18 Questions
What is the primary objective of administering cytokines such as IL-2, IL-7, and IL-15 in T cell recovery?
To promote T cell expansion
Which molecule is involved in the deactivation of T cells?
PD1
Adoptive transfer of which type of cells is used to control GvHD in cellular therapies?
Regulatory cells (CD4, CD25, FOXP3)
What is the primary goal of immune checkpoint inhibitors in cancer treatment?
To overcome the mechanisms by which tumours evade the immune system
What is the primary goal of reducing the risk of GvHD in cancer immunotherapy?
To allow for the injection of a specific quantity of T cells from the donor
Which type of tumour cell killing is dependent on the presence of antigens?
Antigen-dependent
What is the primary mechanism of co-transplant mesenchymal stromal cells in cellular therapy?
Suppressing cell-mediated immune responses
What is the primary challenge in using mesenchymal stromal cells in cellular therapy?
Difficulty in accessing labs with MSCs available
What is a major challenge in the development of T-cell-based therapies?
Optimising the specificity and persistence of engineered T cells
Which type of immune response involves the activation of B cells and plasma cells?
Humoral response
What is the primary objective of specific removal of alloreactive T cells in cellular therapy?
To reduce the risk of GvHD
What is the role of CTLA4 in T-cell activation and deactivation?
Deactivates T cells
What is a critical factor in the immune system's ability to recognize and target tumour cells?
Antigen expression
What is a potential consequence of immune-mediated selection of tumour cells?
Development of more resistant tumour cells
What is a mechanism by which the immune system can eliminate tumour cells?
Immunological cell death
Why is immunotherapy a preferred approach to cancer treatment?
It is better targeted, more personalised, and often has less side effects
What is a consequence of the absence of neoantigens in tumour cells?
Smouldering inflammation and promotion of malignant transformation
How can somatic mutations be used to predict neoantigens in tumour cells?
Based on the type of mutation and HLA type
Learn about immune checkpoint inhibitors, a type of therapy that targets molecules to enhance T cells' ability to recognize and eliminate cancer cells. Understand how they work to overcome tumours' evasion mechanisms and boost the immune system's response.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
