29 Questions
What is the main function of the VH region in an immunoglobulin structure?
Antigen binding
Which process involves the release of histamine from mast cells triggered by antibodies?
Mast cell degranulation
Which Ig region is primarily responsible for activating B lymphocytes?
Fab domain
Which biological function of antibodies involves enhancing phagocytosis of pathogens by macrophages?
Complement activation
Which process involves antibody-dependent cell-mediated cytotoxicity (ADCC)?
B lymphocyte activation
What is responsible for antibody diversity?
Variation in amino acid sequences in variable regions
What stabilizes the structure of the constant region of light chains?
Basic amino acid sequences interacting with CH1 region
Which component determines the class (isotype) of an antibody?
Constant regions of heavy chains
Where are secreted forms of antibodies found?
Mucosal secretions
What stabilizes the structure of IgA antibodies?
(a2k2)n or (a2l2)n, n = 1,2,3,4
What is present in plasma when blood clots?
Antibodies
Which antibody class is most abundant in serum and has four different subclasses with varying biological activity?
IgG
Which antibody plays a significant role in neonatal immunity by crossing the placenta to enter the fetal circulation?
IgG
Which antibody class is predominantly secreted in external secretions like saliva, tears, breast milk, and mucus?
IgA
Which antibody class serves as an antigen receptor on naïve B cells when in its monomeric form?
IgM
Which antibody class can be found minimally in interstitial fluid due to its large size but can still be present in secretions?
IgM
Which antibody class binds to a poly-Ig receptor on the basolateral membrane of an epithelial cell for internalization in secretory IgA formation?
IgA
What is the function of Fc receptors on immune cells?
Activate specific immune cells like monocytes and mast cells
Which immunoglobulins can activate the classical pathway of complement?
IgM and IgG
What is the role of BCR Complex formed by Ig-α/Ig-β?
Signal activation for B cells
Which antibody effector function involves prohibiting attachment of microbes to host surfaces?
Neutralization
What must be true for IgG and IgM antibodies to activate complement?
They must be bound to cell surfaces
Which immune cells recognize antibodies through Fc receptors?
Natural killer (NK) cells
Which type of immune response involves enhanced phagocytosis by macrophages and neutrophils?
Opsonization
What is the mechanism of action in Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC)?
Coating of host cells/microbes with antibodies leading to cytotoxic cell recognition
Which cell type is NOT involved in Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC)?
Eosinophils
In Mast Cell and Basophil degranulation, the process is initiated by binding of which molecule?
IgE
What is the primary function of Fc receptors in the immune response?
Enhanced phagocytosis and cytotoxicity by immune cells
Which process is associated with opsonization in the immune response?
Antibody coating for phagocytosis
Learn about the basic structure of an Ig and the functions of each major region such as VH, VL, CH, and CL. Understand the relationships of these domains with the Fc and Fab domains, as well as the biological functions of antibodies like B lymphocyte activation. This quiz is based on Lecture 8 by Brian Wellensiek, Ph.D., and the book 'Cellular & Molecular Immunology' (Chapter 5, pgs. 103-112).
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
