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Questions and Answers
What are the 'professional' phagocytes in the innate immune system?
What are the 'professional' phagocytes in the innate immune system?
macrophages, neutrophils, and dendritic cells
What is the process by which phagocytes engulf pathogens or particles?
What is the process by which phagocytes engulf pathogens or particles?
phagocytosis
What is the name of the intracellular vesicle formed when a pathogen is engulfed by a phagocyte?
What is the name of the intracellular vesicle formed when a pathogen is engulfed by a phagocyte?
phagosome
What is the process by which neutrophils migrate toward the site of inflammation?
What is the process by which neutrophils migrate toward the site of inflammation?
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Where are dendritic cells mainly located in the body?
Where are dendritic cells mainly located in the body?
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What do macrophages produce within tissues?
What do macrophages produce within tissues?
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What percentage of total circulating leukocytes do neutrophils represent?
What percentage of total circulating leukocytes do neutrophils represent?
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What is the main role of dendritic cells?
What is the main role of dendritic cells?
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What are the two major subsystems of the immune system?
What are the two major subsystems of the immune system?
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What is the main function of the innate immune system?
What is the main function of the innate immune system?
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How does the adaptive immune system respond to each stimulus?
How does the adaptive immune system respond to each stimulus?
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What are some basic immune mechanisms that evolved in ancient plants and animals?
What are some basic immune mechanisms that evolved in ancient plants and animals?
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What is the basis of vaccination?
What is the basis of vaccination?
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What are some potential consequences of immune system dysfunction?
What are some potential consequences of immune system dysfunction?
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What is immunodeficiency?
What is immunodeficiency?
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What are the causes of immunodeficiency?
What are the causes of immunodeficiency?
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What is autoimmunity?
What is autoimmunity?
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Name two common autoimmune diseases.
Name two common autoimmune diseases.
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What are the layered defenses of the immune system?
What are the layered defenses of the immune system?
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What are the types of receptors used by the innate immune system to detect pathogens?
What are the types of receptors used by the innate immune system to detect pathogens?
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What are the structural characteristics of most plant viruses?
What are the structural characteristics of most plant viruses?
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What is the genome composition of the great majority of plant viruses?
What is the genome composition of the great majority of plant viruses?
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Which plant virus is particularly well-known and why?
Which plant virus is particularly well-known and why?
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What is the estimated annual loss in crop yields caused by plant viruses worldwide?
What is the estimated annual loss in crop yields caused by plant viruses worldwide?
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How do plant viruses usually transmit from one plant to another?
How do plant viruses usually transmit from one plant to another?
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How are plant viruses grouped and what does this classification account for?
How are plant viruses grouped and what does this classification account for?
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What is the bridging hypothesis in the context of insect-mediated viral transmission?
What is the bridging hypothesis in the context of insect-mediated viral transmission?
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How do persistent propagative viruses, such as tomato spotted wilt virus (TSWV), differ in terms of viral transmission compared to other classes of plant viruses?
How do persistent propagative viruses, such as tomato spotted wilt virus (TSWV), differ in terms of viral transmission compared to other classes of plant viruses?
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How do soil-borne nematodes transmit viruses?
How do soil-borne nematodes transmit viruses?
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What are plasmodiophorids and how do they transmit viruses?
What are plasmodiophorids and how do they transmit viruses?
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What is the percentage of plant viruses that can be transmitted from generation to generation?
What is the percentage of plant viruses that can be transmitted from generation to generation?
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How do viruses transmitted by seeds infect the plant?
How do viruses transmitted by seeds infect the plant?
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What are examples of viruses transmitted by nematodes?
What are examples of viruses transmitted by nematodes?
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What are examples of viruses transmitted by plasmodiophorids?
What are examples of viruses transmitted by plasmodiophorids?
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Who coined the term 'virus' and when?
Who coined the term 'virus' and when?
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What is the primary defense mechanism employed by plants against viral infection?
What is the primary defense mechanism employed by plants against viral infection?
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When was the RNA of Tobacco Mosaic Virus (TMV) identified as the infectious material?
When was the RNA of Tobacco Mosaic Virus (TMV) identified as the infectious material?
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What are the dimensions of rod-shaped plant viruses?
What are the dimensions of rod-shaped plant viruses?
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How do plant viruses primarily transmit between plants?
How do plant viruses primarily transmit between plants?
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What is the significance of Rhabdoviruses in plant virus transmission?
What is the significance of Rhabdoviruses in plant virus transmission?
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Study Notes
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Immunodeficiency occurs when the immune system is less active than normal, resulting in recurring and life-threatening infections.
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Causes of immunodeficiency include genetic diseases, acquired conditions, or immunosuppressive medication.
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Autoimmunity is a condition where the immune system attacks normal tissues as if they were foreign organisms.
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Common autoimmune diseases include Hashimoto's thyroiditis, rheumatoid arthritis, diabetes mellitus type 1, and systemic lupus erythematosus.
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The immune system protects its host from infection with layered defenses: physical barriers, innate immune system, and adaptive immune system.
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Physical barriers include mechanical barriers (e.g. skin, exoskeletons, cuticles) and chemical barriers (e.g. antibacterial peptides, enzymes, mucus).
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The innate immune system is the body's first line of defense against pathogens. It is triggered by pattern recognition receptors or damaged cells.
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Innate immune defenses are non-specific and do not provide long-lasting immunity against a pathogen.
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The innate immune system uses receptors called toll-like receptors (TLRs) to detect extracellular or endosomal pathogen-associated molecular patterns (PAMPs).
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TLRs are curved proteins with a leucine rich repeats (LRRs) structural motif.
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The innate immune system also has intracellular receptors called NOD-like receptors, RIG-like receptors, and cytosolic DNA sensors to detect intracellular infection or cell damage.
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Plant cells use plasmodesmata for virion transport between cells due to cell wall encasement.
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Plants employ siRNA response to dsRNA as a defense against viral infection, which some viruses suppress.
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Martinus Beijerinck coined the term "virus" in the late 19th century after discovering infectious filtrate in a plant disease.
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The first plant virus, Tobacco Mosaic Virus (TMV), was crystallized in the 1930s but its RNA was not identified as the infectious material until the 1950s.
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Over 50% of plant viruses are rod-shaped, with lengths between 300-500 nm and diameters of 15-20 nm.
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Isometric particles are 25-50 nm in diameter and consist of up to 60 T subunits.
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Transmission of plant viruses can occur through sap or insect vectors.
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Sap transmission can result from agricultural practices or natural contact, and involves viruses such as TMV, potato viruses, and cucumber mosaic viruses.
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Insect transmission involves viruses attaching to the insect's stylet or entering the foregut, with some viruses able to replicate in both the plant and insect.
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Non-persistent transmission occurs when the virus attaches to the insect's stylet and inoculates the next plant, while persistent transmission involves the virus entering the insect's gut and potentially replicating in the salivary glands.
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Rhabdoviruses have been proposed to be insect viruses that replicate in plants, and their chosen insect vectors determine their host range.
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The old world white fly spreading to the US transferred many plant viruses to new hosts, demonstrating the importance of insect vectors in plant virus transmission.
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Test your knowledge about the immune system with this quiz that covers the basic concepts, functions, and components of the immune system including innate and adaptive immunity.