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Questions and Answers

What role does the physiological barrier of the innate immune system primarily play?

  • Recruits other immune cells directly
  • Regulates immune response through body systems (correct)
  • Engulfs and digests pathogens
  • Acts as a physical barrier only

Which component is essential for the endocytic aspect of the innate immune response?

  • Low pH of the stomach
  • Phagocytic cells like macrophages and neutrophils (correct)
  • Cytokine release
  • Skin and mucous membranes

What triggers the inflammatory response in the innate immune system?

  • Detection of injury by pattern recognition receptors (PRRs) (correct)
  • Physiological barriers regulating body temperature
  • Physical barrier of skin and membranes
  • Low pH in the stomach

Which of the following is NOT involved in the antigen presentation process within the innate immune system?

<p>Protection from tissue damage (D)</p> Signup and view all the answers

Which type of barrier is represented by skin and mucous membranes in the innate immune system?

<p>Anatomic barrier (D)</p> Signup and view all the answers

What is the primary role of T helper cells in the immune response?

<p>To secrete cytokines to assist other immune cells (C)</p> Signup and view all the answers

Which cell type is primarily involved in allergic reactions by releasing histamines?

<p>Mast cells (D)</p> Signup and view all the answers

What is the function of granules produced by granulocytes?

<p>To release various mediators during the immune response (D)</p> Signup and view all the answers

Cytotoxic T cells primarily target which kind of pathogens?

<p>Parasites (A)</p> Signup and view all the answers

How do antigen-presenting cells assist T helper cells?

<p>By displaying antigen fragments on MHC (D)</p> Signup and view all the answers

Which of the following is NOT a characteristic function of macrophages?

<p>Storing histamine (A)</p> Signup and view all the answers

What do PMNs primarily respond to during the immune response?

<p>Bacterial infections (A)</p> Signup and view all the answers

Which major histocompatibility complex is important for T cells to recognize antigens?

<p>MHC Class II (B)</p> Signup and view all the answers

Which type of immunodeficiency is characterized by increased risks of malignancy and autoimmune disease due to genetic factors?

<p>Primary immunodeficiency (D)</p> Signup and view all the answers

What is the primary function of T helper cells in the immune response?

<p>To secrete cytokines that assist B cells (A)</p> Signup and view all the answers

Which condition is NOT mentioned as a potential consequence of treatment with immunosuppressant drugs?

<p>Hypertension (C)</p> Signup and view all the answers

Which type of immunity primarily targets microbes that survive phagocytosis?

<p>Cell-mediated immunity (A)</p> Signup and view all the answers

What precaution must be taken with live vaccines in individuals with specific types of immunodeficiencies?

<p>Live vaccines should be avoided (B)</p> Signup and view all the answers

Which of the following is a main role of dental care professionals in treating patients with immunodeficiencies?

<p>Conduct risk assessment and detailed histories (A)</p> Signup and view all the answers

What role do cytokines play in cell-mediated immunity?

<p>They stimulate the production of immune responses (C)</p> Signup and view all the answers

Which type of immunodeficiency is categorized as secondary and is often the result of external factors?

<p>Malnutrition-induced immunodeficiency (A)</p> Signup and view all the answers

How is passive immunity acquired through natural means?

<p>Through mother's antibodies via placenta or breast milk (C)</p> Signup and view all the answers

What defines Type I hypersensitivity reactions?

<p>Rapid response causing anaphylaxis upon re-exposure to an antigen (A)</p> Signup and view all the answers

Which function of T cells naturally suppresses the incidence of autoimmunity?

<p>Natural suppression (B)</p> Signup and view all the answers

In the context of immunodeficiency, which of the following is considered a common effect on dental health?

<p>Periodontal disease (A)</p> Signup and view all the answers

Which aspect of active immunity involves the production of antibodies?

<p>Long-term immunity resulting from vaccination or infection (A)</p> Signup and view all the answers

What is the main function of the complement system in the immune response?

<p>To clear antigen-antibody complexes (C)</p> Signup and view all the answers

Which of the following does NOT describe the characteristics of primary immunodeficiencies?

<p>More common than secondary immunodeficiencies (A)</p> Signup and view all the answers

What is a major consequence of overactive immune responses in hypersensitivity?

<p>Gross tissue damage upon subsequent exposure to an antigen (D)</p> Signup and view all the answers

Which of the following factors is NOT associated with the development of autoimmune diseases?

<p>Direct trauma to tissues (D)</p> Signup and view all the answers

Which autoimmune disease is characterized primarily by xerostomia and dryness of eyes?

<p>Sjögren syndrome (D)</p> Signup and view all the answers

What is a common oral manifestation of pemphigus vulgaris?

<p>Blistering lesions (A)</p> Signup and view all the answers

Which statement about the treatment of autoimmune diseases is true?

<p>Physical therapy may aid in managing symptoms. (A)</p> Signup and view all the answers

Which of the following is an example of a systemic autoimmune disease?

<p>Systemic lupus erythematosus (D)</p> Signup and view all the answers

What is the main purpose of taking a detailed medical history from patients with suspected autoimmune diseases?

<p>To identify potential triggers and management options (B)</p> Signup and view all the answers

Which autoimmune disease is indicated by the presence of ulcerative lesions and typically affects the gingivae?

<p>Mucous membrane pemphigoid (A)</p> Signup and view all the answers

Which treatment option is used to reduce inflammation in autoimmune diseases?

<p>Immunosuppressants (A)</p> Signup and view all the answers

What is the primary function of phagocytic cells in the immune response?

<p>To recognize and bind to specific antigens (D)</p> Signup and view all the answers

Which type of cell is primarily involved in targeting parasites and allergic tissues?

<p>Eosinophil (C)</p> Signup and view all the answers

What role do memory cells play in the immune system?

<p>They remember foreign antibodies for faster response (B)</p> Signup and view all the answers

How are dendritic cells primarily activated in the immune response?

<p>By capturing and processing messengers from pathogens (A)</p> Signup and view all the answers

Which type of leukocyte is involved in the first line of defense against infections?

<p>Neutrophil (C)</p> Signup and view all the answers

What is a key function of natural killer cells in the immune system?

<p>To directly destroy infected cells (A)</p> Signup and view all the answers

What is the primary role of plasma cells in the immune response?

<p>To secrete antibodies (B)</p> Signup and view all the answers

Which cell type is crucial for linking both the innate and adaptive immune systems?

<p>Dendritic cell (C)</p> Signup and view all the answers

What type of cell primarily regulates the immune response to prevent damage to the tissue?

<p>Regulatory T cells (B)</p> Signup and view all the answers

What process do macrophages use to engulf pathogens?

<p>Phagocytosis (B)</p> Signup and view all the answers

Which leukocyte type is most effective in responding to viral infections?

<p>Natural killer cell (C)</p> Signup and view all the answers

What is the primary target of eosinophils in the immune system?

<p>Parasites (D)</p> Signup and view all the answers

What distinguishes the role of T helper cells from B cells in the immune response?

<p>They activate other immune cells (A)</p> Signup and view all the answers

Which cell type is responsible for the secretion of growth factors and cytokines in the immune response?

<p>Neutrophil (C)</p> Signup and view all the answers

Flashcards

Anatomic Barrier

The body's first line of defense, it physically blocks pathogens from entering the body.

Physiological Barrier

These are the physical and chemical processes that help maintain a healthy immune response such as skin, saliva, tears, and stomach acid.

Endocytosis

This process involves cells engulfing and destroying pathogens.

Inflammation

The immune response triggered by injury or infection. It involves recruitment of immune cells and release of chemicals to fight off pathogens and repair damage.

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Antigen Presentation

Displaying parts of a pathogen to T cells, allowing the immune system to recognize and target them.

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Mast Cells

A type of white blood cell that releases histamine and heparin, contributing to inflammation and allergic reactions.

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Basophils

A type of white blood cell that releases chemicals like histamine and heparin, primarily involved in allergic reactions.

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Phagocytes

A type of white blood cell responsible for engulfing and destroying pathogens.

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Neutrophils (PMNs)

A type of phagocyte that is the first responder to infection, quickly moving into the site of inflammation.

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T Helper Cells (Th)

A type of immune cell that helps to coordinate the immune response.

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Cytotoxic T Cells

A type of immune cell that directly kills infected cells and cancer cells.

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Cytokines

Molecules released by immune cells that help to regulate the immune response.

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Phagocytosis

The process where immune cells engulf and digest pathogens.

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Phagocytic Cells

White blood cells that engulf and destroy foreign invaders like bacteria, viruses, and cellular debris.

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Neutrophil

A type of phagocytic cell that is the most common leukocyte in the blood.

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Macrophage

A type of phagocytic cell that develops from monocytes and is found in tissues.

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Eosinophil

A type of phagocytic cell that specializes in targeting parasites and allergic reactions.

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Innate Immunity

The immune system's first line of defense against infection. It is composed of cells and mechanisms that provide immediate protection.

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B Cell

A type of leukocyte that plays a critical role in adaptive immunity. They mature into plasma cells that produce antibodies.

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Antibodies

Proteins that recognize and bind to specific antigens, helping to neutralize and eliminate foreign invaders.

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Adaptive Immunity

The part of the immune system that provides a specific and tailored response to foreign invaders. It involves specialized cells like T cells and B cells.

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T Cell

A type of leukocyte that is involved in adaptive immunity. They mature in the thymus and recognize specific antigens.

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T helper cell

A type of T cell that helps activate other immune cells, including B cells and cytotoxic T cells.

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Antigen-presenting cell

Antigen-presenting cells are specialized cells that capture and process antigens for the immune system.

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Dendritic cell

A type of antigen-presenting cell that captures antigens and migrates to lymph nodes to activate T cells.

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Regulatory T cell

A type of T cell that regulates and controls immune responses, helping to prevent autoimmune diseases.

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Memory T cell

A type of T cell that retains memory of the antigen it encountered, allowing for a quicker and more efficient immune response in the future.

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Immunodeficiency

A group of disorders that occur when the immune system is weakened, leaving the body susceptible to frequent and serious infections.

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Primary Immunodeficiency

Immunodeficiency that is present from birth due to genetic factors.

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Secondary Immunodeficiency

Immunodeficiency that develops later in life due to factors like infections, malnutrition, or medications.

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Autoimmunity

A condition where the immune system mistakenly attacks the body's own tissues, leading to inflammation and damage.

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B Cell Immunodeficiency

A type of immunodeficiency where the body's ability to produce antibodies is impaired.

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T Cell Immunodeficiency

A type of immunodeficiency where the body's ability to produce T cells is impaired.

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Severe Combined Immune Deficiency (SCID)

A severe type of immunodeficiency affecting both B and T cells, making the body highly vulnerable to infections.

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Phagocyte Disorder

A condition where the body's ability to remove bacteria from the bloodstream is impaired, leading to recurrent infections.

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Antibody function

Antibodies produced by B cells, bind to antigens on pathogens, marking them for destruction by complement activation, opsonization and phagocytosis.

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Cell-mediated immunity

Involves T cells that directly target pathogens that cannot be destroyed by phagocytosis, especially virus-infected and cancer cells.

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Active immunity

Immunity acquired through exposure to pathogens, leading to the production of antibodies by the immune system.

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Passive immunity

Immunity provided by receiving pre-made antibodies, like when a mother passes antibodies to her baby.

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Hypersensitivity

Immune response triggers exaggerated, damaging reactions to normally harmless substances, causing inflammation and tissue damage.

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Type I Hypersensitivity: Anaphylaxis

Fastest type of hypersensitivity, occurring within an hour of exposure to an allergen.

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Cytokine Role in Adaptive Immunity

Cytokines are proteins secreted by T helper cells that help B cells multiply and differentiate into plasma cells, which produce antibodies.

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Complement System Function

The complement system is a group of proteins that work together to clear antigen-antibody complexes from the body.

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Autoimmune Disease

A condition where the immune system mistakenly attacks healthy tissues in the body, leading to chronic inflammation and damage.

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Factors Leading to Autoimmunity

Substances, like viruses, that can trigger an autoimmune reaction.

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Emergence of Hidden Antigens

Hidden antigens are body components that were previously not recognized by the immune system. These antigens can be released when tissues are damaged, causing the immune system to mistake them as foreign and attack.

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Drugs and Autoimmunity

Drugs, like penicillin, can sometimes lead to the immune system attacking healthy tissues due to a mistaken identity.

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Immunosuppressants

These medications work by suppressing the immune response, reducing inflammation and slowing down the progression of autoimmune diseases.

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Systemic Lupus Erythematosus (SLE)

A severe autoimmune disease characterized by inflammation and tissue damage in various parts of the body, including the mouth.

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Sjögren Syndrome

Characterized by dry mouth and dry eyes due to the immune system attacking the glands responsible for making saliva and tears.

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Pemphigus Vulgaris

A rare, blistering autoimmune disease that attacks the skin and mucous membranes, leading to painful sores and blisters in the mouth.

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Study Notes

Immunology Overview

  • Immunology is the study of the body's immune system and how it defends against disease.
  • Microbes are microscopic organisms, some pathogenic (disease-causing) and some beneficial. Examples include bacteria, viruses, fungi, protozoa, and algae.
  • Antigens are substances on pathogens that trigger an immune response. Examples include bacteria, viruses, chemicals, toxins, and pollen.
  • Cytokines are small proteins that regulate immune cell activity and growth. Examples include interleukins, interferons, and lymphokines.
  • Antibodies (immunoglobulins) are produced by activated B cells to target and weaken antigens.
  • Phagocytes are immune cells that engulf and destroy pathogens. Examples of phagocytes: macrophages, neutrophils, monocytes, dendritic cells, and granulocytes.
  • Antigen-presenting cells (APCs) process antigens and present them to T cells. Examples of APCs: macrophages, dendritic cells, and B cells.
  • Proteins in the immune system include antibodies, cytokines, and complement proteins. They are chains of amino acids with specific functions.
  • Opsonins coat pathogens, making them more recognizable to phagocytes. Examples include IgG and C3b.
  • Phagocytosis is the process by which phagocytes engulf and destroy pathogens—illustrated by a neutrophil engulfing a bacterium.
  • Apoptosis is programmed cell death. This is important for development and tissue homeostasis.
  • The complement system helps eliminate pathogens and damaged cells, aiding in the body's healing after injury or infection.
  • Polymorphonuclear leukocytes (PMNs) are a type of white blood cell (e.g., neutrophils, eosinophils, basophils, and mast cells); they are the first-line defense against tissue injury, infection, and inflammation.

Key Organs and Tissues of the Immune System

  • Primary organs include bone marrow (where B cells mature), and thymus (where T cells mature).
  • Secondary organs include the spleen, tonsils, skin, and bowel, and mucous membranes (in the nose, throat, bladder, and genitals). These are sites where immune cells interact with pathogens.
  • These organs and tissues work together to support the immune response.

Innate vs. Adaptive Immunity

  • Innate immunity is non-specific and rapid, providing the first line of defense. This includes barriers like skin and mucous membranes, and immune cells like phagocytes. It does not have immunological memory.
  • Adaptive immunity is specific and develops over time, characterized by immunological memory. That means it can recognize previous threats effectively. This includes B and T lymphocytes, and antibody production.

Key Barriers of Innate Immune System

  • Anatomic barriers: Skin, mucous membranes (e.g., respiratory tract, oral cavity).
  • Physiological barriers: Low pH in the stomach, body temperature, and chemical mediators like saliva and tears.
  • Phagocytic/Endocytic barriers: Phagocytes engulf and digest pathogens.
  • Inflammatory barriers: Cytokines and histamines help with response to infection and injury.

Cells of the Immune System

  • White blood cells are crucial immune cells.
  • Overview of different white blood cell types (e.g., macrophages, neutrophils, dendritic cells, natural killer cells, B cells, T cells, eosinophils, basophils, mast cells).

Antibodies (Immunoglobulins)

  • Different types of antibodies (e.g., IgA, IgD, IgE, IgG, IgM).
  • Characteristics and functions of each antibody type.

Immune Response

  • Humoral (antibody-mediated) immunity: B cells produce antibodies targeting pathogens.
  • Cell-mediated immunity: T cells directly attack infected cells.

Acquired/Adaptive Immunity

  • Passive immunity: Receiving antibodies from another source (e.g., mother to fetus).
  • Active immunity: Producing antibodies in response to an infection or vaccination.

Immune Disorders

  • Hypersensitivity (overactive immune response), includes Type I (anaphylaxis), Type II (cytotoxic), Type III (immune complex), and Type IV (cell-mediated).
  • Immunodeficiency (weakened immune response). Describes primary (genetic) and secondary (acquired) immunodeficiency factors.

Autoimmunity

  • Autoimmunity is when the immune system attacks the body's own cells.
  • Factors and consequences.

Dental Implications

  • Importance of taking thorough patient history in dental practice, specifically regarding allergies/hypersensitivities impacting immune responses.
  • Specific autoimmune diseases (e.g., Sjögren's syndrome, systemic lupus erythematosus) or immunodeficiency states and their oral manifestations.

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