Imipramine Overview and Pharmacology

Anti-depressant

Tricyclic Antidepressant

Schizophrenia; short-term treatment of acute mania or mixed episodes associated with bipolar disorder, various forms of depression, enuresis in children

<p>Blocks the reuptake of norepinephrine and serotonin; blocks acetylcholine receptors</p> Signup and view all the answers

<p>Crosses the placenta; enters the breast milk</p> Signup and view all the answers

<p>Liver (CYP) into the active metabolite desipramine</p> Signup and view all the answers

<p>Renal; small amounts in the bile and feces</p> Signup and view all the answers

<p>Assess weight and Body Mass Index (BMI), assess for sexual dysfunction, assess for suicidal tendencies, assess blood pressure and pulse prior to administration, include orthostatic hypertension as part of vital signs during initial treatment period</p> Signup and view all the answers

<p>Complete blood count with differential (CBC w/diff); blood glucose</p> Signup and view all the answers

<p>Administer with food; nighttime administration preferred</p> Signup and view all the answers

<p>Increased sense of well-being, renewed interest in surroundings, improved energy level, decrease in nocturnal enuresis episodes</p> Signup and view all the answers

<p>Drowsiness, fatigue, blurred vision, dry eyes, hypotension, seizures, suicidal ideation, constipation, dry mouth, decreased libido, arrhythmias</p> Signup and view all the answers

<p>Advise patient that it takes 2 weeks or longer until full therapeutic effects are achieved, risk of increased suicidal ideation during initial therapy, caution to avoid activities requiring alertness until effects are known, notify prescriber if visual changes occur, caution to use sunscreen, urine may turn blue-green, avoid alcohol or other CNS depressants</p> Signup and view all the answers