Hypersensitivity Reactions Quiz
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Questions and Answers

Which receptor does histamine act through to contract bronchial smooth muscles?

  • H2 receptor
  • H3 receptor
  • H1 receptor (correct)
  • H4 receptor

What is the result of histamine acting through H2 receptors?

  • Bronchial constriction
  • Vasodilation
  • Decreased gastric acid secretion
  • Increased gastric acid secretion (correct)

What tends to produce higher quantities in atopic individuals?

  • IgM
  • IgA
  • IgE (correct)
  • IgG

What causes Type II (tissue-specific) hypersensitivity reactions?

<p>Complement-mediated lysis (C)</p> Signup and view all the answers

What causes Type III (immune complex–mediated) hypersensitivity reactions?

<p>Formation of immune complexes (B)</p> Signup and view all the answers

What are the most likely immune complexes to have severe pathologic consequences?

<p>Intermediate-sized immune complexes (C)</p> Signup and view all the answers

What can immune complex disease be?

<p>Both systemic and localized (A)</p> Signup and view all the answers

What causes Type IV (cell-mediated) hypersensitivity reactions?

<p>Cytotoxic T lymphocytes (Tc cells) (A)</p> Signup and view all the answers

Which type of hypersensitivity reaction is mediated through the binding of IgE to Fc receptors on mast cells and cross-linking of IgE by antigens?

<p>Type I (IgE-mediated) reactions (A)</p> Signup and view all the answers

What is the most rapid immediate hypersensitivity reaction that can lead to cardiovascular shock?

<p>Anaphylaxis (A)</p> Signup and view all the answers

What are allergens?

<p>Antigens that cause allergic responses (D)</p> Signup and view all the answers

Which type of hypersensitivity reaction is characterized by IgE-mediated mechanisms and immediate onset?

<p>Type I (IgE-mediated) reactions (A)</p> Signup and view all the answers

Which type of hypersensitivity reaction involves immune complex–mediated mechanisms?

<p>Type III (immune complex–mediated) reactions (C)</p> Signup and view all the answers

What are the exaggerated responses against environmental antigens called?

<p>Allergy (D)</p> Signup and view all the answers

What type of response are autoimmunity, alloimmunity, and allergy collectively known as?

<p>Hypersensitivity reactions (B)</p> Signup and view all the answers

Which type of immune deficiencies are caused by genetic defects disrupting lymphocyte development?

<p>Primary immune deficiencies (D)</p> Signup and view all the answers

What is the clinical hallmark of immune deficiency?

<p>Propensity to unusual or recurrent severe infections (B)</p> Signup and view all the answers

Which type of infections are most common in individuals with defects of the cell-mediated immune response?

<p>Fungal and viral infections (C)</p> Signup and view all the answers

What is the range of defects in B-cell function?

<p>Complete lack of the human bursal equivalent function to deficiencies in a single class of immunoglobulins (D)</p> Signup and view all the answers

What are the most common infections in individuals with defects of the humoral immune response or complement function?

<p>Primarily bacterial infections (B)</p> Signup and view all the answers

What are disorders resulting from immune deficiency the clinical sequelae of?

<p>Impaired function of components of the immune or inflammatory response, phagocytes, or complement (C)</p> Signup and view all the answers

What is the failure of mechanisms of self-defense to function in their normal capacity called?

<p>Immune deficiency (A)</p> Signup and view all the answers

Which condition is characterized by complete or partial lack of the thymus and parathyroid glands, and the presence of cardiac anomalies?

<p>DiGeorge syndrome (B)</p> Signup and view all the answers

Which condition results in total lack of T-cell function and a severe lack of B-cell function?

<p>Severe Combined Immunodeficiency (SCID) (B)</p> Signup and view all the answers

Which deficiency results in recurrent life-threatening bacterial infections and unusual disseminated infections with Neisseria spp.?

<p>C3 deficiency (A)</p> Signup and view all the answers

What can result in recurrent life-threatening infections such as septicemia and disseminated pyogenic lesions?

<p>Defects in phagocyte function (D)</p> Signup and view all the answers

What are autoinflammatory disorders characterized by?

<p>Abnormally high levels of inflammation secondary to mutations in control of inflammasome activation or in defects in cellular receptors of cytokines designed to decrease inflammation (C)</p> Signup and view all the answers

What causes acquired immunodeficiencies?

<p>Superimposed conditions such as aging, malnutrition, infections, malignancies, physical or psychologic trauma, environmental factors, some medical treatments, or other diseases (A)</p> Signup and view all the answers

How are deficient antibody production usually treated?

<p>By replacement of missing immunoglobulins with commercial gamma-globulin preparations (C)</p> Signup and view all the answers

How are lymphocyte deficiencies usually treated?

<p>With the replacement of host lymphocytes with transplants of bone marrow, fetal liver, or fetal thymus from a donor (A)</p> Signup and view all the answers

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