Podcast
Questions and Answers
Where does T cell development primarily occur?
Where does T cell development primarily occur?
What are the initial cells known as when they enter the thymus from the bone marrow?
What are the initial cells known as when they enter the thymus from the bone marrow?
Which type of cells initially express both CD4 and CD8 during T cell development?
Which type of cells initially express both CD4 and CD8 during T cell development?
Where does the final maturation of T cells occur?
Where does the final maturation of T cells occur?
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What is the role of tolerance in T cell development?
What is the role of tolerance in T cell development?
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Which type of selection occurs first during T cell development?
Which type of selection occurs first during T cell development?
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What organ is responsible for the initial development of T cells before they migrate to the thymus?
What organ is responsible for the initial development of T cells before they migrate to the thymus?
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Which type of cells do not express CD4 or CD8 when they first enter the thymus?
Which type of cells do not express CD4 or CD8 when they first enter the thymus?
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What are the self-reactive recognition molecules/cells that tolerance helps to prevent from circulating in the bloodstream during T cell development?
What are the self-reactive recognition molecules/cells that tolerance helps to prevent from circulating in the bloodstream during T cell development?
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Which part of the thymus do developing T cells transition to after expressing both CD4 and CD8?
Which part of the thymus do developing T cells transition to after expressing both CD4 and CD8?
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What is the process where a potentially autoreactive B cell can recombine its elements to make it less reactive?
What is the process where a potentially autoreactive B cell can recombine its elements to make it less reactive?
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In which type of tolerance do mechanisms involve the induction of immune tolerance in primary lymphoid organs like bone marrow and thymus?
In which type of tolerance do mechanisms involve the induction of immune tolerance in primary lymphoid organs like bone marrow and thymus?
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Which type of autoimmunity involves predominant injury of an organ or tissue?
Which type of autoimmunity involves predominant injury of an organ or tissue?
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What is the common outcome for B cells that are still self-reactive after undergoing receptor editing?
What is the common outcome for B cells that are still self-reactive after undergoing receptor editing?
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Which of the following is true about B-cell developmental pathways compared to T-cell pathways?
Which of the following is true about B-cell developmental pathways compared to T-cell pathways?
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What is the outcome for T cells after antigen receptor stimulation?
What is the outcome for T cells after antigen receptor stimulation?
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Where does peripheral tolerance induce tolerance outside primary lymphoid organs?
Where does peripheral tolerance induce tolerance outside primary lymphoid organs?
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What is the main purpose of positive selection in thymocytes?
What is the main purpose of positive selection in thymocytes?
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What is the role of Autoimmune regulator (AIRE) in negative selection (central tolerance)?
What is the role of Autoimmune regulator (AIRE) in negative selection (central tolerance)?
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What happens during clonal deletion in negative selection?
What happens during clonal deletion in negative selection?
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Which cell type helps maintain peripheral tolerance for T cells?
Which cell type helps maintain peripheral tolerance for T cells?
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What is the primary focus of negative selection of B cells in the bone marrow?
What is the primary focus of negative selection of B cells in the bone marrow?
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Which outcome is associated with receptor editing in B cell development?
Which outcome is associated with receptor editing in B cell development?
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Why do mature B cells migrate to lymphoid follicles?
Why do mature B cells migrate to lymphoid follicles?
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What role does AIRE play in the thymus during central tolerance?
What role does AIRE play in the thymus during central tolerance?
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What is the primary purpose of positive selection in thymocytes?
What is the primary purpose of positive selection in thymocytes?
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What happens to autoreactive B cells that are strongly self-reactive?
What happens to autoreactive B cells that are strongly self-reactive?
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