Immune System: Response & Composition
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Questions and Answers

What is the primary method for registering attendance at lectures?

  • Verbal confirmation with the lecturer
  • Scanning a QR code at the beginning and end of the lecture via the e-learning system (correct)
  • Manual sign-up sheet at the end of the lecture
  • Submitting a written summary of the lecture content
  • If a student misses a lecture due to illness, what is the procedure for validating their absence?

  • Submission of an affidavit to the One Health Institute
  • No action is needed for a single absence
  • Notification to academic advisor is sufficient
  • Presentation of medical certificate is needed within 5 working days (correct)
  • What happens if a student leaves the classroom during a lecture and attempts to return?

  • The student's participation is invalidated, and they cannot return to the classroom (correct)
  • The student's participation is still valid if they return within 15 minutes
  • The student can return, but must sit at the back of the class
  • The student needs to explain the reason of leaving to the lecturer
  • Where can students access the lecture materials for this course?

    <p>The institute's e-learning platform (B)</p> Signup and view all the answers

    Which of the following best describes the role of the immune system?

    <p>To defend the body against pathogens and abnormal cells (C)</p> Signup and view all the answers

    The first lecture focuses on which broad topic?

    <p>The role of immune response and the composition of the immune system (D)</p> Signup and view all the answers

    What is the minimum lecture attendance required to pass the course?

    <p>50% of lectures (D)</p> Signup and view all the answers

    How are exams conducted in this course?

    <p>Under controlled conditions in computer rooms (C)</p> Signup and view all the answers

    Which of the following is a key distinction between primary and secondary lymphatic organs?

    <p>Primary lymphatic organs are responsible for the tolerogenic response, while secondary lymphatic organs initiate immunogenic immune responses. (A)</p> Signup and view all the answers

    If a patient's adaptive immune response is compromised, which process would be MOST directly affected?

    <p>The ability to generate long-term protection against a previously encountered pathogen. (D)</p> Signup and view all the answers

    Why is prior exposure to a pathogen crucial for the adaptive immune response to be effective?

    <p>It enables the production of pathogen-specific antibodies and the creation of memory cells. (B)</p> Signup and view all the answers

    Which characteristic distinguishes natural immunity from adaptive immunity?

    <p>Adaptive immunity is specific to particular pathogens, while natural immunity targets conserved molecular patterns on microorganisms. (C)</p> Signup and view all the answers

    Following antigen presentation, what is the PRIMARY outcome regarding the adaptive immune response?

    <p>Activation of lymphocytes and their differentiation into effector cells. (D)</p> Signup and view all the answers

    Kitasato's work on diphtheria toxin primarily demonstrated which immunological principle?

    <p>The potential of heat-treated toxins to induce antitoxic immunity. (B)</p> Signup and view all the answers

    Ehrlich's contribution to immunology is best exemplified by:

    <p>His development of a staining method for identifying acid-fast bacteria and the development of Salvarsan. (A)</p> Signup and view all the answers

    Which of the following best describes Mecsnyikov's primary contribution to immunology?

    <p>The concept of cellular immunity through the observation of phagocytosis. (C)</p> Signup and view all the answers

    Chase's experiments significantly advanced the understanding of:

    <p>Cellular immunity by demonstrating the role of white blood cells and transmissible immunity. (B)</p> Signup and view all the answers

    Glick's research on chickens led to the discovery of:

    <p>The differentiation between T-lymphocytes and B-lymphocytes. (D)</p> Signup and view all the answers

    Bordet's work with non-pathogenic substances and red blood cells led him to the discovery of:

    <p>The complement system. (D)</p> Signup and view all the answers

    Kabat's research primarily focused on:

    <p>Identifying the source of antibody activity as being within the gamma-globulin fraction of serum. (C)</p> Signup and view all the answers

    Which of the following statements accurately connects a scientist to their major contribution in immunology?

    <p>Kitasato showed that injecting heat-treated diphtheria toxin into guinea pigs could induce protective immunity. (C)</p> Signup and view all the answers

    Which of the following best describes the role of Pattern Recognition Receptors (PRRs) in the immune system?

    <p>Detect and respond to pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs). (C)</p> Signup and view all the answers

    What is the primary function of secondary lymphoid organs in the adaptive immune response?

    <p>Site where naive lymphocytes encounter antigens, leading to activation and differentiation. (C)</p> Signup and view all the answers

    A researcher is studying a newly discovered virus and identifies a unique double-stranded RNA sequence. According to the information, which type of molecule would likely recognize this viral component?

    <p>Pathogen-associated molecular pattern (PAMP). (C)</p> Signup and view all the answers

    In the context of immune tolerance, what is the primary mechanism that prevents the immune system from attacking self-antigens?

    <p>Elimination or inactivation of immune cells that recognize self-antigens. (D)</p> Signup and view all the answers

    Which of the following is a key difference between the roles of red bone marrow and the thymus in lymphocyte development?

    <p>Red bone marrow is responsible for B-cell maturation, while the thymus is responsible for T-cell maturation. (B)</p> Signup and view all the answers

    A patient experiences tissue damage due to a severe injury. Which type of molecule is most likely to be released as a result of this damage, triggering an immune response?

    <p>Danger-associated molecular pattern (DAMP). (C)</p> Signup and view all the answers

    How do lymphatic capillaries contribute to the initiation of an adaptive immune response?

    <p>By transporting antigens from tissues to lymph nodes. (B)</p> Signup and view all the answers

    Which of the following statements accurately describes the thymus's role in T-cell development?

    <p>It provides an environment for T-cells to mature and differentiate, ensuring self-tolerance. (D)</p> Signup and view all the answers

    What is the functional significance of naive lymphocytes migrating to secondary lymphoid organs?

    <p>to increase the probability of encountering their cognate antigen and initiating an adaptive immune response. (C)</p> Signup and view all the answers

    How would the removal of secondary lymphoid organs impact the adaptive immune system's function?

    <p>Impair the ability to initiate adaptive immune responses to new antigens. (D)</p> Signup and view all the answers

    Which advancement is NOT correctly paired with its respective scientist?

    <p>Robert Koch - Developed pasteurization techniques (D)</p> Signup and view all the answers

    What was the significance of using agar-agar in cultivation techniques, as introduced by Walther Hesse following Robert Koch's work?

    <p>It provided a solid medium for bacterial growth, enabling the isolation of pure cultures. (D)</p> Signup and view all the answers

    Louis Pasteur's experiment with fowl cholera demonstrated that pathogens could be attenuated. What crucial observation led to this discovery?

    <p>Inoculating chickens with old cultures that had lost their virulence protected them from subsequent infection. (D)</p> Signup and view all the answers

    Which of Koch's postulates is most directly addressed by the development of cultivation techniques on solid media?

    <p>The microorganism must be isolated from a diseased organism and grown in pure culture. (A)</p> Signup and view all the answers

    Tyndallization is a method for:

    <p>Fractional sterilization used to kill heat-resistant bacterial spores. (A)</p> Signup and view all the answers

    What was the key advancement that Emil von Behring and Shibasaburo Kitasato contributed to the field of immunology?

    <p>The discovery of antibodies and their role in neutralizing toxins. (C)</p> Signup and view all the answers

    How did Virchow's contribution to cell theory directly challenge earlier beliefs about the origin of life?

    <p>By proving that all cells originate from pre-existing cells, refuting spontaneous generation. (C)</p> Signup and view all the answers

    What significant impact did the development of aseptic techniques have on medical practices, as pioneered by Louis Pasteur?

    <p>It greatly reduced the incidence of post-surgical infections and contamination in laboratories. (A)</p> Signup and view all the answers

    Which of the following best describes the primary objective of the immune system?

    <p>To maintain the body's integrity by defending against foreign substances and diseases. (C)</p> Signup and view all the answers

    The science of immunology encompasses diverse areas EXCEPT:

    <p>Analyzing geological formations to understand the origins of pathogens. (C)</p> Signup and view all the answers

    Which feature is NOT a fundamental characteristic of the immune system?

    <p>Innate ability to recognize all substances as 'self'. (C)</p> Signup and view all the answers

    Which historical figure is credited with using cowpox to protect against smallpox?

    <p>Jenner (B)</p> Signup and view all the answers

    What distinguished those who survived the Athenian plague epidemic according to Thucydides?

    <p>They acquired immunity and did not contract the disease again, allowing them to care for the sick. (C)</p> Signup and view all the answers

    Variolation, a practice used in Eastern societies, involved:

    <p>Inoculating individuals with material from smallpox lesions to induce immunity. (A)</p> Signup and view all the answers

    Which of the following is an accurate description of 'contagium vivum'?

    <p>The idea that disease is caused by invisible, living agents. (A)</p> Signup and view all the answers

    Considering the historical timeline, which event occurred latest?

    <p>Jenner's use of cowpox for vaccination. (D)</p> Signup and view all the answers

    Signup and view all the answers

    Flashcards

    Immune System

    The system that protects the body against diseases through detection and defense mechanisms.

    Immunopathology

    Diseases that arise from improper functioning of the immune system.

    Self vs Non-Self Recognition

    The immune system's ability to distinguish between body's own cells and foreign substances.

    Humoral Immune Response

    Part of the immune response that involves antibodies in body fluids.

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    Cellular Immune Response

    Immune response that involves cells destroying infected or cancerous cells.

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    Variolation

    An early method of immunization using smallpox material to induce immunity.

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    Vaccination

    The process of administering a vaccine to stimulate immunity against diseases.

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    History of Immunology

    The development of immunity concepts from Thucydides to modern vaccination methods.

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    Immune Response

    The body's defense reactions against pathogens or foreign substances.

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    Composition of Immune System

    The various cells, tissues, and organs that work together to defend the body.

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    Natural Immunity

    A type of immunity that is present at birth and does not require prior exposure to pathogens.

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    Complement System

    A series of proteins that enhance the ability of antibodies to clear pathogens.

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    MHC Molecules

    Proteins that display peptide fragments for recognition by T-cells in the immune response.

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    B-Cell Receptors

    Surface receptors on B-lymphocytes that bind to specific antigens.

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    T-Cell Types

    Different subclasses of T-cells that perform various functions in the immune response (e.g., helper, cytotoxic).

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    Immune Tolerance

    The ability of the immune system to recognize the body's own cells and not attack them.

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    Primary Lymphatic Organs

    Bone marrow and thymus where immune cells are formed.

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    Secondary Lymphatic Organs

    Organs like spleen and lymph nodes, involved in immune responses.

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    Adaptive Immunity

    Specific defense mechanisms activated after prior exposure to pathogens.

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    Tolerogenic Response

    Immune system response that promotes tolerance to non-harmful antigens.

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    Antonie van Leeuwenhoek

    Discovered heat-resistant bacterial spores and examined fluids using microscopes.

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    Tyndallisation

    A method for decontaminating heat-sensitive fluids using heat and cooling cycles.

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    Cell Theory

    States that the basic unit of living organisms is the cell.

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    Germ Theory of Disease

    Concept that specific microorganisms cause specific diseases.

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    Pasteurization

    Process of heating to kill harmful bacteria in food and drinks.

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    Koch's Postulates

    Four criteria to establish a causative relationship between a microbe and a disease.

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    Aseptic Techniques

    Methods employed to prevent contamination by pathogens during procedures.

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    Kitasato

    Described bacterial exotoxins and tested antitoxic immunity in 1890.

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    Antitoxins

    Protective substances detected in the blood of immunized animals.

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    Serum Therapy

    Treatment using serum from immunized animals to transfer immunity.

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    Mast Cells

    Cells recognized by Ehrlich, linked to allergy and immune responses.

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    Humoral Immunity

    Immune response involving antibodies in body fluids.

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    Phagocytosis

    Cellular process of engulfing and destroying pathogens.

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    B and T Cells

    Key white blood cells involved in humoral and cellular immunity.

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    PAMP

    Pathogen-associated molecular patterns recognized by the immune system.

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    DAMP

    Danger-associated molecular patterns released from damaged cells.

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    PRRs

    Pattern-recognition receptors that identify PAMPs and DAMPs.

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    Antigen

    Substances that are specifically recognized by immune cells as foreign or abnormal.

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    Intracellular Pathogens

    Pathogens that infect and replicate within the body's own cells.

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    Extracellular Pathogens

    Pathogens that attack from outside the body's cells.

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    Primary Lymphoid Organs

    Sites of blood cell formation, primarily bone marrow and thymus.

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    Thymus

    Organ where T-lymphocytes mature; located behind the sternum.

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    Secondary Lymphoid Organs

    Locations where immune cells encounter antigens and activate immune responses.

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    Bursa of Fabricius

    Primary lymphatic organ in birds for B-lymphocyte maturation.

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    Study Notes

    Immune Response and Composition

    • The role of the immune response and the composition of the immune system were the topics of the lecture.
    • The presentation was given by Dr. Krisztina Szarka.

    Semester Information

    • The teaching institute is the One Health Institute.
    • The head of the institute is Dr. Gabor Kardos.
    • The academic advisor is Dr. Krisztina Szarka.
    • Lecture materials are accessible on the institute's e-learning platform.
    • Attendance at 50% of lectures is mandatory.
    • Attendance is registered via a QR code at the start and end of each lecture.
    • Students who leave during class cannot return and their attendance is marked as invalid.
    • Medical certificates for absence must be submitted within 5 working days.
    • Exams are held in computer rooms under controlled conditions.

    Lecture Topics

    • The lectures cover a range of topics related to the immune system, from the role of immune response and composition of the immune system to specific cell types and functions, immune tolerance, and immunological methods.

    • Specific topics range from the properties and components of natural immunity to details about adaptive immunity, immune regulation, and the roles immune systems play during pregnancy and transplantations, in response to tumours and pathogens.

    • The topics also include discussions of the complement system, MHC molecules, antigen presentation, B- and T-cell receptors, and clonal selection.

    • Additional topics include antibody structure and function, different types of T-cells and their roles, immune tolerance and hypersensitivity, and immune responses related to pregnancy and immunotherapies. The presentation also includes topics on immunoserological methods I and II.

    Science of Immunology

    • Immunology is the study of the immune system's function and how it responds to infection, tumors, and other harmful substances.
    • It encompasses medical, veterinary and biological sciences.
    • The focus is on maintaining the body's integrity by identifying and destroying foreign substances.
    • It includes aspects of the immune system like diversity, specificity, memory, self/non-self recognition, and the immune system's structure and function.
    • Other components of the field include diseases of the immune system (immunopathology, autoimmunity, allergies, and cancers).
    • Additional topics include immunodeficiency states, blood banks, transfusions, transplantation, and immunopharmacology.
    • Aspects include immunity, immunochemistry, and immunobiology.

    History of Immunology

    • Significant figures in the field of immunology are highlighted, including their respective contributions to the field with dates and specific methods and procedures (e.g., Koch, Jenner, Pasteur.)
    • The development of microbiology is explored, linking critical milestones to respective figures, and detailed events.
    • The history encompasses the development of understanding disease mechanisms in terms of specific micro-organisms, and methods they used.
    • Concepts of immunity, like clonal selection, and development of early vaccines are noted, along with specifics of experiments (e.g., testing toxins, vaccines, and antibodies).
    • Later researchers such as Ehrlich and others are mentioned, their discoveries and corresponding theories.

    Theories Explaining Antigen-Antibody Binding

    • Theories like the selectivity theory (Ehrlich, 1900) and Instructional theory (Bein and Haurowitz, 1930s and 1940s) explain how antigens and antibodies interact.
    • Understanding the concept of antigen-antibody binding through these and other theories is key to understanding aspects of immunology.

    Natural vs. Acquired Immunity

    • Natural immunity and acquired immunity are discussed in comparison.
    • Key information and features are presented in different categories, enabling a clear differentiation and a better understanding of each type.

    Basic Definitions

    • Key terms and concepts (e.g., PAMPs, PRRs, DAMPs, etc., and their relation to the immune system's function and reactions) related to the immune system's response and components are described.
    • The functions of each component are covered in detail, enhancing understanding of how different structures contribute to immune system efficiency.

    Primary and Secondary Lymphatic Organs

    • Primary lymphatic organs are explained, in particular the red bone marrow and the thymus, as the sites for the formation and development of lymphocytes.
    • Secondary organs are detailed as well, including locations of lymphocytes activation, proliferation and differentiation.
    • Specific locations within the body are identified.

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    Description

    Lecture by Dr. Krisztina Szarka. Focuses on the role and composition of the immune system. Course details include attendance policies, e-learning platform access, and exam procedures at the One Health Institute.

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