Immunology Quiz on T and B Cells

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Questions and Answers

Which cytokine is essential for the multiplication and activity of T helper cells, T cytotoxic cells, B cells, and NK cells?

  • Interleukin-6
  • Interleukin-1
  • Interleukin-2 (correct)
  • Tumor Necrosis Factor-alpha

Which of these best describes the function of Tumor Necrosis Factor-alpha?

  • Is necessary to encourage proliferation of T helper cells.
  • Acts as a chemotactic molecule to attract immune cells.
  • Helps activate T cells and phagocytes. (correct)
  • Induces the differentiation of B cells into plasma cells.

What is the primary mechanism by which T-cytotoxic cells destroy target cells?

  • By stimulating the production of cytokines in the target cell.
  • By releasing cytolytic enzymes, toxic cytokines, and perforins. (correct)
  • By producing antibodies that bind to target cells.
  • By engulfing and digesting target cells directly.

Which cells are directly activated by binding to antigen/MHC Class II complexes on Antigen Presenting Cells (APCs)?

<p>T helper cells (C)</p> Signup and view all the answers

Why are antibodies unable to destroy virus-infected cells directly?

<p>They are too large to enter living cells. (C)</p> Signup and view all the answers

Which type of immunity is primarily associated with B cells?

<p>Humoral immunity (B)</p> Signup and view all the answers

What is the primary function of T cells in the immune response?

<p>Mediating cellular immunity (A)</p> Signup and view all the answers

What is required for B cell activation?

<p>Encountering an antigen complementary to their surface immunoglobulin receptor, and receiving cytokine signals from T helper cells (D)</p> Signup and view all the answers

What is the role of the plasma cells?

<p>Secreting antibodies (A)</p> Signup and view all the answers

What is clonal selection in the context of B cells?

<p>The proliferation of a single type of B cell (C)</p> Signup and view all the answers

How do memory B cells differ from plasma cells?

<p>Memory cells live longer than plasma cells (A)</p> Signup and view all the answers

What is the role of MHC Class II molecules on B cells?

<p>To present antigens to T helper cells (A)</p> Signup and view all the answers

Which of the following is NOT a direct function of antibodies?

<p>Direct destruction of antigens (A)</p> Signup and view all the answers

What process involves antibodies clumping antigens together?

<p>Agglutination (A)</p> Signup and view all the answers

What is the process by which antibodies block specific sites on bacterial toxins or viruses?

<p>Neutralization (C)</p> Signup and view all the answers

What is the primary role of plasma cells in humoral immunity?

<p>To produce and secrete antibodies (C)</p> Signup and view all the answers

Which type of immunity results from the transfer of antibodies from a mother to her baby through breast milk?

<p>Naturally acquired passive immunity (D)</p> Signup and view all the answers

What is the primary cause of the lag period in the primary humoral response?

<p>The time it takes for B cells to proliferate into plasma cells (B)</p> Signup and view all the answers

What is the primary role of T-regulatory cells in the immune response?

<p>To suppress the activity of other immune cells after an antigen has been cleared (A)</p> Signup and view all the answers

Which cells are activated by the presentation of antigens associated with MHC Class II molecules?

<p>T-helper cells (B)</p> Signup and view all the answers

How do memory cells contribute to the secondary immune response?

<p>They recognize the antigen and quickly produce antibody (C)</p> Signup and view all the answers

What is the immediate consequence of an antigen binding to a B lymphocyte during the primary response?

<p>The B lymphocyte begins to proliferate and form a clone of plasma cells (D)</p> Signup and view all the answers

T-cytotoxic cells are triggered via presenting antigens bound to what type of cell surface receptor?

<p>MHC Class I (B)</p> Signup and view all the answers

What is a key difference between the primary and secondary humoral immune responses?

<p>The secondary response reaches a higher antibody level more rapidly (B)</p> Signup and view all the answers

What is the function of cytokines in the immune response?

<p>Regulate and coordinate the activity of immune cells (B)</p> Signup and view all the answers

In the context of the immune system, what is the role of T-memory cells?

<p>To provide a rapid secondary response upon subsequent exposure to the same antigen. (C)</p> Signup and view all the answers

Besides antibody production, what is another important function of activated B cells?

<p>Formation of memory cells (C)</p> Signup and view all the answers

If an individual is exposed to an antigen for the third time, how will the antibody response generally compare to the second exposure?

<p>The response will be even faster and greater than the secondary response (C)</p> Signup and view all the answers

Which of the following is an example of artificially acquired active immunity?

<p>Vaccination with attenuated pathogens (C)</p> Signup and view all the answers

What molecule is found on the surface of T-helper cells?

<p>CD4 (B)</p> Signup and view all the answers

Why is precipitated antigen easier for phagocytes to bind and engulf?

<p>It is concentrated into larger complexes (A)</p> Signup and view all the answers

During the primary immune response, what is the function of T-helper cell cytokines in relation to B cells?

<p>They trigger the proliferation of B cells into plasma cells. (D)</p> Signup and view all the answers

What is the function of the T cell receptor (TCR)?

<p>To interact with processed antigen/MHC complexes on the surface of other cells. (A)</p> Signup and view all the answers

Which process is a direct consequence of complement fixation triggered by antibody binding?

<p>Lysis of the target cell. (D)</p> Signup and view all the answers

What is the primary role of T-cytotoxic cells?

<p>To directly kill abnormal cells like virus-infected or cancerous cells (D)</p> Signup and view all the answers

Flashcards

Humoral Immunity

A type of immunity that involves antibodies produced by B cells. Antibodies circulate in the blood and bind to specific antigens, neutralizing them or marking them for destruction by other immune cells. This type of immunity is effective against extracellular pathogens like bacteria and viruses.

Cell-mediated Immunity

A type of immunity that involves T cells, which directly attack infected cells or cancer cells. T cells recognize antigens presented on the surface of infected cells and destroy them.

How do T helper cells activate B cells?

Innate immune cells like macrophages engulf pathogens and present fragments of these pathogens on their surface using MHC II molecules. T helper cells recognize these fragments and activate B cells to produce specific antibodies.

How are B cells activated?

B cells can bind to specific antigens using their surface immunoglobulins. This binding, along with signals from T helper cells, activates the B cell.

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What happens after B cell activation?

Activated B cells proliferate and differentiate into plasma cells, which secrete antibodies. A small subset of activated B cells become memory cells, which can quickly respond to a future infection by the same antigen.

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Clonal Selection

A process where a specific B cell clone proliferates and differentiates into antibody-secreting plasma cells after encountering its specific antigen.

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Neutralization by Antibody

Antibodies can block the active sites of toxins or viruses, preventing them from binding to host cells and causing damage.

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Agglutination (Clumping) by antibodies

Antibodies can bind to the same antigen on multiple pathogens, causing them to clump together. This clumping makes it easier for phagocytes to engulf and destroy multiple pathogens at once.

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Precipitation by Antibody

Antibodies can bind to soluble antigens, forming large complexes that precipitate out of the solution. These precipitates are easier for phagocytes to clear from the body.

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Complement Fixation by Antibody

Antibodies can activate the complement system, a series of proteins in the blood that can lyse (destroy) cells, opsonize (mark) for phagocytosis, or promote inflammation.

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Primary Immune Response

The initial exposure to an antigen, where the immune system encounters a foreign substance for the first time.

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Secondary Immune Response

The subsequent exposure to an antigen, where the immune system reacts faster and more effectively due to memory cells.

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B lymphocytes

Specific types of white blood cells that differentiate into plasma cells when activated by antigens.

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Plasma cells

Mature B cells that produce and secrete antibodies into the bloodstream.

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Antibodies

Proteins produced by plasma cells that bind to specific antigens, neutralizing them or marking them for destruction.

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Lag Period

The time lag between antigen exposure and the detection of antibodies in the blood.

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Memory B cells

Special type of B cells generated during a primary response, capable of recognizing the same antigen quickly upon subsequent exposure.

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Antigens

Substances that stimulate an immune response, typically proteins or parts of proteins.

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Phagocytosis

The process of engulfing and destroying foreign objects, such as bacteria, by specialized cells like macrophages.

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Complement System

A protein cascade involved in the immune response, leading to the lysis (destruction) of target cells.

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Tumor Necrosis Factor-alpha (TNF-alpha)

A type of immune cell that helps activate other immune cells, like T cells, and phagocytes. It is secreted by activated macrophages.

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T Cytotoxic cells

A type of immune cell that directly kills infected or cancerous cells. It recognizes and destroys infected cells by releasing cytotoxic enzymes, cytokines, and perforins.

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T Helper Activation

The process of T helper cell activation that involves recognition of an antigen presented by an Antigen Presenting Cell (APC) in association with MHC Class II.

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T Cytotoxic Cells

A type of immune cell that directly kills infected or cancerous cells. It recognizes and destroys infected cells by releasing cytotoxic enzymes, cytokines, and perforins.

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T Cytotoxic Cells

A type of immune cell that directly kills infected or cancerous cells. It recognizes and destroys infected cells by releasing cytotoxic enzymes, cytokines, and perforins.

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Active Immunity

Immunity developed after encountering a pathogen or vaccine.

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Passive Immunity

Immunity gained from receiving antibodies from another source, like a mother or through injections.

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T-helper Cells (CD4+)

A type of T cell that helps activate other immune cells by secreting signaling molecules called cytokines.

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T-cytotoxic Cells (CD8+)

A type of T cell that directly kills infected cells or cancer cells by releasing toxic substances.

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T-regulatory Cells

A type of T cell that helps to regulate the immune response by suppressing the activity of other immune cells.

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T-memory Cells

Special memory cells that can quickly recognize and mount a response to a previously encountered antigen.

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Cytokines

Small proteins secreted by cells of the immune system that act as signaling molecules, coordinating the immune response.

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Immunity

A protective response of the immune system against harmful invaders like pathogens.

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Study Notes

Humoral vs Cell-Mediated Immunity

  • B cells are responsible for humoral immunity.
  • T cells are responsible for cell-mediated immunity.
  • The success of the immune system relies on the interaction between humoral and cell-mediated responses.

Humoral Immunity

  • B cells are responsible for humoral immunity.
  • They deal with antigens that are easily "seen".
  • Humoral immunity eliminates bacteria, neutralizes bacterial toxins, and prevents viral infection.
  • B cells function as Antigen Presenting Cells (APCs) by engulfing immunoglobulin/antigen complexes, digesting the antigen, and presenting the fragments on MHC II molecules on their surface.
  • T-helper cells bind to the MHC II/antigen complex and release cytokines to stimulate B-cell proliferation.
  • B cell activation occurs when an antigen binds to the surface immunoglobulin receptor on a B cell, and it receives chemical signals (cytokines) from T helper cells.
  • Activated B cells proliferate and differentiate into antibody-secreting plasma cells and memory cells.
  • Clonal selection is the proliferation of a single type of B cell.
  • Memory cells live longer than plasma cells and reside in peripheral tissues. They are ready to fight the same antigen in a subsequent exposure.

Antibodies

  • Antibodies circulate through blood and lymph, binding to antigens.
  • Antibodies themselves cannot destroy antigens.
  • Antibody-antigen complexes lead to neutralization, agglutination, precipitation, or complement fixation.
  • Neutralization blocks specific sites on bacterial toxins or viruses, preventing them from harming cells.
  • Agglutination causes clumping of antibody-antigen complexes, which are then degraded by phagocytes.
  • Precipitation causes soluble molecules to cross-link into large complexes, which settle out of solution. This makes it easier for phagocytes to engulf and destroy the antigen.
  • Complement fixation involves antibodies binding to antigenic determinants, triggering complement fixation and lysis of target cells.

Humoral Immunity - Primary and Secondary Responses

  • Humoral immunity depends on the maturation of B lymphocytes into plasma cells.
  • Plasma cells produce and secrete antibodies.
  • Two types of responses occur in the development of humoral immunity: Primary and Secondary responses.
  • A primary response occurs when the antigen is first introduced. There is a lag period (about 1 week) before antibodies can be detected in the blood. This is the time needed for cytokines from T-helper cells to trigger B-cell proliferation into plasma cells that make antibodies. During the same time, a small portion of activated B cells will develop into memory cells.
  • A secondary response occurs upon second or subsequent exposures to the antigen. Antibodies rise sooner and reach a higher level due to memory cells from the primary response. Memory cells recognize the antigen and respond more efficiently.

Cell-Mediated Immunity

  • Different types of T cells exist and participate in various aspects of the immune response.
  • T cell maturation occurs in the thymus gland.
  • Mature T cells travel to peripheral lymphoid tissues to wait for antigen encounters.
  • The T-cell receptor (TCR) has two polypeptide chains forming a groove that interacts with processed antigen/MHC complexes.
  • T-helper cells (CD4+) are activated by binding to antigen presented with MHC Class II molecules on Antigen-Presenting Cells (APCs).
  • T-helper cells stimulate B-cells proliferation and other parts of the immune response.
  • T-cytotoxic cells (CD8+) are activated by binding to antigen presented with MHC class I molecules. Those target abnormal infected or transformed body cells.
  • T-regulatory cells release cytokines to suppress the activity of B and T cells when the antigen has been inactivated.

Cytokines

  • Cytokines are regulatory proteins made by many immune cells.
  • They primarily come from T-helper cells and macrophages.
  • Some cytokines mediate inflammation (e.g., fever, chemotaxis).
  • Others act as communication signals between different immune cells (e.g., B cells, T cells, and macrophages).
  • Examples of cytokines include Interleukin-1, Tumor Necrosis Factor-alpha, and Interleukin-2.

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