Immune System Cells: Neutrophils and Eosinophils
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Questions and Answers

Where do T cells originate from?

  • Spleen and thymus
  • Lymph nodes and red bone marrow
  • Kidneys and pancreas
  • Fetal liver and adult bone marrow (correct)
  • What is the main site of maturation for T cells?

  • Lymph nodes
  • Bone marrow
  • Spleen
  • Thymus (correct)
  • What is the primary marker expressed by double negative (DN) T cells?

  • CD4
  • CD8
  • TCR (correct)
  • CD3
  • After gene rearrangement of the TCR, what do thymocytes express?

    <p>Both CD4 and CD8</p> Signup and view all the answers

    Where are the most immature thymocytes found?

    <p>Subcapsular sinus</p> Signup and view all the answers

    What is the consequence of thymus involution with age?

    <p>Decreased output of mature T cells</p> Signup and view all the answers

    Where do neutrophils and eosinophils mostly develop?

    <p>Bone marrow</p> Signup and view all the answers

    Which cytokines stimulate the maturation of eosinophils from their myeloid precursors?

    <p>Granulocyte monocyte colony stimulating factor (G-MCSF)</p> Signup and view all the answers

    Where are some eosinophils normally present in the body?

    <p>Mucosal linings of respiratory, gastrointestinal, and genitourinary tracts</p> Signup and view all the answers

    What is the primary function of basophils in the immune system?

    <p>Release of histamine in allergic reactions</p> Signup and view all the answers

    From where do monocytes/macrophages originate?

    <p>Bone marrow</p> Signup and view all the answers

    What is the collective term for monocytes/macrophages in the immune system?

    <p>Mononuclear phagocyte system</p> Signup and view all the answers

    Which cells are the source of tissue resident macrophages?

    <p>Monocytes</p> Signup and view all the answers

    What is the cytokine responsible for the maturation of dendritic cells?

    <p>Flt3 ligand</p> Signup and view all the answers

    Which cells are widely distributed in lymphoid tissues, mucosal epithelium, and organ parenchyma?

    <p>Macrophages</p> Signup and view all the answers

    What is the important function of mast cells in allergic diseases?

    <p>Mediator release like histamine</p> Signup and view all the answers

    Which cells have multiple cytoplasmic projections making them efficient antigen presenting cells?

    <p>Dendritic cells</p> Signup and view all the answers

    What lineage do myeloid cells, including neutrophils and eosinophils, derive from?

    <p>Hematopoietic stem cell</p> Signup and view all the answers

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