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Questions and Answers
What is the definition of primary immune deficiency?
Which of the following best describes the cause of B cell deficiency?
Autoantibodies are best defined as:
What is a common characteristic of primary immune deficiency disorders?
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Which of the following symptoms is NOT commonly associated with immune deficiency?
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Immune deficiency can involve deficiencies in which of the following components?
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Which type of immune disorder involves an exaggerated immune response?
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What is a significant outcome for individuals with severe primary immune deficiency?
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What is the condition characterized by a lack of B cell differentiation into plasma cells?
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Which type of immunodeficiency is classified as primary immune deficiency?
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Which immunodeficiency is frequently associated with diminished antibody production?
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What is the primary characteristic of Common Variable Immunodeficiency (CVID)?
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Which type of deficiency is most associated with X-linked Agammaglobulinemia?
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Which immunodeficiency is the first to be identified historically?
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Which diagnostic result is typically seen in a patient with X-linked Agammaglobulinemia?
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Select the immunodeficiency classified as a secondary deficiency.
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Which of the following is NOT a sign of Primary Immune Deficiency (PID)?
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What indicates a potential combined B and T cell immunodeficiency?
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Which of the following statements about B-cell deficiencies is true?
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Which condition is a result of autoimmune responses?
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Which of the following is a warning sign indicating the necessity for intravenous antibiotics?
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In the context of immunodeficiencies, which does NOT represent a common symptom of PID?
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What is a characteristic of T cell immunodeficiency?
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Which of the following is associated with autoimmune disorders?
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Study Notes
Immune Deficiency Overview
- Primary immune deficiency (PID) involves abnormalities in the immune system, making individuals more susceptible to infections.
- Conditions can stem from defects in phagocytic cells, B lymphocytes, T lymphocytes, or the complement system.
- Symptoms typically manifest in infancy or early childhood, with many affected individuals not surviving to adulthood.
Classification of Immune Deficiency
- Primary immune deficiency: Congenital or inherited.
- Secondary immune deficiency: Acquired due to environmental factors.
B Cell Deficiencies
- B cell deficiencies are characterized by insufficient antibody production.
- First type: Results from lack of differentiation of B-cell precursors into mature B cells, leading to absent plasma cells.
- Second type: Occurs when B cells fail to differentiate into plasma cells adequately.
Types of B Cell Deficiencies
- X-linked Agammaglobulinemia (Bruton Type): First identified immunodeficiency disorder, affecting IgG levels severely.
- Common Variable Immunodeficiency (CVID): Marked by low or absent levels of IgG, often leading to frequent infections.
- Selective immunodeficiency: Involves specific deficiencies in IgA, IgM, or IgG.
Signs and Symptoms of Primary Immune Deficiency
- Frequent or unusual infections.
- Prolonged diarrhea and poor childhood growth.
- 10 warning signs for PID include:
- Eight or more ear infections within a year.
- Multiple sinus infections within a year.
- Recurrent pneumonia episodes or deep skin/organ abscesses.
- Persistent thrush in the mouth/skin.
- Need for intravenous antibiotics for infection treatment.
- Additional signs like poor growth and recurrent deep-seated infections (e.g., meningitis, sepsis).
Autoimmune Disorders and Hypersensitivity
- Autoimmune disorders involve the body producing antibodies against its own cells.
- Allergies and hypersensitivity are exaggerated immune responses, categorized into five types based on the immunologic mechanism involved.
Gammopathy
- Gammopathy refers to abnormal levels of immunoglobulins in the blood.
- Hypogammaglobulinemia: Diminished antibody production, commonly seen in immunodeficiencies.
Diagnostic Tests
- Confirmation of immune deficiencies typically involves measuring immunoglobulin levels.
- Low IgG levels (e.g., below 200 mg/dl) with normal white blood cell counts can indicate an immune deficiency disorder.
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Description
Explore the complexities of immune deficiencies, including primary and secondary types, and learn about B cell deficiencies that affect antibody production. This quiz covers the underlying causes, symptoms, and classifications of various immunodeficiency disorders. Test your knowledge on the subject and gain a deeper understanding of immune system disorders.
