L-17 Immunity: Active vs Passive
45 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which characteristic differentiates passive immunity from active immunity?

  • Induction of immunological memory
  • Immediate but temporary protection (correct)
  • Requirement for recipient B and T lymphocytes activation
  • Production of antibodies by the recipient's immune system
  • A newborn receives antibodies from its mother through breastfeeding. What type of immunity is this?

  • Artificial active immunity
  • Natural active immunity
  • Natural passive immunity (correct)
  • Artificial passive immunity
  • What is a key limitation of passive immunity compared to active immunity?

  • Delayed onset of protection
  • Inability to neutralize toxins
  • Lack of long-term protection (correct)
  • Requirement for multiple doses
  • Which process describes the artificial acquisition of active immunity?

    <p>Vaccination against measles (D)</p> Signup and view all the answers

    Why doesn't passive immunity result in immunological memory?

    <p>There is no involvement of the recipient's B and T lymphocytes (A)</p> Signup and view all the answers

    Which type of immunity is conferred by receiving human immune serum globulin (HISG)?

    <p>Passive artificial immunity (D)</p> Signup and view all the answers

    What is the primary source of antibodies in antivenom?

    <p>Animals exposed to the venom (B)</p> Signup and view all the answers

    Which of the following describes the mechanism of action for antithymocyte immunoglobulin in thymic transplant recipients?

    <p>Reducing rejection by providing antibodies targeting human T cells. (A)</p> Signup and view all the answers

    Which of the subsequent scenarios is most suitable for administering measles immune globulin?

    <p>Preventative measure after a confirmed exposure in an unvaccinated individual. (C)</p> Signup and view all the answers

    RhoGAM is administered to prevent Rh incompatibility. In which of the following scenarios would it be most appropriate to administer RhoGAM?

    <p>An Rh-negative mother carrying an Rh-positive fetus (D)</p> Signup and view all the answers

    What is the primary benefit of live attenuated vaccines?

    <p>They can produce a stronger and more natural immune response. (D)</p> Signup and view all the answers

    Which of the following is a disadvantage of live vaccines?

    <p>They may cause an inflammatory response. (D)</p> Signup and view all the answers

    What type of immunity do live attenuated vaccines primarily develop?

    <p>Both humoral and cell-mediated immunity. (D)</p> Signup and view all the answers

    Which statement correctly describes live reassortant vaccines?

    <p>They consist of a mix of human and non-human viruses. (B)</p> Signup and view all the answers

    Why should live attenuated vaccines be avoided in immunocompromised individuals?

    <p>They may revert to a pathogenic form. (A)</p> Signup and view all the answers

    Which type of vaccine requires multiple doses and possibly boosters?

    <p>Inactivated vaccine (C)</p> Signup and view all the answers

    What is a characteristic of inactivated fractional vaccines?

    <p>Can include toxoids (C)</p> Signup and view all the answers

    Which vaccine is an example of an inactivated whole cell vaccine?

    <p>Polio (IPV) (A)</p> Signup and view all the answers

    What is required to make pure polysaccharide vaccines more effective in children under 2 years old?

    <p>Conjugation (B)</p> Signup and view all the answers

    Which type of vaccine links an immunogenic protein with a polysaccharide?

    <p>Conjugate vaccine (D)</p> Signup and view all the answers

    Which of the following vaccines is NOT a fractional vaccine?

    <p>Hepatitis A (C)</p> Signup and view all the answers

    Which of the following statements is true regarding inactivated DNA vaccines?

    <p>Japan Encephalitis Virus vaccine is an example. (D)</p> Signup and view all the answers

    What is the immune response primarily associated with inactivated vaccines?

    <p>Humoral response only (D)</p> Signup and view all the answers

    Which of the following vaccines is specifically designed for military personnel?

    <p>Plague (B)</p> Signup and view all the answers

    Why are live vaccines contraindicated for immunocompromised individuals?

    <p>They can cause disease in these individuals. (D)</p> Signup and view all the answers

    What is the primary function of mRNA within dendritic cells (DCs)?

    <p>To be translated into protein and presented to T cells (C)</p> Signup and view all the answers

    Which agency does not administer the Vaccine Adverse Event Reporting System (VAERS)?

    <p>WHO (A)</p> Signup and view all the answers

    What is included in the Vaccine Information Sheet (VIS)?

    <p>Information about potential adverse effects and who should receive the vaccine (B)</p> Signup and view all the answers

    Who is allowed to report an adverse event to VAERS?

    <p>Anyone, including caregivers and parents (C)</p> Signup and view all the answers

    What is the minimum requirement for a person to report an adverse event to VAERS?

    <p>They only need to suspect a link to the vaccine (C)</p> Signup and view all the answers

    Which of the following describes how herd immunity protects non-immune individuals?

    <p>By interrupting disease transmission, reducing the chance of exposure for non-immune individuals. (B)</p> Signup and view all the answers

    What is the primary difference between active and passive immunity?

    <p>Active immunity results in immunological memory, while passive immunity does not. (D)</p> Signup and view all the answers

    What is the herd immunity threshold (HIT)?

    <p>The proportion of a population that needs to be immune to prevent disease spread effectively. (D)</p> Signup and view all the answers

    Why are intramuscular (IM) vaccines generally preferred over intravenous (IV) vaccines?

    <p>IM vaccines stimulate the immune system more effectively due to antigen precipitation and uptake by dendritic cells. (D)</p> Signup and view all the answers

    What is the main reason oral vaccines are sometimes less effective than injected vaccines?

    <p>Many antigens in oral vaccines are destroyed by stomach acidity before they can stimulate an immune response. (C)</p> Signup and view all the answers

    What is the meaning of $R_0$ (R naught)?

    <p>The average number of people likely to be infected by one infected individual. (A)</p> Signup and view all the answers

    Which factor primarily determines the herd immunity threshold (HIT) for a given pathogen?

    <p>The $R_0$ value of the pathogen. (A)</p> Signup and view all the answers

    What is the difference between natural and artificial active immunity?

    <p>Natural active immunity is acquired through exposure to a pathogen, while artificial active immunity is acquired through vaccination. (A)</p> Signup and view all the answers

    What is the primary mechanism by which Zinplava helps treat Clostridioides difficile infections?

    <p>It binds to and neutralizes the bacterial toxin produced by <em>C. difficile</em>. (C)</p> Signup and view all the answers

    Why is it important to develop vaccines that mimic the natural pathogen as closely as possible?

    <p>To stimulate an immune response that closely resembles the response to a natural infection, including appropriate antibodies and memory cells. (A)</p> Signup and view all the answers

    What is the main advantage of a live attenuated nasal vaccine like FluMist?

    <p>Stimulates a mucosal immune response with SIgA antibodies in the respiratory tract, appropriate for influenza. (B)</p> Signup and view all the answers

    Which of the following is a disadvantage of passive immunity?

    <p>Lack of long-term immunological memory. (B)</p> Signup and view all the answers

    What is the purpose of adjuvants in some vaccines?

    <p>To enhance the immune response to the vaccine antigen. (A)</p> Signup and view all the answers

    Which of the following is a primary limitation in the development of synthetic antitoxins or antivenoms?

    <p>Difficulty in replicating the complex structure of natural antibodies or binding agents. (B)</p> Signup and view all the answers

    In the context of vaccine administration, what is a key advantage of subcutaneous (SQ) vaccines, similar to intramuscular (IM) vaccines?

    <p>They allow for efficient antigen uptake, processing, and presentation by dendritic cells. (C)</p> Signup and view all the answers

    Flashcards

    Active Immunity

    Immunity developed through the body's own response to pathogens, often via vaccines or infections.

    Passive Immunity

    Immunity acquired by receiving antibodies from another source, providing immediate but temporary protection.

    Herd Immunity

    When a large percentage of a population is immune to a disease, protecting those who are not immune.

    Vaccination

    The process of introducing a vaccine to stimulate an immune response for protection against disease.

    Signup and view all the flashcards

    R0 & Herd Immunity Threshold

    R0 is the basic reproduction number; the threshold shows the percentage of immunity needed to prevent disease spread.

    Signup and view all the flashcards

    Human Immune Serum Globulin (HISG)

    Serum pooled from individuals previously exposed to a pathogen, containing antibodies for immunity.

    Signup and view all the flashcards

    Hyperimmune Serum

    Serum from individuals with high levels of specific antibodies, typically after recent exposure to an infection.

    Signup and view all the flashcards

    IVIG

    Intravenous immunoglobulin, a treatment containing primarily IgG antibodies pooled from healthy donors.

    Signup and view all the flashcards

    RhoGAM

    An immunoglobulin given to Rh-negative mothers to prevent Rh incompatibility during pregnancy.

    Signup and view all the flashcards

    Inactivated Vaccine

    Uses dead or inactivated pathogens or parts of them to stimulate an immune response.

    Signup and view all the flashcards

    Live Attenuated Vaccine

    Modified organisms that can multiply but are non-pathogenic, mimicking natural infection.

    Signup and view all the flashcards

    Live Vaccines

    Contain live pathogens, allowing longer exposure and mimicking infections to build immunity.

    Signup and view all the flashcards

    Cell-Mediated Immunity (CMI)

    Immune response that involves the activation of immune cells rather than antibodies.

    Signup and view all the flashcards

    Live Recombinant Vaccine

    Combines genes from human pathogens with non-pathogenic organisms for immunization.

    Signup and view all the flashcards

    mRNA uptake by DCs

    Dendritic cells take up mRNA to translate it into protein and activate T cells.

    Signup and view all the flashcards

    MHC molecules role

    MHC molecules present processed proteins to T cells for activation and memory cell formation.

    Signup and view all the flashcards

    B cells function

    B cells also process mRNA, presenting proteins to TH cells for memory B cell production.

    Signup and view all the flashcards

    VAERS

    Vaccine Adverse Event Reporting System, tracking vaccine safety post-immunization.

    Signup and view all the flashcards

    Whole Cell Inactivated Vaccine

    Vaccines using the entire killed pathogen.

    Signup and view all the flashcards

    Fractional Protein Vaccine

    Vaccine containing parts of the pathogen's proteins.

    Signup and view all the flashcards

    Toxoid Vaccine

    Vaccine made from inactivated toxins of bacteria.

    Signup and view all the flashcards

    Subunit Vaccine

    Contains specific proteins from a pathogen, not whole organisms.

    Signup and view all the flashcards

    Conjugate Vaccine

    Links poorly immunogenic part of pathogen to a protein.

    Signup and view all the flashcards

    Polysaccharide Vaccine - Pure

    Uses pure polysaccharides, but weak immunity in kids under 2.

    Signup and view all the flashcards

    DNA Vaccine

    Contains DNA that codes for pathogen proteins; replicates in bacteria.

    Signup and view all the flashcards

    RNA Vaccine

    Uses mRNA that instructs the body to make a protein for immunity.

    Signup and view all the flashcards

    Inactivated Vaccine Properties

    Offers humoral response, may need multiple doses, safe for immunocompromised.

    Signup and view all the flashcards

    Zinplava

    A medication that binds to neutralize the bacterial toxin in C. difficile infections.

    Signup and view all the flashcards

    Passive Protection

    Immunity obtained from antibodies collected from another organism, like horses or ophiophagous birds.

    Signup and view all the flashcards

    Synthetic Antitoxins

    Man-made antibodies intended to neutralize specific toxins, but not yet successful.

    Signup and view all the flashcards

    Natural Active Immunity

    Immunity gained from actual disease exposure through infection.

    Signup and view all the flashcards

    Artificial Active Immunity

    Immunity gained from vaccines or intentional exposure to an antigen.

    Signup and view all the flashcards

    R0 (R naught)

    Basic reproduction number indicating how many people one infected person will likely infect.

    Signup and view all the flashcards

    Herd Immunity Threshold (HIT)

    Percentage of the population that needs to be immune to interrupt disease transmission.

    Signup and view all the flashcards

    Measles HIT

    Measles has an R0 of 12-18 and requires approximately 95% immunity for herd immunity.

    Signup and view all the flashcards

    Vaccination Principles

    Vaccines should mimic natural pathogens and stimulate a similar immune response safely.

    Signup and view all the flashcards

    Oral Vaccines

    Vaccines taken by mouth, often less effective due to stomach acidity.

    Signup and view all the flashcards

    Nasal Vaccines

    Administered through the nose, promoting a local immune response.

    Signup and view all the flashcards

    IM Vaccine Advantages

    Intramuscular vaccines are effective due to better antigen uptake and immune response.

    Signup and view all the flashcards

    IV Vaccine Limitations

    Intravenous vaccines are less effective as antigens are cleared rapidly from the body.

    Signup and view all the flashcards

    Study Notes

    Immunity

    • Immunity is protection from infectious agents
    • Active immunity is a consequence of a person's immunological response to a microbe, thereby developing their own immunity response
    • Passive immunity is the consequence of one person receiving preformed immunity made by another person

    Active Immunity

    • Active immunity is acquired via contact with an antigen through infectious processes, or by intentional exposure to an antigen before an infection
    • Active immunity results in a long-term protection due to the activation of memory T and B lymphocytes
    • Slower to develop compared to passive immunity
    • Requires T and B lymphocyte activation, proliferation, and differentiation
    • Can be acquired naturally or artificially (through vaccines).

    Passive Immunity

    • Passive immunity is acquired through exposure to antibodies or by receiving serum containing antibodies
    • Passive immunity provides rapid protection as the antibodies are immediately present
    • Passive immunity is temporary because the antibodies have a short half-life, and degrade quickly, thus the protection provided declines over time
    • Does not involve the recipient's own immune system response
    • Can be acquired naturally (e.g., maternal antibodies) or artificially (e.g., antibody injections)

    Examples of Passive Immunity

    • Natural: maternal antibodies to the fetus or infant
    • Artificial:
      • Human Immune Serum Globulin (HISG) - serum from various individuals exposed to the pathogens
      • Hyperimmune/convalescent serum from recent exposures (high titers of a specific antibody)
      • Antitoxin/antivenom - antibodies against toxins or venoms (from animals exposed)
      • Measles immune globulin (PEP)
      • Rabies immune globulin (RIG)
      • Tetanus immune globulin (TIG)
      • RhoGAM
      • Varizig
      • Zinplava (bezlotoxumab)
      • Antitoxins/antivenoms

    Active Protection

    • Active immune protection of the patient involves exposure to the pathogen which triggers the development of an active immune response
    • The disease may be mild or subclinical; however, exposure to the pathogen still provides antibodies and immunity for future protection
    • Vaccines: intentional exposure to the pathogen or part of the pathogen (or toxin) creates an active immune response

    Herd Immunity

    • Herd immunity occurs when a large enough portion of the population is immune to a disease, the transmission is interrupted, and the non-immune individuals are protected
    • Effectiveness depends on the susceptibility of the pathogen/disease and on the proportion of the population that is immune, as well as their vaccination rates

    R0 & Herd Immunity Threshold (HIT)

    • R0 (R naught): A mathematical calculation determining the number of infections a single infected individual is likely to cause
    • Herd Immunity Threshold (HIT): The percentage of the population required to be immune in order for herd immunity to be effective; highly dependent on the R0 of that pathogen.

    Vaccine Types

    • Live: Utilizes live organisms that are made non-pathogenic
      • Can exhibit a stronger and more natural response
    • Inactivated: Utilizes whole organisms (dead or inactive), or parts of the organism (proteins, polysaccharides, or toxins)
      • Examples: Whole dead pathogens (Polio, Hepatitis A, Rabies, Cholera, Plague), Toxoid (Tetanus, Diphtheria, DTaP, DT, TD, Tdap), Subunit (Influenza, Acellular Pertussis), Conjugate (Pneumococcal, Meningicoccal, Hib), Pure Polysaccharide (Pneumococcal, Salmonella Typhi), DNA (Japanese Encephalitis Virus), RNA (various types)

    Vaccine Administration Classes

    • IM: Intramuscular, more effective. Tissues full of DCs for efficient uptake processing and presentation
    • IV: Intravenous, less effective. Antigen cleared quickly by the complement. Splenic macrophages

    Vaccine Safety

    • VAERS (Vaccine Adverse Event Reporting System): A national vaccine safety surveillance program administered by the CDC and FDA.
    • VIS (Vaccine Information Sheet): Provided to the patient or their guardian regarding vaccine information, including potential adverse effects, what to watch for, who should get the vaccine, and when to seek medical help

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Description

    Explore the concepts of immunity with a focus on active and passive immunity. Understand how each type offers protection and their mechanisms of action. This quiz will test your knowledge of immunological responses and the roles of lymphocytes.

    More Like This

    Active vs Passive Immunity
    10 questions
    Immunity Concepts Quiz
    10 questions
    Immunization Overview
    32 questions
    Use Quizgecko on...
    Browser
    Browser