18 Questions
What is the primary function of CD8+ cytotoxic T lymphocytes?
To kill infected cells
Which MHC pathway is associated with the recognition of protein antigens from microbes that live in the cytoplasm of infected cells?
Class I MHC pathway
What is the role of CD4+ helper T lymphocytes in the immune response?
To stimulate the production of antibodies against extracellular microbes
How do protein antigens from microbes that are endocytosed by macrophages and B lymphocytes enter the MHC pathway?
Through the class II MHC pathway
What is the main difference between the class I and class II MHC pathways?
The source of the antigen
What is the ultimate goal of MHC-associated antigen presentation by CD8+ and CD4+ effector T cells?
To eliminate infected cells and extracellular microbes
Where are protein antigens of microbes concentrated after entering the body?
In the lymph nodes
What is the primary function of dendritic cells in T cell-dependent immune responses?
To induce T-dependent responses
What type of APC is responsible for presenting antigens to effector T cells in cell-mediated immune reactions?
Macrophages
Which type of T cells are reactivated by macrophages to induce killing of ingested microbes?
CD4+ helper T cells
What promotes the entry of naive T lymphocytes into the T cell zones of lymph nodes?
CCR7
How long does it take for a T cell response to begin in the lymph nodes after a microbial antigen is introduced at any site in the body?
12 to 18 hours
Which type of T cells recognize peptide antigens displayed by MHC molecules of antigen-presenting cells?
Both CD4+ and CD8+ T cells
What is the term for the property of T cells that requires them to recognize peptides only when displayed by an individual's MHC molecules?
MHC restriction
Where are microbial antigens located in host cells that are recognized by CD8+ cytotoxic T lymphocytes?
In the cytosol and nucleus
What is the function of MHC molecules in the immune system?
To capture and display antigens to lymphocytes
What type of T cells recognize and respond to extracellular and intracellular microbes internalized into vesicular compartments in host cells?
CD4+ helper T lymphocytes
What is the term for the process by which protein antigens are captured, broken down, and displayed for recognition by T lymphocytes?
Antigen processing
Learn about the different mechanisms of the immune system in response to microbial infections, including the role of T cells, B lymphocytes, and antibodies. Understand how the immune system eliminates extracellular and intracellular microbes.
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