Impact of Combined Oral Contraceptives on Cancer Risk

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Questions and Answers

Which class of progestins do norethindrone and norethindrone acetate belong to?

  • Estranes (correct)
  • Gonanes
  • Dienogest
  • Antiandrogenic progestins

Which progestin in the estranes category is mentioned to have more estrogenic activity compared to other progestins in the same class?

  • Ethynodiol diacetate (correct)
  • Norgestrel
  • Norethindrone
  • Levonorgestrel

What is the class of progestins that include norgestrel and levonorgestrel?

  • Estranes
  • Antiandrogenic progestins
  • Dienogest
  • Gonanes (correct)

Drospirenone is related to which other compound mentioned above?

<p>Spironolactone (D)</p> Signup and view all the answers

Which compound derived from drospirenone is mentioned as having antiandrogenic activity?

<p>Cyproterone acetate (C)</p> Signup and view all the answers

In monophasic COCs, drospirenone is estimated to have an antiandrogenic activity equivalent to how much spironolactone?

<p>25 mg (D)</p> Signup and view all the answers

Which type of cancer is NOT associated with reduced risk with COC use?

<p>Cervical cancer (C)</p> Signup and view all the answers

What is the likely risk factor for chlamydia infections in women using COCs?

<p>Sexual exposure (D)</p> Signup and view all the answers

Which of the following STIs is NOT associated with COC use?

<p>Human immunodeficiency virus (A)</p> Signup and view all the answers

What is the impact of COC use on pelvic inflammatory disease (PID)?

<p>No correlation (D)</p> Signup and view all the answers

Which of the following is a potential benefit of COC use?

<p>Reduced risk of ovarian cancer (D)</p> Signup and view all the answers

What is the correlation between COC use and bacterial vaginosis?

<p>Variable results (A)</p> Signup and view all the answers

Which generation of progestins used in combined oral contraceptive pills includes Norethindrone acetate?

<p>First generation (B)</p> Signup and view all the answers

Which progestin, listed in the text, has a distinct classification from others?

<p>Cyproterone acetate (C)</p> Signup and view all the answers

Which one of these progestins is NOT classified under the second generation?

<p>Norgestimate (A)</p> Signup and view all the answers

Which progestin belongs to the first generation but NOT to the second generation?

<p>Norethynodrel (C)</p> Signup and view all the answers

According to the information, which generation of progestins includes Gestodene?

<p>Third generation (D)</p> Signup and view all the answers

Under what circumstances can a provider be reasonably certain that a patient is not pregnant?

<p>If the patient has no symptoms or signs of pregnancy and meets any of the specified criteria (A)</p> Signup and view all the answers

What is the typical timeframe for a patient to return for the contraceptive implant after receiving a single injection of DMPA?

<p>Within 5 days of the first day of her next menstrual period (D)</p> Signup and view all the answers

What is the primary reason for offering a single injection of DMPA before the contraceptive implant?

<p>To avoid the need for implant removal if the repeat urine pregnancy test is positive (B)</p> Signup and view all the answers

According to the Quick Start Algorithm for Hormonal Contraception, what is an indication that a patient is not pregnant?

<p>The patient is within 7 days from the first day of menstrual bleeding (A)</p> Signup and view all the answers

What is a reliable method of contraception, according to the text?

<p>Correctly and consistently using a reliable method of contraception (D)</p> Signup and view all the answers

What is the purpose of the checklist used to assess the possibility of pregnancy?

<p>To rule out pregnancy in a patient (A)</p> Signup and view all the answers

What additional contraception is required if two or more consecutive hormonal pills are missed?

<p>Backup contraception, such as male or female condoms is needed (C)</p> Signup and view all the answers

What happens to the risk of ovulation if two or more pills are missed?

<p>The risk of ovulation is increased (C)</p> Signup and view all the answers

When should emergency contraception be used if pills were missed in the first week of the cycle?

<p>If unprotected intercourse occurred during this week (C)</p> Signup and view all the answers

What happens if pills were missed in the last week of hormone pills?

<p>The patient should finish that last week of hormone pills, then skip week 4, and immediately move on to a new pill pack the next day (A)</p> Signup and view all the answers

Which of the following statements is true regarding the use of progestin-containing contraceptives at the same time as ulipristal acetate?

<p>It decreases the efficacy of ulipristal acetate (D)</p> Signup and view all the answers

What happens if one pill is missed?

<p>No additional contraception is required (D)</p> Signup and view all the answers

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Study Notes

Quick Start Algorithm for Hormonal Contraception

  • Providers may offer a single injection of DMPA and ask the patient to return for the implant within 5 days of the first day of her next menstrual period to avoid the need for implant removal if the repeat urine pregnancy test is positive.

Pregnancy Assessment

  • A provider can be reasonably certain that a patient is not pregnant if she has no symptoms or signs of pregnancy and meets any of the following criteria:
    • Has not had intercourse since last normal menses.
    • Has been correctly and consistently using a reliable method of contraception.
    • Is within 7 days from the first day of menstrual bleeding.

Contraceptives and Cancer

  • COC use is associated with a slightly increased risk of developing cervical cancer.
  • COC use is associated with a reduced risk of developing ovarian and endometrial cancers.

Contraceptives and STI Acquisition

  • COC use positively correlates with chlamydia infections but not with gonorrhea, herpes simplex virus-2, trichomoniasis, syphilis, and human papillomavirus.
  • COCs may be associated with increased rates of chlamydia, but not with pelvic inflammatory disease (PID).

Missed Pills

  • If one pill is missed, the patient can take the missed pill as soon as possible and continue with the usual regimen.
  • If two or more pills are missed, the remaining pills should be taken at the usual time, and backup contraception is generally needed.
  • If two or more pills are missed in the first week of the cycle and unprotected intercourse occurs, use of emergency contraception may be necessary.

Progestins

  • There are different classes of progestins, including estranes (e.g. norethindrone, norethindrone acetate), gonanes (e.g. norgestrel, levonorgestrel), and antiandrogenic progestins (e.g. drospirenone, dienogest, cyproterone acetate).
  • Antiandrogenic progestins have some antiandrogenic activity and are sometimes referred to as fourth-generation progestins.
  • Drospirenone is a weak antiandrogen that has progestogenic, antiandrogenic, and anti-mineralocorticoid activity.

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