Autoimmune Diseases Tolerance
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Questions and Answers

What is the term used to describe the absence of specific immune response to a particular antigen in a fully immunocompetent person?

  • Immune suppression
  • Auto tolerance (correct)
  • Antigenic response
  • Immunocompetence
  • Which mechanism is responsible for the breakdown leading to autoimmune diseases?

  • Genetic predisposition
  • Release of sequestrated antigens
  • Exposure to microbial antigens
  • Decrease in suppressor T cell function (correct)
  • In autoimmune diseases, what can lead to the production of autoantibodies and sensitized T cells to self tissues?

  • Decrease in suppressor T cell function
  • Release of microbial antigens
  • Exposure to sequestrated antigens
  • Altered self antigens under the effect of drugs (correct)
  • What familial factor is associated with autoimmune diseases?

    <p>Genetic predisposition</p> Signup and view all the answers

    Which type of tissue antigens are sequestrated and may lead to immunological response if accidentally released into circulation?

    <p>Eye lens antigens</p> Signup and view all the answers

    Which factor may result in the appearance of new antigens under the effect of drugs, chemicals, or viral infection?

    <p>Altered self antigens</p> Signup and view all the answers

    Which mechanism of tissue damage involves autoantibodies stimulating the surface of thyroid cells, leading to overproduction of thyroid hormones?

    <p>Cytotoxic reactions (type II)</p> Signup and view all the answers

    What is the mechanism of tissue damage in rheumatoid arthritis and systemic lupus erythematosus?

    <p>Immune complex deposition (type III)</p> Signup and view all the answers

    In which condition do T-cell deficiencies manifest as neonatal hypocalcaemic tetany followed by recurrent viral, fungal, and protozoal infections early in life?

    <p>DiGeorge's Syndrome</p> Signup and view all the answers

    Which disorder is manifested by repeated pyogenic bacterial infections 6-9 months after birth, and normal control of viral infections?

    <p>X-Linked infantile hypogammaglobulinaemia</p> Signup and view all the answers

    What is the most common condition associated with selective immunoglobulin deficiency, characterized by recurrent respiratory tract infections?

    <p>Selective IgA deficiency</p> Signup and view all the answers

    Which treatment is indicated for X-Linked infantile hypogammaglobulinaemia to maintain adequate levels of serum immunoglobulins?

    <p>Gammaglobulin injections every 3-4 weeks</p> Signup and view all the answers

    Which treatment should be avoided in selective IgA deficiency to prevent hypersensitivity reactions?

    <p>Gammaglobulin injections</p> Signup and view all the answers

    What is the main source for T cell formation and differentiation?

    <p>Thymus</p> Signup and view all the answers

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