10 Questions
What process do macrophages use to absorb MBT?
phagocytosis
What proteins of MBT determine the virulence properties of the pathogen?
CFP10 and ESAT6
What type of cytokines do macrophages secrete to attract T-lymphocytes?
anti-inflammatory interleukins
What do T-lymphocytes read from the macrophage membrane?
information about antigens
What do T-lymphocytes become after reading information from the macrophage membrane?
memory cells
What is the outcome of macrophages absorbing MBT through phagocytosis?
Macrophages are destroyed and die.
Why do macrophages present antigens to T-lymphocytes after absorbing MBT?
To trigger an immune response against the pathogen.
How do T-lymphocytes respond to the antigens presented by macrophages?
They turn into memory cells.
What is the role of anti-inflammatory cytokines secreted by macrophages?
To attract T-lymphocytes to the focus of infection.
What is the significance of the CFP10 and ESAT6 proteins in MBT?
They determine the virulence properties of the pathogen.
Study Notes
Sensitization
- In the area where the pathogen is located, macrophages actively absorb Mycobacterium tuberculosis (MBT) through phagocytosis, leading to their destruction and death.
- Specific antigens of MBT, including CFP10 and ESAT6 proteins, which determine the pathogen's virulence properties, are presented on the surface of the macrophage cell membrane.
- These antigens are presented to T-lymphocytes, allowing them to recognize and respond to the infection.
- Macrophages secrete anti-inflammatory cytokines, specifically interleukins, which attract T-lymphocytes to the site of infection.
- T-lymphocytes read information about antigens from the macrophage membrane and differentiate into memory cells, allowing them to retain immune memory and respond to future infections.
Sensitization
- In the area where the pathogen is located, macrophages actively absorb Mycobacterium tuberculosis (MBT) through phagocytosis, leading to their destruction and death.
- Specific antigens of MBT, including CFP10 and ESAT6 proteins, which determine the pathogen's virulence properties, are presented on the surface of the macrophage cell membrane.
- These antigens are presented to T-lymphocytes, allowing them to recognize and respond to the infection.
- Macrophages secrete anti-inflammatory cytokines, specifically interleukins, which attract T-lymphocytes to the site of infection.
- T-lymphocytes read information about antigens from the macrophage membrane and differentiate into memory cells, allowing them to retain immune memory and respond to future infections.
Macrophages respond to Mycobacterium bovis infection through phagocytosis, antigen presentation, and cytokine secretion, attracting T-lymphocytes to the site of infection.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
