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Questions and Answers
Which type of hypersensitivity reaction involves IgE attracting basophils and mast cells?
Which type of hypersensitivity reaction involves IgE attracting basophils and mast cells?
In hemolytic disease of the newborn, what is the underlying mechanism that leads to the destruction of fetal red blood cells?
In hemolytic disease of the newborn, what is the underlying mechanism that leads to the destruction of fetal red blood cells?
What is the primary characteristic of Type III hypersensitivity reactions that distinguishes them from Type II reactions?
What is the primary characteristic of Type III hypersensitivity reactions that distinguishes them from Type II reactions?
Which of the following is the main cell type mediating Type IV hypersensitivity reactions?
Which of the following is the main cell type mediating Type IV hypersensitivity reactions?
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What is the mechanism of action of medications like antihistamines in treating mild Type I hypersensitivity reactions?
What is the mechanism of action of medications like antihistamines in treating mild Type I hypersensitivity reactions?
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Which autoimmune disease is characterized by antibodies attacking the acetylcholine receptors at the neuromuscular junction?
Which autoimmune disease is characterized by antibodies attacking the acetylcholine receptors at the neuromuscular junction?
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What is the rationale behind using Rhogam to prevent hemolytic disease of the newborn?
What is the rationale behind using Rhogam to prevent hemolytic disease of the newborn?
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What is the primary mechanism that causes tissue damage in Type II hypersensitivity reactions?
What is the primary mechanism that causes tissue damage in Type II hypersensitivity reactions?
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Why are systemic lupus erythematosus (SLE) reactions considered a Type III hypersensitivity?
Why are systemic lupus erythematosus (SLE) reactions considered a Type III hypersensitivity?
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A patient presents with redness, induration, and inflammation at the site of a tuberculin skin test. Which type of hypersensitivity reaction is responsible for this response?
A patient presents with redness, induration, and inflammation at the site of a tuberculin skin test. Which type of hypersensitivity reaction is responsible for this response?
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What is the primary mechanism by which histamine contributes to the clinical manifestations of Type I hypersensitivity reactions?
What is the primary mechanism by which histamine contributes to the clinical manifestations of Type I hypersensitivity reactions?
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Following a blood transfusion, a patient develops dark urine, chills, and lower back pain. Which type of hypersensitivity reaction is most likely occurring?
Following a blood transfusion, a patient develops dark urine, chills, and lower back pain. Which type of hypersensitivity reaction is most likely occurring?
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What is the role of regulatory T lymphocytes in the immune system?
What is the role of regulatory T lymphocytes in the immune system?
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Why does anaphylaxis constitute a life-threatening Type I hypersensitivity reaction?
Why does anaphylaxis constitute a life-threatening Type I hypersensitivity reaction?
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Contrast the roles of cytotoxic T lymphocytes and helper T lymphocytes in adaptive immunity.
Contrast the roles of cytotoxic T lymphocytes and helper T lymphocytes in adaptive immunity.
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Which of the following hypersensitivity reactions involves the formation of immune complexes that deposit in tissues, leading to inflammation and tissue damage?
Which of the following hypersensitivity reactions involves the formation of immune complexes that deposit in tissues, leading to inflammation and tissue damage?
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What is the primary mechanism by which cytotoxic T lymphocytes eliminate target cells?
What is the primary mechanism by which cytotoxic T lymphocytes eliminate target cells?
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Which of the following is an example of autoimmunity?
Which of the following is an example of autoimmunity?
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Which of the following is the primary mechanism behind Graves disease?
Which of the following is the primary mechanism behind Graves disease?
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What is the role of IgE in Type I hypersensitivity reactions?
What is the role of IgE in Type I hypersensitivity reactions?
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In the context of Type I hypersensitivity, what is the function of histamine?
In the context of Type I hypersensitivity, what is the function of histamine?
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Which statement best describes the mechanism by which Rhogam prevents hemolytic disease of the newborn?
Which statement best describes the mechanism by which Rhogam prevents hemolytic disease of the newborn?
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What is the underlying cause of the delayed nature of Type IV hypersensitivity reactions compared to Type I hypersensitivity?
What is the underlying cause of the delayed nature of Type IV hypersensitivity reactions compared to Type I hypersensitivity?
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Which of the following characteristics distinguishes Type I diabetes mellitus from Type II diabetes mellitus in terms of immune system involvement?
Which of the following characteristics distinguishes Type I diabetes mellitus from Type II diabetes mellitus in terms of immune system involvement?
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Which of the following is a key difference between innate and adaptive immunity?
Which of the following is a key difference between innate and adaptive immunity?
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What is the mechanism of action of beta-adrenergic drugs in treating Type I hypersensitivity reactions?
What is the mechanism of action of beta-adrenergic drugs in treating Type I hypersensitivity reactions?
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Why are Type III hypersensitivity reactions not tissue specific?
Why are Type III hypersensitivity reactions not tissue specific?
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What role do macrophages play in Type IV hypersensitivity reactions?
What role do macrophages play in Type IV hypersensitivity reactions?
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Which of the following best explains the role of T helper lymphocytes in adaptive immunity?
Which of the following best explains the role of T helper lymphocytes in adaptive immunity?
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In the context of transfusion reactions, what is the mechanism by which recipient antibodies cause harm?
In the context of transfusion reactions, what is the mechanism by which recipient antibodies cause harm?
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Flashcards
Innate Immunity
Innate Immunity
The body's first line of defense, consisting of physical barriers and immune cells.
Adaptive Immunity
Adaptive Immunity
Immune response that develops over time with specific targets; involves memory.
Hypersensitivity
Hypersensitivity
An exaggerated immune response causing tissue damage.
Autoimmunity
Autoimmunity
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Type I Hypersensitivity
Type I Hypersensitivity
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Type II Hypersensitivity
Type II Hypersensitivity
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Type III Hypersensitivity
Type III Hypersensitivity
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Type IV Hypersensitivity
Type IV Hypersensitivity
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Anaphylaxis
Anaphylaxis
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Graves Disease
Graves Disease
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Myasthenia Gravis
Myasthenia Gravis
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Hemolytic Disease of the Newborn
Hemolytic Disease of the Newborn
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IgE
IgE
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Epinephrine
Epinephrine
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Vasodilation
Vasodilation
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Natural Killer Cells
Natural Killer Cells
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Neutrophils
Neutrophils
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Macrophages
Macrophages
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Cytotoxic T Lymphocytes
Cytotoxic T Lymphocytes
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B cells
B cells
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B Memory Cells
B Memory Cells
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Immune Deficiency
Immune Deficiency
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Autoimmune Disorder
Autoimmune Disorder
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Contact Hypersensitivity
Contact Hypersensitivity
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Transfusion Reaction
Transfusion Reaction
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Histamine
Histamine
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Delated Hypersensitivity
Delated Hypersensitivity
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Study Notes
Immune System Dysfunction Overview
- This presentation covers immune system dysfunction, including hypersensitivity reactions and immunodeficiencies.
- It details various types of immune dysfunction, their causes, symptoms, and treatments.
Innate and Adaptive Immunity
- Innate immunity is the body's first line of defense against pathogens.
- Adaptive immunity develops in response to specific pathogens.
- Passive immunity is when preformed antibodies are transferred.
Types of Hypersensitivity Reactions
- Type I (Immediate):
- Mediated by antibodies (IgE).
- Rapid response (within minutes of exposure).
- Characterized by histamine release leading to reactions such as hives, asthma, and anaphylaxis.
- Often associated with allergies and allergens.
- Type II (Antibody-mediated):
- Antibodies attack antigens on specific cells.
- Complement activation and phagocytosis are involved.
- Cell-mediated cytotoxicity also occurs in some cases.
- Examples include Graves' disease and myasthenia gravis, and transfusion reactions.
- Type III (Immune complex):
- Immune complexes form and accumulate.
- Immune/phagocytic systems fail to clear these complexes.
- Leads to inflammation and tissue damage.
- Systemic lupus erythematosus is an example.
- Type IV (Cell-mediated):
- Delayed response (hours to days).
- T-cells initiate an inflammatory response.
- Macrophages and lymphocytes are involved.
- Contact dermatitis and tuberculin-type hypersensitivity are examples.
Specific Hypersensitivity Examples
-
Contact hypersensitivity:
- Epidermal issue occurring 48-72 hours after exposure.
- Tuberculin-Type hypersensitivity is an example.
-
Tuberculin-type hypersensitivity:
- Response in previously infected individuals from exposure to tuberculin antigen.
- 48-72 hours after exposure, it shows redness, induration (hardening), and inflammation at the injection site.
- Positive tuberculin test results indicate possible previous infection.
Transfusion Reaction
- Pathophysiology: Recipient antibodies attack donor red blood cells.
- Clinical Manifestations: Dark urine, difficulties breathing, chills, fever, nausea, lower back/chest pain.
- Treatment: Stopping the transfusion, administering Benadryl and Tylenol, supporting the airway.
- Symptoms are often immediate.
Hemolytic Disease of the Newborn
- Pathophysiology (Erythroblastosis Fetalis): Rh-negative mother is sensitized to Rh-positive fetal blood antigens.
- Clinical Manifestations: Jaundice, anemia, hydrops fetalis, hepatosplenomegaly, decreased clotting factors.
- Prevention (using RhoGAM): Preventing the mother's sensitization or treating unprevented cases in pregnancy/labor (often administered during/after first pregnancy).
Autoimmunity
- Abnormal immune responses against own tissues.
- Examples include rheumatoid arthritis, type 1 diabetes, Graves' disease, and systemic lupus erythematosus, -Autoimmune responses can be directed against various tissue types.
Excessive Immune Dysfunction
- Describes conditions where the immune system response is too high or abnormal.
- Includes autoimmunity and hypersensitivity reactions.
Summary of Treatment
- Mild-Moderate Reactions: Antihistamines, beta-adrenergics, corticosteroids, anticholinergics, and IgE therapy—prevention.
- Severe Reactions: IgE therapy, epinephrine, prevention.
Glossary
- E/P: Exposure/provocation
- TI: Treatment implications
- CM: Clinical manifestations
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