Immunoglobulin Antibodies: Structure and Classes
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Questions and Answers

What does a high ratio of IgM to IgG in the bloodstream indicate?

  • The infection is in its early stages (correct)
  • The infection is in its later stages
  • The infection has been resolved
  • The patient has a strong immune response

What is the main function of IgA antibodies?

  • Cause allergic reactions
  • Neutralize extracellular pathogens and toxins
  • Initiate the immune response
  • Provide localized protection of mucosal surfaces (correct)

What is the main function of IgD antibodies on the B cell surface?

  • Provide localized protection of mucosal surfaces
  • Cause allergic reactions
  • Activate B cells to initiate an immune response (correct)
  • Neutralize extracellular pathogens

Which type of antibody is responsible for allergic reactions?

<p>IgE (D)</p> Signup and view all the answers

What is the main role of antibodies in the humoral immune response?

<p>Neutralize extracellular pathogens and toxins (B)</p> Signup and view all the answers

What is the half-life of IgD antibodies in the serum?

<p>3 days (D)</p> Signup and view all the answers

Which factor determines how strongly and stably an antibody binds to a specific antigen?

<p>Affinity (D)</p> Signup and view all the answers

In the context of antibodies, what does avidity depend on?

<p>The number of identical binding sites on the antigen (B)</p> Signup and view all the answers

How do multimeric antibodies like pentameric IgM compare in terms of affinity and avidity to monomeric antibodies?

<p>Lower affinity but higher avidity (A)</p> Signup and view all the answers

What is cross reactivity in the context of antibodies?

<p>When an antibody binds to a different antigen than the one it was produced against (D)</p> Signup and view all the answers

Why can multimeric antibodies still effectively defend against pathogens despite having lower affinity?

<p>They have multiple binding sites for antigens (D)</p> Signup and view all the answers

How do epitopes contribute to cross reactivity?

<p>Epitopes correspond to small regions that can exhibit molecular identities similar to other antigens (D)</p> Signup and view all the answers

What region of an antibody molecule is responsible for forming the antigen binding site?

<p>V region (D)</p> Signup and view all the answers

Which region of an antibody molecule displays wide variation in amino acid sequences?

<p>V region (B)</p> Signup and view all the answers

What is the function of the C-region of an antibody molecule?

<p>Forms the Fc fragment (C)</p> Signup and view all the answers

Which type of immunoglobulin has heavy chains known as gamma-chains?

<p>IgG (A)</p> Signup and view all the answers

What are the two main types of light chains found in antibody molecules?

<p>Kappa and Lambda (B)</p> Signup and view all the answers

Where are the polypeptide protein sequences responsible for the differences in immunoglobulin heavy chains primarily found?

<p>Fc fragment (C)</p> Signup and view all the answers

Which of the following statements about IgM antibodies is true?

<p>They are the first antibodies produced during an infection. (B)</p> Signup and view all the answers

Which of the following functions is not associated with IgG antibodies?

<p>Agglutinating antigens (A)</p> Signup and view all the answers

Which of the following statements about IgG antibodies is false?

<p>They are dimers. (C)</p> Signup and view all the answers

During the course of an infection, which of the following sequences is observed in the bloodstream?

<p>IgM spike, then IgM decrease as IgG increases (D)</p> Signup and view all the answers

Which of the following statements about antibody valency is true?

<p>Valency is determined by the number of Y-like units (monomers) that form the antibody. (D)</p> Signup and view all the answers

Which of the following statements about antibody location is false?

<p>IgM can be found in the placenta. (D)</p> Signup and view all the answers

What type of antibodies are generated in a natural response or artificial immunization?

<p>Polyclonal antibodies (A)</p> Signup and view all the answers

Which type of antibodies are produced by a single clone and have a single specificity?

<p>Monoclonal antibodies (D)</p> Signup and view all the answers

What is the main advantage of monoclonal antibodies over polyclonal antibodies in terms of batch-to-batch variation?

<p>Batch consistency (C)</p> Signup and view all the answers

Which application involves monoclonal antibodies that recognize tumor antigens radiolabeled with iodine I-131?

<p>Diagnostic imaging (D)</p> Signup and view all the answers

Why are monoclonal antibodies considered powerful tools for clinical diagnostic tests?

<p>Provide reproducible results (A)</p> Signup and view all the answers

In what aspect do artificial antibodies derived from different B lymphocytes cell lines differ from those derived from a single B cell clone?

<p>Variability in specificity (A)</p> Signup and view all the answers

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