Immune System Dysfunction
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Questions and Answers

Which type of hypersensitivity reaction involves IgE attracting basophils and mast cells?

  • Type I (correct)
  • Type IV
  • Type III
  • Type II
  • In hemolytic disease of the newborn, what is the underlying mechanism that leads to the destruction of fetal red blood cells?

  • The fetus produces antibodies against the mother's red blood cells.
  • The mother's immune system directly attacks the fetal platelets, leading to secondary red blood cell destruction.
  • The mother produces antibodies against the fetus's red blood cells. (correct)
  • The fetus's immune system attacks its own red blood cells due to a genetic defect.
  • What is the primary characteristic of Type III hypersensitivity reactions that distinguishes them from Type II reactions?

  • Type III reactions are not tissue specific, with immune complexes depositing in various tissues, while Type II reactions target antigens on specific cell surfaces. (correct)
  • Type III reactions are immediate, unlike the delayed response seen in Type II reactions.
  • Type III reactions involve cell-mediated cytotoxicity, while Type II reactions involve antibody-antigen complexes.
  • Type III reactions are tissue specific, while Type II reactions are not.
  • Which of the following is the main cell type mediating Type IV hypersensitivity reactions?

    <p>Lymphocytes (A)</p> Signup and view all the answers

    What is the mechanism of action of medications like antihistamines in treating mild Type I hypersensitivity reactions?

    <p>They block histamine receptors, preventing histamine from binding and causing its effects. (B)</p> Signup and view all the answers

    Which autoimmune disease is characterized by antibodies attacking the acetylcholine receptors at the neuromuscular junction?

    <p>Myasthenia gravis (C)</p> Signup and view all the answers

    What is the rationale behind using Rhogam to prevent hemolytic disease of the newborn?

    <p>Rhogam contains anti-Rh antibodies that bind to and neutralize fetal Rh-positive red blood cells in the mother's circulation, preventing her from producing her own antibodies. (D)</p> Signup and view all the answers

    What is the primary mechanism that causes tissue damage in Type II hypersensitivity reactions?

    <p>Antibody-mediated complement activation and cell lysis (D)</p> Signup and view all the answers

    Why are systemic lupus erythematosus (SLE) reactions considered a Type III hypersensitivity?

    <p>Because antigen-antibody complexes deposit in various tissues, causing inflammation. (D)</p> Signup and view all the answers

    A patient presents with redness, induration, and inflammation at the site of a tuberculin skin test. Which type of hypersensitivity reaction is responsible for this response?

    <p>Type IV (B)</p> Signup and view all the answers

    What is the primary mechanism by which histamine contributes to the clinical manifestations of Type I hypersensitivity reactions?

    <p>It increases mucus secretion, vascular permeability and vasodilation, and smooth muscle contraction. (A)</p> Signup and view all the answers

    Following a blood transfusion, a patient develops dark urine, chills, and lower back pain. Which type of hypersensitivity reaction is most likely occurring?

    <p>Type II (D)</p> Signup and view all the answers

    What is the role of regulatory T lymphocytes in the immune system?

    <p>They suppress other immune cells to maintain tolerance and prevent autoimmunity. (D)</p> Signup and view all the answers

    Why does anaphylaxis constitute a life-threatening Type I hypersensitivity reaction?

    <p>It induces a systemic inflammatory response causing vasodilation, throat constriction, and bronchoconstriction, compromising airway and circulation. (D)</p> Signup and view all the answers

    Contrast the roles of cytotoxic T lymphocytes and helper T lymphocytes in adaptive immunity.

    <p>Cytotoxic T lymphocytes destroy target cells, while helper T lymphocytes secrete cytokines to activate other immune cells. (C)</p> Signup and view all the answers

    Which of the following hypersensitivity reactions involves the formation of immune complexes that deposit in tissues, leading to inflammation and tissue damage?

    <p>Type III (C)</p> Signup and view all the answers

    What is the primary mechanism by which cytotoxic T lymphocytes eliminate target cells?

    <p>Inducing apoptosis (programmed cell death) in target cells (D)</p> Signup and view all the answers

    Which of the following is an example of autoimmunity?

    <p>Rheumatoid arthritis (D)</p> Signup and view all the answers

    Which of the following is the primary mechanism behind Graves disease?

    <p>Antibodies stimulating the thyroid gland to produce excess thyroid hormone (A)</p> Signup and view all the answers

    What is the role of IgE in Type I hypersensitivity reactions?

    <p>Sensitizing mast cells and basophils by binding to their Fc receptors (A)</p> Signup and view all the answers

    In the context of Type I hypersensitivity, what is the function of histamine?

    <p>Vasodilation, increased vascular permeability, and smooth muscle constriction (A)</p> Signup and view all the answers

    Which statement best describes the mechanism by which Rhogam prevents hemolytic disease of the newborn?

    <p>It binds to and neutralizes fetal Rh-positive red blood cells in the maternal circulation, preventing maternal sensitization. (C)</p> Signup and view all the answers

    What is the underlying cause of the delayed nature of Type IV hypersensitivity reactions compared to Type I hypersensitivity?

    <p>Type IV reactions require the migration and activation of T cells, which takes time. (A)</p> Signup and view all the answers

    Which of the following characteristics distinguishes Type I diabetes mellitus from Type II diabetes mellitus in terms of immune system involvement?

    <p>Type I involves autoimmune destruction of pancreatic beta cells, while Type II involves insulin resistance. (B)</p> Signup and view all the answers

    Which of the following is a key difference between innate and adaptive immunity?

    <p>Innate immunity is rapid and immediate, while adaptive immunity develops over time and has memory. (D)</p> Signup and view all the answers

    What is the mechanism of action of beta-adrenergic drugs in treating Type I hypersensitivity reactions?

    <p>Stimulating bronchodilation and reducing the release of mediators from mast cells (A)</p> Signup and view all the answers

    Why are Type III hypersensitivity reactions not tissue specific?

    <p>Because the immune complexes formed can deposit in various tissues and organs. (D)</p> Signup and view all the answers

    What role do macrophages play in Type IV hypersensitivity reactions?

    <p>Presenting antigens to T cells and releasing cytokines to amplify the immune response. (D)</p> Signup and view all the answers

    Which of the following best explains the role of T helper lymphocytes in adaptive immunity?

    <p>Secreting cytokines that activate other immune cells, such as B cells and cytotoxic T lymphocytes (B)</p> Signup and view all the answers

    In the context of transfusion reactions, what is the mechanism by which recipient antibodies cause harm?

    <p>Antibodies bind to donor red blood cell antigens, leading to complement activation and cell lysis or phagocytosis. (B)</p> Signup and view all the answers

    Flashcards

    Innate Immunity

    The body's first line of defense, consisting of physical barriers and immune cells.

    Adaptive Immunity

    Immune response that develops over time with specific targets; involves memory.

    Hypersensitivity

    An exaggerated immune response causing tissue damage.

    Autoimmunity

    Immune system mistakenly attacks the body's own cells.

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    Type I Hypersensitivity

    Immediate allergic reaction mediated by IgE antibodies.

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    Type II Hypersensitivity

    Antibody-mediated destruction of cells through complement activation.

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    Type III Hypersensitivity

    Immune complexes form and promote inflammation; not tissue-specific.

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    Type IV Hypersensitivity

    Delayed reaction mediated by T cells and macrophages.

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    Anaphylaxis

    Severe, life-threatening allergic reaction requiring immediate treatment.

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    Graves Disease

    An autoimmune disorder that results in hyperthyroidism.

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    Myasthenia Gravis

    Autoimmune condition affecting nerve signaling to muscles, leading to weakness.

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    Hemolytic Disease of the Newborn

    Condition where maternal antibodies attack fetal red blood cells, leading to anemia.

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    IgE

    Immunoglobulin involved in allergic reactions.

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    Epinephrine

    A medication used to treat severe allergic reactions like anaphylaxis.

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    Vasodilation

    Widening of blood vessels that increases blood flow and can cause redness and swelling.

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    Natural Killer Cells

    Immune cells that target non-self cells for destruction.

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    Neutrophils

    White blood cells that are the first responders to infection, targeting microorganisms.

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    Macrophages

    Large immune cells that engulf and digest cellular debris and pathogens.

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    Cytotoxic T Lymphocytes

    T cells that kill infected or cancerous cells directly.

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    B cells

    Lymphocytes that produce antibodies to neutralize pathogens.

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    B Memory Cells

    Long-lived B cells that remember past infections for quicker responses.

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    Immune Deficiency

    A state where the immune system's ability to fight infections is weakened.

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    Autoimmune Disorder

    Condition where the immune system attacks the body's own tissues.

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    Contact Hypersensitivity

    A delayed reaction causing inflammation from skin contact with an allergen.

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    Transfusion Reaction

    When recipient antibodies attack donor red blood cells in a transfusion.

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    Histamine

    A chemical released during allergic reactions, causing symptoms like vasodilation.

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    Delated Hypersensitivity

    Reaction mediated by T cells occurring 48-72 hours after exposure.

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    Study Notes

    Immune System Dysfunction Overview

    • This presentation covers immune system dysfunction, including hypersensitivity reactions and immunodeficiencies.
    • It details various types of immune dysfunction, their causes, symptoms, and treatments.

    Innate and Adaptive Immunity

    • Innate immunity is the body's first line of defense against pathogens.
    • Adaptive immunity develops in response to specific pathogens.
    • Passive immunity is when preformed antibodies are transferred.

    Types of Hypersensitivity Reactions

    • Type I (Immediate):
      • Mediated by antibodies (IgE).
      • Rapid response (within minutes of exposure).
      • Characterized by histamine release leading to reactions such as hives, asthma, and anaphylaxis.
      • Often associated with allergies and allergens.
    • Type II (Antibody-mediated):
      • Antibodies attack antigens on specific cells.
      • Complement activation and phagocytosis are involved.
      • Cell-mediated cytotoxicity also occurs in some cases.
      • Examples include Graves' disease and myasthenia gravis, and transfusion reactions.
    • Type III (Immune complex):
      • Immune complexes form and accumulate.
      • Immune/phagocytic systems fail to clear these complexes.
      • Leads to inflammation and tissue damage.
      • Systemic lupus erythematosus is an example.
    • Type IV (Cell-mediated):
      • Delayed response (hours to days).
      • T-cells initiate an inflammatory response.
      • Macrophages and lymphocytes are involved.
      • Contact dermatitis and tuberculin-type hypersensitivity are examples.

    Specific Hypersensitivity Examples

    • Contact hypersensitivity:

      • Epidermal issue occurring 48-72 hours after exposure.
      • Tuberculin-Type hypersensitivity is an example.
    • Tuberculin-type hypersensitivity:

      • Response in previously infected individuals from exposure to tuberculin antigen.
      • 48-72 hours after exposure, it shows redness, induration (hardening), and inflammation at the injection site.
      • Positive tuberculin test results indicate possible previous infection.

    Transfusion Reaction

    • Pathophysiology: Recipient antibodies attack donor red blood cells.
    • Clinical Manifestations: Dark urine, difficulties breathing, chills, fever, nausea, lower back/chest pain.
    • Treatment: Stopping the transfusion, administering Benadryl and Tylenol, supporting the airway.
      • Symptoms are often immediate.

    Hemolytic Disease of the Newborn

    • Pathophysiology (Erythroblastosis Fetalis): Rh-negative mother is sensitized to Rh-positive fetal blood antigens.
    • Clinical Manifestations: Jaundice, anemia, hydrops fetalis, hepatosplenomegaly, decreased clotting factors.
    • Prevention (using RhoGAM): Preventing the mother's sensitization or treating unprevented cases in pregnancy/labor (often administered during/after first pregnancy).

    Autoimmunity

    • Abnormal immune responses against own tissues.
    • Examples include rheumatoid arthritis, type 1 diabetes, Graves' disease, and systemic lupus erythematosus, -Autoimmune responses can be directed against various tissue types.

    Excessive Immune Dysfunction

    • Describes conditions where the immune system response is too high or abnormal.
    • Includes autoimmunity and hypersensitivity reactions.

    Summary of Treatment

    • Mild-Moderate Reactions: Antihistamines, beta-adrenergics, corticosteroids, anticholinergics, and IgE therapy—prevention.
    • Severe Reactions: IgE therapy, epinephrine, prevention.

    Glossary

    • E/P: Exposure/provocation
    • TI: Treatment implications
    • CM: Clinical manifestations

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