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Questions and Answers
Which characteristic differentiates passive immunity from active immunity?
Which characteristic differentiates passive immunity from active immunity?
A newborn receives antibodies from its mother through breastfeeding. What type of immunity is this?
A newborn receives antibodies from its mother through breastfeeding. What type of immunity is this?
What is a key limitation of passive immunity compared to active immunity?
What is a key limitation of passive immunity compared to active immunity?
Which process describes the artificial acquisition of active immunity?
Which process describes the artificial acquisition of active immunity?
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Why doesn't passive immunity result in immunological memory?
Why doesn't passive immunity result in immunological memory?
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Which type of immunity is conferred by receiving human immune serum globulin (HISG)?
Which type of immunity is conferred by receiving human immune serum globulin (HISG)?
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What is the primary source of antibodies in antivenom?
What is the primary source of antibodies in antivenom?
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Which of the following describes the mechanism of action for antithymocyte immunoglobulin in thymic transplant recipients?
Which of the following describes the mechanism of action for antithymocyte immunoglobulin in thymic transplant recipients?
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Which of the subsequent scenarios is most suitable for administering measles immune globulin?
Which of the subsequent scenarios is most suitable for administering measles immune globulin?
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RhoGAM is administered to prevent Rh incompatibility. In which of the following scenarios would it be most appropriate to administer RhoGAM?
RhoGAM is administered to prevent Rh incompatibility. In which of the following scenarios would it be most appropriate to administer RhoGAM?
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What is the primary benefit of live attenuated vaccines?
What is the primary benefit of live attenuated vaccines?
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Which of the following is a disadvantage of live vaccines?
Which of the following is a disadvantage of live vaccines?
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What type of immunity do live attenuated vaccines primarily develop?
What type of immunity do live attenuated vaccines primarily develop?
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Which statement correctly describes live reassortant vaccines?
Which statement correctly describes live reassortant vaccines?
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Why should live attenuated vaccines be avoided in immunocompromised individuals?
Why should live attenuated vaccines be avoided in immunocompromised individuals?
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Which type of vaccine requires multiple doses and possibly boosters?
Which type of vaccine requires multiple doses and possibly boosters?
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What is a characteristic of inactivated fractional vaccines?
What is a characteristic of inactivated fractional vaccines?
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Which vaccine is an example of an inactivated whole cell vaccine?
Which vaccine is an example of an inactivated whole cell vaccine?
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What is required to make pure polysaccharide vaccines more effective in children under 2 years old?
What is required to make pure polysaccharide vaccines more effective in children under 2 years old?
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Which type of vaccine links an immunogenic protein with a polysaccharide?
Which type of vaccine links an immunogenic protein with a polysaccharide?
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Which of the following vaccines is NOT a fractional vaccine?
Which of the following vaccines is NOT a fractional vaccine?
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Which of the following statements is true regarding inactivated DNA vaccines?
Which of the following statements is true regarding inactivated DNA vaccines?
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What is the immune response primarily associated with inactivated vaccines?
What is the immune response primarily associated with inactivated vaccines?
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Which of the following vaccines is specifically designed for military personnel?
Which of the following vaccines is specifically designed for military personnel?
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Why are live vaccines contraindicated for immunocompromised individuals?
Why are live vaccines contraindicated for immunocompromised individuals?
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What is the primary function of mRNA within dendritic cells (DCs)?
What is the primary function of mRNA within dendritic cells (DCs)?
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Which agency does not administer the Vaccine Adverse Event Reporting System (VAERS)?
Which agency does not administer the Vaccine Adverse Event Reporting System (VAERS)?
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What is included in the Vaccine Information Sheet (VIS)?
What is included in the Vaccine Information Sheet (VIS)?
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Who is allowed to report an adverse event to VAERS?
Who is allowed to report an adverse event to VAERS?
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What is the minimum requirement for a person to report an adverse event to VAERS?
What is the minimum requirement for a person to report an adverse event to VAERS?
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Which of the following describes how herd immunity protects non-immune individuals?
Which of the following describes how herd immunity protects non-immune individuals?
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What is the primary difference between active and passive immunity?
What is the primary difference between active and passive immunity?
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What is the herd immunity threshold (HIT)?
What is the herd immunity threshold (HIT)?
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Why are intramuscular (IM) vaccines generally preferred over intravenous (IV) vaccines?
Why are intramuscular (IM) vaccines generally preferred over intravenous (IV) vaccines?
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What is the main reason oral vaccines are sometimes less effective than injected vaccines?
What is the main reason oral vaccines are sometimes less effective than injected vaccines?
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What is the meaning of $R_0$ (R naught)?
What is the meaning of $R_0$ (R naught)?
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Which factor primarily determines the herd immunity threshold (HIT) for a given pathogen?
Which factor primarily determines the herd immunity threshold (HIT) for a given pathogen?
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What is the difference between natural and artificial active immunity?
What is the difference between natural and artificial active immunity?
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What is the primary mechanism by which Zinplava helps treat Clostridioides difficile infections?
What is the primary mechanism by which Zinplava helps treat Clostridioides difficile infections?
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Why is it important to develop vaccines that mimic the natural pathogen as closely as possible?
Why is it important to develop vaccines that mimic the natural pathogen as closely as possible?
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What is the main advantage of a live attenuated nasal vaccine like FluMist?
What is the main advantage of a live attenuated nasal vaccine like FluMist?
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Which of the following is a disadvantage of passive immunity?
Which of the following is a disadvantage of passive immunity?
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What is the purpose of adjuvants in some vaccines?
What is the purpose of adjuvants in some vaccines?
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Which of the following is a primary limitation in the development of synthetic antitoxins or antivenoms?
Which of the following is a primary limitation in the development of synthetic antitoxins or antivenoms?
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In the context of vaccine administration, what is a key advantage of subcutaneous (SQ) vaccines, similar to intramuscular (IM) vaccines?
In the context of vaccine administration, what is a key advantage of subcutaneous (SQ) vaccines, similar to intramuscular (IM) vaccines?
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Flashcards
Active Immunity
Active Immunity
Immunity developed through the body's own response to pathogens, often via vaccines or infections.
Passive Immunity
Passive Immunity
Immunity acquired by receiving antibodies from another source, providing immediate but temporary protection.
Herd Immunity
Herd Immunity
When a large percentage of a population is immune to a disease, protecting those who are not immune.
Vaccination
Vaccination
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R0 & Herd Immunity Threshold
R0 & Herd Immunity Threshold
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Human Immune Serum Globulin (HISG)
Human Immune Serum Globulin (HISG)
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Hyperimmune Serum
Hyperimmune Serum
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IVIG
IVIG
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RhoGAM
RhoGAM
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Inactivated Vaccine
Inactivated Vaccine
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Live Attenuated Vaccine
Live Attenuated Vaccine
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Live Vaccines
Live Vaccines
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Cell-Mediated Immunity (CMI)
Cell-Mediated Immunity (CMI)
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Live Recombinant Vaccine
Live Recombinant Vaccine
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mRNA uptake by DCs
mRNA uptake by DCs
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MHC molecules role
MHC molecules role
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B cells function
B cells function
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VAERS
VAERS
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Whole Cell Inactivated Vaccine
Whole Cell Inactivated Vaccine
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Fractional Protein Vaccine
Fractional Protein Vaccine
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Toxoid Vaccine
Toxoid Vaccine
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Subunit Vaccine
Subunit Vaccine
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Conjugate Vaccine
Conjugate Vaccine
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Polysaccharide Vaccine - Pure
Polysaccharide Vaccine - Pure
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DNA Vaccine
DNA Vaccine
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RNA Vaccine
RNA Vaccine
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Inactivated Vaccine Properties
Inactivated Vaccine Properties
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Zinplava
Zinplava
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Passive Protection
Passive Protection
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Synthetic Antitoxins
Synthetic Antitoxins
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Natural Active Immunity
Natural Active Immunity
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Artificial Active Immunity
Artificial Active Immunity
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R0 (R naught)
R0 (R naught)
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Herd Immunity Threshold (HIT)
Herd Immunity Threshold (HIT)
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Measles HIT
Measles HIT
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Vaccination Principles
Vaccination Principles
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Oral Vaccines
Oral Vaccines
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Nasal Vaccines
Nasal Vaccines
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IM Vaccine Advantages
IM Vaccine Advantages
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IV Vaccine Limitations
IV Vaccine Limitations
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Study Notes
Immunity
- Immunity is protection from infectious agents
- Active immunity is a consequence of a person's immunological response to a microbe, thereby developing their own immunity response
- Passive immunity is the consequence of one person receiving preformed immunity made by another person
Active Immunity
- Active immunity is acquired via contact with an antigen through infectious processes, or by intentional exposure to an antigen before an infection
- Active immunity results in a long-term protection due to the activation of memory T and B lymphocytes
- Slower to develop compared to passive immunity
- Requires T and B lymphocyte activation, proliferation, and differentiation
- Can be acquired naturally or artificially (through vaccines).
Passive Immunity
- Passive immunity is acquired through exposure to antibodies or by receiving serum containing antibodies
- Passive immunity provides rapid protection as the antibodies are immediately present
- Passive immunity is temporary because the antibodies have a short half-life, and degrade quickly, thus the protection provided declines over time
- Does not involve the recipient's own immune system response
- Can be acquired naturally (e.g., maternal antibodies) or artificially (e.g., antibody injections)
Examples of Passive Immunity
- Natural: maternal antibodies to the fetus or infant
- Artificial:
- Human Immune Serum Globulin (HISG) - serum from various individuals exposed to the pathogens
- Hyperimmune/convalescent serum from recent exposures (high titers of a specific antibody)
- Antitoxin/antivenom - antibodies against toxins or venoms (from animals exposed)
- Measles immune globulin (PEP)
- Rabies immune globulin (RIG)
- Tetanus immune globulin (TIG)
- RhoGAM
- Varizig
- Zinplava (bezlotoxumab)
- Antitoxins/antivenoms
Active Protection
- Active immune protection of the patient involves exposure to the pathogen which triggers the development of an active immune response
- The disease may be mild or subclinical; however, exposure to the pathogen still provides antibodies and immunity for future protection
- Vaccines: intentional exposure to the pathogen or part of the pathogen (or toxin) creates an active immune response
Herd Immunity
- Herd immunity occurs when a large enough portion of the population is immune to a disease, the transmission is interrupted, and the non-immune individuals are protected
- Effectiveness depends on the susceptibility of the pathogen/disease and on the proportion of the population that is immune, as well as their vaccination rates
R0 & Herd Immunity Threshold (HIT)
- R0 (R naught): A mathematical calculation determining the number of infections a single infected individual is likely to cause
- Herd Immunity Threshold (HIT): The percentage of the population required to be immune in order for herd immunity to be effective; highly dependent on the R0 of that pathogen.
Vaccine Types
- Live: Utilizes live organisms that are made non-pathogenic
- Can exhibit a stronger and more natural response
- Inactivated: Utilizes whole organisms (dead or inactive), or parts of the organism (proteins, polysaccharides, or toxins)
- Examples: Whole dead pathogens (Polio, Hepatitis A, Rabies, Cholera, Plague), Toxoid (Tetanus, Diphtheria, DTaP, DT, TD, Tdap), Subunit (Influenza, Acellular Pertussis), Conjugate (Pneumococcal, Meningicoccal, Hib), Pure Polysaccharide (Pneumococcal, Salmonella Typhi), DNA (Japanese Encephalitis Virus), RNA (various types)
Vaccine Administration Classes
- IM: Intramuscular, more effective. Tissues full of DCs for efficient uptake processing and presentation
- IV: Intravenous, less effective. Antigen cleared quickly by the complement. Splenic macrophages
Vaccine Safety
- VAERS (Vaccine Adverse Event Reporting System): A national vaccine safety surveillance program administered by the CDC and FDA.
- VIS (Vaccine Information Sheet): Provided to the patient or their guardian regarding vaccine information, including potential adverse effects, what to watch for, who should get the vaccine, and when to seek medical help
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Description
Explore the concepts of immunity with a focus on active and passive immunity. Understand how each type offers protection and their mechanisms of action. This quiz will test your knowledge of immunological responses and the roles of lymphocytes.