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Questions and Answers
What is the main characteristic of Anaphylaxis?
What is the main characteristic of Anaphylaxis?
Which of the following describes Severe Combined Immunodeficiency Disease (SCID)?
Which of the following describes Severe Combined Immunodeficiency Disease (SCID)?
What distinguishes active immunity from passive immunity?
What distinguishes active immunity from passive immunity?
What is a common symptom of Allergic Rhinitis (Hay Fever)?
What is a common symptom of Allergic Rhinitis (Hay Fever)?
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Which of the following statements about allergies is incorrect?
Which of the following statements about allergies is incorrect?
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What is the primary role of T helper cells in the immune response?
What is the primary role of T helper cells in the immune response?
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Where are lymphocytes primarily formed?
Where are lymphocytes primarily formed?
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What is the main function of antibodies?
What is the main function of antibodies?
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Which lymphocyte is primarily responsible for cell-mediated immunity?
Which lymphocyte is primarily responsible for cell-mediated immunity?
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What is the role of T memory cells?
What is the role of T memory cells?
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Which part of an antibody determines its function?
Which part of an antibody determines its function?
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What is the main function of T regulatory cells?
What is the main function of T regulatory cells?
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Which of the following lymphatic structures is where lymphocytes encounter antigens?
Which of the following lymphatic structures is where lymphocytes encounter antigens?
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What condition is characterized by an abnormally high white blood cell count often indicating infection or inflammation?
What condition is characterized by an abnormally high white blood cell count often indicating infection or inflammation?
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Which type of leukemia progresses more slowly and affects lymphoid cells?
Which type of leukemia progresses more slowly and affects lymphoid cells?
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What is the primary role of the epidermis in the immune system?
What is the primary role of the epidermis in the immune system?
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What component of the skin helps to retain moisture and creates an unfavorable environment for some microbes?
What component of the skin helps to retain moisture and creates an unfavorable environment for some microbes?
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Which part of the respiratory tract helps filter out larger particles from inhaled air?
Which part of the respiratory tract helps filter out larger particles from inhaled air?
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How do normal flora contribute to the body's immune defense?
How do normal flora contribute to the body's immune defense?
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What role does sebum play in protecting the skin from pathogens?
What role does sebum play in protecting the skin from pathogens?
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Which of the following statements is true regarding mucus in the respiratory tract?
Which of the following statements is true regarding mucus in the respiratory tract?
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What role do basophils play in the immune response?
What role do basophils play in the immune response?
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Natural Killer (NK) cells are primarily involved in which aspect of immune defense?
Natural Killer (NK) cells are primarily involved in which aspect of immune defense?
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Which of the following describes the process of diapedesis?
Which of the following describes the process of diapedesis?
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What is the main effect of histamine during an inflammatory response?
What is the main effect of histamine during an inflammatory response?
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Cytokines are important in the immune response because they serve as:
Cytokines are important in the immune response because they serve as:
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Which component of the immune system is primarily involved in responding to parasitic infections?
Which component of the immune system is primarily involved in responding to parasitic infections?
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What triggers the process of chemotaxis in white blood cells?
What triggers the process of chemotaxis in white blood cells?
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What characterizes the localized response known as inflammation?
What characterizes the localized response known as inflammation?
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What role do T cells play in the immune response?
What role do T cells play in the immune response?
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Which type of white blood cell is primarily involved in allergic reactions?
Which type of white blood cell is primarily involved in allergic reactions?
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What is the main function of macrophages in the immune system?
What is the main function of macrophages in the immune system?
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What does leukopenia refer to?
What does leukopenia refer to?
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Which cytokine group is primarily responsible for inhibiting viral replication?
Which cytokine group is primarily responsible for inhibiting viral replication?
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Which white blood cell type is responsible for predominantly fighting bacterial infections?
Which white blood cell type is responsible for predominantly fighting bacterial infections?
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What is the primary function of dendritic cells in the immune response?
What is the primary function of dendritic cells in the immune response?
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Which component stimulates white blood cell production in bone marrow?
Which component stimulates white blood cell production in bone marrow?
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Study Notes
Immune System Overview
- Immune system protects against pathogens: bacteria, viruses, fungi, protozoans, and parasitic worms.
- Pathogens can lead to a variety of infections and diseases in humans.
Pathogen Types
- Bacteria: Single-celled microorganisms that can cause infections.
- Viruses: Tiny agents that reproduce only inside host cells.
- Fungi: Includes yeasts, molds, and mushrooms; some are infectious.
- Protozoans: Single-celled organisms causing diseases such as malaria.
- Parasitic Worms: Multicellular organisms living in the body, causing infections.
White Blood Cells (Leukocytes)
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Granulocytes:
- Neutrophils: Most common, vital for fighting bacterial infections.
- Eosinophils: Combat allergic reactions and parasitic infections.
- Basophils: Release histamine for inflammatory responses.
- Mast Cells: Similar to basophils, contribute to allergic reactions.
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Agranulocytes:
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Lymphocytes:
- T Cells: Central to cell-mediated immunity and regulate the immune response.
- B Cells: Produce antibodies targeting specific pathogens.
- NK Cells: Destroy infected or cancerous cells without prior activation.
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Monocytes:
- Macrophages: Large cells that engulf pathogens.
- Dendritic Cells: Present antigens to T cells, initiating immune response.
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Lymphocytes:
Cytokines
- Interleukin (IL): Signaling molecules regulating immune cell functions.
- Tumor Necrosis Factor (TNF): Promotes inflammation and induces cell death.
- Colony-Stimulating Factor (CSF): Stimulates white blood cell production.
- Interferon (IFN): Inhibits viral replication and activates immune cells.
White Blood Cell Tests
- White Blood Cell Count (WBC): Measures total white blood cell levels.
- White Blood Cell Differential: Analyzes the proportion of different white blood cells.
White Blood Cell Disorders
- Leukopenia: Low WBC count, raises infection risk.
- Leukocytosis: High WBC count, indicates infection or inflammation.
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Leukemia: Blood cancer characterized by abnormal WBC overproduction:
- Chronic Myeloid: Slow progressing, affects myeloid cells.
- Acute Myeloid: Rapid progression, affects myeloid cells.
- Chronic Lymphoid: Slow progressing, affects lymphoid cells.
- Acute Lymphoid: Rapid progression, affects lymphoid cells.
Innate (Nonspecific) Immunity
- Acts as the first line of defense against pathogens.
- Skin: Physical barrier; exfoliation removes microbes.
- Normal Flora: Beneficial microbes competing with harmful ones.
Components of Skin that Support Immunity
- Epidermis: Outer skin layer; sheds dead cells.
- Dermis: Contains blood vessels and supports the epidermis.
- Sebum and Sweat: Inhibit microbial growth via acidity and salts.
Mucous Membranes
- Epithelial and connective tissue form barriers in mucous membranes.
- Mucus: Captures pathogens; secreted by goblet cells.
Respiratory Tract Defense
- Nasal mucus and vibrissae filter inhaled particles.
- Basophils and mast cells trigger allergic responses.
Antimicrobial Proteins and Inflammation
- Cytokines: Regulate immune responses.
- Complement System: Enhances pathogen lysis and inflammation.
- Inflammation presents as redness, swelling, and pain; involves various chemicals that improve blood flow and immune cell migration.
Phagocytosis and Immune Recognition
- Immune cells recognize and destroy foreign pathogens.
- Tumors can express foreign antigens, prompting an immune response.
Lymphocyte Formation and Activation
- Formation: Lymphocytes produced in red bone marrow and mature in the thymus.
- Secondary Lymphatic Structures: Lymph nodes and spleen activate lymphocytes upon encountering antigens.
T Cell and B Cell Functions
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T Cells:
- Helper T Cells: Activate B cells and macrophages.
- Cytotoxic T Cells: Kill infected or abnormal cells.
- Regulatory T Cells: Prevent autoimmune responses.
- Memory T Cells: Offer rapid response upon re-exposure.
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B Cells:
- Plasma Cells: Produce antibodies.
- Memory B Cells: Facilitate faster response to reinfections.
Antibody Structure and Functions
- Y-shaped Structure: Two heavy and two light chains; variable regions bind to specific antigens.
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Functions:
- Neutralization: Prevents pathogen entry into cells.
- Artificial Immunity: Injection of pre-formed antibodies for immediate protection.
Immune System Disorders
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Allergies: Overreactive immune responses to non-harmful substances.
- Includes allergic rhinitis, hives, asthma, and anaphylaxis.
- SCID: Severe genetic disorders impeding immune function; high infection susceptibility.
- AIDS: Caused by HIV, weakening the immune system and increasing vulnerability to infections.
Key Principles of Immune Function
- Three Rs: Recognize, React, Remember guide immune system actions.
- Active Immunity: Involves the body's production of antibodies.
- Passive Immunity: Acquired through received antibodies, offering immediate defense.
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Description
Test your knowledge on the immune system and various pathogens. This quiz covers bacteria, viruses, fungi, protozoans, and parasitic worms, exploring their structures and the infections they can cause. Understand how these infectious agents affect human health and the body's defense mechanisms.