20 Questions
What is the only function of the T cell receptor (TCR)?
Directly signal T cells for activation
How many identical antigen receptor molecules does each T cell bear on its surface?
Approximately 30,000
Where do T cells develop from precursor cells?
Thymus
What determines the antigen specificity of a lymphocyte?
DNA sequences encoding the variable regions of the TCR
What is a distinctive feature of T cells in recognizing antigens?
Recognizing short peptide fragments of pathogen's protein antigens bound to MHC molecules
What is the structure of the TCR receptor?
$\alpha:\beta$ heterodimer linked by a disulphide bond
What is the function of TCR in recognizing antigens?
Recognizes short peptide fragments of pathogen's protein antigens bound to MHC molecules
What determines the fate of T cells?
Specificity of their antigen recognition
What is the similarity between TCR and antibody molecules?
Closely related in structure
What is the number of binding sites on the TCR?
One
What is the role of the short hinge region in TCR?
It contains a cysteine residue that forms the disulphide link between the 2 chains
What distinguishes CD4 and CD8 T cells?
Expression of cell surface proteins CD4, CD8
What is the consequence of MHC1 expression on non-nucleated cells like red blood cells?
They can go undetected by cytotoxic T cells
What is the role of CD4/8 co-receptors during antigen recognition?
They associate with the TCR and bind to sites on the MHC molecule
What is the function of CD4 T cells when they recognize peptides bound to MHC2 on B cells?
They stimulate Ab production
How do T cells recognize antigens?
In the form of peptide bound to MHC
What is the consequence of stable peptide binding to MHC molecules?
Enhancement of the signal generated from the TCR binding the peptide:MHC complex
How are MHC1 and MHC2 distributed on cells?
MHC1 and MHC2 are distributed differently on cells
What is the function of CD8 cytotoxic T cells?
Specialized to kill any cell they recognize
How do T cells respond to short amino acid sequences of proteins?
They recognize these sequences when presented as peptide:MHC complexes
Test your knowledge of T cell development, antigen recognition, and antigen presentation in immunology with this quiz. Challenge yourself with questions about the origin of lymphocytes, T cell maturation in the thymus, and the determination of antigen specificity.
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