Immunology Quiz

Play an AI-generated podcast conversation about this lesson

What is the only function of the T cell receptor (TCR)?

Directly signal T cells for activation (correct)
Recognize and bind antigen directly
Secrete antibodies
Recognize long peptide fragments of pathogen's protein antigens

How many identical antigen receptor molecules does each T cell bear on its surface?

Approximately 30,000 (correct)
Approximately 50,000
Approximately 40,000
Approximately 20,000

Where do T cells develop from precursor cells?

Bone marrow
Lymph nodes
Spleen
Thymus (correct)

What determines the antigen specificity of a lymphocyte?

DNA sequences encoding the variable regions of the TCR (C) Signup and view all the answers

What is a distinctive feature of T cells in recognizing antigens?

Recognizing short peptide fragments of pathogen's protein antigens bound to MHC molecules (A) Signup and view all the answers

What is the structure of the TCR receptor?

$\alpha:\beta$ heterodimer linked by a disulphide bond (C) Signup and view all the answers

What is the function of TCR in recognizing antigens?

Recognizes short peptide fragments of pathogen's protein antigens bound to MHC molecules (C) Signup and view all the answers

What determines the fate of T cells?

Specificity of their antigen recognition (A) Signup and view all the answers

What is the similarity between TCR and antibody molecules?

Closely related in structure (D) Signup and view all the answers

What is the number of binding sites on the TCR?

One (A) Signup and view all the answers

What is the role of the short hinge region in TCR?

It contains a cysteine residue that forms the disulphide link between the 2 chains (B) Signup and view all the answers

What distinguishes CD4 and CD8 T cells?

Expression of cell surface proteins CD4, CD8 (A) Signup and view all the answers

What is the consequence of MHC1 expression on non-nucleated cells like red blood cells?

They can go undetected by cytotoxic T cells (A) Signup and view all the answers

What is the role of CD4/8 co-receptors during antigen recognition?

They associate with the TCR and bind to sites on the MHC molecule (B) Signup and view all the answers

What is the function of CD4 T cells when they recognize peptides bound to MHC2 on B cells?

They stimulate Ab production (C) Signup and view all the answers

How do T cells recognize antigens?

In the form of peptide bound to MHC (B) Signup and view all the answers

What is the consequence of stable peptide binding to MHC molecules?

Enhancement of the signal generated from the TCR binding the peptide:MHC complex (C) Signup and view all the answers

How are MHC1 and MHC2 distributed on cells?

MHC1 and MHC2 are distributed differently on cells (A) Signup and view all the answers

What is the function of CD8 cytotoxic T cells?

Specialized to kill any cell they recognize (C) Signup and view all the answers

How do T cells respond to short amino acid sequences of proteins?

They recognize these sequences when presented as peptide:MHC complexes (D) Signup and view all the answers