Podcast
Questions and Answers
Which leukocyte comprises over 50% of all leukocytes and are identified as polymorphic leukocytes?
Which leukocyte comprises over 50% of all leukocytes and are identified as polymorphic leukocytes?
- Monocytes
- Basophils
- Eosinophils
- Neutrophils (correct)
Which type of leukocyte differentiates into macrophages when it migrates into tissues?
Which type of leukocyte differentiates into macrophages when it migrates into tissues?
- Monocytes (correct)
- Neutrophils
- Lymphocytes
- Eosinophils
Which of the following is a function of basophils?
Which of the following is a function of basophils?
- Producing antibodies.
- Directly attacking virus-infected cells.
- Phagocytizing bacteria in acute infections.
- Releasing histamine to promote inflammation. (correct)
Eosinophils are most effective against which type of pathogen?
Eosinophils are most effective against which type of pathogen?
Which leukocytes are primarily located in lymphoid tissue (lymph nodes, spleen, etc) rather than in the bloodstream?
Which leukocytes are primarily located in lymphoid tissue (lymph nodes, spleen, etc) rather than in the bloodstream?
Which of the following is NOT a granulocyte?
Which of the following is NOT a granulocyte?
What is the primary function of T lymphocytes (T cells)?
What is the primary function of T lymphocytes (T cells)?
What is the role of B lymphocytes (B cells) in the immune system?
What is the role of B lymphocytes (B cells) in the immune system?
What primary role do interleukins and colony-stimulating factors play in the context of leukopoiesis?
What primary role do interleukins and colony-stimulating factors play in the context of leukopoiesis?
Regarding the maturation and storage of granulocytes, what is accurate based on the provided information?
Regarding the maturation and storage of granulocytes, what is accurate based on the provided information?
How is leukemia characterized, and what are its primary effects on the body?
How is leukemia characterized, and what are its primary effects on the body?
What is the typical treatment approach for leukemia?
What is the typical treatment approach for leukemia?
What is indicated by the terms 'acute' and 'chronic' when classifying leukemia?
What is indicated by the terms 'acute' and 'chronic' when classifying leukemia?
Which substance, found in both saliva and lacrimal fluid, helps to combat bacteria through its enzymatic action?
Which substance, found in both saliva and lacrimal fluid, helps to combat bacteria through its enzymatic action?
What is the primary function of mucin in the respiratory and digestive tracts?
What is the primary function of mucin in the respiratory and digestive tracts?
Which of the following is NOT a typical sign of inflammation?
Which of the following is NOT a typical sign of inflammation?
What is the role of inflammatory chemicals released during the inflammatory process?
What is the role of inflammatory chemicals released during the inflammatory process?
What is the primary function of interferon secreted by virus-infected cells?
What is the primary function of interferon secreted by virus-infected cells?
How does interferon contribute to anti-cancer effects?
How does interferon contribute to anti-cancer effects?
What is the complement system?
What is the complement system?
What is the function of C3b, a component of the complement system?
What is the function of C3b, a component of the complement system?
Where do immature lymphocytes, known as B-cells, primarily undergo maturation?
Where do immature lymphocytes, known as B-cells, primarily undergo maturation?
What is the primary role of plasma cells in the humoral immune response?
What is the primary role of plasma cells in the humoral immune response?
What is the fate of B-cell clones that do not differentiate into plasma cells during a humoral immune response?
What is the fate of B-cell clones that do not differentiate into plasma cells during a humoral immune response?
What is the defining characteristic of an immunocompetent lymphocyte?
What is the defining characteristic of an immunocompetent lymphocyte?
Where does antigen challenge typically occur, leading to the activation of lymphocytes?
Where does antigen challenge typically occur, leading to the activation of lymphocytes?
What is the primary function of pyrogens in the context of fever?
What is the primary function of pyrogens in the context of fever?
Why is a moderate fever considered helpful in fighting infection?
Why is a moderate fever considered helpful in fighting infection?
What is the role of MHC I (major histocompatibility complex) in the context of natural killer (NK) cells?
What is the role of MHC I (major histocompatibility complex) in the context of natural killer (NK) cells?
How do natural killer (NK) cells recognize and target virus-infected or cancerous cells?
How do natural killer (NK) cells recognize and target virus-infected or cancerous cells?
Which of the following is NOT a key player in adaptive immune mechanisms?
Which of the following is NOT a key player in adaptive immune mechanisms?
What is the function of the major histocompatibility complex (MHC)?
What is the function of the major histocompatibility complex (MHC)?
Where do T-cells mature and what two crucial traits do they acquire during this process?
Where do T-cells mature and what two crucial traits do they acquire during this process?
What is the origin of lymphocytes, and what initially determines whether a lymphocyte will become a B- or T-lymphocyte?
What is the origin of lymphocytes, and what initially determines whether a lymphocyte will become a B- or T-lymphocyte?
What is the primary cause of infectious mononucleosis?
What is the primary cause of infectious mononucleosis?
Which of the following best describes leukopenia?
Which of the following best describes leukopenia?
What distinguishes innate (nonspecific) defenses from adaptive (specific) defenses?
What distinguishes innate (nonspecific) defenses from adaptive (specific) defenses?
Which of the following is an example of a DAMP (Damage-Associated Molecular Pattern)?
Which of the following is an example of a DAMP (Damage-Associated Molecular Pattern)?
What is the role of Toll-like receptors in the innate immune system?
What is the role of Toll-like receptors in the innate immune system?
How do PAMPs and DAMPs contribute to the immune response?
How do PAMPs and DAMPs contribute to the immune response?
What is the primary feature of adaptive immunity?
What is the primary feature of adaptive immunity?
Which event would likely trigger the release of DAMPs?
Which event would likely trigger the release of DAMPs?
Flashcards
Leukocytes
Leukocytes
The only complete cells in the blood.
Neutrophils
Neutrophils
The most abundant type of white blood cell, these phagocytic cells engulf and destroy bacteria.
Eosinophils
Eosinophils
A type of white blood cell containing large red granules, they are essential in fighting parasitic infections.
Basophils
Basophils
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Agranulocytes
Agranulocytes
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Lymphocytes
Lymphocytes
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Monocytes
Monocytes
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Macrophages
Macrophages
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Leukopoiesis
Leukopoiesis
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Hormonal Regulation of Leukopoiesis
Hormonal Regulation of Leukopoiesis
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Leukemia
Leukemia
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Acute vs. Chronic Leukemia
Acute vs. Chronic Leukemia
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Effects of Leukemia on Bone Marrow
Effects of Leukemia on Bone Marrow
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Leukocytosis
Leukocytosis
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Infectious Mononucleosis
Infectious Mononucleosis
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Leukopenia
Leukopenia
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Innate Immunity
Innate Immunity
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Adaptive Immunity
Adaptive Immunity
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PAMPs (Pathogen-Associated Molecular Patterns)
PAMPs (Pathogen-Associated Molecular Patterns)
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DAMPs (Damage-Associated Molecular Patterns)
DAMPs (Damage-Associated Molecular Patterns)
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B cells
B cells
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B cell maturation and antibody diversity
B cell maturation and antibody diversity
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B cell receptor (BCR)
B cell receptor (BCR)
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Humoral immune response
Humoral immune response
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Plasma cells
Plasma cells
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Interferon
Interferon
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Complement
Complement
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Chemotaxis
Chemotaxis
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Diapedesis
Diapedesis
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Margination
Margination
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Inflammation
Inflammation
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Inflammatory chemicals
Inflammatory chemicals
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Mucin
Mucin
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What is the MHC (Major Histocompatibility Complex)?
What is the MHC (Major Histocompatibility Complex)?
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What is an antigen?
What is an antigen?
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What are Natural Killer Cells?
What are Natural Killer Cells?
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What is Fever?
What is Fever?
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What is the MAC (Membrane Attack Complex)?
What is the MAC (Membrane Attack Complex)?
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What are T lymphocytes?
What are T lymphocytes?
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What are B lymphocytes?
What are B lymphocytes?
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What are Macrophages?
What are Macrophages?
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Study Notes
Innate Immunity
- Protects against foreign substances/abnormal cells without identifying them using generalized carbohydrate/lipid cell surface markers.
- Features include opsonization, lysis of pathogens, chemotaxis, inflammation, and cell activation.
Adaptive Immunity
- Acquired immunity involving lymphocyte subpopulations.
- Recognizes specific cell surface proteins.
- Subclones itself to create a targeted immune response through different mechanisms.
Complement System
- Composed of at least 20 plasma proteins.
- Activated components amplify inflammatory responses.
- Features include direct destruction of invading microbes (membrane attack complex), vasodilation and increased permeability of capillaries/venules, chemotaxis, and enhancement of phagocytosis.
Innate Defenses
-
Skin and mucous membranes.
- Acidic secretions (skin, vagina, stomach) deter bacterial growth
- Enzymes (lysozyme in saliva, respiratory mucus, lacrimal fluid, protein-digesting enzymes in stomach) also act as defenses
- Mucin traps microorganisms
- Defensins—broad-spectrum antimicrobial peptides secreted by mucous membranes and skin.
-
Other chemicals such as lipids that are toxic to bacteria.
Inflammation
- Response to injury—characterized by redness, heat, swelling, and pain.
- Prevents spread of microorganisms to nearby tissues.
- Disposes of cell debris and pathogens.
- Sets the stage for repair processes.
- Alerts the adaptive immune system.
- Inflammatory chemicals (e.g., histamine, kinins, prostaglandins, complement) are released; activate inflammation; and promote arteriole dilation, capillary leakiness.
- Also attracts immune cells to the injury/infection site.
Interferon
- Secreted by virus-infected cells to diffuse to nearby non-infected cells.
- Blocks protein synthesis and degrades viral RNA.
- Activates macrophages and natural killer cells to fight foreign invaders.
Natural Killer (NK) Cells
- Part of the innate immune system.
- Not specific to a particular antigen.
- Attack virus-infected and cancer cells.
- Triggered by a combination of cell stress marker expression and lack of protective MHC 1.
- Cells infected with viruses or cancer reduce their expression of MHC 1(major histocompatibility complex).
Leukocytes
- Formed elements in complete blood cells (less than 1% of total volume).
- Usually 4,800-10,800 per microliter (WBC)
- Protect against bacteria, viruses, parasites, toxins, and tumor cells.
- Can leave the bloodstream to mount immune or inflammatory responses.
- Leukocytosis (count > 11,000/µL)—body's response to bacterial or viral invasion; number can double within hours.
- Granulocytes and Agranulocytes -Granulocytes: neutrophils, eosinophils, and basophils -Agranulocytes: lymphocytes and monocytes
Granulocytes
- Neutrophils (50–70%): phagocytes that ingest and destroy bacteria (acute infections)
- Eosinophils (2-4%): target parasitic worms and modulate immune responses, allergies, and asthma.
- Basophils (0.5–1%): rarest WBCs with granules containing histamine (vasodilator).
Agranulocytes
- Lymphocytes (25–45%): a second most common leukocyte that have dark purple nuclei and pale blue cytoplasm, lymphocytes are found in lymph nodes, spleen and so on. T-cells and B-cells.
- T cells: directly attack virus-infected cells or tumor cells.
- B cells: generate plasma cells that produce antibodies.
- Monocytes (3-8%): largest leukocytes. In tissues, differentiate into macrophages. Phagocytic in chronic infections (e.g., TB).
Fever
- Body's thermostat normally set at 37°C.
- Reset by pyrogens released from leukocytes and macrophages exposed to bacteria or other foreign substances.
- Moderate fever is helpful: speeds up metabolic rate, and causes liver and spleen to sequester iron and zinc.
- High fevers can be dangerous.
T-cells
- Migrate to thymus for maturation (2–3 days).
- Acquire immunocompetence and self-tolerance.
- Only about 2% of T cells succeed in maturation.
- Positive selection: T cells recognize self-MHC proteins. Failure to recognize leads to apoptosis.
- Negative selection: T cells must not recognize self-antigens. Failure to not recognize leads to survival.
B-cells
- Immature lymphocytes mature in bone marrow.
- Self-reactive lymphocytes are removed.
- Display unique receptors on cells to react to foreign antigens.
- Differentiate into plasma cells, which produce antibodies; or become memory cells able to initiate a secondary defense (usually faster).
Adaptive Mechanisms
- B lymphocytes (humoral immunity)
- T lymphocytes (cell-mediated immunity)
- Macrophages (antigen-presenting cells)
Lymphocytes
- Originate in red bone marrow.
- Initially identical.
- Mature into B or T lymphocytes based on their maturation location.
- Immunocompetence—able to recognize its specific antigens; self-tolerance—does not react to "self" antigens.
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Description
Test your knowledge on the different types of leukocytes and their functions in the human immune system. This quiz covers topics including the characteristics of granulocytes, lymphocytes, and their roles in leukopoiesis and diseases such as leukemia. Challenge yourself to identify each type and its importance!