Podcast
Questions and Answers
What is the major antibody isotype found in mucosal lymphoid tissues?
What is the major antibody isotype found in mucosal lymphoid tissues?
- IgA (correct)
- IgM
- IgG3
- IgG1
Which enzyme plays a key role in the mechanism of isotype switching of antibodies?
Which enzyme plays a key role in the mechanism of isotype switching of antibodies?
- Fc receptors
- Activation-induced deaminase (AID) (correct)
- TGF-β
- CD40
Which type of antibody is best for microbes opsonization?
Which type of antibody is best for microbes opsonization?
- IgA
- IgM
- IgG (correct)
- IgE
Which type of cells are best for eliminating helminths?
Which type of cells are best for eliminating helminths?
Which type of cells produce the first antibody, IgM, in response to an antigen?
Which type of cells produce the first antibody, IgM, in response to an antigen?
What is the function of the neonatal Fc receptor (FcRn)?
What is the function of the neonatal Fc receptor (FcRn)?
Which cytokine is associated with the production of IgA?
Which cytokine is associated with the production of IgA?
Where does affinity maturation occur in B cells?
Where does affinity maturation occur in B cells?
Which enzyme plays a critical role in somatic mutation during affinity maturation?
Which enzyme plays a critical role in somatic mutation during affinity maturation?
What is a major source of IgA antibodies in mucosal tissues against nonprotein antigens?
What is a major source of IgA antibodies in mucosal tissues against nonprotein antigens?
Which type of antigens stimulate proliferation and differentiation of B cells without T cell help?
Which type of antigens stimulate proliferation and differentiation of B cells without T cell help?
What is the estimated frequency of mutations per cell per division during affinity maturation due to somatic hypermutation?
What is the estimated frequency of mutations per cell per division during affinity maturation due to somatic hypermutation?
Where do memory cells from T-dependent antibody responses reside?
Where do memory cells from T-dependent antibody responses reside?
What type of antigens require T cell help for B cell activation?
What type of antigens require T cell help for B cell activation?
In which population of B lymphocytes are most blood circulating IgM antibodies produced?
In which population of B lymphocytes are most blood circulating IgM antibodies produced?
What is the difference between T-dependent and T-independent activation of B cells?
What is the difference between T-dependent and T-independent activation of B cells?
Why do most soluble protein antigens not stimulate high levels of B cell activation?
Why do most soluble protein antigens not stimulate high levels of B cell activation?
What is the outcome of isotype switching in B cells?
What is the outcome of isotype switching in B cells?
Which process leads to the production of antibodies with improved capacity to bind and neutralize microbes?
Which process leads to the production of antibodies with improved capacity to bind and neutralize microbes?
How do B cells recognize their specific antigens?
How do B cells recognize their specific antigens?
What is the role of Toll-like receptors (TLRs) in B cell activation?
What is the role of Toll-like receptors (TLRs) in B cell activation?
How do activated helper T cells stimulate B cells?
How do activated helper T cells stimulate B cells?
What happens if there is a mutation in the CD40L gene?
What happens if there is a mutation in the CD40L gene?
'IgE functions to eliminate helminths' - Which cytokine stimulates the switching to IgE class antibodies?
'IgE functions to eliminate helminths' - Which cytokine stimulates the switching to IgE class antibodies?
How do T-dependent and T-independent activation of B cells differ in terms of receptor affinity?
How do T-dependent and T-independent activation of B cells differ in terms of receptor affinity?
