA
What is necessary to form a biologically active protein?
Transcription, mRNA processing, and translation
What can mutations at the transcriptional level induce?
Changes in regulatory sequences
What can mutations that do not result in amino acid substitution affect?
Transcription, RNA processing, translation, or protein stability
Where do most random breakpoints lie?
In intergenic DNA or in introns
What is necessary to form a biologically active protein?
Transcription from gene to mRNA and then translation into polypeptide
How can mutations inside the coding sequence impact gene expression?
By impacting gene expression at the transcriptional level
What can mutations in regulatory elements alter?
The abundance (expression level) of the mRNA or the time or cell type in which the gene is expressed
Explore the impacts of mutations on different stages of gene expression, from transcription to translation, and the formation of biologically active proteins. Dive into the molecular bases of human genetic diseases with insights from Ayman I Elkady, Prof. of Molecular Biology.
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