Podcast
Questions and Answers
Which treatment method is specifically aimed at reducing autoantibody levels?
Which treatment method is specifically aimed at reducing autoantibody levels?
- Plasmapheresis (correct)
- Antibody Therapy
- Steroids
- Biologic Agents
Which cytokine is crucial for the activation of cytotoxic T-lymphocytes?
Which cytokine is crucial for the activation of cytotoxic T-lymphocytes?
- IL-10
- IL-2 (correct)
- TNF-β
- IL-4
Class II MHC molecules are primarily expressed on which type of cells?
Class II MHC molecules are primarily expressed on which type of cells?
- APCs (correct)
- CD8+ T Cells
- Endothelial Cells
- Red Blood Cells
Which mechanism is primarily used by cytotoxic T cells to destroy infected cells?
Which mechanism is primarily used by cytotoxic T cells to destroy infected cells?
Which type of cells produce interferons in response to viral infections?
Which type of cells produce interferons in response to viral infections?
What immunoglobulin is present in the blood of newborns?
What immunoglobulin is present in the blood of newborns?
What is the primary function of the Fc-fragment of an antibody?
What is the primary function of the Fc-fragment of an antibody?
Which cytokine is essential for promoting interferon-gamma production?
Which cytokine is essential for promoting interferon-gamma production?
Which pair of immunoglobulins is recognized for its antitumor activity?
Which pair of immunoglobulins is recognized for its antitumor activity?
What causes tumor development even in the presence of an immune response?
What causes tumor development even in the presence of an immune response?
Which molecule is known to function as a complement inhibitor?
Which molecule is known to function as a complement inhibitor?
Which characteristic is true regarding induced tolerance?
Which characteristic is true regarding induced tolerance?
What process ensures the transfer of immunoglobulins from blood to mucous membrane secretions?
What process ensures the transfer of immunoglobulins from blood to mucous membrane secretions?
Which type of cells play a significant role in phagocytosis in the human body?
Which type of cells play a significant role in phagocytosis in the human body?
What is the primary function of Th1 cells in the immune response?
What is the primary function of Th1 cells in the immune response?
Identifying what type of immune defense is performed by the adaptive immune system is key. Which is true?
Identifying what type of immune defense is performed by the adaptive immune system is key. Which is true?
What mechanism allows non-specific defense factors to act without prior exposure?
What mechanism allows non-specific defense factors to act without prior exposure?
Which is not a humoral factor of non-specific defense?
Which is not a humoral factor of non-specific defense?
Which cells are preferentially activated by Toll-like receptors (TLRs)?
Which cells are preferentially activated by Toll-like receptors (TLRs)?
What process primarily occurs within the thymus to ensure tolerance to intrinsic antigens?
What process primarily occurs within the thymus to ensure tolerance to intrinsic antigens?
The differentiation and counting of leukocyte types is typically performed with what technique?
The differentiation and counting of leukocyte types is typically performed with what technique?
What is the main function of NK cells?
What is the main function of NK cells?
Which molecules are necessary for the activation of naive CD4+ T-lymphocytes?
Which molecules are necessary for the activation of naive CD4+ T-lymphocytes?
What receptor is primarily involved in the activation of B lymphocytes?
What receptor is primarily involved in the activation of B lymphocytes?
What type of cells are responsible for antibody production in the humoral immune response?
What type of cells are responsible for antibody production in the humoral immune response?
Which protein initiates the classical pathway of the complement system?
Which protein initiates the classical pathway of the complement system?
What is the primary role of regulatory T cells (Treg)?
What is the primary role of regulatory T cells (Treg)?
What does the CD4 molecule primarily bind to?
What does the CD4 molecule primarily bind to?
Which immunoglobulin predominates in upper respiratory tract secretions?
Which immunoglobulin predominates in upper respiratory tract secretions?
What structure is needed for a T cell to interact with an antigen-presenting cell?
What structure is needed for a T cell to interact with an antigen-presenting cell?
Cytotoxic T cells primarily recognize infected cells through which mechanism?
Cytotoxic T cells primarily recognize infected cells through which mechanism?
Which surface markers are used to identify T-lymphocytes?
Which surface markers are used to identify T-lymphocytes?
What reflects the functional status of the humoral immune system?
What reflects the functional status of the humoral immune system?
What is the primary function of type I interferons in immune responses?
What is the primary function of type I interferons in immune responses?
When are NK cells activated?
When are NK cells activated?
Which method involves the use of labelled antigens to detect specific substances?
Which method involves the use of labelled antigens to detect specific substances?
CD19 is a crucial marker for identifying which type of immune cells?
CD19 is a crucial marker for identifying which type of immune cells?
How is the antigen or antibody typically labelled in an ELISA assay?
How is the antigen or antibody typically labelled in an ELISA assay?
What is the role of Th2 cells in the immune response?
What is the role of Th2 cells in the immune response?
What is the purpose of the EAC-rosette formation reaction?
What is the purpose of the EAC-rosette formation reaction?
What is the main function of Toll-like receptors (TLRs) in the immune system?
What is the main function of Toll-like receptors (TLRs) in the immune system?
Which immunoglobulin is primarily involved in immediate-type hypersensitivity reactions?
Which immunoglobulin is primarily involved in immediate-type hypersensitivity reactions?
Which type of immune response involves T lymphocytes?
Which type of immune response involves T lymphocytes?
What indicates the clinical manifestation of hypersensitivity?
What indicates the clinical manifestation of hypersensitivity?
Which characterizes anaphylaxis?
Which characterizes anaphylaxis?
What cells participate primarily in the DHT reaction?
What cells participate primarily in the DHT reaction?
Hemolytic disease of the newborn typically results from which condition?
Hemolytic disease of the newborn typically results from which condition?
Which interleukin is crucial for eosinophil activation during allergic reactions?
Which interleukin is crucial for eosinophil activation during allergic reactions?
What process ensures the specific diversity of antibodies?
What process ensures the specific diversity of antibodies?
Which technique is used to produce monoclonal antibodies?
Which technique is used to produce monoclonal antibodies?
Cytotoxic effects of T-Killer cells are primarily due to which mechanism?
Cytotoxic effects of T-Killer cells are primarily due to which mechanism?
Flashcards
Plasmapheresis: How does it work?
Plasmapheresis: How does it work?
A procedure that removes autoantibodies from the blood to treat autoimmune diseases.
What role does IL-2 play in immunity?
What role does IL-2 play in immunity?
A cytokine that is essential for the activation and proliferation of cytotoxic T-lymphocytes.
Where are Class II MHC molecules found?
Where are Class II MHC molecules found?
Antigen-presenting cells (APCs) express MHC class II molecules on their surface.
How do cytotoxic T cells destroy target cells?
How do cytotoxic T cells destroy target cells?
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What cells produce interferons?
What cells produce interferons?
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Which antibody is important for newborn immunity?
Which antibody is important for newborn immunity?
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What does the Fc fragment of an antibody do?
What does the Fc fragment of an antibody do?
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What is the main function of the Fc fragment of an antibody?
What is the main function of the Fc fragment of an antibody?
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How do NK cells kill?
How do NK cells kill?
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What activates naive CD4+ T cells?
What activates naive CD4+ T cells?
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What activates B lymphocytes for a T-dependent antigen?
What activates B lymphocytes for a T-dependent antigen?
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Which cells produce antibodies?
Which cells produce antibodies?
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What protein starts the classical complement pathway?
What protein starts the classical complement pathway?
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What is the primary function of Treg?
What is the primary function of Treg?
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What does CD4 bind to?
What does CD4 bind to?
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Which immunoglobulin is abundant in the respiratory tract?
Which immunoglobulin is abundant in the respiratory tract?
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What structure allows T cell and antigen-presenting cell interaction?
What structure allows T cell and antigen-presenting cell interaction?
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How do T-killers recognize their target cells?
How do T-killers recognize their target cells?
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What is the function of Type I interferons?
What is the function of Type I interferons?
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How are NK cells activated?
How are NK cells activated?
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Which cells express CD19?
Which cells express CD19?
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What is the role of Th2 cells in the immune response?
What is the role of Th2 cells in the immune response?
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What do TLRs recognize?
What do TLRs recognize?
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CD3 and CD19
CD3 and CD19
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Serum Immunoglobulin Levels
Serum Immunoglobulin Levels
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ELISA
ELISA
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Enzymatic Labeling in ELISA
Enzymatic Labeling in ELISA
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EAC-Rosette Formation
EAC-Rosette Formation
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Immediate-Type Hypersensitivity (IHT)
Immediate-Type Hypersensitivity (IHT)
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Delayed-Type Hypersensitivity (DHT)
Delayed-Type Hypersensitivity (DHT)
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Clinical Manifestation of Hypersensitivity
Clinical Manifestation of Hypersensitivity
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Anaphylaxis
Anaphylaxis
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Cells involved in a DHT reaction
Cells involved in a DHT reaction
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Hemolytic Disease of the Newborn
Hemolytic Disease of the Newborn
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IL-5
IL-5
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Antibody Diversity
Antibody Diversity
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Hybridoma Technology
Hybridoma Technology
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Cytotoxicity of T-Killers
Cytotoxicity of T-Killers
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What cytokine promotes IFN-γ production?
What cytokine promotes IFN-γ production?
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Which immunoglobulins have antitumor activity?
Which immunoglobulins have antitumor activity?
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What causes tumor development despite an immune response?
What causes tumor development despite an immune response?
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What molecule acts as a complement inhibitor?
What molecule acts as a complement inhibitor?
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How does induced tolerance form?
How does induced tolerance form?
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How are immunoglobulins transported from the blood to mucosal secretions?
How are immunoglobulins transported from the blood to mucosal secretions?
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Which cells are phagocytic in the body?
Which cells are phagocytic in the body?
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What is the primary function of Th1 cells?
What is the primary function of Th1 cells?
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Which system does NOT contribute to non-specific defense?
Which system does NOT contribute to non-specific defense?
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What is true about non-specific defense factors?
What is true about non-specific defense factors?
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Which of these is NOT a humoral factor of non-specific defense?
Which of these is NOT a humoral factor of non-specific defense?
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Which cells are preferentially activated via TLRs?
Which cells are preferentially activated via TLRs?
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What process ensures tolerance to self-antigens in the thymus?
What process ensures tolerance to self-antigens in the thymus?
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Which microscopy technique identifies different leukocyte types?
Which microscopy technique identifies different leukocyte types?
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What cells are important for recognizing and killing cells that lack MHC I expression?
What cells are important for recognizing and killing cells that lack MHC I expression?
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What molecules present intracellular protein fragments to CTLs?
What molecules present intracellular protein fragments to CTLs?
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What molecules present processed antigens to Th cells?
What molecules present processed antigens to Th cells?
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Study Notes
Treatment Methods for Autoimmune Diseases
- Plasmapheresis removes autoantibodies from the blood, treating autoimmune diseases.
Cytokine Roles in Immune Cell Activation
- Interleukin-2 (IL-2) is essential for activating and proliferating cytotoxic T lymphocytes.
MHC Expression on Cell Types
- Class II MHC molecules are primarily expressed on antigen-presenting cells (APCs).
T-Killer Cell Mechanisms
- Cytotoxic T cells induce apoptosis (programmed cell death) in abnormal cells.
Interferon Production
- Leukocytes, including dendritic cells, produce interferons in response to viral threats.
Immunoglobulin in Newborns
- IgG is the immunoglobulin transferred across the placenta to provide passive immunity to newborns.
Antibody Fc Fragment Function
- The Fc fragment of an antibody interacts with receptors on innate immune cells, such as macrophages and neutrophils, activating them.
Natural Killer (NK) Cell Characteristics
- NK cells directly kill target cells without phagocytosis, inducing apoptosis.
CD4+ T-cell Activation
- MHC Class II molecules and co-stimulatory signals from CD80 are needed for CD4+ T cell activation.
B-Lymphocyte Activation
- The B-cell receptor (BCR) binds to antigens, initiating B cell activation, especially in response to T-dependent antigens.
Antibody Production
- Plasma cells are differentiated B cells that secrete antibodies.
Complement System Activation
- The classical complement pathway is triggered by the C1 complex binding to immune complexes.
Regulatory T Cell (Treg) Function
- Regulatory T cells (Tregs) suppress excessive immune responses and maintain immune tolerance.
CD4 Molecule Binding
- The CD4 molecule on helper T cells binds to MHC Class II molecules on antigen-presenting cells, initiating an immune response.
Immunoglobulin in Mucosal Secretions
- IgA is the main immunoglobulin in healthy human upper respiratory tract secretions.
T Cell-APC Interaction
- The immunological synapse is the contact region where T cells and antigen-presenting cells (APCs) interact to recognize antigens and trigger responses.
T-Killer Cell Interaction
- T-killer cells interact with MHC Class I molecules (especially during viral infections).
Type I Interferon Function
- Type I interferons (alpha and beta) are crucial for antiviral immunity by inhibiting viral replication and activating immune cells.
NK Cell Activation
- NK cell activation happens when they detect the absence of MHC Class I molecules on a cell surface, often indicative of infection or cancer.
B-Cell Marker
- CD19 is a surface marker specific for B cells.
Th2 Cell Role
- Th2 cells promote humoral immunity by activating B cells to produce antibodies, and play a role in allergic responses.
TLR (Toll-like Receptor) Function
- TLRs recognize pathogen-associated molecular patterns (PAMPs) and activate innate immune responses.
Interferon-Gamma Promotion
- Interleukin 12 (IL-12) promotes the production of interferon-gamma (IFN-γ).
Immunoglobulins in Antitumor Immunity
- IgG and IgM can be involved in targeting and neutralizing tumor cells.
Tumor Development & Immunity
- Tumours develop when tumour antigens aren't appropriately recognised or targeted by the immune system, potentially due to immune tolerance or suppression.
Complement Inhibitors
- DAF (Decay-Accelerating Factor) regulates complement activation by accelerating the decay of C3 and C5 convertases.
Induced Immune Tolerance
- Induced tolerance is acquired later in life, maintaining immune homeostasis.
Immunoglobulin Transport
- Transcytosis is the process that moves immunoglobulins, like IgA, across epithelial cells to mucosal secretions.
Phagocytic Cells
- Macrophages, neutrophils, and dendritic cells are all phagocytic cells involved in eliminating pathogens.
Th1 Cell Function
- Th1 cells primarily mediate cell-mediated immunity, responding strongly to intracellular pathogens.
Hemolytic Disease of the Newborn
- Hemolytic disease occurs when Rh-negative mothers develop antibodies against Rh-positive fetal blood cells, damaging fetal red blood cells,.
Eosinophil Activation
- IL-5 stimulates eosinophil activation in allergic reactions.
Antibody Diversity
- Recombination of gene segments during B cell development generates the antibody diversity.
Monoclonal Antibody Production
- Hybridoma technology fuses B cells with myeloma cells to produce monoclonal antibodies.
T-Killer Mechanism
- T-killer cells kill target cells by releasing perforins (form pores) and granzymes (induce apoptosis), inducing programmed cell death through enzyme perforation.
Non-Specific vs. Adaptive Immunity
- The adaptive immune system (B and T lymphocytes) is specific, whereas non-specific defense mechanisms (innate) are immediate.
Non-Specific Immune Mechanisms
- Non-specific defense mechanisms act without prior exposure to a pathogen and involve complement, lysozyme, interferons and inflammatory response.
Toll-like Receptors (TLRs) Activation
- TLRs activate macrophages, dendritic cells, neutrophils, and B cells to recognize pathogenic patterns (PAMPs).
Immune Tolerance Mechanisms
- Positive and Negative selection in the thymus ensures tolerance to self-antigens by removing T cells that strongly recognise them.
Leukocyte Identification
- Light microscopy is used to identify and count leukocytes (e.g., different types of lymphocytes), based on the morphological characteristics of various types of leukocytes in blood smears.
Lymphocyte Markers
- CD3 and CD19 identify T cells and B cells, respectively.
Functional status of Immune System
- Serum immunoglobulin levels reflect the status of the humoral immune system.
Immunoassay Techniques
- ELISA (Enzyme-Linked Immunosorbent Assay) is an immunoassay that uses enzymes as labels, while Radioimmunoassay, Fluorescent Immunoassay and Western Blot are other forms of immunoassays..
Lymphocyte Quantification
- EAC-rosettes are used to count lymphocytes, particularly T lymphocytes.
Hypersensitivity Types
- Immediate hypersensitivity (IHT) is mediated by IgE, while delayed hypersensitivity (DHT) involves T lymphocytes.
Hypersensitivity Manifestations
- Hypersensitivity reactions result in tissue damage due to excessive immune responses.
Anaphylaxis Features
- Anaphylaxis is a severe and potentially life-threatening allergic reaction that has a rapid onset.
Delayed Hypersensitivity Cell Involvement
- DHT involves T lymphocytes, particularly CD4+ lymphocytes, triggering cell-mediated immunity.
Rh and ABO Incompatibilities
- Rh incompatibility is a cause of hemolytic disease in newborns, related to the immune response to Rh factor, leading to damage of fetal red blood cells.
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Description
Test your knowledge on various treatment methods and mechanisms related to autoimmune diseases. This quiz covers topics such as cytokine roles, MHC expression, T-killer cell functions, and more. Dive into the specifics of immune responses and treatments in this comprehensive assessment.
