Immunology: Innate Immune Response and Pathogenic Infection

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10 Questions

What is the primary function of the lymphatic system in the immune response?

To act as a transport network

Eosinophils are primarily involved in fighting viral infections.

False

What is the difference between natural and artificial immunity?

Natural immunity is acquired through exposure to a pathogen, whereas artificial immunity is acquired through vaccination or immunotherapy.

The process of antigen presentation is crucial for the activation of ______________ cells.

T

Which of the following cells is involved in the recognition of cancer cells and virally infected cells?

Natural killer cells

The emergence of new pathogens is solely due to genetic mutations.

False

What is the primary role of mast cells in the immune response?

To release histamine and other chemical mediators during allergic reactions.

The ______________ system is responsible for the transport of lymphocytes and other immune cells throughout the body.

lymphatic

Match the following types of immune cells with their functions:

Macrophages = Phagocytosis Neutrophils = Antigen presentation Dendritic cells = Phagocytosis Natural killer cells = Recognition of cancer cells and virally infected cells

What is the primary goal of immunotherapy strategies?

To treat autoimmune diseases and cancer

Study Notes

Barriers to Infection

  • Physical barriers: prevent pathogenic infection in animals and plants
  • Chemical barriers: prevent pathogenic infection in animals and plants
  • Microbiota barriers: prevent pathogenic infection in animals and plants

Innate Immune Response

  • Includes steps in an inflammatory response
  • Characteristics and roles of:
    • Macrophages
    • Neutrophils
    • Dendritic cells
    • Eosinophils
    • Natural killer cells
    • Mast cells
    • Complement proteins
    • Interferons

Initiation of Immune Response

  • Antigen presentation: crucial for initiating immune response
  • Distinction between self-antigens and non-self antigens
  • Types of pathogens: cellular and non-cellular
  • Allergens: triggers immune response

Acquiring Immunity

  • Lymphatic system: transport network for immune response
  • Lymph nodes: sites for antigen recognition by T and B lymphocytes
  • Components of adaptive immune response:
    • B lymphocytes and antibodies
    • Helper T cells
    • Cytotoxic T cells
  • Natural immunity: occurs through exposure or infection
  • Artificial immunity: acquired through vaccination or medical intervention
  • Active immunity: results from natural exposure or vaccination
  • Passive immunity: results from transfer of antibodies

Disease Challenges and Strategies

  • Emergence of new pathogens: impact of globalization
  • Re-emergence of known pathogens: impact of globalization
  • Impact of European arrival on Aboriginal and Torres Strait Islander peoples
  • Scientific strategies to identify and control pathogens:
    • Identify pathogen and host
    • Determine modes of transmission
    • Implement measures to control transmission
  • Vaccination programs: maintain herd immunity
  • Immunotherapy strategies:
    • Monoclonal antibodies for autoimmune diseases
    • Monoclonal antibodies for cancer treatment

This quiz covers the physical, chemical, and microbiota barriers that prevent pathogenic infections in animals and plants, as well as the steps of the innate immune response and the roles of various immune cells.

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