Immunology Quiz on Antibodies and Immunity
47 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which immunoglobulin class is primarily responsible for protecting mucous membranes and internal cavities from infection?

  • IgE
  • IgA (correct)
  • IgG
  • IgD
  • Immunoglobulin D (IgD) is the first antibody produced during an infection.

    False (B)

    What is the primary function of IgE?

    IgE is involved in allergic reactions, drug sensitivity, anaphylaxis, and immediate hypersensitivity. It also helps fight parasitic diseases.

    The ______ class of antibodies is known for enhancing phagocytosis, neutralizing toxins and viruses, and protecting the fetus and newborn.

    <p>IgG</p> Signup and view all the answers

    Match the immunoglobulin class with its correct location:

    <p>IgA = Mucous membranes and internal cavities IgD = B-cell surface, blood, and lymph IgE = Basophils and mast cells IgG = Blood, lymph, and intestine IgM = Blood, lymph, and B-cell surface</p> Signup and view all the answers

    Which of the following is NOT a function of antibodies?

    <p>Directly killing pathogens (D)</p> Signup and view all the answers

    Immunity is only obtained through vaccination.

    <p>False (B)</p> Signup and view all the answers

    What is the definition of immunity?

    <p>Immunity is the state of protection against infectious disease obtained through an immune response, previous infection, or other non-immunological factors.</p> Signup and view all the answers

    What is the primary function of the thymus?

    <p>Development of T lymphocytes (A)</p> Signup and view all the answers

    The spleen weighs approximately 500 grams in adults.

    <p>False (B)</p> Signup and view all the answers

    What term is used to describe the body's ability to distinguish between 'self' and 'non-self'?

    <p>Immune recognition</p> Signup and view all the answers

    T lymphocytes mature in the ______.

    <p>thymus</p> Signup and view all the answers

    Match the immune organs with their primary functions:

    <p>Thymus = Maturation of T lymphocytes Bone marrow = Origin of B lymphocytes Spleen = Traps blood-borne antigens Tonsils = Defense against pathogens entering the throat</p> Signup and view all the answers

    What is an antigen?

    <p>Anything that can trigger an immune response (C)</p> Signup and view all the answers

    Autoimmune diseases occur when the immune system attacks 'non-self' cells.

    <p>False (B)</p> Signup and view all the answers

    What does MHC stand for?

    <p>Major histocompatibility complex</p> Signup and view all the answers

    Which type of vaccine contains living, non-virulent strains of microbes?

    <p>Attenuated vaccines (C)</p> Signup and view all the answers

    The oral polio vaccine contains killed poliomyelitis viruses.

    <p>False (B)</p> Signup and view all the answers

    Name one vaccine that uses recombinant DNA technology.

    <p>Hepatitis B vaccine (HepB)</p> Signup and view all the answers

    Diphtheria and tetanus vaccines are examples of ______ vaccines.

    <p>toxoid</p> Signup and view all the answers

    Which of the following is an example of a vaccine containing killed organisms?

    <p>Rabies vaccine (C)</p> Signup and view all the answers

    Passive immunity provides long-term protection against infections.

    <p>False (B)</p> Signup and view all the answers

    Match the following types of vaccines with their descriptions:

    <p>Attenuated = Contains living non-virulent strains Killed = Contains whole, killed microorganisms Toxoid = Nonpoisonous treated exotoxin Recombinant DNA = Incorporates DNA from multiple sources</p> Signup and view all the answers

    What is the function of the immune globulin (IG) in passive artificially acquired immunity?

    <p>To provide immediate protection against specific infections.</p> Signup and view all the answers

    What type of antigen is involved in allergic reactions?

    <p>Allergen (B)</p> Signup and view all the answers

    The immune system does not differentiate among different types of pathogens.

    <p>False (B)</p> Signup and view all the answers

    Where do T cells mature?

    <p>Thymus</p> Signup and view all the answers

    B cells and T cells are types of ______ involved in the immune response.

    <p>lymphocytes</p> Signup and view all the answers

    Match the following T cell types with their functions:

    <p>Helper T cells (CD4) = Activate B cells and killer T cells Cytotoxic T cells (CD8) = Attack infected and cancer cells Suppressor T cells = Regulate the immune response Memory T cells = Provide long-term immunity</p> Signup and view all the answers

    What is the primary role of Helper T cells?

    <p>Activate B cells and killer T cells (A)</p> Signup and view all the answers

    Cytotoxic T cells are specialized in attacking cells infected by viruses and bacteria.

    <p>True (A)</p> Signup and view all the answers

    What process involves a phagocyte displaying an antigen fragment from an invader?

    <p>Antigen presentation</p> Signup and view all the answers

    What protein do cytotoxic T cells release to lyse infected cells?

    <p>Perforin (C)</p> Signup and view all the answers

    Suppressor T cells are responsible for activating the immune system during an infection.

    <p>False (B)</p> Signup and view all the answers

    What is the primary function of plasma cells?

    <p>To produce antibodies.</p> Signup and view all the answers

    B lymphocytes are formed in the _______.

    <p>bone marrow</p> Signup and view all the answers

    Which type of immune response involves B cells?

    <p>Humoral response (A)</p> Signup and view all the answers

    Memory T cells do not play a role in immunity.

    <p>False (B)</p> Signup and view all the answers

    What happens to B cells after they are activated by helper T cells?

    <p>They divide to produce clones, forming plasma cells and B memory cells.</p> Signup and view all the answers

    What type of immunity involves the transfer of antibodies from mother to fetus across the placenta?

    <p>IgG (B)</p> Signup and view all the answers

    Artificially acquired active immunity is usually long-lasting.

    <p>True (A)</p> Signup and view all the answers

    What is the main difference between naturally acquired active immunity and artificially acquired active immunity?

    <p>Naturally acquired active immunity is generated through exposure to natural pathogens, while artificially acquired active immunity is induced through vaccinations.</p> Signup and view all the answers

    The immunity obtained from colostrum during breastfeeding is called ___________.

    <p>naturally acquired passive immunity</p> Signup and view all the answers

    Match the immunoglobulin types with their modes of transfer:

    <p>IgG = Transfer across the placenta IgA = Transfer during breastfeeding</p> Signup and view all the answers

    Which of the following is an example of artificially acquired passive immunity?

    <p>Intravenous gamma globulin injection (B)</p> Signup and view all the answers

    Antiserum is a type of actively acquired immunity.

    <p>False (B)</p> Signup and view all the answers

    What type of vaccine contains weakened pathogens?

    <p>Attenuated vaccine</p> Signup and view all the answers

    Flashcards

    Allergen

    Antigen that triggers an allergic reaction, often to harmless substances like egg.

    Immune system

    The body's third line of defense, specifically targeting and neutralizing pathogens.

    Lymphocytes

    White blood cells crucial for the immune response, responsible for recognizing and destroying specific pathogens.

    T cells (T lymphocytes)

    Lymphocytes that mature in the thymus, responsible for cell-mediated immunity.

    Signup and view all the flashcards

    Helper T cell (CD4)

    A type of T cell responsible for activating other immune cells like B cells and killer T cells.

    Signup and view all the flashcards

    Cytotoxic T cell (CD8) or Killer T cell

    A type of T cell responsible for directly killing infected cells and cancer cells.

    Signup and view all the flashcards

    Suppressor T cell

    A type of T cell that helps regulate the immune response, preventing overactivation and autoimmunity.

    Signup and view all the flashcards

    Memory T cell

    A type of T cell that remembers past infections and allows for faster response to subsequent exposures.

    Signup and view all the flashcards

    Thymus

    A greyish, flat, bilobed organ where T lymphocytes (T cells) develop and mature.

    Signup and view all the flashcards

    Bone Marrow

    The primary site where B lymphocytes (B cells) are generated.

    Signup and view all the flashcards

    Lymph Nodes

    Bean-shaped clusters of tissue that filter lymph fluid and contain immune cells.

    Signup and view all the flashcards

    Spleen

    A large organ that traps blood-borne antigens, containing red pulp (with red blood cells and macrophages) and white pulp (with T lymphocytes).

    Signup and view all the flashcards

    Tonsils

    Tissue masses located in the throat, containing immune cells like lymphocytes, macrophages, mast cells, and granulocytes.

    Signup and view all the flashcards

    Peyer's Patches

    Clusters of lymphatic tissue found in the lining of the small intestine, capturing intestinal antigens.

    Signup and view all the flashcards

    Self vs. Non-Self

    The process by which the immune system distinguishes between the body's own cells ('self') and foreign substances ('non-self').

    Signup and view all the flashcards

    Perforin

    A protein released by cytotoxic T cells that creates holes in infected cells, causing them to burst and die.

    Signup and view all the flashcards

    Antibodies

    Defensive proteins produced by B cells that bind to specific antigens, helping to neutralize them.

    Signup and view all the flashcards

    Plasma cell

    A type of B cell that produces antibodies in large amounts.

    Signup and view all the flashcards

    Immunity

    The ability of the immune system to respond more quickly and effectively to a pathogen that the body has encountered before.

    Signup and view all the flashcards

    What are antibodies?

    They are also called immunoglobulins, which are classified into five distinct groups.

    Signup and view all the flashcards

    What is IgA and what's its function?

    It is found in tears, saliva, colostrum, and other secretions. This antibody provides immunity to the infant digestive tract.

    Signup and view all the flashcards

    What is IgE and what's its function?

    It triggers allergic reactions, drug sensitivity, anaphylaxis, and immediate hypersensitivity. It also fights against parasitic diseases.

    Signup and view all the flashcards

    What does the IgD antibody do?

    It's role in the serum is not fully understood. On the B cell surface, it initiates the immune response.

    Signup and view all the flashcards

    What is the IgM antibody?

    It's the first antibody produced during an infection. It's effective against microbes and agglutinating antigens.

    Signup and view all the flashcards

    What does IgG antibody do?

    It enhances phagocytosis, neutralizes toxins and viruses, and protects the fetus and newborn. It can be transferred through the placenta.

    Signup and view all the flashcards

    Define immunity.

    It's the state of being protected against infectious diseases. It can be obtained through immunization, previous infection, or other non-immunological factors.

    Signup and view all the flashcards

    What is natural immunity?

    It refers to immunity acquired through natural exposure to a pathogen or antigen. It occurs when the individual is naturally infected and develops an immune response.

    Signup and view all the flashcards

    Naturally Acquired Active Immunity

    Acquired immunity developed when the body produces its own antibodies in response to exposure to a specific antigen. This typically occurs after contracting an illness or being exposed to an organism, leading to long-lasting immunity.

    Signup and view all the flashcards

    Naturally Acquired Passive Immunity

    Acquired immunity developed when antibodies are received passively from another source, like a mother to her baby across the placenta or through breast milk.

    Signup and view all the flashcards

    Artificially Acquired Active Immunity

    Acquired immunity developed when an antigen is deliberately introduced through vaccination. This stimulates the body to produce antibodies and memory cells against specific diseases.

    Signup and view all the flashcards

    Artificially Acquired Passive Immunity

    Acquired immunity developed when pre-made antibodies (immunoglobulins) from someone else are injected into the body. This provides immediate but temporary protection.

    Signup and view all the flashcards

    Antigen

    A substance, usually a weakened or deactivated form of a pathogen, used in vaccines to stimulate an immune response.

    Signup and view all the flashcards

    Attenuated Pathogen

    A weakened or inactive form of a pathogen used in vaccines to stimulate an immune response without causing the disease.

    Signup and view all the flashcards

    Inactivated Pathogen

    A type of vaccine containing inactivated pathogens or parts of pathogens that cannot cause disease but still elicit an immune response.

    Signup and view all the flashcards

    Attenuated Vaccine

    A type of vaccine containing weakened, non-disease causing versions of the pathogen. These vaccines mimic the natural infection, stimulating the immune system without causing illness.

    Signup and view all the flashcards

    Inactivated Vaccine

    A type of vaccine containing killed or inactivated pathogens or their components. These vaccines expose the immune system to the pathogen's antigens without causing illness.

    Signup and view all the flashcards

    Subunit Vaccine

    A type of vaccine containing fragments of the pathogen, such as proteins, carbohydrates or other molecules, which trigger an immune response. This type is safer because it does not contain the whole pathogen, and can be used to target specific parts of the pathogen.

    Signup and view all the flashcards

    Toxoid Vaccine

    A type of vaccine containing a toxin that has been detoxified but still retains the ability to trigger an immune response. The immune system produces antibodies against the toxin, providing protection against the actual toxin.

    Signup and view all the flashcards

    Recombinant Vaccine

    A type of vaccine formulated using recombinant DNA technology, which inserts pathogen genes into harmless carrier organisms or cells, allowing those cells to produce pathogen antigens. These antigens stimulate an immune response without the risks associated with using whole pathogens.

    Signup and view all the flashcards

    Passive Immunity

    A type of immunity acquired through the direct administration of antibodies, rather than the body's own production. This provides immediate but temporary protection against the pathogen.

    Signup and view all the flashcards

    Passive Artificially Acquired Immunity

    A type of passive immunity obtained from a source other than the individual needing protection. This comes in the form of either antiserum or immune globulin.

    Signup and view all the flashcards

    Antiserum

    A type of passive immunity obtained from injecting an animal with an antigen, causing the animal to produce antibodies. The antibodies are then extracted from the animal's serum and administered to a person in need of protection.

    Signup and view all the flashcards

    Study Notes

    Introduction to Specific Immunity

    • The second line of defense, while powerful, is not perfect.
    • It cannot eliminate all pathogens.
    • It does not have memory of past infections.
    • A third line of defense (specific immunity) is needed for these limitations.

    Immune System

    • The immune system is a network of cells, tissues, and organs working together to protect the body from foreign invaders.
    • The system comprises cells and chemical barriers to prevent pathogens from entering.
    • If pathogens enter, the immune system attempts to stop them from causing harm, leading to symptoms of disease.
    • Pathogens can multiply, release toxins, and damage cells.

    Learning Objectives

    • Define antibodies and antigens.
    • Define the immune system.
    • Identify organs of the immune system.
    • Describe the immune system.
    • Describe the different types of B and T lymphocytes.
    • Describe the five classes of antibodies.
    • Define immunity.
    • Explain the different types of immunity.

    Terminology

    • Antigen: Any foreign material (bacteria, virus, toxins) triggering an immune response.
    • Antibody: A protein produced as a result of an immune response to an antigen.
    • Immune: Free from the possibility of acquiring a specific infectious disease.

    Terminology - Humoral Immunity

    • Immunity involving B lymphocytes transforming into plasma cells producing antibodies targeting specific antigens.

    Terminology - Cell-Mediated Immunity

    • Immune response not involving antibodies, but involving the activation of phagocytes and antigen-specific cytotoxic T-lymphocytes releasing cytokines in response to antigens.

    Specific Defenses (Third Line of Defense)

    • The third line of defense, also known as the immune system, is a powerful, targeted defense mechanism.
    • It recognizes, attacks, and remembers pathogens.
    • Specific cells and antibodies are produced to combat pathogens effectively.

    Organs of the Immune System

    • Thymus: A greyish, flat, bilobed lymphoid organ. Site of T cell development and maturation. Weighs 10g in infants and 3g in adults.
    • Bone Marrow: Origin site for B lymphocytes (B cells).
    • Lymph Nodes: Bean-shaped clusters throughout the lymphatic system.
    • Spleen: 5 inches long, 200g. Traps blood-borne antigens. Contains red pulp with erythrocytes, macrophages, and white pulp with T lymphocytes.
    • Tonsils: Contain lymphocytes, macrophages, mast cells, and granulocytes.
    • Peyer's Patches: Located in the small intestine's lower layers.

    Functions of the Immune System

    • Differentiation: between self and non-self (foreign) cells.
    • Destruction: of non-self (foreign) cells.

    Specialized Cells in Immune System

    • T lymphocytes (T cells): Involved in cell-mediated immunity.
      • Come in different types, including helper T cells (CD4), cytotoxic T cells (killer T cells, CD8), suppressor T cells, and memory T cells.
      • Develop and mature in the thymus, an organ situated under the breastbone.
      • Helper T cells (CD4) activate B cells and killer T cells.
      • Cytotoxic T cells (CD8) attack infected body cells and cancer cells using perforin.
      • Suppressor T cells regulate the immune response.
      • Memory T cells provide long-term immunity.
    • B lymphocytes (B cells): Involved in humoral immunity.
      • Formed in bone marrow, migrate to lymph nodes or spleen.
      • Produce antibodies in response to antigens.
      • When activated, divide to produce plasma cells which create antibodies and memory cells.

    Overview of the Immune Response

    • The immune system recognizes, attacks, destroys, and remembers each pathogen that enters the body through specific cells and antibodies.

    "Self" and "Nonself"

    • The body's immune system identifies and distinguishes between "self" (body's own cells) and "nonself" or foreign cells or organisms with special markers.
    • The major histocompatibility complex (MHC) is a group of molecules marking the body's cells. This helps prevent attack on body cells.
    • The immune system recognizes any cells without the MHC marker as "non-self."

    Antigens

    • Anything that can trigger the immune response (like microbes).

    Autoimmune Diseases

    • Can occur when the immune system mistakes "self" for "non-self" and attacks its own cells and tissues (e.g., arthritis, diabetes).

    Allergies

    • The immune system responds to harmless substances as antigens (e.g., pollen, eggs).
    • These responses can cause allergies.

    Types of acquired immunity

    • Naturally acquired active immunity: results from infection
    • Naturally acquired passive immunity: transfer of antibodies from a mother
    • Artificially acquired active immunity: vaccination
    • Artificially acquired passive immunity: introduction of antibodies

    Vaccines

    • Attenuated microbes: Vaccines containing living but weakened strains of microbes produce an immune response. Examples include MMR (measles, mumps, and rubella).
    • Killed organisms/inactivated viruses or viral antigens: Vaccines contain inactivated microbes. Examples include rabies and influenza vaccines.
    • Fragments of microorganisms: Fragment-based vaccines (e.g., Haemophilus influenzae type b) contain segments of pathogen.
    • Recombinant DNA technology: Vaccines utilize DNA from multiple sources and combine them for creating an immunity response. Examples include HepB, DTAP, HepA, and HPV vaccines
    • Toxoids: These are treated toxins that produce an immune response without toxicity and examples include diphtheria and tetanus vaccines.

    Immune Globulin (IG)

    • Antibodies are acquired through blood
    • Provides temporary protection.
      -IgA, IgD, IgE, IgG, IgM -IgA: protect mucous membrane and internal cavities against infection by providing immunity to infant digestive tract. -IgD: found in B cell surface, blood, and lymph. On B cell surface, it initiate immune response. -IgE: caused allergies, drug sensitivity, anaphylaxia and immediate hypersensitivity, basically it will fight against parasitic disease. -IgG: enhances phagocytosis, neutralizes toxins and viruses, protects fetus and newborn. -IgM: first antibodies produced during and infection that fight against microbes and agglutinating antigens.

    Types of Immunity

    • Innate immunity: Nonspecific, first line of defense against pathogens, mediated by immune cells like macrophages, dendritic cells, natural killer (NK) cells, and certain granulocytes (neutrophils, basophils, eosinophils).
    • Adaptive immunity: Specific and involves B and T lymphocytes. The body develops specific immunity to pathogens through exposure.

    Antibody Classes (Immunoglobulins)

    • There are five primary antibody classes, each with unique functions: IgA, IgE, IgD, IgM, and IgG.

    Consequences of Antibody Binding

    • Agglutination: clumping foreign agents.
    • Opsonization: coating to promote phagocytosis.
    • Neutralization: blocking toxin or virus activity.
    • Antibody-dependent cell-mediated cytotoxicity: targeting infected/cancerous cells.

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Description

    Test your knowledge on immunoglobulin classes, their functions, and key immune concepts. This quiz covers antibody roles, the immune system's structure, and definitions related to immunity. Perfect for students of immunology or anyone interested in understanding the immune system better.

    Use Quizgecko on...
    Browser
    Browser