Podcast
Questions and Answers
MHC displays foreign peptides to activate ______ cells.
MHC displays foreign peptides to activate ______ cells.
T-helper
The generation of diversity allows lymphocytes to theoretically bind to any ______.
The generation of diversity allows lymphocytes to theoretically bind to any ______.
antigen
Mature ______ cells are responsible for producing antibodies.
Mature ______ cells are responsible for producing antibodies.
B
Clonal selection results in the formation of effector cells and ______ cells.
Clonal selection results in the formation of effector cells and ______ cells.
The major antigen presenting cell is the ______.
The major antigen presenting cell is the ______.
Antigen presenting cells include Dendritic cells, Macrophages, and ______.
Antigen presenting cells include Dendritic cells, Macrophages, and ______.
The Major Histocompatibility Complex (MHC) is crucial for presenting antigen on a ______ protein.
The Major Histocompatibility Complex (MHC) is crucial for presenting antigen on a ______ protein.
Lymphocytes include B-cells, plasma cells, antibodies, and ______.
Lymphocytes include B-cells, plasma cells, antibodies, and ______.
The concept of diversity is important in adaptive ______.
The concept of diversity is important in adaptive ______.
Adaptive immunity involves a ______ strategy for detecting foreign proteins.
Adaptive immunity involves a ______ strategy for detecting foreign proteins.
Dendritic cells, macrophages, and B-cells are considered ______ APC.
Dendritic cells, macrophages, and B-cells are considered ______ APC.
MHC Class I is found on all ______ cells in vertebrates.
MHC Class I is found on all ______ cells in vertebrates.
The principal players in the adaptive immune system are ______.
The principal players in the adaptive immune system are ______.
Activated B-cells become ______ cells and secrete antibodies.
Activated B-cells become ______ cells and secrete antibodies.
T-helper cells express the glycoprotein ______ and recognize MHC Class II.
T-helper cells express the glycoprotein ______ and recognize MHC Class II.
MHC restriction refers to the ______ that must be met for T-cell recognition.
MHC restriction refers to the ______ that must be met for T-cell recognition.
B-cell receptors (BCR) are membrane-bound ______.
B-cell receptors (BCR) are membrane-bound ______.
The ratio of CD4+ to CD8+ T-cells is typically ______:1.
The ratio of CD4+ to CD8+ T-cells is typically ______:1.
The concept of presenting antigen on a SELF protein helps in the process of ______ within the immune system.
The concept of presenting antigen on a SELF protein helps in the process of ______ within the immune system.
To maintain tolerance to self-proteins, MHC displays a self peptide in Class 1 and 2 to test T-cells for ______.
To maintain tolerance to self-proteins, MHC displays a self peptide in Class 1 and 2 to test T-cells for ______.
During the clonal selection of lymphocytes, some cells differentiate into ______ cells that remain in the body for long-term immunity.
During the clonal selection of lymphocytes, some cells differentiate into ______ cells that remain in the body for long-term immunity.
In the collaboration between innate and adaptive immunity, the first step involves a ______ response to the introduced pathogen.
In the collaboration between innate and adaptive immunity, the first step involves a ______ response to the introduced pathogen.
Dendritic cells, macrophages, and B-cells are examples of antigen presenting ______.
Dendritic cells, macrophages, and B-cells are examples of antigen presenting ______.
The generation of diversity in lymphocytes allows for many combinations to be formed before the ______ ones are deleted.
The generation of diversity in lymphocytes allows for many combinations to be formed before the ______ ones are deleted.
Dendritic cells make contact with pathogens and communicate to ______ in lymph nodes.
Dendritic cells make contact with pathogens and communicate to ______ in lymph nodes.
B-cells mature in the ______.
B-cells mature in the ______.
The self receptor for professional antigen presenting cells is ______.
The self receptor for professional antigen presenting cells is ______.
T-cells express a unique antigen binding receptor known as ______.
T-cells express a unique antigen binding receptor known as ______.
Non-professional antigen presenting cells utilize ______ as their self receptor.
Non-professional antigen presenting cells utilize ______ as their self receptor.
Activated B-cells lose their cell surface and become ______ cells.
Activated B-cells lose their cell surface and become ______ cells.
T-helper cells recognize antigens presented by ______ class MHC.
T-helper cells recognize antigens presented by ______ class MHC.
The ratio of CD4+ to CD8+ T-cells is approximately ______:1.
The ratio of CD4+ to CD8+ T-cells is approximately ______:1.
What role do antigen presenting cells (APCs) play in adaptive immunity?
What role do antigen presenting cells (APCs) play in adaptive immunity?
What component is essential for the recognition of antigens by T-cells?
What component is essential for the recognition of antigens by T-cells?
Which type of lymphocyte is primarily responsible for helping activate other immune cells?
Which type of lymphocyte is primarily responsible for helping activate other immune cells?
What is the significance of diversity in the adaptive immune system?
What is the significance of diversity in the adaptive immune system?
In adaptive immunity, what is the primary indicator that a T-cell can recognize an antigen?
In adaptive immunity, what is the primary indicator that a T-cell can recognize an antigen?
What is the role of MHC Class I in the immune system?
What is the role of MHC Class I in the immune system?
Which process allows lymphocytes to develop a diverse range of antigen recognition?
Which process allows lymphocytes to develop a diverse range of antigen recognition?
During the collaboration between innate and adaptive immunity, which step involves the activation of T and B cells?
During the collaboration between innate and adaptive immunity, which step involves the activation of T and B cells?
What types of cells do mature B cells develop into after activation?
What types of cells do mature B cells develop into after activation?
How do dendritic cells primarily contribute to the adaptive immune response?
How do dendritic cells primarily contribute to the adaptive immune response?
What type of molecules are B-cell receptors (BCR)?
What type of molecules are B-cell receptors (BCR)?
What is the primary function of dendritic cells in the immune system?
What is the primary function of dendritic cells in the immune system?
Which statement accurately describes MHC Class I molecules?
Which statement accurately describes MHC Class I molecules?
What is the approximate difference in lifespan between activated B-cells and plasma cells?
What is the approximate difference in lifespan between activated B-cells and plasma cells?
Which cells primarily have the role of presenting antigens to T-cells?
Which cells primarily have the role of presenting antigens to T-cells?
How do T cytotoxic (TC) cells differentiate from T-helper (TH) cells?
How do T cytotoxic (TC) cells differentiate from T-helper (TH) cells?
What is the main role of professional antigen presenting cells (APCs)?
What is the main role of professional antigen presenting cells (APCs)?
What feature distinguishes professional APCs from non-professional APCs?
What feature distinguishes professional APCs from non-professional APCs?
What is the primary reason for detecting a SELF protein in combination with a foreign protein during the adaptive immune response?
What is the primary reason for detecting a SELF protein in combination with a foreign protein during the adaptive immune response?
What is a major role of Major Histocompatibility Complex (MHC) in adaptive immunity?
What is a major role of Major Histocompatibility Complex (MHC) in adaptive immunity?
Which characteristic differentiates professional antigen presenting cells (APCs) from non-professional APCs?
Which characteristic differentiates professional antigen presenting cells (APCs) from non-professional APCs?
What aspect of adaptive immunity is primarily influenced by the diversity of lymphocytes?
What aspect of adaptive immunity is primarily influenced by the diversity of lymphocytes?
During the adaptive immune response, which cells are primarily involved in the initial detection of foreign proteins?
During the adaptive immune response, which cells are primarily involved in the initial detection of foreign proteins?
What is the primary role of MHC Class I molecules in the immune response?
What is the primary role of MHC Class I molecules in the immune response?
Which statement accurately describes the process of clonal selection in lymphocytes?
Which statement accurately describes the process of clonal selection in lymphocytes?
In the collaboration between innate and adaptive immunity, at which step do lymphocytes receive activation signals?
In the collaboration between innate and adaptive immunity, at which step do lymphocytes receive activation signals?
What characterizes the generation of diversity among lymphocytes?
What characterizes the generation of diversity among lymphocytes?
Which of the following is true regarding the role of dendritic cells in adaptive immunity?
Which of the following is true regarding the role of dendritic cells in adaptive immunity?
Which cells recognize antigens presented by MHC Class I molecules?
Which cells recognize antigens presented by MHC Class I molecules?
Which protein is primarily responsible for identifying self in professional antigen presenting cells?
Which protein is primarily responsible for identifying self in professional antigen presenting cells?
What is the primary function of chemokines and cytokines secreted by dendritic cells?
What is the primary function of chemokines and cytokines secreted by dendritic cells?
What type of immunity do dendritic cells link together?
What type of immunity do dendritic cells link together?
In which organ do T-cells mature?
In which organ do T-cells mature?
The process by which lymphocytes generate a diverse range of antigen receptors is known as ______ generation.
The process by which lymphocytes generate a diverse range of antigen receptors is known as ______ generation.
What distinguishes professional antigen presenting cells (APCs) from non-professional APCs?
What distinguishes professional antigen presenting cells (APCs) from non-professional APCs?
What is the approximate lifespan of activated B-cells compared to plasma cells?
What is the approximate lifespan of activated B-cells compared to plasma cells?
Which type of T-cells primarily express CD4 glycoprotein?
Which type of T-cells primarily express CD4 glycoprotein?
Activated T and B cells continue interactions in the lymph node for differentiation and ______ of lymphocytes.
Activated T and B cells continue interactions in the lymph node for differentiation and ______ of lymphocytes.
Dendritic cells are considered the major ______ presenting cell.
Dendritic cells are considered the major ______ presenting cell.
The Major Histocompatibility Complex (MHC) is essential for presenting antigen on a ______ protein.
The Major Histocompatibility Complex (MHC) is essential for presenting antigen on a ______ protein.
In adaptive immunity, T-cells that help activate other immune cells are known as ______ cells.
In adaptive immunity, T-cells that help activate other immune cells are known as ______ cells.
Antigen presenting cells (APCs) include dendritic cells, macrophages, and ______.
Antigen presenting cells (APCs) include dendritic cells, macrophages, and ______.
The primary role of dendritic cells in the immune system is to present antigens to ______ cells.
The primary role of dendritic cells in the immune system is to present antigens to ______ cells.
The diversity of lymphocytes is important for enabling responses to a wide variety of ______.
The diversity of lymphocytes is important for enabling responses to a wide variety of ______.
Dendritic cells connect with pathogens and communicate to ______ in lymph nodes.
Dendritic cells connect with pathogens and communicate to ______ in lymph nodes.
MHC Class II is primarily associated with ______ antigen presenting cells.
MHC Class II is primarily associated with ______ antigen presenting cells.
T cytotoxic (TC) cells recognize antigens bound to ______ Class 1.
T cytotoxic (TC) cells recognize antigens bound to ______ Class 1.
The receptor/antigen binding site on cells is part of the Major ______ Complex.
The receptor/antigen binding site on cells is part of the Major ______ Complex.
Humans possess about ______ trillion lymphocytes circulating in their body.
Humans possess about ______ trillion lymphocytes circulating in their body.
Activated B-cells lose their cell surface and convert into ______ cells.
Activated B-cells lose their cell surface and convert into ______ cells.
What is the primary function of Major Histocompatibility Complex (MHC) in adaptive immunity?
What is the primary function of Major Histocompatibility Complex (MHC) in adaptive immunity?
Which statement best describes the nature of antigen presenting cells (APCs) in adaptive immunity?
Which statement best describes the nature of antigen presenting cells (APCs) in adaptive immunity?
How do T-cells differentiate into their functional subsets in response to an antigen?
How do T-cells differentiate into their functional subsets in response to an antigen?
In the context of adaptive immunity, what is meant by the term 'self receptor'?
In the context of adaptive immunity, what is meant by the term 'self receptor'?
What is the primary outcome of the collaboration between innate and adaptive immunity after a pathogen is introduced?
What is the primary outcome of the collaboration between innate and adaptive immunity after a pathogen is introduced?
Which statement correctly describes the function of dendritic cells in the immune response?
Which statement correctly describes the function of dendritic cells in the immune response?
How do lymphocytes achieve diversity in recognizing antigens?
How do lymphocytes achieve diversity in recognizing antigens?
What role do memory cells play in the adaptive immune system?
What role do memory cells play in the adaptive immune system?
What is a significant characteristic of MHC Class II molecules in relation to T-helper cells?
What is a significant characteristic of MHC Class II molecules in relation to T-helper cells?
Which of the following statements about professional antigen presenting cells (APCs) is true?
Which of the following statements about professional antigen presenting cells (APCs) is true?
What is the primary role of MHC Class I molecules?
What is the primary role of MHC Class I molecules?
Which characteristic best distinguishes oxidized professional antigen presenting cells from non-professional antigen presenting cells?
Which characteristic best distinguishes oxidized professional antigen presenting cells from non-professional antigen presenting cells?
What is the significant outcome of dendritic cells interacting with pathogens?
What is the significant outcome of dendritic cells interacting with pathogens?
What is the approximate ratio of CD4+ T helper cells to CD8+ T cytotoxic cells in a healthy immune system?
What is the approximate ratio of CD4+ T helper cells to CD8+ T cytotoxic cells in a healthy immune system?
How do B-cells transform after activation?
How do B-cells transform after activation?
Which feature is exclusive to T cytotoxic (TC) cells compared to T-helper (TH) cells?
Which feature is exclusive to T cytotoxic (TC) cells compared to T-helper (TH) cells?
What process does 'MHC restriction' refer to in T-cell recognition?
What process does 'MHC restriction' refer to in T-cell recognition?
What role does the MHC Class I play in the immune system?
What role does the MHC Class I play in the immune system?
What is a consequence of the generation of diversity in lymphocytes?
What is a consequence of the generation of diversity in lymphocytes?
During clonal selection, lymphocytes differentiate into which types of cells?
During clonal selection, lymphocytes differentiate into which types of cells?
What is the primary function of dendritic cells in the adaptive immune response?
What is the primary function of dendritic cells in the adaptive immune response?
Which step follows the introduction of a pathogen in the collaboration between innate and adaptive immunity?
Which step follows the introduction of a pathogen in the collaboration between innate and adaptive immunity?
Which cells are known as antigen presenting cells (APCs) in adaptive immunity?
Which cells are known as antigen presenting cells (APCs) in adaptive immunity?
What role does the Major Histocompatibility Complex (MHC) play in the immune response?
What role does the Major Histocompatibility Complex (MHC) play in the immune response?
Why is diversity important in the adaptive immune system?
Why is diversity important in the adaptive immune system?
What distinguishes T-helper cells from T-cytotoxic cells?
What distinguishes T-helper cells from T-cytotoxic cells?
What is the significance of memory in the adaptive immune response?
What is the significance of memory in the adaptive immune response?
Which cells are classified as professional antigen presenting cells?
Which cells are classified as professional antigen presenting cells?
Which class of MHC is found on professional antigen presenting cells?
Which class of MHC is found on professional antigen presenting cells?
What type of cells primarily respond to antigens presented on MHC Class I?
What type of cells primarily respond to antigens presented on MHC Class I?
What feature distinguishes T-helper cells from T-cytotoxic cells?
What feature distinguishes T-helper cells from T-cytotoxic cells?
Which of the following accurately describes the properties of MHC molecules?
Which of the following accurately describes the properties of MHC molecules?
The primary players in the adaptive immune system primarily consist of which type of cells?
The primary players in the adaptive immune system primarily consist of which type of cells?
What is the lifespan of activated B-cells compared to plasma cells?
What is the lifespan of activated B-cells compared to plasma cells?
Flashcards
Adaptive Immunity
Adaptive Immunity
Adaptive immunity is a specific defense mechanism of the immune system that targets and remembers specific pathogens. It involves recognizing foreign invaders, mounting a tailored response, and developing memory for future encounters.
Antigen Presenting Cells (APCs)
Antigen Presenting Cells (APCs)
Antigen-presenting cells (APCs) are immune cells that capture and display foreign antigens to T cells, initiating an adaptive immune response. Some important APCs include dendritic cells, macrophages, and B cells.
Major Histocompatibility Complex (MHC)
Major Histocompatibility Complex (MHC)
The Major Histocompatibility Complex (MHC) is a group of genes responsible for producing proteins that act as 'self receptors' on the surface of cells. They present antigen fragments to T cells, enabling the immune system to distinguish self from non-self.
Lymphocytes
Lymphocytes
Signup and view all the flashcards
Immunological Memory
Immunological Memory
Signup and view all the flashcards
Cell Replication
Cell Replication
Signup and view all the flashcards
Professional APCs
Professional APCs
Signup and view all the flashcards
Dendritic Cells
Dendritic Cells
Signup and view all the flashcards
B-cells
B-cells
Signup and view all the flashcards
T-cells
T-cells
Signup and view all the flashcards
What is the Major Histocompatibility Complex (MHC)?
What is the Major Histocompatibility Complex (MHC)?
Signup and view all the flashcards
How is diversity generated in the immune system?
How is diversity generated in the immune system?
Signup and view all the flashcards
What is clonal selection?
What is clonal selection?
Signup and view all the flashcards
What are antigen presenting cells (APCs)?
What are antigen presenting cells (APCs)?
Signup and view all the flashcards
How does the body activate an adaptive immune response when a pathogen enters?
How does the body activate an adaptive immune response when a pathogen enters?
Signup and view all the flashcards
Study Notes
Adaptive Immunity Lecture Notes
- Lecture 3: Introduction to immune system, November 14, 2024
- Learning Outcomes:
- Introduction to cells and molecules in adaptive immunity
- Differences between innate and adaptive immunity
- Antigen presentation on self proteins to another cell
- Importance of diversity in adaptive immunity
- Understanding the role of "time" (memory) in adaptive immunity
- Adaptive Immunity Explained:
- Antigen-presenting cells (APCs) such as dendritic cells, macrophages, and B-cells are vital.
- These cells display antigens using major histocompatibility complex (MHC) molecules, which are critical for T cell recognition.
- Lymphocytes – including B-cells, plasma cells, antibodies, and T-cells (helper and cytotoxic) – are key.
- Diversity is essential for recognizing a wide array of pathogens.
- Memory is an important component of the adaptive immune response.
- Innate vs. Adaptive Immunity Comparison:
- Innate: Response time is from minutes to hours. Specialized for general responses, limited diversity. Components include barriers, phagocytes, and pattern recognition molecules. Repetitive exposure shows no difference in response.
- Adaptive: Response time is days. Highly diverse, adapting to improve with each exposure. Components include lymphocytes, antigen-specific receptors, and antibodies. Highly specialized response with each subsequent exposure.
- Lymphocytes:
- Major players in the adaptive immune system
- Account for 20-40% of white blood cells (WBCs)
- ~99% of cells in the lymph
- Circulate at ~1 trillion cells
- Three main types: B-cells, T-cells, and Natural Killer (NK) cells.
- B-Cells and Plasma Cells:
- Mature in the bone marrow (BM)
- Synthesize and display B-cell receptors (BCRs) which include membrane-bound antibodies (~15,000-30,000 per cell).
- Each B-cell has a unique antibody type.
- Activated B-cells become plasma cells which lose cell-surface receptors and begin secreting antibodies (200-1000 molecules/second).
- Lifespan is 1-2 weeks.
- T-Cells:
- Mature in the thymus
- Display unique T-cell receptors (TCRs) that recognize processed antigens bound to MHC molecules (important for recognizing 'self').
- Divided into types:
- Helper T-cells (Th cells) recognize MHC class II molecules
- Cytotoxic T-cells (Tc cells) recognize MHC class I molecules.
- CD4+ to CD8+ ratio is approximately 2:1
- Antigen Presenting Cells:
- Many cell types act as professional and non-professional antigen presenting cells (APCs) to present antigen to other cells.
- Professional APCs include dendritic cells (DCs), macrophages, and B cells (MHC Class II).
- Non-professional APCs are other nucleated cells (MHC Class I)
- Major Histocompatibility Complex (MHC):
- Proteins that present antigens to T cells
- Found on cell membranes
- Genetically diverse
- Class I: Found on all nucleated cells
- Class II: Found on professional APCs (DCs, macrophages, B cells)
- MHC Restriction: The conditions necessary for T cell activation, i.e. the T cell receptor must recognize the peptide on the MHC molecule, so the conditions must be right.
- Correct MHC-peptide combination is necessary for T cell activation.
- Importance of MHC:
- It is essential for the immune system to accurately identify healthy cells versus those that are infected. This discrimination plays a vital role in the activation of T cells, as well as in screening them for autoreactivity, which helps to prevent autoimmunity. Moreover, maintaining tolerance to self-proteins is crucial to avert unwanted immune responses against the body’s own tissues.
- Foreign peptides must be presented on MHC molecules for proper recognition.
- Generation of Diversity:
- Random generation of recognition molecules
- Each lymphocyte has multiple receptors of one specificity
- Enormous diversity allows the body to bind virtually any antigen.
- Clonal Selection:
- Lymphocytes recognize the specific antigen and proliferate
- This process generates effector cells to deal with the pathogen
- Some lymphocytes remain as memory cells for more effective subsequent responses.
- Collaboration Between Innate and Adaptive Immunity:
- A critical link between the two systems
- Pathogens are recognized and presented to appropriate T and B cells in lymph nodes.
- Activated lymphocytes proliferate and differentiate.
- Antibody production and memory cell generation are pivotal.
- Summary of Adaptive Immunity:
- Diverse for antigen recognition.
- Antigen presentation by APCs (especially DCs) is necessary.
- Antibody production is critical.
- Memory cells are for future responses.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.