Immune Checkpoint Inhibitors

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What is the primary objective of administering cytokines such as IL-2, IL-7, and IL-15 in T cell recovery?

To promote T cell expansion (correct)

To selectively remove alloreactive T cells

To suppress cell-mediated immune responses

To enhance humoral immune response

Which molecule is involved in the deactivation of T cells?

MHC II

CD4

PD1 (correct)

TCR

Adoptive transfer of which type of cells is used to control GvHD in cellular therapies?

Regulatory cells (CD4, CD25, FOXP3) (correct)

Dendritic cells

Mesenchymal stromal cells

Cytotoxic T cells

What is the primary goal of immune checkpoint inhibitors in cancer treatment?

To overcome the mechanisms by which tumours evade the immune system Signup and view all the answers

What is the primary goal of reducing the risk of GvHD in cancer immunotherapy?

To allow for the injection of a specific quantity of T cells from the donor Signup and view all the answers

Which type of tumour cell killing is dependent on the presence of antigens?

Antigen-dependent Signup and view all the answers

What is the primary mechanism of co-transplant mesenchymal stromal cells in cellular therapy?

Suppressing cell-mediated immune responses Signup and view all the answers

What is the primary challenge in using mesenchymal stromal cells in cellular therapy?

Difficulty in accessing labs with MSCs available Signup and view all the answers

What is a major challenge in the development of T-cell-based therapies?

Optimising the specificity and persistence of engineered T cells Signup and view all the answers

Which type of immune response involves the activation of B cells and plasma cells?

Humoral response Signup and view all the answers

What is the primary objective of specific removal of alloreactive T cells in cellular therapy?

To reduce the risk of GvHD Signup and view all the answers

What is the role of CTLA4 in T-cell activation and deactivation?

Deactivates T cells Signup and view all the answers

What is a critical factor in the immune system's ability to recognize and target tumour cells?

Antigen expression Signup and view all the answers

What is a potential consequence of immune-mediated selection of tumour cells?

Development of more resistant tumour cells Signup and view all the answers

What is a mechanism by which the immune system can eliminate tumour cells?

Immunological cell death Signup and view all the answers

Why is immunotherapy a preferred approach to cancer treatment?

It is better targeted, more personalised, and often has less side effects Signup and view all the answers

What is a consequence of the absence of neoantigens in tumour cells?

Smouldering inflammation and promotion of malignant transformation Signup and view all the answers

How can somatic mutations be used to predict neoantigens in tumour cells?

Based on the type of mutation and HLA type Signup and view all the answers