Immune System Overview
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Questions and Answers

What are the 'professional' phagocytes in the innate immune system?

macrophages, neutrophils, and dendritic cells

What is the process by which phagocytes engulf pathogens or particles?

phagocytosis

What is the name of the intracellular vesicle formed when a pathogen is engulfed by a phagocyte?

phagosome

What is the process by which neutrophils migrate toward the site of inflammation?

<p>chemotaxis</p> Signup and view all the answers

Where are dendritic cells mainly located in the body?

<p>skin, nose, lungs, stomach, and intestines</p> Signup and view all the answers

What do macrophages produce within tissues?

<p>enzymes, complement proteins, and cytokines</p> Signup and view all the answers

What percentage of total circulating leukocytes do neutrophils represent?

<p>50% to 60%</p> Signup and view all the answers

What is the main role of dendritic cells?

<p>serve as a link between the bodily tissues and the innate and adaptive immune systems</p> Signup and view all the answers

What are the two major subsystems of the immune system?

<p>The innate immune system and the adaptive immune system.</p> Signup and view all the answers

What is the main function of the innate immune system?

<p>It provides a preconfigured response to broad groups of situations and stimuli.</p> Signup and view all the answers

How does the adaptive immune system respond to each stimulus?

<p>It provides a tailored response by learning to recognize molecules it has previously encountered.</p> Signup and view all the answers

What are some basic immune mechanisms that evolved in ancient plants and animals?

<p>Phagocytosis, antimicrobial peptides called defensins, and the complement system.</p> Signup and view all the answers

What is the basis of vaccination?

<p>The process of acquired immunity, which creates an immunological memory leading to an enhanced response to subsequent encounters with the same pathogen.</p> Signup and view all the answers

What are some potential consequences of immune system dysfunction?

<p>Autoimmune diseases, inflammatory diseases, and cancer.</p> Signup and view all the answers

What is immunodeficiency?

<p>Immunodeficiency occurs when the immune system is less active than normal, resulting in recurring and life-threatening infections.</p> Signup and view all the answers

What are the causes of immunodeficiency?

<p>Causes of immunodeficiency include genetic diseases, acquired conditions, or immunosuppressive medication.</p> Signup and view all the answers

What is autoimmunity?

<p>Autoimmunity is a condition where the immune system attacks normal tissues as if they were foreign organisms.</p> Signup and view all the answers

Name two common autoimmune diseases.

<p>Hashimoto's thyroiditis, rheumatoid arthritis</p> Signup and view all the answers

What are the layered defenses of the immune system?

<p>Physical barriers, innate immune system, and adaptive immune system.</p> Signup and view all the answers

What are the types of receptors used by the innate immune system to detect pathogens?

<p>Toll-like receptors (TLRs), NOD-like receptors, RIG-like receptors, and cytosolic DNA sensors.</p> Signup and view all the answers

What are the structural characteristics of most plant viruses?

<p>Most plant viruses are rod-shaped, with protein discs forming a tube surrounding the viral genome; isometric particles are another common structure.</p> Signup and view all the answers

What is the genome composition of the great majority of plant viruses?

<p>The great majority of plant viruses have an RNA genome, which is usually small and single stranded (ss), but some viruses have double-stranded (ds) RNA, ssDNA or dsDNA genomes.</p> Signup and view all the answers

Which plant virus is particularly well-known and why?

<p>Tobacco mosaic virus (TMV) is well-known as it was the first virus to be discovered.</p> Signup and view all the answers

What is the estimated annual loss in crop yields caused by plant viruses worldwide?

<p>Plant viruses cause an estimated US$60 billion loss in crop yields worldwide each year.</p> Signup and view all the answers

How do plant viruses usually transmit from one plant to another?

<p>To transmit from one plant to another, plant viruses usually involve vectors, such as insects, as most plants do not move.</p> Signup and view all the answers

How are plant viruses grouped and what does this classification account for?

<p>Plant viruses are grouped into 73 genera and 49 families, but these figures relate only to cultivated plants, which represent only a tiny fraction of the total number of plant species.</p> Signup and view all the answers

What is the bridging hypothesis in the context of insect-mediated viral transmission?

<p>The bridging hypothesis proposes that in non-persistent and semi-persistent viruses, the helper component binds to the specific domain of the coat protein, creating a bridge that aids in insect-mediated viral transmission.</p> Signup and view all the answers

How do persistent propagative viruses, such as tomato spotted wilt virus (TSWV), differ in terms of viral transmission compared to other classes of plant viruses?

<p>Persistent propagative viruses, such as TSWV, have a lipid coat surrounding the proteins that is not seen in other classes of plant viruses. It has been proposed that these viruses bind via these proteins and are then taken into the insect cell by receptor-mediated endocytosis.</p> Signup and view all the answers

How do soil-borne nematodes transmit viruses?

<p>Soil-borne nematodes acquire and transmit viruses by feeding on infected roots. The virions attach to the stylet (feeding organ) or to the gut when they feed on an infected plant and can then detach during later feeding to infect other plants.</p> Signup and view all the answers

What are plasmodiophorids and how do they transmit viruses?

<p>Plasmodiophorids are soil borne zoosporic protozoa that are not phytopathogenic themselves, but parasitic. They transmit a number of virus genera, both persistently and non-persistently, by becoming associated with the plant roots. They also create wounds in the plant's root through which other viruses can enter.</p> Signup and view all the answers

What is the percentage of plant viruses that can be transmitted from generation to generation?

<p>About 20% of plant viruses can be transmitted from generation to generation.</p> Signup and view all the answers

How do viruses transmitted by seeds infect the plant?

<p>When viruses are transmitted by seeds, the seed is infected in the generative cells and the virus is maintained in the germ cells and sometimes, but less often, in the seed coat.</p> Signup and view all the answers

What are examples of viruses transmitted by nematodes?

<p>Examples of viruses that can be transmitted by nematodes include tobacco ringspot virus and tobacco rattle virus.</p> Signup and view all the answers

What are examples of viruses transmitted by plasmodiophorids?

<p>Examples of viruses transmitted by plasmodiophorids include Polymyxa graminis, which transmits plant viral diseases in cereal crops, and Polymyxa betae, which transmits Beet necrotic yellow vein virus.</p> Signup and view all the answers

Who coined the term 'virus' and when?

<p>Martinus Beijerinck coined the term 'virus' in the late 19th century.</p> Signup and view all the answers

What is the primary defense mechanism employed by plants against viral infection?

<p>Plants employ siRNA response to dsRNA as a defense against viral infection.</p> Signup and view all the answers

When was the RNA of Tobacco Mosaic Virus (TMV) identified as the infectious material?

<p>The RNA of Tobacco Mosaic Virus (TMV) was identified as the infectious material in the 1950s.</p> Signup and view all the answers

What are the dimensions of rod-shaped plant viruses?

<p>Rod-shaped plant viruses are over 50% in length between 300-500 nm and in diameters of 15-20 nm.</p> Signup and view all the answers

How do plant viruses primarily transmit between plants?

<p>Transmission of plant viruses can occur through sap or insect vectors.</p> Signup and view all the answers

What is the significance of Rhabdoviruses in plant virus transmission?

<p>Rhabdoviruses have been proposed to be insect viruses that replicate in plants, and their chosen insect vectors determine their host range.</p> Signup and view all the answers

Study Notes

  • Immunodeficiency occurs when the immune system is less active than normal, resulting in recurring and life-threatening infections.

  • Causes of immunodeficiency include genetic diseases, acquired conditions, or immunosuppressive medication.

  • Autoimmunity is a condition where the immune system attacks normal tissues as if they were foreign organisms.

  • Common autoimmune diseases include Hashimoto's thyroiditis, rheumatoid arthritis, diabetes mellitus type 1, and systemic lupus erythematosus.

  • The immune system protects its host from infection with layered defenses: physical barriers, innate immune system, and adaptive immune system.

  • Physical barriers include mechanical barriers (e.g. skin, exoskeletons, cuticles) and chemical barriers (e.g. antibacterial peptides, enzymes, mucus).

  • The innate immune system is the body's first line of defense against pathogens. It is triggered by pattern recognition receptors or damaged cells.

  • Innate immune defenses are non-specific and do not provide long-lasting immunity against a pathogen.

  • The innate immune system uses receptors called toll-like receptors (TLRs) to detect extracellular or endosomal pathogen-associated molecular patterns (PAMPs).

  • TLRs are curved proteins with a leucine rich repeats (LRRs) structural motif.

  • The innate immune system also has intracellular receptors called NOD-like receptors, RIG-like receptors, and cytosolic DNA sensors to detect intracellular infection or cell damage.

  • Plant cells use plasmodesmata for virion transport between cells due to cell wall encasement.

  • Plants employ siRNA response to dsRNA as a defense against viral infection, which some viruses suppress.

  • Martinus Beijerinck coined the term "virus" in the late 19th century after discovering infectious filtrate in a plant disease.

  • The first plant virus, Tobacco Mosaic Virus (TMV), was crystallized in the 1930s but its RNA was not identified as the infectious material until the 1950s.

  • Over 50% of plant viruses are rod-shaped, with lengths between 300-500 nm and diameters of 15-20 nm.

  • Isometric particles are 25-50 nm in diameter and consist of up to 60 T subunits.

  • Transmission of plant viruses can occur through sap or insect vectors.

  • Sap transmission can result from agricultural practices or natural contact, and involves viruses such as TMV, potato viruses, and cucumber mosaic viruses.

  • Insect transmission involves viruses attaching to the insect's stylet or entering the foregut, with some viruses able to replicate in both the plant and insect.

  • Non-persistent transmission occurs when the virus attaches to the insect's stylet and inoculates the next plant, while persistent transmission involves the virus entering the insect's gut and potentially replicating in the salivary glands.

  • Rhabdoviruses have been proposed to be insect viruses that replicate in plants, and their chosen insect vectors determine their host range.

  • The old world white fly spreading to the US transferred many plant viruses to new hosts, demonstrating the importance of insect vectors in plant virus transmission.

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Test your knowledge about the immune system with this quiz that covers the basic concepts, functions, and components of the immune system including innate and adaptive immunity.

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