18 Questions
Where do T cells originate from?
Fetal liver and adult bone marrow
What is the main site of maturation for T cells?
Thymus
What is the primary marker expressed by double negative (DN) T cells?
TCR
After gene rearrangement of the TCR, what do thymocytes express?
Both CD4 and CD8
Where are the most immature thymocytes found?
Subcapsular sinus
What is the consequence of thymus involution with age?
Decreased output of mature T cells
Where do neutrophils and eosinophils mostly develop?
Bone marrow
Which cytokines stimulate the maturation of eosinophils from their myeloid precursors?
Granulocyte monocyte colony stimulating factor (G-MCSF)
Where are some eosinophils normally present in the body?
Mucosal linings of respiratory, gastrointestinal, and genitourinary tracts
What is the primary function of basophils in the immune system?
Release of histamine in allergic reactions
From where do monocytes/macrophages originate?
Bone marrow
What is the collective term for monocytes/macrophages in the immune system?
Mononuclear phagocyte system
Which cells are the source of tissue resident macrophages?
Monocytes
What is the cytokine responsible for the maturation of dendritic cells?
Flt3 ligand
Which cells are widely distributed in lymphoid tissues, mucosal epithelium, and organ parenchyma?
Macrophages
What is the important function of mast cells in allergic diseases?
Mediator release like histamine
Which cells have multiple cytoplasmic projections making them efficient antigen presenting cells?
Dendritic cells
What lineage do myeloid cells, including neutrophils and eosinophils, derive from?
Hematopoietic stem cell
Learn about the migration, function, and lifespan of neutrophils and eosinophils in response to microbial infections. Understand how these cells are produced in the bone marrow and the factors that stimulate their maturation.
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