Immunology Quiz: Leukocytes
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Questions and Answers

Which leukocyte comprises over 50% of all leukocytes and are identified as polymorphic leukocytes?

  • Monocytes
  • Basophils
  • Eosinophils
  • Neutrophils (correct)

Which type of leukocyte differentiates into macrophages when it migrates into tissues?

  • Monocytes (correct)
  • Neutrophils
  • Lymphocytes
  • Eosinophils

Which of the following is a function of basophils?

  • Producing antibodies.
  • Directly attacking virus-infected cells.
  • Phagocytizing bacteria in acute infections.
  • Releasing histamine to promote inflammation. (correct)

Eosinophils are most effective against which type of pathogen?

<p>Parasitic worms (D)</p> Signup and view all the answers

Which leukocytes are primarily located in lymphoid tissue (lymph nodes, spleen, etc) rather than in the bloodstream?

<p>Lymphocytes (B)</p> Signup and view all the answers

Which of the following is NOT a granulocyte?

<p>Lymphocyte (C)</p> Signup and view all the answers

What is the primary function of T lymphocytes (T cells)?

<p>Acting directly against virus-infected and tumor cells (B)</p> Signup and view all the answers

What is the role of B lymphocytes (B cells) in the immune system?

<p>Giving rise to plasma cells that produce antibodies (C)</p> Signup and view all the answers

What primary role do interleukins and colony-stimulating factors play in the context of leukopoiesis?

<p>They regulate the production of leukocytes based on the body's needs. (D)</p> Signup and view all the answers

Regarding the maturation and storage of granulocytes, what is accurate based on the provided information?

<p>Bone marrow primarily stores mature granulocytes, typically containing significantly more than are found in circulating blood. (C)</p> Signup and view all the answers

How is leukemia characterized, and what are its primary effects on the body?

<p>Leukemia is a cancer of white blood cells where unspecialized and mitotic cells overtake the bone marrow, leading to anemia and clotting problems. (A)</p> Signup and view all the answers

What is the typical treatment approach for leukemia?

<p>Irradiation and administration of anti-leukemic drugs, potentially followed by a bone marrow transplant. (D)</p> Signup and view all the answers

What is indicated by the terms 'acute' and 'chronic' when classifying leukemia?

<p>'Acute' indicates a rapid onset from blast-type cells, whereas 'chronic' indicates slower progression from cells at later stages. (B)</p> Signup and view all the answers

Which substance, found in both saliva and lacrimal fluid, helps to combat bacteria through its enzymatic action?

<p>Lysozyme (D)</p> Signup and view all the answers

What is the primary function of mucin in the respiratory and digestive tracts?

<p>To trap microorganisms (D)</p> Signup and view all the answers

Which of the following is NOT a typical sign of inflammation?

<p>Numbness (C)</p> Signup and view all the answers

What is the role of inflammatory chemicals released during the inflammatory process?

<p>To promote arteriole dilation and increase capillary leakiness. (D)</p> Signup and view all the answers

What is the primary function of interferon secreted by virus-infected cells?

<p>To block protein synthesis and degrade viral RNA in nearby cells (A)</p> Signup and view all the answers

How does interferon contribute to anti-cancer effects?

<p>By activating macrophages and mobilizing natural killer cells (C)</p> Signup and view all the answers

What is the complement system?

<p>A group of at least 20 plasma proteins that amplify the inflammatory process (A)</p> Signup and view all the answers

What is the function of C3b, a component of the complement system?

<p>It functions as an opsonin. (D)</p> Signup and view all the answers

Where do immature lymphocytes, known as B-cells, primarily undergo maturation?

<p>Bone marrow (D)</p> Signup and view all the answers

What is the primary role of plasma cells in the humoral immune response?

<p>Producing and secreting specific antibodies (C)</p> Signup and view all the answers

What is the fate of B-cell clones that do not differentiate into plasma cells during a humoral immune response?

<p>They remain as memory cells that can be activated later. (C)</p> Signup and view all the answers

What is the defining characteristic of an immunocompetent lymphocyte?

<p>Display of a unique receptor able to react to one &amp; only one foreign antigen (D)</p> Signup and view all the answers

Where does antigen challenge typically occur, leading to the activation of lymphocytes?

<p>Spleen or lymph node (C)</p> Signup and view all the answers

What is the primary function of pyrogens in the context of fever?

<p>To reset and elevate the body's thermostat. (C)</p> Signup and view all the answers

Why is a moderate fever considered helpful in fighting infection?

<p>It speeds up the metabolic rate and sequesters iron and zinc, hindering bacterial growth. (A)</p> Signup and view all the answers

What is the role of MHC I (major histocompatibility complex) in the context of natural killer (NK) cells?

<p>MHC I inhibits NK cells, preventing them from attacking healthy cells that express sufficient MHC I. (A)</p> Signup and view all the answers

How do natural killer (NK) cells recognize and target virus-infected or cancerous cells?

<p>By detecting a combination of stress marker expression and a lack of protective MHC I. (C)</p> Signup and view all the answers

Which of the following is NOT a key player in adaptive immune mechanisms?

<p>Natural killer cells (C)</p> Signup and view all the answers

What is the function of the major histocompatibility complex (MHC)?

<p>To mark a cell as “self” and present antigens. (B)</p> Signup and view all the answers

Where do T-cells mature and what two crucial traits do they acquire during this process?

<p>Thymus; immunocompetence and self-tolerance. (D)</p> Signup and view all the answers

What is the origin of lymphocytes, and what initially determines whether a lymphocyte will become a B- or T-lymphocyte?

<p>Red bone marrow; the location where it matures. (A)</p> Signup and view all the answers

What is the primary cause of infectious mononucleosis?

<p>Epstein-Barr virus. (A)</p> Signup and view all the answers

Which of the following best describes leukopenia?

<p>An abnormally low white blood cell count. (A)</p> Signup and view all the answers

What distinguishes innate (nonspecific) defenses from adaptive (specific) defenses?

<p>Innate defenses do not require specific identification of foreign substances, while adaptive defenses do. (A)</p> Signup and view all the answers

Which of the following is an example of a DAMP (Damage-Associated Molecular Pattern)?

<p>DNA in the cytoplasm. (A)</p> Signup and view all the answers

What is the role of Toll-like receptors in the innate immune system?

<p>Recognizing PAMPs to trigger phagocytosis and inflammation. (A)</p> Signup and view all the answers

How do PAMPs and DAMPs contribute to the immune response?

<p>They activate the innate immune system by indicating something is wrong, without needing specific recognition of a microorganism. (C)</p> Signup and view all the answers

What is the primary feature of adaptive immunity?

<p>Targeted immune response carried out by specific lymphocyte subpopulations. (B)</p> Signup and view all the answers

Which event would likely trigger the release of DAMPs?

<p>A sprained ankle. (D)</p> Signup and view all the answers

Flashcards

Leukocytes

The only complete cells in the blood.

Neutrophils

The most abundant type of white blood cell, these phagocytic cells engulf and destroy bacteria.

Eosinophils

A type of white blood cell containing large red granules, they are essential in fighting parasitic infections.

Basophils

The rarest type of white blood cell, they release histamine and other inflammatory chemicals.

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Agranulocytes

White blood cells that lack visible granules in their cytoplasm, including lymphocytes and monocytes.

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Lymphocytes

A type of agranulocyte with a large dark nucleus, they are either T cells or B cells, both crucial in immunity.

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Monocytes

A type of agranulocyte that differentiates into macrophages in tissues, they are important phagocytes for chronic infections.

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Macrophages

The cells that mature from monocytes in tissues and are powerful phagocytes, actively engulfing and destroying pathogens.

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Leukopoiesis

The process of producing white blood cells, primarily occurring in the bone marrow.

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Hormonal Regulation of Leukopoiesis

Hormones that regulate leukopoiesis, including interleukins and colony-stimulating factors, ensure the body produces the correct number of white blood cells as needed.

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Leukemia

Cancer of white blood cells, typically characterized by the uncontrolled proliferation of a single cell's descendants.

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Acute vs. Chronic Leukemia

Acute leukemia is derived from blast-type cells, while chronic leukemia originates from cells at later stages of development.

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Effects of Leukemia on Bone Marrow

The bone marrow becomes overwhelmed by cancerous cells, leading to a range of complications, including anemia, clotting problems, and susceptibility to infections.

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Leukocytosis

A condition characterized by the presence of an abnormally high number of white blood cells, often a sign of infection or inflammation. It's actually a complex process that involves many different types of white blood cells, each with a specific task in fighting off infection.

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Infectious Mononucleosis

A specific type of infection caused by the Epstein-Barr virus, characterized by a high number of abnormal lymphocytes. Symptoms may include fatigue, sore throat, fever, and swollen lymph nodes.

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Leukopenia

A condition characterized by an abnormally low number of white blood cells in the blood. It can be caused by various factors, including certain medications, infections, and bone marrow problems.

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Innate Immunity

A component of the immune system that provides a non-specific, rapid response to infection and tissue damage. It is the body's first line of defense against foreign invaders.

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Adaptive Immunity

A component of the immune system that provides a specific, targeted response against specific pathogens. It's the 'smart' arm of the immune system, recognizing and attacking specific invaders.

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PAMPs (Pathogen-Associated Molecular Patterns)

Molecules associated with pathogens that are recognized by the innate immune system. They act as alarm signals that trigger an immune response.

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DAMPs (Damage-Associated Molecular Patterns)

Molecules associated with tissue damage that are recognized by the innate immune system. They signal the need for repair and trigger an immune response.

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B cells

A type of lymphocyte that matures in the bone marrow and is responsible for the humoral immune response. B cells are unique because they produce antibodies, which are specific proteins that recognize and bind to foreign antigens.

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B cell maturation and antibody diversity

A process where mature B cells generate a diverse range of antibodies with different specificities. This ensures the immune system can recognize a wide variety of pathogens.

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B cell receptor (BCR)

A unique protein found on the surface of B cells that binds to specific antigens. This interaction triggers the activation of the B cell to produce antibodies.

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Humoral immune response

A type of immune response mediated by B cells that is characterized by the production of antibodies.

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Plasma cells

Activated B cells differentiate into these antibody-producing factories, churning out specific antibodies that target the invading antigen.

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Interferon

Secreted by virus-infected cells, interferon diffuses to nearby non-infected cells and prevents viral replication by blocking protein synthesis and degrading viral RNA. It is also a potent anti-cancer agent.

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Complement

A group of plasma proteins that circulate in an inactive state, but when activated, they amplify all aspects of inflammation. C3b is a key component that acts as an opsonin, marking pathogens for destruction.

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Chemotaxis

The process by which neutrophils and other white blood cells are attracted to the site of injury or infection by chemical signals released from damaged cells or other immune cells.

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Diapedesis

The process by which white blood cells squeeze through the walls of blood vessels and enter tissues, where they can fight infection or inflammation.

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Margination

The process by which white blood cells adhere to the lining of blood vessels at the site of inflammation.

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Inflammation

A nonspecific defense mechanism that involves a coordinated response of the body to injury or infection. Characterized by redness, heat, swelling, and pain.

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Inflammatory chemicals

A group of chemicals released by damaged cells, macrophages, or lymphocytes, that contribute to inflammation. Histamine, kinins, prostaglandins, and complement are key examples.

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Mucin

A sticky substance produced by mucous membranes and digestive and respiratory passages, that traps microorganisms and prevents their spread.

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What is the MHC (Major Histocompatibility Complex)?

A group of proteins found on the surface of almost all cells in the body that help the immune system recognize "self" cells. Each MHC protein has a groove where it can bind to antigens (self or foreign). MHC stands for Major Histocompatibility Complex.

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What is an antigen?

Molecules that can trigger an immune response by binding to specific receptors on immune cells.

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What are Natural Killer Cells?

These cells are part of the innate immune system, meaning they are not specific to a particular antigen. They don't need to recognize a specific antigen and can attack cells that are infected with viruses or cancerous cells.

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What is Fever?

A fever is a symptom of an immune response during which the body temperature is raised above the normal range (around 37 degrees Celsius). Pyrogens released by leukocytes (like macrophages) during infection can reset the body's thermostat, causing a fever.

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What is the MAC (Membrane Attack Complex)?

A complex of proteins, primarily produced by the complement system of the immune system, that can create pores in the membranes of target cells (like bacteria or virus-infected cells) and help destroy them.

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What are T lymphocytes?

A type of lymphocyte that matures in the thymus and is responsible for cell-mediated immunity. T cells can directly attack infected cells or cancer cells.

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What are B lymphocytes?

A type of lymphocyte that matures in the bone marrow and is responsible for humoral immunity. B cells produce antibodies that can bind to antigens and neutralize or mark them for destruction.

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What are Macrophages?

These are cells that engulf and destroy pathogens. They are part of both the innate and adaptive immune systems. They help initiate an immune response by 'presenting' antigens to other immune cells.

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Study Notes

Innate Immunity

  • Protects against foreign substances/abnormal cells without identifying them using generalized carbohydrate/lipid cell surface markers.
  • Features include opsonization, lysis of pathogens, chemotaxis, inflammation, and cell activation.

Adaptive Immunity

  • Acquired immunity involving lymphocyte subpopulations.
  • Recognizes specific cell surface proteins.
  • Subclones itself to create a targeted immune response through different mechanisms.

Complement System

  • Composed of at least 20 plasma proteins.
  • Activated components amplify inflammatory responses.
  • Features include direct destruction of invading microbes (membrane attack complex), vasodilation and increased permeability of capillaries/venules, chemotaxis, and enhancement of phagocytosis.

Innate Defenses

  • Skin and mucous membranes.

    • Acidic secretions (skin, vagina, stomach) deter bacterial growth
    • Enzymes (lysozyme in saliva, respiratory mucus, lacrimal fluid, protein-digesting enzymes in stomach) also act as defenses
    • Mucin traps microorganisms
    • Defensins—broad-spectrum antimicrobial peptides secreted by mucous membranes and skin.
  • Other chemicals such as lipids that are toxic to bacteria.

Inflammation

  • Response to injury—characterized by redness, heat, swelling, and pain.
  • Prevents spread of microorganisms to nearby tissues.
  • Disposes of cell debris and pathogens.
  • Sets the stage for repair processes.
  • Alerts the adaptive immune system.
  • Inflammatory chemicals (e.g., histamine, kinins, prostaglandins, complement) are released; activate inflammation; and promote arteriole dilation, capillary leakiness.
  • Also attracts immune cells to the injury/infection site.

Interferon

  • Secreted by virus-infected cells to diffuse to nearby non-infected cells.
  • Blocks protein synthesis and degrades viral RNA.
  • Activates macrophages and natural killer cells to fight foreign invaders.

Natural Killer (NK) Cells

  • Part of the innate immune system.
  • Not specific to a particular antigen.
  • Attack virus-infected and cancer cells.
  • Triggered by a combination of cell stress marker expression and lack of protective MHC 1.
  • Cells infected with viruses or cancer reduce their expression of MHC 1(major histocompatibility complex).

Leukocytes

  • Formed elements in complete blood cells (less than 1% of total volume).
    • Usually 4,800-10,800 per microliter (WBC)
    • Protect against bacteria, viruses, parasites, toxins, and tumor cells.
    • Can leave the bloodstream to mount immune or inflammatory responses.
    • Leukocytosis (count > 11,000/µL)—body's response to bacterial or viral invasion; number can double within hours.
    • Granulocytes and Agranulocytes -Granulocytes: neutrophils, eosinophils, and basophils -Agranulocytes: lymphocytes and monocytes

Granulocytes

  • Neutrophils (50–70%): phagocytes that ingest and destroy bacteria (acute infections)
  • Eosinophils (2-4%): target parasitic worms and modulate immune responses, allergies, and asthma.
  • Basophils (0.5–1%): rarest WBCs with granules containing histamine (vasodilator).

Agranulocytes

  • Lymphocytes (25–45%): a second most common leukocyte that have dark purple nuclei and pale blue cytoplasm, lymphocytes are found in lymph nodes, spleen and so on. T-cells and B-cells.
    • T cells: directly attack virus-infected cells or tumor cells.
    • B cells: generate plasma cells that produce antibodies.
  • Monocytes (3-8%): largest leukocytes. In tissues, differentiate into macrophages. Phagocytic in chronic infections (e.g., TB).

Fever

  • Body's thermostat normally set at 37°C.
  • Reset by pyrogens released from leukocytes and macrophages exposed to bacteria or other foreign substances.
  • Moderate fever is helpful: speeds up metabolic rate, and causes liver and spleen to sequester iron and zinc.
  • High fevers can be dangerous.

T-cells

  • Migrate to thymus for maturation (2–3 days).
  • Acquire immunocompetence and self-tolerance.
  • Only about 2% of T cells succeed in maturation.
  • Positive selection: T cells recognize self-MHC proteins. Failure to recognize leads to apoptosis.
  • Negative selection: T cells must not recognize self-antigens. Failure to not recognize leads to survival.

B-cells

  • Immature lymphocytes mature in bone marrow.
  • Self-reactive lymphocytes are removed.
  • Display unique receptors on cells to react to foreign antigens.
  • Differentiate into plasma cells, which produce antibodies; or become memory cells able to initiate a secondary defense (usually faster).

Adaptive Mechanisms

  • B lymphocytes (humoral immunity)
  • T lymphocytes (cell-mediated immunity)
  • Macrophages (antigen-presenting cells)

Lymphocytes

  • Originate in red bone marrow.
  • Initially identical.
  • Mature into B or T lymphocytes based on their maturation location.
  • Immunocompetence—able to recognize its specific antigens; self-tolerance—does not react to "self" antigens.

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Test your knowledge on the different types of leukocytes and their functions in the human immune system. This quiz covers topics including the characteristics of granulocytes, lymphocytes, and their roles in leukopoiesis and diseases such as leukemia. Challenge yourself to identify each type and its importance!

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