10 Questions
Which IgG subclass has a shorter hinge region with a rigid poly-proline double helix?
IgG2
Which IgG subclass is very susceptible to cleavage by proteolytic enzymes like papain and plasmin?
IgG3
At what age do 'adult' concentrations of IgG2 isotype are usually reached?
6-7 years
Which IgG subclass binds to the Fc-receptor of phagocytic cells and activates the complement cascade?
IgG1
Which IgG isotype is associated with recurring airway/respiratory infections in infants?
IgG2
What role does IgG4 play in the immune system?
Unknown role
What is the valence of IgM in its pentameric form?
10
Which statement about IgA is correct?
It is important in mucosal immunity
Where is IgD primarily found in the body?
On B cell surfaces
What is the main function of IgE in the immune system?
Binding to Fc receptors on basophils and mast cells
Test your knowledge on the structural differences between IgG subclasses, including the hinge length, amino acid residues, and presence of disulfide bridges. Understand how these variances influence their flexibility and susceptibility to proteolytic enzymes.
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