Podcast
Questions and Answers
Which cytokine is essential for the multiplication and activity of T helper cells, T cytotoxic cells, B cells, and NK cells?
Which cytokine is essential for the multiplication and activity of T helper cells, T cytotoxic cells, B cells, and NK cells?
- Interleukin-6
- Interleukin-1
- Interleukin-2 (correct)
- Tumor Necrosis Factor-alpha
Which of these best describes the function of Tumor Necrosis Factor-alpha?
Which of these best describes the function of Tumor Necrosis Factor-alpha?
- Is necessary to encourage proliferation of T helper cells.
- Acts as a chemotactic molecule to attract immune cells.
- Helps activate T cells and phagocytes. (correct)
- Induces the differentiation of B cells into plasma cells.
What is the primary mechanism by which T-cytotoxic cells destroy target cells?
What is the primary mechanism by which T-cytotoxic cells destroy target cells?
- By stimulating the production of cytokines in the target cell.
- By releasing cytolytic enzymes, toxic cytokines, and perforins. (correct)
- By producing antibodies that bind to target cells.
- By engulfing and digesting target cells directly.
Which cells are directly activated by binding to antigen/MHC Class II complexes on Antigen Presenting Cells (APCs)?
Which cells are directly activated by binding to antigen/MHC Class II complexes on Antigen Presenting Cells (APCs)?
Why are antibodies unable to destroy virus-infected cells directly?
Why are antibodies unable to destroy virus-infected cells directly?
Which type of immunity is primarily associated with B cells?
Which type of immunity is primarily associated with B cells?
What is the primary function of T cells in the immune response?
What is the primary function of T cells in the immune response?
What is required for B cell activation?
What is required for B cell activation?
What is the role of the plasma cells?
What is the role of the plasma cells?
What is clonal selection in the context of B cells?
What is clonal selection in the context of B cells?
How do memory B cells differ from plasma cells?
How do memory B cells differ from plasma cells?
What is the role of MHC Class II molecules on B cells?
What is the role of MHC Class II molecules on B cells?
Which of the following is NOT a direct function of antibodies?
Which of the following is NOT a direct function of antibodies?
What process involves antibodies clumping antigens together?
What process involves antibodies clumping antigens together?
What is the process by which antibodies block specific sites on bacterial toxins or viruses?
What is the process by which antibodies block specific sites on bacterial toxins or viruses?
What is the primary role of plasma cells in humoral immunity?
What is the primary role of plasma cells in humoral immunity?
Which type of immunity results from the transfer of antibodies from a mother to her baby through breast milk?
Which type of immunity results from the transfer of antibodies from a mother to her baby through breast milk?
What is the primary cause of the lag period in the primary humoral response?
What is the primary cause of the lag period in the primary humoral response?
What is the primary role of T-regulatory cells in the immune response?
What is the primary role of T-regulatory cells in the immune response?
Which cells are activated by the presentation of antigens associated with MHC Class II molecules?
Which cells are activated by the presentation of antigens associated with MHC Class II molecules?
How do memory cells contribute to the secondary immune response?
How do memory cells contribute to the secondary immune response?
What is the immediate consequence of an antigen binding to a B lymphocyte during the primary response?
What is the immediate consequence of an antigen binding to a B lymphocyte during the primary response?
T-cytotoxic cells are triggered via presenting antigens bound to what type of cell surface receptor?
T-cytotoxic cells are triggered via presenting antigens bound to what type of cell surface receptor?
What is a key difference between the primary and secondary humoral immune responses?
What is a key difference between the primary and secondary humoral immune responses?
What is the function of cytokines in the immune response?
What is the function of cytokines in the immune response?
In the context of the immune system, what is the role of T-memory cells?
In the context of the immune system, what is the role of T-memory cells?
Besides antibody production, what is another important function of activated B cells?
Besides antibody production, what is another important function of activated B cells?
If an individual is exposed to an antigen for the third time, how will the antibody response generally compare to the second exposure?
If an individual is exposed to an antigen for the third time, how will the antibody response generally compare to the second exposure?
Which of the following is an example of artificially acquired active immunity?
Which of the following is an example of artificially acquired active immunity?
What molecule is found on the surface of T-helper cells?
What molecule is found on the surface of T-helper cells?
Why is precipitated antigen easier for phagocytes to bind and engulf?
Why is precipitated antigen easier for phagocytes to bind and engulf?
During the primary immune response, what is the function of T-helper cell cytokines in relation to B cells?
During the primary immune response, what is the function of T-helper cell cytokines in relation to B cells?
What is the function of the T cell receptor (TCR)?
What is the function of the T cell receptor (TCR)?
Which process is a direct consequence of complement fixation triggered by antibody binding?
Which process is a direct consequence of complement fixation triggered by antibody binding?
What is the primary role of T-cytotoxic cells?
What is the primary role of T-cytotoxic cells?
Flashcards
Humoral Immunity
Humoral Immunity
A type of immunity that involves antibodies produced by B cells. Antibodies circulate in the blood and bind to specific antigens, neutralizing them or marking them for destruction by other immune cells. This type of immunity is effective against extracellular pathogens like bacteria and viruses.
Cell-mediated Immunity
Cell-mediated Immunity
A type of immunity that involves T cells, which directly attack infected cells or cancer cells. T cells recognize antigens presented on the surface of infected cells and destroy them.
How do T helper cells activate B cells?
How do T helper cells activate B cells?
Innate immune cells like macrophages engulf pathogens and present fragments of these pathogens on their surface using MHC II molecules. T helper cells recognize these fragments and activate B cells to produce specific antibodies.
How are B cells activated?
How are B cells activated?
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What happens after B cell activation?
What happens after B cell activation?
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Clonal Selection
Clonal Selection
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Neutralization by Antibody
Neutralization by Antibody
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Agglutination (Clumping) by antibodies
Agglutination (Clumping) by antibodies
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Precipitation by Antibody
Precipitation by Antibody
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Complement Fixation by Antibody
Complement Fixation by Antibody
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Primary Immune Response
Primary Immune Response
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Secondary Immune Response
Secondary Immune Response
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B lymphocytes
B lymphocytes
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Plasma cells
Plasma cells
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Antibodies
Antibodies
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Lag Period
Lag Period
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Memory B cells
Memory B cells
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Antigens
Antigens
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Phagocytosis
Phagocytosis
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Complement System
Complement System
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Tumor Necrosis Factor-alpha (TNF-alpha)
Tumor Necrosis Factor-alpha (TNF-alpha)
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T Cytotoxic cells
T Cytotoxic cells
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T Helper Activation
T Helper Activation
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T Cytotoxic Cells
T Cytotoxic Cells
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T Cytotoxic Cells
T Cytotoxic Cells
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Active Immunity
Active Immunity
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Passive Immunity
Passive Immunity
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T-helper Cells (CD4+)
T-helper Cells (CD4+)
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T-cytotoxic Cells (CD8+)
T-cytotoxic Cells (CD8+)
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T-regulatory Cells
T-regulatory Cells
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T-memory Cells
T-memory Cells
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Cytokines
Cytokines
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Immunity
Immunity
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Study Notes
Humoral vs Cell-Mediated Immunity
- B cells are responsible for humoral immunity.
- T cells are responsible for cell-mediated immunity.
- The success of the immune system relies on the interaction between humoral and cell-mediated responses.
Humoral Immunity
- B cells are responsible for humoral immunity.
- They deal with antigens that are easily "seen".
- Humoral immunity eliminates bacteria, neutralizes bacterial toxins, and prevents viral infection.
- B cells function as Antigen Presenting Cells (APCs) by engulfing immunoglobulin/antigen complexes, digesting the antigen, and presenting the fragments on MHC II molecules on their surface.
- T-helper cells bind to the MHC II/antigen complex and release cytokines to stimulate B-cell proliferation.
- B cell activation occurs when an antigen binds to the surface immunoglobulin receptor on a B cell, and it receives chemical signals (cytokines) from T helper cells.
- Activated B cells proliferate and differentiate into antibody-secreting plasma cells and memory cells.
- Clonal selection is the proliferation of a single type of B cell.
- Memory cells live longer than plasma cells and reside in peripheral tissues. They are ready to fight the same antigen in a subsequent exposure.
Antibodies
- Antibodies circulate through blood and lymph, binding to antigens.
- Antibodies themselves cannot destroy antigens.
- Antibody-antigen complexes lead to neutralization, agglutination, precipitation, or complement fixation.
- Neutralization blocks specific sites on bacterial toxins or viruses, preventing them from harming cells.
- Agglutination causes clumping of antibody-antigen complexes, which are then degraded by phagocytes.
- Precipitation causes soluble molecules to cross-link into large complexes, which settle out of solution. This makes it easier for phagocytes to engulf and destroy the antigen.
- Complement fixation involves antibodies binding to antigenic determinants, triggering complement fixation and lysis of target cells.
Humoral Immunity - Primary and Secondary Responses
- Humoral immunity depends on the maturation of B lymphocytes into plasma cells.
- Plasma cells produce and secrete antibodies.
- Two types of responses occur in the development of humoral immunity: Primary and Secondary responses.
- A primary response occurs when the antigen is first introduced. There is a lag period (about 1 week) before antibodies can be detected in the blood. This is the time needed for cytokines from T-helper cells to trigger B-cell proliferation into plasma cells that make antibodies. During the same time, a small portion of activated B cells will develop into memory cells.
- A secondary response occurs upon second or subsequent exposures to the antigen. Antibodies rise sooner and reach a higher level due to memory cells from the primary response. Memory cells recognize the antigen and respond more efficiently.
Cell-Mediated Immunity
- Different types of T cells exist and participate in various aspects of the immune response.
- T cell maturation occurs in the thymus gland.
- Mature T cells travel to peripheral lymphoid tissues to wait for antigen encounters.
- The T-cell receptor (TCR) has two polypeptide chains forming a groove that interacts with processed antigen/MHC complexes.
- T-helper cells (CD4+) are activated by binding to antigen presented with MHC Class II molecules on Antigen-Presenting Cells (APCs).
- T-helper cells stimulate B-cells proliferation and other parts of the immune response.
- T-cytotoxic cells (CD8+) are activated by binding to antigen presented with MHC class I molecules. Those target abnormal infected or transformed body cells.
- T-regulatory cells release cytokines to suppress the activity of B and T cells when the antigen has been inactivated.
Cytokines
- Cytokines are regulatory proteins made by many immune cells.
- They primarily come from T-helper cells and macrophages.
- Some cytokines mediate inflammation (e.g., fever, chemotaxis).
- Others act as communication signals between different immune cells (e.g., B cells, T cells, and macrophages).
- Examples of cytokines include Interleukin-1, Tumor Necrosis Factor-alpha, and Interleukin-2.
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