Immunocompetent Cells: B&T Lymphocytes & Kinin System

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Questions and Answers

What is the primary responsibility of B cells in the immune system?

  • Proliferating and forming lymphoblasts
  • Secreting antibodies (correct)
  • Eliminating antigens
  • Differentiating into effector cells

What is the primary function of the plasma cells in the immune system?

  • Secreting antibodies (correct)
  • Proliferating and forming lymphoblasts
  • Differentiating into memory cells
  • Secreting cytokines

What type of cells are responsible for cytotoxic immunity?

  • T helper cells
  • Plasma cells
  • Cytotoxic T cells (correct)
  • Suppressor T cells

What is the fate of naive lymphocytes upon interaction with antigens and cytokines?

<p>They undergo proliferation (D)</p> Signup and view all the answers

What is the morphology of resting B and T lymphocytes?

<p>Small and motile (D)</p> Signup and view all the answers

What do effector cells of the T cell lineage include?

<p>Cytotoxic T cells (A)</p> Signup and view all the answers

What enzyme is responsible for inactivating the remaining kinin during the passage of plasma through the lung?

<p>Angiotensin converting enzyme (B)</p> Signup and view all the answers

What is the initial event that triggers the production of kinin?

<p>Activation of Hageman factor by contact with negatively charged surfaces (A)</p> Signup and view all the answers

What is the direct action of kallikrein on complement C5?

<p>Conversion of C5 to C5a (C)</p> Signup and view all the answers

Which of the following is not a function of kinin?

<p>Activation of the intrinsic clotting system (A)</p> Signup and view all the answers

What role does the enzyme kallikrein play in the production of kinin?

<p>Cleaves high molecular weight kininogen to produce bradykinin (B)</p> Signup and view all the answers

Which T cell subpopulation is restricted to recognizing antigen bound to class II MHC molecules?

<p>T cells expressing the membrane glycoprotein CD4 (C)</p> Signup and view all the answers

Which of the following is NOT a function of T cells?

<p>The T cells are involved in the secretion of antibodies (B)</p> Signup and view all the answers

What is the typical ratio of CD4 to CD8 cells in peripheral blood?

<p>2:1 (B)</p> Signup and view all the answers

Which of the following molecules is present on B cells and other APCs, and acts as a receptor for CD28?

<p>B7 family of molecules (B)</p> Signup and view all the answers

Which of the following cytokines secreted by Th cells is NOT responsible for activating B cells, T cells, or other cells that participate in the immune response?

<p>IL-17 (B)</p> Signup and view all the answers

Which of the following functions as a co-stimulatory molecule in conjunction with TCR engagement during activation of T cells?

<p>CD28 (A)</p> Signup and view all the answers

What is the primary role of cytotoxic T lymphocytes (CTLs)?

<p>To recognize and eliminate altered self cells (D)</p> Signup and view all the answers

How many chains does the T cell receptor (TCR) consist of and what are they?

<p>Two chains, either α and β or γ and δ (C)</p> Signup and view all the answers

What type of cell does a Th1 response mainly activate?

<p>Macrophages and certain T cells (B)</p> Signup and view all the answers

Which cell is activated when it interacts with an antigen-class I MHC complex on the surface of an altered cell?

<p>Cytotoxic T cells (Tc) (C)</p> Signup and view all the answers

Which chains of the TCR exhibit marked sequence variation?

<p>The amino terminal domains of both chains (D)</p> Signup and view all the answers

What is the structural similarity between the TCR and immunoglobulin?

<p>They have similar domain structures (D)</p> Signup and view all the answers

What is the primary function of the positively charged amino acid residues in the TCR transmembrane domains?

<p>To interact with the chains of the signal transducing CD3 complex (A)</p> Signup and view all the answers

How many hypervariable regions exist in the TCR variable domain?

<p>Three (A)</p> Signup and view all the answers

Which kinin system component is a potent agent that increases vascular permeability?

<p>Bradykinin (B)</p> Signup and view all the answers

Which TCR component forms a disulphide link with the other chain?

<p>The connecting sequence (C)</p> Signup and view all the answers

Which statement best describes the structural homology between TCR C and V domains and immunoglobulin V and C domains?

<p>The TCR domains show minor structural differences compared to immunoglobulin domains (A)</p> Signup and view all the answers

What is the length of the transmembrane region in the TCR chains?

<p>21-22 amino acids (D)</p> Signup and view all the answers

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