Podcast
Questions and Answers
What is the primary objective of administering cytokines such as IL-2, IL-7, and IL-15 in T cell recovery?
What is the primary objective of administering cytokines such as IL-2, IL-7, and IL-15 in T cell recovery?
- To promote T cell expansion (correct)
- To selectively remove alloreactive T cells
- To suppress cell-mediated immune responses
- To enhance humoral immune response
Which molecule is involved in the deactivation of T cells?
Which molecule is involved in the deactivation of T cells?
- MHC II
- CD4
- PD1 (correct)
- TCR
Adoptive transfer of which type of cells is used to control GvHD in cellular therapies?
Adoptive transfer of which type of cells is used to control GvHD in cellular therapies?
- Regulatory cells (CD4, CD25, FOXP3) (correct)
- Dendritic cells
- Mesenchymal stromal cells
- Cytotoxic T cells
What is the primary goal of immune checkpoint inhibitors in cancer treatment?
What is the primary goal of immune checkpoint inhibitors in cancer treatment?
What is the primary goal of reducing the risk of GvHD in cancer immunotherapy?
What is the primary goal of reducing the risk of GvHD in cancer immunotherapy?
Which type of tumour cell killing is dependent on the presence of antigens?
Which type of tumour cell killing is dependent on the presence of antigens?
What is the primary mechanism of co-transplant mesenchymal stromal cells in cellular therapy?
What is the primary mechanism of co-transplant mesenchymal stromal cells in cellular therapy?
What is the primary challenge in using mesenchymal stromal cells in cellular therapy?
What is the primary challenge in using mesenchymal stromal cells in cellular therapy?
What is a major challenge in the development of T-cell-based therapies?
What is a major challenge in the development of T-cell-based therapies?
Which type of immune response involves the activation of B cells and plasma cells?
Which type of immune response involves the activation of B cells and plasma cells?
What is the primary objective of specific removal of alloreactive T cells in cellular therapy?
What is the primary objective of specific removal of alloreactive T cells in cellular therapy?
What is the role of CTLA4 in T-cell activation and deactivation?
What is the role of CTLA4 in T-cell activation and deactivation?
What is a critical factor in the immune system's ability to recognize and target tumour cells?
What is a critical factor in the immune system's ability to recognize and target tumour cells?
What is a potential consequence of immune-mediated selection of tumour cells?
What is a potential consequence of immune-mediated selection of tumour cells?
What is a mechanism by which the immune system can eliminate tumour cells?
What is a mechanism by which the immune system can eliminate tumour cells?
Why is immunotherapy a preferred approach to cancer treatment?
Why is immunotherapy a preferred approach to cancer treatment?
What is a consequence of the absence of neoantigens in tumour cells?
What is a consequence of the absence of neoantigens in tumour cells?
How can somatic mutations be used to predict neoantigens in tumour cells?
How can somatic mutations be used to predict neoantigens in tumour cells?
