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Immunology: Allograft Rejection and Histocompatibility

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Immunology: Allograft Rejection and Histocompatibility

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Questions and Answers

What triggers massive brain inflammation in multiple sclerosis?

Autoantibodies

Microglia

Autoreactive CD4+ Th1 and Th17 cells (correct)

Autoreactive CD8+ T cells

What is the primary function of autoreactive CD8+ T cells in autoimmune diseases?

Presenting antigens to T cells

Producing autoantibodies

Supporting inflammation

Directly killing self-antigen-expressing cells (correct)

What is the main consequence of autoreactive T cells crossing the blood-brain barrier in multiple sclerosis?

Demyelination of neurons (correct)

Rejection of transplanted tissues

Production of autoantibodies

Inflammation of the pancreas

What is the primary function of microglia in the central nervous system?

Brain-resident macrophages Signup and view all the answers

What is the primary difference between autograft and allograft?

Genetic identity of donors Signup and view all the answers

What serves as alloantigens in graft rejection?

Both major and minor histocompatibility molecules Signup and view all the answers

What is the typical outcome of transplanting tissues between non-identical individuals?

Accelerated rejection Signup and view all the answers

What is the primary function of hematopoietic stem cells in transplantation?

Giving rise to immune cells Signup and view all the answers

What is the primary mechanism of autoantibody support in inflammation?

Unclear mechanism Signup and view all the answers

What is the primary role of T cells in allograft rejection?

Mediating allograft rejection Signup and view all the answers