Immune Deficiency Quiz

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Which type of immune deficiency is characterized by a single nucleotide mis-sense mutation in the beta-2 Integrin gene?

Primary immune deficiency

Secondary immune deficiency

SCID

Canine leukocyte Adhesion Deficiency (correct)

What is the main difference between primary and secondary immune deficiencies?

Primary immune deficiencies are more common than secondary immune deficiencies

Primary immune deficiencies are caused by pathogens, while secondary immune deficiencies are caused by cytokine signaling

Primary immune deficiencies are inherited, while secondary immune deficiencies are not (correct)

Primary immune deficiencies are treatable, while secondary immune deficiencies are not

What is the most common cause of secondary immune deficiency?

Pathogens

Age

Cytokine signaling

Chronic disease (correct)

Which type of immune deficiency is clinically apparent in early life and has an increased mortality chance?

Primary immune deficiency (D) Signup and view all the answers

What is the characteristic feature of Canine leukocyte Adhesion Deficiency (CLAD)?

All of the above (D) Signup and view all the answers

Which breed is commonly affected by Canine leukocyte Adhesion Deficiency (CLAD)?

Irish Setter (C) Signup and view all the answers

What is the main function of white blood cells in the immune system?

Eliminating pathogens (D) Signup and view all the answers

What does persistent neutrophilia indicate in Canine leukocyte Adhesion Deficiency (CLAD)?

Impaired neutrophil function (B) Signup and view all the answers

Which type of immune deficiency is caused by a mutation in a gene associated with the immune response?

Primary immune deficiency (B) Signup and view all the answers

What is the likelihood of finding Canine leukocyte Adhesion Deficiency (CLAD) in a clinic?

Low (B) Signup and view all the answers

Which breed is affected by a mutation for key cytokines (IL-2, 4, 7, 9, 15) leading to immune system failure?

Basset Hound (C) Signup and view all the answers

Which breed is affected by a mutation for lymphocyte formation inhibiting the immune response once maternal immunity has waned?

Jack Russel Terrier (B) Signup and view all the answers

Which breed is affected by a mutation impacting T & B cell receptors, inhibiting somatic mutation to different antigens, and has a clinical diagnosis that is not straightforward?

Arabian horse (C) Signup and view all the answers

Which factor may not be a useful marker for immunodeficiency syndromes?

Lymphopenia (A) Signup and view all the answers

Which factor is associated with age-related decline in immune function?

Malnutrition (A) Signup and view all the answers

Which factor can suppress the immune response and increase infection susceptibility?

Glucocorticoids (A) Signup and view all the answers

What might be the underlying cause if an animal shows reduced concentrations of cytokines and reduced T lymphocyte function?

Malnutrition (C) Signup and view all the answers

Which type of immune deficiency is characterized by a single nucleotide mis-sense mutation in the beta-2 Integrin gene?

Canine leukocyte Adhesion Deficiency (CLAD) Signup and view all the answers

Which factor can suppress the immune response and increase infection susceptibility?

Age, chronic disease, infection, therapeutics Signup and view all the answers

Which breed is affected by a mutation for key cytokines (IL-2, 4, 7, 9, 15) leading to immune system failure?

Irish Setter Signup and view all the answers

What is the main function of white blood cells in the immune system?

Eliminating pathogens Signup and view all the answers

What is the likelihood of finding Canine leukocyte Adhesion Deficiency (CLAD) in a clinic?

Rare Signup and view all the answers

What is the characteristic feature of Canine leukocyte Adhesion Deficiency (CLAD)?

Abnormal blood clotting & Impaired immune system Signup and view all the answers

What is the most common cause of secondary immune deficiency?

Physiological or pathological change within the immune system Signup and view all the answers

What are the breed-specific mutations associated with Severe Combined Immunodeficiency (SCID) in dogs and horses?

Basset Hound: Mutation for key cytokines (IL-2, 4, 7, 9, 15). Jack Russel Terrier: Mutation for Lymphocyte formation. Arabian horse: Mutation impacts T & B cell receptors. Signup and view all the answers

What are the clinical manifestations of Severe Combined Immunodeficiency (SCID) in Arabian horses?

Pyrexia, respiratory complications, diarrhea. Signup and view all the answers

What are the potential causes of lymphopenia?

Chronic stress, immune deficiency syndromes. Signup and view all the answers

What are the secondary immune deficiencies discussed in the text?

Age-related decline, specific infectious disease, chronic stress, malnutrition. Signup and view all the answers

What factors can suppress the immune response and increase infection susceptibility?

Glucocorticoids (e.g. due to chronic stress), chronic stress, malnutrition. Signup and view all the answers

What factors can increase immune function?

Low intensity exercise. Signup and view all the answers

What is the significance of reduced concentrations of cytokines and reduced T lymphocyte function?

It indicates malnutrition and reduced immune function. Signup and view all the answers

What should be considered if an animal shows recurrent infections, neutrophilia or lymphopenia, and susceptibility to infection?

An immune deficiency should be considered. Signup and view all the answers

Immune Deficiency Quiz

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Questions and Answers

Which type of immune deficiency is characterized by a single nucleotide mis-sense mutation in the beta-2 Integrin gene?

What is the main difference between primary and secondary immune deficiencies?

What is the most common cause of secondary immune deficiency?

Which type of immune deficiency is clinically apparent in early life and has an increased mortality chance?

What is the characteristic feature of Canine leukocyte Adhesion Deficiency (CLAD)?

Which breed is commonly affected by Canine leukocyte Adhesion Deficiency (CLAD)?

What is the main function of white blood cells in the immune system?

What does persistent neutrophilia indicate in Canine leukocyte Adhesion Deficiency (CLAD)?

Which type of immune deficiency is caused by a mutation in a gene associated with the immune response?

What is the likelihood of finding Canine leukocyte Adhesion Deficiency (CLAD) in a clinic?

Which breed is affected by a mutation for key cytokines (IL-2, 4, 7, 9, 15) leading to immune system failure?

Which breed is affected by a mutation for lymphocyte formation inhibiting the immune response once maternal immunity has waned?

Which breed is affected by a mutation impacting T & B cell receptors, inhibiting somatic mutation to different antigens, and has a clinical diagnosis that is not straightforward?

Which factor may not be a useful marker for immunodeficiency syndromes?

Which factor is associated with age-related decline in immune function?

Which factor can suppress the immune response and increase infection susceptibility?

What might be the underlying cause if an animal shows reduced concentrations of cytokines and reduced T lymphocyte function?

Which type of immune deficiency is characterized by a single nucleotide mis-sense mutation in the beta-2 Integrin gene?

Which factor can suppress the immune response and increase infection susceptibility?

Which breed is affected by a mutation for key cytokines (IL-2, 4, 7, 9, 15) leading to immune system failure?

What is the main function of white blood cells in the immune system?

What is the likelihood of finding Canine leukocyte Adhesion Deficiency (CLAD) in a clinic?

What is the characteristic feature of Canine leukocyte Adhesion Deficiency (CLAD)?

What is the most common cause of secondary immune deficiency?

What are the breed-specific mutations associated with Severe Combined Immunodeficiency (SCID) in dogs and horses?

What are the clinical manifestations of Severe Combined Immunodeficiency (SCID) in Arabian horses?

What are the potential causes of lymphopenia?

What are the secondary immune deficiencies discussed in the text?

What factors can suppress the immune response and increase infection susceptibility?

What factors can increase immune function?

What is the significance of reduced concentrations of cytokines and reduced T lymphocyte function?

What should be considered if an animal shows recurrent infections, neutrophilia or lymphopenia, and susceptibility to infection?

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