Immunology: Innate and Adaptive Immunity

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Questions and Answers

What is the primary function of helper T cells in the immune response?

  • To break down foreign proteins into fragments
  • To engulf and destroy foreign pathogens
  • To directly kill infected cells
  • To recognize and bind to foreign antigens on MHC proteins (correct)

Which type of immunity involves the rapid recognition and destruction of foreign antigens?

  • Adaptive immunity
  • Specific immunity
  • Cell-mediated immunity
  • Innate immunity (correct)

What characterizes the adaptive immune system?

  • It can only produce antibodies but not cell-mediated responses.
  • It provides immediate defense against all pathogens regardless of type.
  • It includes T lymphocytes and B lymphocytes that respond to specific antigens. (correct)
  • It relies solely on physical barriers like skin.

How do B lymphocytes respond when they encounter a foreign antigen?

<p>They engulf the antigen, process it, and present fragments on MHC proteins. (C)</p> Signup and view all the answers

What might be the consequence of having an abnormally low number of helper T cells?

<p>Decreased activation of cytotoxic T cells (C)</p> Signup and view all the answers

What role do MHC proteins play in the immune response?

<p>They display protein fragments for recognition by T cells. (D)</p> Signup and view all the answers

What type of cells are primarily responsible for inducing apoptosis in infected cells?

<p>Cytotoxic T cells (C)</p> Signup and view all the answers

Which of the following statements about antigen presentation is true?

<p>MHC proteins display fragments of proteins present in the cell. (D)</p> Signup and view all the answers

Flashcards

Innate Immunity

The immune response that is rapid and nonspecific, targeting foreign antigens immediately.

Adaptive Immunity

A specialized immune response that recognizes specific antigens and mounts tailored responses.

Cell-mediated Immunity

A type of adaptive immunity where T lymphocytes target and respond to foreign antigens.

Humoral Immunity

A component of adaptive immunity involving B lymphocytes that produce antibodies against antigens.

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MHC Proteins

Major histocompatibility complex proteins that display protein fragments (antigens) on cell surfaces.

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Helper T Cells

T cells that recognize antigens and activate B lymphocytes and cytotoxic T cells through cytokine release.

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B Lymphocytes

Immune cells that bind to foreign antigens and produce antibodies after activation by helper T cells.

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Cytotoxic T Cells

Immune cells that destroy infected cells by inducing apoptosis after activation by helper T cells.

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Study Notes

Innate and Adaptive Immunity

  • Innate immunity is rapid and non-specific, destroying foreign antigens.
  • Adaptive immunity is specific, divided into cell-mediated and humoral immunity, targeting particular antigens.

Cell-Mediated Immunity

  • T lymphocytes recognize antigens displayed by MHC proteins on other cells.
  • MHC proteins display fragments of proteins inside a cell.
  • Cells infected with pathogens display foreign antigens on MHC proteins.
  • Helper T cells recognize antigens presented by MHC proteins.
  • They release cytokines, triggering B lymphocyte division.

Helper T Cell Role

  • Helper T cells bind antigens displayed by B lymphocytes.
  • B lymphocytes engulf foreign antigens, breaking them down.
  • Fragments are presented on MHC proteins.
  • Helper T cells trigger B lymphocyte division and antibody production.
  • They also bind antigens on macrophages and dendritic cells.
  • This stimulates other immune responses, like macrophage phagocytosis and cytotoxic T cell activation.

Implications of Low Helper T Cell Count

  • A low count of helper T cells affects cytotoxic T cell and B lymphocyte activation.
  • B lymphocytes produce antibodies to target invading pathogens.
  • MHC protein expression is independent of helper T cell count, allowing antigen presentation.

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