10 Questions
What triggers massive brain inflammation in multiple sclerosis?
Autoreactive CD4+ Th1 and Th17 cells
What is the primary function of autoreactive CD8+ T cells in autoimmune diseases?
Directly killing self-antigen-expressing cells
What is the main consequence of autoreactive T cells crossing the blood-brain barrier in multiple sclerosis?
Demyelination of neurons
What is the primary function of microglia in the central nervous system?
Brain-resident macrophages
What is the primary difference between autograft and allograft?
Genetic identity of donors
What serves as alloantigens in graft rejection?
Both major and minor histocompatibility molecules
What is the typical outcome of transplanting tissues between non-identical individuals?
Accelerated rejection
What is the primary function of hematopoietic stem cells in transplantation?
Giving rise to immune cells
What is the primary mechanism of autoantibody support in inflammation?
Unclear mechanism
What is the primary role of T cells in allograft rejection?
Mediating allograft rejection
Learn about the role of minor histocompatibility antigens in allograft rejection, direct and indirect allorecognition, and the importance of immunosuppressive drugs. Understand how T cells respond to donor cells and the process of graft rejection.
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