Immunity and Infectious Diseases Overview
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Questions and Answers

Which of the following is NOT a mechanism of immune evasion employed by viruses?

  • Infection of immune cells
  • Production of viral proteins that inhibit complement activation (correct)
  • Blocking the transport of MHC molecules to the cell surface.
  • Encoding of viral proteins that mimic host cell receptors
  • Which virus is known to infect B lymphocytes?

  • Epstein-Barr Virus (correct)
  • HIV
  • Measles virus
  • Cytomegalovirus
  • Which of the following is NOT an example of an antibody-mediated response to a viral infection?

  • Neutralization of free virus
  • Cytotoxic T lymphocyte (CTL) activity (correct)
  • Antibody-dependent cell-mediated cytotoxicity (ADCC)
  • Phagocytosis of virus-infected cells by macrophages
  • What is the role of interferon (IFN) in the innate immune response to viral infections?

    <p>Inducing anti-viral effects within infected cells (C)</p> Signup and view all the answers

    Which of the following viruses is known to infect both T lymphocytes and macrophages?

    <p>HIV (C)</p> Signup and view all the answers

    What is the main function of cytotoxic T lymphocytes (CTLs) in the immune response to viruses?

    <p>Destroying virus-infected cells (B)</p> Signup and view all the answers

    How does the vaccinia virus evade the immune system?

    <p>By encoding IFN-α and β receptor homologs (A)</p> Signup and view all the answers

    Which of the following represents the adaptive response to viral infection?

    <p>Production of antibodies and cytotoxic T lymphocytes (D)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of Mycobacterium tuberculosis?

    <p>It is primarily spread through mosquito bites. (B)</p> Signup and view all the answers

    Which of these is a common type of E. coli found in the gut that is generally harmless to humans?

    <p>E. coli Nissle 1917 (C)</p> Signup and view all the answers

    What is the main function of antimicrobial peptides in the innate immune response against bacteria?

    <p>They directly kill bacteria. (A)</p> Signup and view all the answers

    Which of the following is NOT a mechanism of the innate immune response to bacterial infection?

    <p>Cytokine production by cytotoxic T lymphocytes. (D)</p> Signup and view all the answers

    How does opsonization contribute to the immune response against bacteria?

    <p>It enhances the ability of phagocytes to engulf bacteria. (D)</p> Signup and view all the answers

    Which of these is an example of antibody-mediated response against bacteria?

    <p>Blocking bacterial toxins by specific antibodies. (B)</p> Signup and view all the answers

    How do cytotoxic T lymphocytes (CTLs) contribute to the adaptive immune response against bacteria?

    <p>They kill infected cells that harbor intracellular bacteria. (D)</p> Signup and view all the answers

    Which of the following bacterial types is particularly resistant to lysis by the complement system?

    <p>Gram-positive bacteria (B)</p> Signup and view all the answers

    What is the primary mechanism of the immune response against Mycobacterium tuberculosis?

    <p>Phagocytosis by macrophages and cell-mediated response by T cells. (C)</p> Signup and view all the answers

    How does the immune system respond to Plasmodium, the parasite that causes malaria?

    <p>Primarily by antibody-mediated response. (D)</p> Signup and view all the answers

    Which of the following immune cells is crucial for the antibody-dependent cell-mediated cytotoxicity (ADCC) response against parasites?

    <p>Natural killer (NK) cells (B)</p> Signup and view all the answers

    What is the primary function of IgE antibodies in the immune response against parasites?

    <p>They bind to mast cells and eosinophils, leading to degranulation and parasite killing. (B)</p> Signup and view all the answers

    Which of the following is NOT a barrier against fungal infections?

    <p>Inflammation (B)</p> Signup and view all the answers

    How do neutrophils contribute to the innate immune response against fungi?

    <p>They kill fungi through phagocytosis. (A)</p> Signup and view all the answers

    Why is the adaptive immune response against fungi considered not well characterized?

    <p>There is limited research on the adaptive immune response to fungi compared to other pathogens (A)</p> Signup and view all the answers

    Which of these statements best describes the role of the immune system in preventing and combating fungal infections?

    <p>Both innate and adaptive immune systems play significant roles in defending against fungal infections. (B)</p> Signup and view all the answers

    What is the main factor contributing to the success of the human papillomavirus (HPV) vaccine?

    <p>The vaccine triggers the production of antibodies against the virus, preventing infection. (A)</p> Signup and view all the answers

    Which of the following is NOT a way that the innate immune system combats viral infections?

    <p>Activation of cytotoxic T lymphocytes (CTLs). (C)</p> Signup and view all the answers

    What is the primary role of Cytotoxic T lymphocytes (CTLs) in viral infections?

    <p>Directly killing cells infected with the virus. (A)</p> Signup and view all the answers

    Why are antiviral drugs generally less effective than vaccines for preventing viral infections?

    <p>Antiviral drugs target a limited number of viral proteins. (A)</p> Signup and view all the answers

    Which of the following is NOT considered an innate response to viral infection?

    <p>Activation of cytotoxic T lymphocytes (CTLs). (B)</p> Signup and view all the answers

    How does interferon (IFN) play a role in fighting viral infections?

    <p>IFN inhibits viral replication in infected cells. (C)</p> Signup and view all the answers

    Which type of immune cell is responsible for antibody-dependent cell-mediated cytotoxicity (ADCC)?

    <p>NK cells (D)</p> Signup and view all the answers

    What is the primary function of Natural Killer Cells (NK cells) in the context of viral infections?

    <p>Destroying virus-infected cells. (D)</p> Signup and view all the answers

    Which of the following is an example of an oncogenic virus that can cause cancer?

    <p>Human papillomavirus (HPV) (A)</p> Signup and view all the answers

    How does the immune system's memory help fight infections?

    <p>It allows the immune system to recognize and clear the pathogen faster during subsequent exposures. (D)</p> Signup and view all the answers

    Flashcards

    Innate Immunity

    The first line of defense with physical barriers and immune responses.

    Adaptive Immunity

    Immunity that develops over time and targets specific pathogens.

    Immune Memory

    The ability to remember past infections and respond quickly to re-infection.

    Neutralizing Antibody

    An antibody that blocks the infectivity of pathogens like viruses.

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    Cytotoxic T Lymphocytes (CTL)

    T cells that kill cancer cells and cells infected by viruses.

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    Natural Killer (NK) Cells

    Cells that destroy infected or cancerous body cells.

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    Interferon (IFN)

    Proteins produced by cells in response to infections, helping to fight viruses.

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    Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC)

    A mechanism where immune cells kill targets coated with antibodies.

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    Inflammation

    A response to injury that can increase blood flow and immune activity at the site.

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    Oncogenic Virus

    A virus that can cause cancer.

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    NK Cells

    Natural Killer cells that lyse virus-infected cells without prior sensitization.

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    Antibody-mediated Response

    An adaptive immune response involving antibodies neutralizing free viruses and ADCC.

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    ADCC

    Antibody-dependent cell-mediated cytotoxicity, where immune cells kill infected cells tagged by antibodies.

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    Viral Immune Evasion

    Strategies used by viruses to escape detection and destruction by the immune system.

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    Antigen Presentation

    The process of showing viral fragments on MHC class I molecules to activate CTLs.

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    Tuberculosis (TB)

    A bacterial infection caused by Mycobacterium tuberculosis, leading to millions of cases and deaths annually.

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    E.Coli

    A gut bacterium that is mostly harmless but some strains, like O157:H7, can cause severe food poisoning.

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    Innate Response

    Immediate, non-specific immune response against pathogens through barriers like skin and antimicrobial peptides.

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    Phagocytosis

    The process by which cells engulf and digest pathogens, important for innate immunity.

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    Adaptive Response

    A specific immune response that develops over time, involving antibodies and T-cells.

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    Gram-positive Bacteria

    Bacteria with a thick cell wall that are resistant to certain immune responses like complement lysis.

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    Malaria

    A mosquito-borne disease caused by Plasmodium, leading to millions of cases and deaths globally.

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    IgE

    An antibody associated with allergic reactions and defense against parasites.

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    Candidiasis

    An opportunistic fungal infection caused by Candida albicans, common in immunocompromised individuals.

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    Opsonization

    The process where pathogens are marked for destruction by antibodies or complement proteins.

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    Complement System

    A group of proteins that enhance the ability of antibodies and phagocytes to clear pathogens.

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    Phagocytosis (Ab-mediated)

    Phagocytosis enhanced by antibodies that mark pathogens for destruction.

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    Study Notes

    Immunity to Infections

    • Immunity to infections involves innate and adaptive immunity, along with immune memory
    • Innate immunity includes physical and chemical barriers, interferon (IFN) system, complement system, phagocytosis/opsonization, and natural killer (NK) cells
    • Adaptive immunity includes neutralizing antibody, antibody-mediated phagocytosis, antibody-dependent cell-mediated cytotoxicity (ADCC), and cytotoxic T lymphocytes (CTL)
    • Immune memory involves resistance for long periods after infection, along with memory cells

    Infectious Diseases

    • Infectious diseases cause a substantial number of deaths annually, with cardiovascular conditions causing more deaths than infectious diseases
    • Infectious diseases cause an estimated 14.9 million deaths annually, while cardiovascular conditions account for 16.7 million deaths
    • Respiratory infections account for 3.96 million deaths annually
    • HIV/AIDS accounted for 2.77 million deaths in 2023
    • Diarrheal diseases cause 1.8 million deaths annually
    • Tuberculosis causes 1.56 million deaths annually
    • Vaccine-preventable childhood diseases contribute to 1.12 million deaths annually

    Immunity to Viruses

    • The innate response to viral infections includes antiviral effects caused by interferon (IFN), lysis of infected cells by NK cells and inflammation
    • The antibody-mediated response involves virus neutralization and antibody-dependent cell-mediated cytotoxicity (ADCC) by NK cells, macrophages and neutrophils
    • The cell-mediated response involves cytotoxic T lymphocytes (CTLs, CD8 T cells)
    • Viruses can evade the immune system by infecting immune cells

    Immunity to Bacteria

    • Innate responses include antimicrobial peptides, complement-mediated lysis, phagocytosis, involving pattern recognition receptors (PRRs) and pathogen-associated molecular patterns (PAMPs), and opsonization
    • Adaptive responses involve antibody-mediated responses like agglutination, blocking of toxins, and neutralizing toxins, phagocytosis, and cytotoxic T lymphocytes (CTLs) for intracellular infections.
    • Gram-positive bacteria are resistant to lysis by the complement system, and Gram-negative bacteria are susceptible to neutralizing antibodies, phagocytosis and the complement system

    Immunity to Parasites

    • Innate responses to parasitic infections include complement-mediated lysis, phagocytosis (involving pattern recognition receptors (PRRs) and pathogen-associated molecular patterns (PAMPs)), and opsonization.
    • Adaptive responses to parasitic infections include antibody-mediated responses like agglutination and blocking, phagocytosis by antibodies (Ab-mediated), and antibody-dependent cell-mediated cytotoxicity (ADCC)
    • IgE/mast cell/eosinophil responses are also involved in adaptive immunity to parasites

    Immunity to Fungi

    • Innate responses to fungal infections include the body's barriers like skin and normal bacterial flora, phagocytosis by neutrophils, and complement-mediated lysis and opsonization
    • Adaptive responses are not well characterized but may involve antibodies and likely T cell response

    Viral Immune Evasion

    • Viruses can infect immune cells, such as B cells, T cells, and macrophages, to escape the immune system.
    • Some viruses encode homologs of the body's interferon receptors, such as vaccinia virus.
    • Adenovirus E3 protein blocks the transport of MHC to the cell surface, preventing the presentation of viral antigens to the immune system.

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    Description

    This quiz explores the concepts of immunity, including innate and adaptive immunity, and the role of immune memory. Additionally, it discusses the impact of infectious diseases on global health, including mortality statistics and specific diseases like HIV/AIDS and respiratory infections.

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