Immunology Quiz
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Questions and Answers

What is the only function of the T cell receptor (TCR)?

  • Directly signal T cells for activation (correct)
  • Recognize and bind antigen directly
  • Secrete antibodies
  • Recognize long peptide fragments of pathogen's protein antigens

    • How many identical antigen receptor molecules does each T cell bear on its surface?

  • Approximately 30,000 (correct)
  • Approximately 50,000
  • Approximately 40,000
  • Approximately 20,000

    • Where do T cells develop from precursor cells?

  • Bone marrow
  • Lymph nodes
  • Spleen
  • Thymus (correct)

    • What determines the antigen specificity of a lymphocyte?

    <p>DNA sequences encoding the variable regions of the TCR</p> Signup and view all the answers

    What is a distinctive feature of T cells in recognizing antigens?

    <p>Recognizing short peptide fragments of pathogen's protein antigens bound to MHC molecules</p> Signup and view all the answers

    What is the structure of the TCR receptor?

    <p>$\alpha:\beta$ heterodimer linked by a disulphide bond</p> Signup and view all the answers

    What is the function of TCR in recognizing antigens?

    <p>Recognizes short peptide fragments of pathogen's protein antigens bound to MHC molecules</p> Signup and view all the answers

    What determines the fate of T cells?

    <p>Specificity of their antigen recognition</p> Signup and view all the answers

    What is the similarity between TCR and antibody molecules?

    <p>Closely related in structure</p> Signup and view all the answers

    What is the number of binding sites on the TCR?

    <p>One</p> Signup and view all the answers

    What is the role of the short hinge region in TCR?

    <p>It contains a cysteine residue that forms the disulphide link between the 2 chains</p> Signup and view all the answers

    What distinguishes CD4 and CD8 T cells?

    <p>Expression of cell surface proteins CD4, CD8</p> Signup and view all the answers

    What is the consequence of MHC1 expression on non-nucleated cells like red blood cells?

    <p>They can go undetected by cytotoxic T cells</p> Signup and view all the answers

    What is the role of CD4/8 co-receptors during antigen recognition?

    <p>They associate with the TCR and bind to sites on the MHC molecule</p> Signup and view all the answers

    What is the function of CD4 T cells when they recognize peptides bound to MHC2 on B cells?

    <p>They stimulate Ab production</p> Signup and view all the answers

    How do T cells recognize antigens?

    <p>In the form of peptide bound to MHC</p> Signup and view all the answers

    What is the consequence of stable peptide binding to MHC molecules?

    <p>Enhancement of the signal generated from the TCR binding the peptide:MHC complex</p> Signup and view all the answers

    How are MHC1 and MHC2 distributed on cells?

    <p>MHC1 and MHC2 are distributed differently on cells</p> Signup and view all the answers

    What is the function of CD8 cytotoxic T cells?

    <p>Specialized to kill any cell they recognize</p> Signup and view all the answers

    How do T cells respond to short amino acid sequences of proteins?

    <p>They recognize these sequences when presented as peptide:MHC complexes</p> Signup and view all the answers

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