Immunomodulators in Dermatology
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Immunomodulators in Dermatology

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Questions and Answers

Which drug is a prodrug and inhibits T-cell proliferation?

  • Leflunomide (correct)
  • Sulfasalazine
  • Hydroxychloroquine
  • Methotrexate

    • Which targeted synthetic DMARD is administered orally and indicated for rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, polyarticular juvenile idiopathic arthritis, and ulcerative colitis?

  • Tofacitinib (correct)
  • Baricitinib
  • Tocilizumab
  • Anakinra

    • Which drug is a folate antagonist and is considered first-line for rheumatoid arthritis?

  • Sulfasalazine
  • Methotrexate (correct)
  • Leflunomide
  • Hydroxychloroquine

    • Which drug should be reserved for severe, progressive rheumatoid arthritis that has not responded to safer DMARDs?

    <p>Cyclosporine</p> Signup and view all the answers

    Which drug carries a black box warning for fatal toxicities of the bone marrow, liver, lungs, and kidneys?

    <p>Leflunomide</p> Signup and view all the answers

    Which drug is indicated for IV therapy of adults with moderate to severe RA who have not responded to one or more TNF inhibitors?

    <p>Rituximab</p> Signup and view all the answers

    Which targeted synthetic DMARD carries a black box warning for serious or fatal infection risk, heart-related events, cancer, and blood clots?

    <p>Baricitinib</p> Signup and view all the answers

    Which conventional DMARD has side effects including nausea, hair loss, mouth ulcers, and hepatoxicity?

    <p>Methotrexate</p> Signup and view all the answers

    Which drug is considered a last choice and is used for rejection of transplanted organs?

    <p>Cyclosporine</p> Signup and view all the answers

    Which drug is associated with the need for G6PD testing, baseline eye exam, and routine eye screens due to potential toxic retinopathy?

    <p>Hydroxychloroquine</p> Signup and view all the answers

    Which type of drugs are biologic DMARDs?

    <p>Immunosuppressive drugs</p> Signup and view all the answers

    What is the risk associated with all biologic DMARDs?

    <p>Serious infections and perhaps cancer</p> Signup and view all the answers

    How are biologic DMARDs manufactured?

    <p>Using recombinant DNA technology</p> Signup and view all the answers

    What is a type of biologic DMARD?

    <p>Monoclonal antibody drugs (MAbs)</p> Signup and view all the answers

    What is the MOA of adalimumab (Humira)?

    <p>Binds to and neutralizes tumor necrosis factor (TNF)</p> Signup and view all the answers

    What is the MOA of rituximab (Rituxan)?

    <p>Binds with CD20 antigen exclusively on the surface of B lymphocytes</p> Signup and view all the answers

    What is the MOA of abatacept (Orencia)?

    <p>T-cell activation inhibitor</p> Signup and view all the answers

    For which condition is adalimumab (Humira) indicated?

    <p>Moderate to severe RA who have not responded adequately to one or more DMARDs</p> Signup and view all the answers

    What is the target of rituximab (Rituxan)?

    <p>CD20 antigen exclusively on the surface of B lymphocytes</p> Signup and view all the answers

    What is the common risk associated with all biologic DMARDs?

    <p>Risk for serious infections and perhaps cancer</p> Signup and view all the answers

    Biologic DMARDs are not immunosuppressive drugs.

    <p>False</p> Signup and view all the answers

    Biologic DMARDs are usually combined with methotrexate.

    <p>True</p> Signup and view all the answers

    MAbs are proteins derived only from human sources.

    <p>False</p> Signup and view all the answers

    Adalimumab is indicated for mild rheumatoid arthritis.

    <p>False</p> Signup and view all the answers

    Rituximab binds to and neutralizes tumor necrosis factor (TNF).

    <p>False</p> Signup and view all the answers

    Rituximab is indicated for moderate to severe rheumatoid arthritis.

    <p>False</p> Signup and view all the answers

    Abatacept is a T-cell activation inhibitor.

    <p>True</p> Signup and view all the answers

    Interleukin antagonists are used in the treatment of moderate to severe RA.

    <p>True</p> Signup and view all the answers

    All biologic DMARDs pose a risk for serious infections and perhaps cancer.

    <p>True</p> Signup and view all the answers

    Abatacept is the only drug in its class.

    <p>True</p> Signup and view all the answers

    Rheumatoid arthritis is not listed as an indication for tofacitinib (Xeljanz).

    <p>False</p> Signup and view all the answers

    Sulfasalazine (Azulfidine) is a first-line drug for rheumatoid arthritis.

    <p>False</p> Signup and view all the answers

    Leflunomide (Arava) is not indicated for systemic lupus erythematosus (SLE) or malaria.

    <p>False</p> Signup and view all the answers

    Cyclosporine (Gengraf) does not require G6PD testing.

    <p>False</p> Signup and view all the answers

    Tofacitinib (Xeljanz) carries a black box warning for serious or fatal infection risk, heart-related events, cancer, and blood clots.

    <p>True</p> Signup and view all the answers

    Biologic DMARDs tend to have a delayed onset of 3-6 months for full therapeutic effect.

    <p>False</p> Signup and view all the answers

    Methotrexate (Rheumatrex, Trexall) is indicated for the treatment of rheumatoid arthritis, psoriasis, juvenile idiopathic arthritis (JIA), and oncology.

    <p>True</p> Signup and view all the answers

    Rituximab + methotrexate is indicated for subcutaneous therapy of adults with moderate to severe rheumatoid arthritis who have not responded to one or more TNF inhibitors.

    <p>False</p> Signup and view all the answers

    Baricitinib (Olumiant) has a 16% risk of patients developing infection.

    <p>True</p> Signup and view all the answers

    NSAIDs such as aspirin and celecoxib are not used in the management of gout.

    <p>False</p> Signup and view all the answers

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