Imipramine (Tofranil) Overview Flashcards
12 Questions
100 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the pharmacologic class of Imipramine?

  • Monoamine oxidase inhibitor
  • Atypical antidepressant
  • Selective serotonin reuptake inhibitor
  • Tricyclic antidepressant (correct)
  • What is the therapeutic class of Imipramine?

    Antidepressant; treatment of nocturnal enuresis in children

    What is an off-label use of Imipramine?

    Intrac-table pain, anxiety disorders, withdrawal syndromes from alcohol and cocaine

    Imipramine should be discontinued abruptly.

    <p>False</p> Signup and view all the answers

    Imipramine can cause paradoxical diaphoresis.

    <p>True</p> Signup and view all the answers

    What are the common side effects of Imipramine?

    <p>Sedation, drowsiness, blurred vision, dry mouth, cardiovascular symptoms.</p> Signup and view all the answers

    Which condition is a contraindication for Imipramine?

    <p>Acute recovery after myocardial infarction</p> Signup and view all the answers

    Match the following drugs with their association with Imipramine:

    <p>Cimetidine = Inhibits metabolism of Imipramine Clonidine = Reverses antihypertensive effects Disulfiram = Leads to delirium and tachycardia MAOIs = May result in neuroleptic malignant syndrome</p> Signup and view all the answers

    What laboratory tests can be affected by Imipramine?

    <p>Blood glucose tests, serum bilirubin, alkaline phosphatase</p> Signup and view all the answers

    Herbal supplements such as St. John's wort should not be used with Imipramine as they may cause serotonin syndrome (SES).

    <p>True</p> Signup and view all the answers

    What is the recommended action in case of Imipramine overdose?

    <p>General supportive measures are recommended.</p> Signup and view all the answers

    Which of the following is another drug in the same class as Imipramine?

    <p>Amitriptyline</p> Signup and view all the answers

    Study Notes

    Pharmacologic and Therapeutic Class

    • Imipramine is classified as a tricyclic antidepressant (TCA).
    • Therapeutically used to treat major depression and nocturnal enuresis in children.

    Actions and Uses

    • Blocks reuptake of serotonin and norepinephrine in nerve terminals.
    • Primary use for major depression; also occasionally for bed-wetting in children.
    • Off-label applications include managing chronic pain, anxiety disorders, and substance withdrawal syndromes.
    • Therapeutic effects may take 2 or more weeks to manifest.

    Administration Alerts

    • Paradoxical diaphoresis may mislead diagnosis of other conditions like hypoglycemia.
    • Common anticholinergic side effects include dry mouth, dizziness, blurred vision, and weight changes.
    • Abrupt discontinuation can lead to rebound effects like irritability and sleeplessness.
    • Classified as pregnancy category C.

    Pharmacokinetics

    • Onset of action typically occurs in less than 1 hour.
    • Peak plasma concentration reached in 1-2 hours when taken orally and 30 minutes via intramuscular injection.
    • Duration of action is variable.

    Adverse Effects

    • Notable side effects include sedation, drowsiness, blurred vision, and cardiovascular events like dysrhythmias and hypertension.
    • Black Box Warning indicates increased risk of suicidal thoughts and behavior in young populations with depressive disorders.
    • Not recommended for pediatric use due to safety concerns.

    Contraindications

    • Should not be administered post-myocardial infarction, in patients with bundle-branch conduction defects, narrow-angle glaucoma, or severe kidney/liver impairment.
    • Contraindicated within 14 days of MAOI discontinuation.

    Drug Interactions

    • Use with other CNS depressants can enhance sedation effects.
    • Cimetidine may increase serum levels of imipramine; monitor for toxicity.
    • Possible reversal of clonidine's antihypertensive effects when combined with imipramine.
    • Concurrent use with St. John's wort may trigger serotonin syndrome.

    Lab Tests

    • Alters blood glucose test results.
    • May lead to elevated levels of bilirubin and alkaline phosphatase in serum.

    Herbal/Food Interactions

    • Evening primrose oil or ginkgo may lower seizure threshold.
    • St. John's wort used alongside can induce serotonin syndrome.

    Treatment of Overdose

    • No specific antidote for imipramine overdose; general supportive care is essential.
    • Focus on ensuring airway, ventilation, and oxygenation with cardiac monitoring.
    • Gastric lavage or administration of activated charcoal may be indicated.

    Other Drugs in this Class

    • Related drugs include:
      • Amitriptyline (Elavil)
      • Amoxapine
      • Clomipramine (Anafranil)
      • Desipramine (Norpramin)
      • Doxepin (Silenor)
      • Maprotiline
      • Nortriptyline (Aventyl, Pamelor)
      • Protriptyline (Vivactil)
      • Trimipramine (Surmontil)

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Description

    This quiz provides key information about Imipramine, its pharmacologic and therapeutic classes, as well as its actions and uses. Perfect for students studying pharmacology or preparing for exams on antidepressants.

    More Like This

    Use Quizgecko on...
    Browser
    Browser