14 Questions
What is the term used to describe the absence of specific immune response to a particular antigen in a fully immunocompetent person?
Auto tolerance
Which mechanism is responsible for the breakdown leading to autoimmune diseases?
Decrease in suppressor T cell function
In autoimmune diseases, what can lead to the production of autoantibodies and sensitized T cells to self tissues?
Altered self antigens under the effect of drugs
What familial factor is associated with autoimmune diseases?
Genetic predisposition
Which type of tissue antigens are sequestrated and may lead to immunological response if accidentally released into circulation?
Eye lens antigens
Which factor may result in the appearance of new antigens under the effect of drugs, chemicals, or viral infection?
Altered self antigens
Which mechanism of tissue damage involves autoantibodies stimulating the surface of thyroid cells, leading to overproduction of thyroid hormones?
Cytotoxic reactions (type II)
What is the mechanism of tissue damage in rheumatoid arthritis and systemic lupus erythematosus?
Immune complex deposition (type III)
In which condition do T-cell deficiencies manifest as neonatal hypocalcaemic tetany followed by recurrent viral, fungal, and protozoal infections early in life?
DiGeorge's Syndrome
Which disorder is manifested by repeated pyogenic bacterial infections 6-9 months after birth, and normal control of viral infections?
X-Linked infantile hypogammaglobulinaemia
What is the most common condition associated with selective immunoglobulin deficiency, characterized by recurrent respiratory tract infections?
Selective IgA deficiency
Which treatment is indicated for X-Linked infantile hypogammaglobulinaemia to maintain adequate levels of serum immunoglobulins?
Gammaglobulin injections every 3-4 weeks
Which treatment should be avoided in selective IgA deficiency to prevent hypersensitivity reactions?
Gammaglobulin injections
What is the main source for T cell formation and differentiation?
Thymus
Test your knowledge about autoimmune diseases and the concept of auto tolerance. Explore the etiology of autoimmune diseases and the breakdown of mechanisms that maintain tolerance to self antigens.
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