Immunology Chapter 1

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Questions and Answers

What is the primary focus of immunology?

  • To understand how the body protects itself from diseases (correct)
  • To analyze the chemical composition of molecules
  • To study the genetic makeup of organisms
  • To explore the nutritional needs of the immune system

What is active immunity?

  • A state of immunity where the host can easily be infected
  • Immunity gained from the introduction of antibodies from another organism
  • A temporary immunity gained through exposure to a disease
  • Immunity developed through the body's own immune responses (correct)

What does passive immunity involve?

  • Long-term immunity developed through vaccination
  • Introduction of antibodies from an external source (correct)
  • Immediate immune response to pathogens
  • Production of antibodies by the host

What are epitopes?

<p>Regions on an antigen that are recognized by antibodies (B)</p> Signup and view all the answers

How does the body develop an immune response?

<p>By combining products that stimulate a specific immune response (D)</p> Signup and view all the answers

What is a characteristic of passive immunity?

<p>It provides immediate but temporary protection (D)</p> Signup and view all the answers

What best describes the immune state of susceptibility?

<p>The body is vulnerable to infections and diseases (B)</p> Signup and view all the answers

What is the role of antibodies in the immune response?

<p>To neutralize and bind to specific antigens (B)</p> Signup and view all the answers

Which statement about antigens is correct?

<p>They can contain different epitopes that trigger immune responses (C)</p> Signup and view all the answers

Which type of immunity involves the adaptive immune response?

<p>Active immunity (C)</p> Signup and view all the answers

What is immunogenicity primarily associated with?

<p>The ability to trigger an immune response (C)</p> Signup and view all the answers

Which of the following terms are often used interchangeably?

<p>Antigenicity and immunogenicity (C)</p> Signup and view all the answers

What do surface receptors on T cells influence?

<p>The ability to recognize pathogens (C)</p> Signup and view all the answers

How is the duration of immunogenicity typically described?

<p>In terms of lifelong and short-term effects (D)</p> Signup and view all the answers

Which statement accurately reflects the nature of all molecules concerning immunogenicity?

<p>All molecules possess some level of immunogenicity. (D)</p> Signup and view all the answers

What is NOT a characteristic of long-term immunogenicity?

<p>It can involve short-term efficacy. (B)</p> Signup and view all the answers

Which aspect of immunogenicity is closely tied to the efficacy of a molecule?

<p>The ability to provide lifelong immunity (D)</p> Signup and view all the answers

What influence do T cell surface receptors have in the immune system?

<p>They enhance the response to antigens. (D)</p> Signup and view all the answers

What is the primary distinction between antigenicity and immunogenicity?

<p>Immunogenicity identifies the strength of the immune response generated. (B)</p> Signup and view all the answers

Which of the following best describes antigenicity?

<p>The specific binding of antigens to antibodies. (D)</p> Signup and view all the answers

In the context of immunology, what does 'therapeutre' likely refer to?

<p>The administration of antigens to provoke an immune response. (D)</p> Signup and view all the answers

Which of the following statements about secreted antibodies (ab) is correct?

<p>They are involved in both antigenicity and immunogenicity. (A)</p> Signup and view all the answers

What would be an example of a product that is likely to provoke an immune response when injected?

<p>A vaccine containing attenuated pathogens. (B)</p> Signup and view all the answers

Which factor is essential for an antigen to be considered immunogenic?

<p>It has to be foreign to the host. (A)</p> Signup and view all the answers

How does the concept of antigenicity relate to the effectiveness of vaccines?

<p>Vaccines must possess antigenicity to elicit an immune response. (B)</p> Signup and view all the answers

What role do secreted antibodies play in the immune system?

<p>They identify and neutralize antigens. (C)</p> Signup and view all the answers

What type of immune system responds immediately to invaders?

<p>Innate immune system (A)</p> Signup and view all the answers

Which type of molecules are known to be non-immunogenic?

<p>Lipids (A)</p> Signup and view all the answers

What characteristic do haptens possess?

<p>They cannot provoke an immune response independently (D)</p> Signup and view all the answers

Which immune system component does NOT respond immediately?

<p>Adaptive immune system (C)</p> Signup and view all the answers

What type of molecules are regarded as immunogenic?

<p>Polysaccharides and proteins (B)</p> Signup and view all the answers

Which of the following is NOT a characteristic of the innate immune system?

<p>Specific to pathogens (D)</p> Signup and view all the answers

Which of these molecules may act as haptens?

<p>Lipids (D)</p> Signup and view all the answers

What are the types of immune protection primarily provided by polysaccharides?

<p>Non-specific immunity (D)</p> Signup and view all the answers

What type of substances are primarily classified as immunogens?

<p>Proteins and glycoproteins (D)</p> Signup and view all the answers

How many types of proteins or glycoproteins are stated to function as immunogens?

<p>Two types (D)</p> Signup and view all the answers

Which of the following correctly identifies the chemical nature of the majority of immunogens?

<p>Proteins (B)</p> Signup and view all the answers

Which of these substances is NOT typically considered an immunogen?

<p>Synthetic polymers (B)</p> Signup and view all the answers

What is the main role of immunogens in the immune system?

<p>To trigger an immune response (B)</p> Signup and view all the answers

In the context of the immune system, which category do lipoproteins fall under?

<p>Immunogenic substances (A)</p> Signup and view all the answers

What aspect of immunogens is essential for their recognition by the immune system?

<p>Their chemical nature (B)</p> Signup and view all the answers

Which characteristic is important for a substance to be classified as an immunogen?

<p>Ability to elicit a specific immune response (C)</p> Signup and view all the answers

What is the primary role of an immunogen?

<p>To specifically bind antibodies or receptors (A)</p> Signup and view all the answers

What characterizes innate immunity compared to adaptive immunity?

<p>It provides immediate protection (C)</p> Signup and view all the answers

Which of the following statements about haptens is true?

<p>Haptens require a carrier protein to elicit an immune response (A)</p> Signup and view all the answers

What is NOT a characteristic of the 1st line of immune defense?

<p>Involvement of white blood cells (B)</p> Signup and view all the answers

What is the role of NK (Natural Killer) cells in the immune response?

<p>To destroy abnormal or infected cells (C)</p> Signup and view all the answers

Which of the following describes the concept of immunological memory?

<p>The ability to remember pathogens for rapid response upon subsequent exposure (A)</p> Signup and view all the answers

What can inappropriate immune responses lead to?

<p>Allergic reactions and autoimmune diseases (B)</p> Signup and view all the answers

Which component is primarily involved in the inflammatory response?

<p>Phagocytes (A)</p> Signup and view all the answers

How does fever function in the body's immune response?

<p>By creating an unsuitable environment for pathogens (A)</p> Signup and view all the answers

What is a common outcome of the maximal immune response?

<p>It results in immediate but short-lived protection (D)</p> Signup and view all the answers

Which of the following is NOT part of the 2nd line of immune defense?

<p>Skin barriers (D)</p> Signup and view all the answers

What is one function of complement proteins in immune response?

<p>Directly kill bacterial cells (C)</p> Signup and view all the answers

What describes the lag time in the immune response?

<p>The delay before the immune system recognizes a pathogen (C)</p> Signup and view all the answers

What is a consequence of the presence of immunological memory in a host?

<p>Faster response upon subsequent exposures to the same pathogen (B)</p> Signup and view all the answers

Flashcards

Immunology

The science of how the body protects itself from diseases and infection.

Immunity

The state where the body is resistant to infection and disease.

Active Immunity

Immunity acquired through the body's own immune response.

Passive Immunity

Immunity acquired from external sources.

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Antibodies

Immune proteins that bind to antigens, a type of intruder.

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Antigen

A substance that triggers an immune response.

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Epitope/antigen determinant

Specific region of an antigen that antibodies bind to.

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Active regions of the antigen

Parts of the antigen that activate the immune system.

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Immune response

The body's defensive reaction to antigens.

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Susceptible (invulnerable)

Describes how a body is vulnerable or not vulnerable to particular diseases.

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Antigenicity

The ability of a substance to combine specifically with antibodies.

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Immunogenicity

The ability of a substance to elicit an immune response.

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Breast milk antigenicity

The property of breast milk substances to combine with antibodies.

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Breast milk immunogenicity

Ability of breast milk substances to cause an immune response.

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Injection of secreted antibodies

Administering antibodies to provide temporary immunity.

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Products

Substances produced by a process or organism

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Immunogenicity definition

The ability of a molecule to induce an immune response.

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Long-term efficacy

How effectively something works over a long period.

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Short-term efficacy

How effectively something works immediately.

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Immunogenicity of molecules

All molecules have the ability to trigger an immune response (immunogenicity), but not all can be recognized by immune system (antigenicity).

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Surface receptors on T cells

Proteins on the surface of T cells that bind to specific molecules to trigger immune response.

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Immunogenicity & Antigenicity

Antigenicity is a part of immunogenicity. Molecules that can trigger an immune response have antigenicity.

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Lifelong efficacy

The efficiency of something that persists throughout a lifetime.

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What are immunogens?

Substances that trigger an immune response. They are typically proteins, glycoproteins, or lipoproteins.

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What is the chemical nature of most immunogens?

The vast majority of immunogens are proteins.

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What are the two main types of immunogens?

Proteins and glycoproteins are the main types of immunogens.

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Are all proteins immunogens?

No, not all proteins are immunogens. Some are very similar to our own body's proteins and don't trigger an immune response.

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What are lipoproteins?

Lipoproteins are molecules that combine lipids (fats) and proteins.

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Are lipoproteins immunogens?

Yes, some lipoproteins can act as immunogens.

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What does 'pure' mean in the context of immunogens?

Pure immunogens refer to isolated and purified proteins, glycoproteins, or lipoproteins that are capable of triggering an immune response.

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Why are pure immunogens important?

Pure immunogens are used in vaccines to specifically target the immune system against a particular pathogen.

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Innate Immunity

The body's natural, non-specific defense system that is present from birth and responds immediately to threats.

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What are the two types of immune responses?

The immune system has two main types of responses: innate and adaptive immunity. These responses work together to protect the body from infection.

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What makes a substance immunogenic?

A substance is considered immunogenic when it can trigger an immune response. This means the body recognizes it as foreign and mounts a defense.

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What makes a substance non-immunogenic?

A substance is considered non-immunogenic when it cannot trigger an immune response on its own. The body might not recognize it as foreign or it might be too small.

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Haptens

Small molecules that are not immunogenic on their own but become immunogenic when bound to a larger carrier molecule. They can trigger an immune response when attached to a strong immunogen.

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What are some examples of immunogenic substances?

Many substances, such as proteins, polysaccharides, and certain nucleic acids, are immunogenic. Lipids, generally, are not immunogenic.

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What is the difference between an immunogen and antigen?

An immunogen is a substance that can trigger an immune response, while an antigen is any substance that can bind to an antibody. All immunogens are antigens, but not all antigens are immunogens.

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Immunogen

A substance that can induce an immune response and create immunological memory.

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What are the main lines of defense in the immune system?

The immune system has three lines of defense: First line (barriers like skin and mucus), Second line (nonspecific processes like inflammation), and Third line (adaptive immunity with specific responses).

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First line of defense

The initial barrier against pathogens, including skin, mucous membranes, and bodily secretions.

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Second line of defense

Nonspecific immune mechanisms, like inflammation and the action of natural killer cells, that act quickly against invaders.

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Third line of defense

Adaptive immunity, where the immune system specifically recognizes and targets antigens, producing memory cells for future encounters.

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What are the characteristics of the innate immune response?

The innate immune response is non-specific, meaning it acts against a broad range of pathogens, and is immediate, providing rapid protection.

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What are the characteristics of the adaptive immune response?

The adaptive immune response is specific, targeting specific antigens, and generates immunological memory, leading to faster and stronger responses upon re-exposure.

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What is immunological memory?

The ability of the adaptive immune system to 'remember' specific antigens and mount a faster and more potent response upon subsequent encounters.

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What are the consequences of inappropriate immune responses?

Inappropriate immune responses can lead to allergies or autoimmune diseases, where the immune system attacks the body's own cells or harmless substances.

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What is inflammation?

A localized response to tissue damage caused by infection or injury, characterized by redness, swelling, heat, and pain.

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What are the roles of NK cells and phagocytes in immunity?

Natural Killer (NK) cells destroy infected or cancerous cells, while phagocytes engulf and digest microbes and debris.

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Study Notes

Chapter 1: Immunology

  • Immunology: Science of how the body defends itself against disease

  • Immunity: State of being protected from a disease due to prior exposure; resistance to infection

  • Active Immunity: Body produces its own antibodies

    • Develops after exposure to the antigen
    • Long-lasting, often lifelong
    • Examples: Infection, vaccination
  • Passive Immunity: Antibodies obtained from an outside source

    • Short-term protection
    • Examples: Maternal antibodies, antibody injections

Active vs. Passive Immunity

  • Active: Body produces antibodies

    • Mechanism: Direct infection, vaccination
    • Duration: Long-term
    • Response: Gradual building of immunity
  • Passive: Antibodies are transferred

    • Mechanism: Mother to baby (placenta, breast milk), therapeutic injections
    • Duration: Short-term
    • Response: Immediate but temporary protection

Antigens vs. Antibodies

  • Antigens: Molecules stimulating an immune response

    • Often complex structures, typically proteins or carbohydrates
    • Have specific sites (epitopes) recognized by antibodies
    • Can be foreign (pathogens) or self (autoimmune)
  • Antibodies (Immunoglobulins): Specialized proteins; bind to antigens

    • Recognize and neutralize specific antigens
    • Crucial for antibody-mediated immunity

Immunogenicity vs. Antigenicity

  • Antigenicity: Ability of a substance to combine with antibodies & T-cell receptors
  • Immunogenicity: Ability to induce an immune response

Types of Immune Systems

  • Innate Immune System: Rapid, non-specific response. - First and second line of defense - No memory or prior sensitization - Components: Physical barriers, phagocytes, inflammation, fever

  • Adaptive Immune System: Specific, slower response. - Third line of defense - Exhibits a "memory" capacity, stronger response to subsequent exposure - Components: Lymphocytes, antibodies

Innate Immunity (Non-specific)

  • Attributes: Immediate defense; broad range, non-specific actions.
  • Components: Physical barriers, phagocytes, inflammation, fever, natural killer (NK) cells
  • Effective against wide range of pathogens.
  • No memory of pathogens.

Adaptive Immunity (Specific)

  • Attributes: Develops after exposure; highly specific.
  • Components: B cells, T cells, and antibodies
  • Mechanism: Recognizes specific antigens; has memory cells
  • Response: More potent, and better response at second encounter of pathogen.

Cellular Components of the Immune System (Page 2)

  • Innate: Natural killer (NK) cells, macrophages, neutrophils, dendritic cells, eosinophils, basophils, mast cells, complement system

  • Adaptive: B cells, T cells

  • Types of T cells: Helper T cells (CD4+), Cytotoxic T cells (CD8+)

  • Types of B cells: Plasma cells (antibody production)

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