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Questions and Answers
Which of the following is NOT a mechanism of immune evasion employed by viruses?
Which of the following is NOT a mechanism of immune evasion employed by viruses?
Which virus is known to infect B lymphocytes?
Which virus is known to infect B lymphocytes?
Which of the following is NOT an example of an antibody-mediated response to a viral infection?
Which of the following is NOT an example of an antibody-mediated response to a viral infection?
What is the role of interferon (IFN) in the innate immune response to viral infections?
What is the role of interferon (IFN) in the innate immune response to viral infections?
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Which of the following viruses is known to infect both T lymphocytes and macrophages?
Which of the following viruses is known to infect both T lymphocytes and macrophages?
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What is the main function of cytotoxic T lymphocytes (CTLs) in the immune response to viruses?
What is the main function of cytotoxic T lymphocytes (CTLs) in the immune response to viruses?
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How does the vaccinia virus evade the immune system?
How does the vaccinia virus evade the immune system?
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Which of the following represents the adaptive response to viral infection?
Which of the following represents the adaptive response to viral infection?
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Which of the following is NOT a characteristic of Mycobacterium tuberculosis?
Which of the following is NOT a characteristic of Mycobacterium tuberculosis?
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Which of these is a common type of E. coli found in the gut that is generally harmless to humans?
Which of these is a common type of E. coli found in the gut that is generally harmless to humans?
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What is the main function of antimicrobial peptides in the innate immune response against bacteria?
What is the main function of antimicrobial peptides in the innate immune response against bacteria?
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Which of the following is NOT a mechanism of the innate immune response to bacterial infection?
Which of the following is NOT a mechanism of the innate immune response to bacterial infection?
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How does opsonization contribute to the immune response against bacteria?
How does opsonization contribute to the immune response against bacteria?
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Which of these is an example of antibody-mediated response against bacteria?
Which of these is an example of antibody-mediated response against bacteria?
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How do cytotoxic T lymphocytes (CTLs) contribute to the adaptive immune response against bacteria?
How do cytotoxic T lymphocytes (CTLs) contribute to the adaptive immune response against bacteria?
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Which of the following bacterial types is particularly resistant to lysis by the complement system?
Which of the following bacterial types is particularly resistant to lysis by the complement system?
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What is the primary mechanism of the immune response against Mycobacterium tuberculosis?
What is the primary mechanism of the immune response against Mycobacterium tuberculosis?
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How does the immune system respond to Plasmodium, the parasite that causes malaria?
How does the immune system respond to Plasmodium, the parasite that causes malaria?
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Which of the following immune cells is crucial for the antibody-dependent cell-mediated cytotoxicity (ADCC) response against parasites?
Which of the following immune cells is crucial for the antibody-dependent cell-mediated cytotoxicity (ADCC) response against parasites?
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What is the primary function of IgE antibodies in the immune response against parasites?
What is the primary function of IgE antibodies in the immune response against parasites?
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Which of the following is NOT a barrier against fungal infections?
Which of the following is NOT a barrier against fungal infections?
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How do neutrophils contribute to the innate immune response against fungi?
How do neutrophils contribute to the innate immune response against fungi?
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Why is the adaptive immune response against fungi considered not well characterized?
Why is the adaptive immune response against fungi considered not well characterized?
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Which of these statements best describes the role of the immune system in preventing and combating fungal infections?
Which of these statements best describes the role of the immune system in preventing and combating fungal infections?
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What is the main factor contributing to the success of the human papillomavirus (HPV) vaccine?
What is the main factor contributing to the success of the human papillomavirus (HPV) vaccine?
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Which of the following is NOT a way that the innate immune system combats viral infections?
Which of the following is NOT a way that the innate immune system combats viral infections?
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What is the primary role of Cytotoxic T lymphocytes (CTLs) in viral infections?
What is the primary role of Cytotoxic T lymphocytes (CTLs) in viral infections?
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Why are antiviral drugs generally less effective than vaccines for preventing viral infections?
Why are antiviral drugs generally less effective than vaccines for preventing viral infections?
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Which of the following is NOT considered an innate response to viral infection?
Which of the following is NOT considered an innate response to viral infection?
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How does interferon (IFN) play a role in fighting viral infections?
How does interferon (IFN) play a role in fighting viral infections?
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Which type of immune cell is responsible for antibody-dependent cell-mediated cytotoxicity (ADCC)?
Which type of immune cell is responsible for antibody-dependent cell-mediated cytotoxicity (ADCC)?
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What is the primary function of Natural Killer Cells (NK cells) in the context of viral infections?
What is the primary function of Natural Killer Cells (NK cells) in the context of viral infections?
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Which of the following is an example of an oncogenic virus that can cause cancer?
Which of the following is an example of an oncogenic virus that can cause cancer?
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How does the immune system's memory help fight infections?
How does the immune system's memory help fight infections?
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Flashcards
Innate Immunity
Innate Immunity
The first line of defense with physical barriers and immune responses.
Adaptive Immunity
Adaptive Immunity
Immunity that develops over time and targets specific pathogens.
Immune Memory
Immune Memory
The ability to remember past infections and respond quickly to re-infection.
Neutralizing Antibody
Neutralizing Antibody
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Cytotoxic T Lymphocytes (CTL)
Cytotoxic T Lymphocytes (CTL)
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Natural Killer (NK) Cells
Natural Killer (NK) Cells
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Interferon (IFN)
Interferon (IFN)
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Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC)
Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC)
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Inflammation
Inflammation
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Oncogenic Virus
Oncogenic Virus
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NK Cells
NK Cells
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Antibody-mediated Response
Antibody-mediated Response
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ADCC
ADCC
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Viral Immune Evasion
Viral Immune Evasion
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Antigen Presentation
Antigen Presentation
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Tuberculosis (TB)
Tuberculosis (TB)
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E.Coli
E.Coli
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Innate Response
Innate Response
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Phagocytosis
Phagocytosis
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Adaptive Response
Adaptive Response
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Gram-positive Bacteria
Gram-positive Bacteria
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Malaria
Malaria
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IgE
IgE
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Candidiasis
Candidiasis
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Opsonization
Opsonization
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Complement System
Complement System
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Phagocytosis (Ab-mediated)
Phagocytosis (Ab-mediated)
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Study Notes
Immunity to Infections
- Immunity to infections involves innate and adaptive immunity, along with immune memory
- Innate immunity includes physical and chemical barriers, interferon (IFN) system, complement system, phagocytosis/opsonization, and natural killer (NK) cells
- Adaptive immunity includes neutralizing antibody, antibody-mediated phagocytosis, antibody-dependent cell-mediated cytotoxicity (ADCC), and cytotoxic T lymphocytes (CTL)
- Immune memory involves resistance for long periods after infection, along with memory cells
Infectious Diseases
- Infectious diseases cause a substantial number of deaths annually, with cardiovascular conditions causing more deaths than infectious diseases
- Infectious diseases cause an estimated 14.9 million deaths annually, while cardiovascular conditions account for 16.7 million deaths
- Respiratory infections account for 3.96 million deaths annually
- HIV/AIDS accounted for 2.77 million deaths in 2023
- Diarrheal diseases cause 1.8 million deaths annually
- Tuberculosis causes 1.56 million deaths annually
- Vaccine-preventable childhood diseases contribute to 1.12 million deaths annually
Immunity to Viruses
- The innate response to viral infections includes antiviral effects caused by interferon (IFN), lysis of infected cells by NK cells and inflammation
- The antibody-mediated response involves virus neutralization and antibody-dependent cell-mediated cytotoxicity (ADCC) by NK cells, macrophages and neutrophils
- The cell-mediated response involves cytotoxic T lymphocytes (CTLs, CD8 T cells)
- Viruses can evade the immune system by infecting immune cells
Immunity to Bacteria
- Innate responses include antimicrobial peptides, complement-mediated lysis, phagocytosis, involving pattern recognition receptors (PRRs) and pathogen-associated molecular patterns (PAMPs), and opsonization
- Adaptive responses involve antibody-mediated responses like agglutination, blocking of toxins, and neutralizing toxins, phagocytosis, and cytotoxic T lymphocytes (CTLs) for intracellular infections.
- Gram-positive bacteria are resistant to lysis by the complement system, and Gram-negative bacteria are susceptible to neutralizing antibodies, phagocytosis and the complement system
Immunity to Parasites
- Innate responses to parasitic infections include complement-mediated lysis, phagocytosis (involving pattern recognition receptors (PRRs) and pathogen-associated molecular patterns (PAMPs)), and opsonization.
- Adaptive responses to parasitic infections include antibody-mediated responses like agglutination and blocking, phagocytosis by antibodies (Ab-mediated), and antibody-dependent cell-mediated cytotoxicity (ADCC)
- IgE/mast cell/eosinophil responses are also involved in adaptive immunity to parasites
Immunity to Fungi
- Innate responses to fungal infections include the body's barriers like skin and normal bacterial flora, phagocytosis by neutrophils, and complement-mediated lysis and opsonization
- Adaptive responses are not well characterized but may involve antibodies and likely T cell response
Viral Immune Evasion
- Viruses can infect immune cells, such as B cells, T cells, and macrophages, to escape the immune system.
- Some viruses encode homologs of the body's interferon receptors, such as vaccinia virus.
- Adenovirus E3 protein blocks the transport of MHC to the cell surface, preventing the presentation of viral antigens to the immune system.
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Description
This quiz explores the concepts of immunity, including innate and adaptive immunity, and the role of immune memory. Additionally, it discusses the impact of infectious diseases on global health, including mortality statistics and specific diseases like HIV/AIDS and respiratory infections.