40 Questions
The IL-2 signaling through its receptor (IL-2R) promotes T cell survival, expansion, and differentiation into regulatory T cells.
False
Costimulatory signals provided by APCs, proinflammatory cytokines, and IL-2 are critical for T cell activation but do not impact proliferation and differentiation into effector T cells.
False
B7 molecules (CD80 and CD86) are expressed on the surface of T cells in response to microbial products and various cytokines.
False
CD28 engagement promotes the production of interleukin-4 (IL-4) and the expression of other cytokines necessary for T cell activation and function.
False
In APC-T cell interactions, B7 molecules interact with the CD28 receptor on APCs to provide essential costimulatory signals.
False
Costimulatory signals are not important for T cell activation.
False
If an APC presents a self-antigen without costimulatory signals, the T cell may become tolerant to the self-antigen.
True
CD28 is a cell surface antigen expressed on T cells that is involved in T cell activation.
True
Activation of APCs by microbial products leads to an increase in the expression of costimulators.
True
Cytokines are not involved in promoting the production of IL-2 by cells.
False
CTLA-4 competes with CD28 for binding to B7 molecules on APCs.
True
CD28-B7 interactions result in the inhibition of T cell activation.
False
PD-1 sends activating signals upon binding to its ligand.
False
B7 molecules are expressed on the surface of T cells in response to microbial products.
False
CD28 engagement promotes the production of interleukin-2 (IL-2) in T cells.
True
Modulation of the B7/CD28 interaction for therapeutic purposes involves enhancing inhibitory signals.
False
CD28 interacts with CD86 (B7.2) on the surface of APCs to provide a crucial second signal for T cell activation.
False
The interaction between B7 molecules and CD28 receptor is essential for T cell activation.
True
Innate immune responses triggered by microbial pathogens do not lead to the upregulation of costimulatory molecules on APCs.
False
Costimulatory blockade interferes with the interaction between MHC complex and T cell receptor.
False
Interleukin-2 (IL-2) promotes the expansion of activated T cells and supports their effector functions.
True
Manipulation of B7/CD28 interaction for therapeutic purposes is only relevant for treating allergies.
False
Costimulatory blockade is approved for the treatment of Rheumatoid Arthritis (RA) and tissue transplant.
True
CD80 and CD86 are downregulated on APCs upon encountering microbial pathogens.
False
Manipulation of B7/CD28 interaction for therapeutic purposes is not relevant in influencing T cell activation.
False
IL-2 primarily acts in an autocrine manner to stimulate the proliferation and differentiation of T cells.
True
Surrogate Light Chain Transition is a crucial step in the activation and proliferation of T cells.
False
Costimulatory signals provided by APCs and IL-2 are sufficient for T cell activation but not for proliferation and differentiation.
False
Manipulation of B7/CD28 interaction for therapeutic purposes is not related to regulating immune responses against pathogens.
False
The expression of costimulators in APC-T cell interactions is not influenced by microbial products and cytokines.
False
Costimulatory signals are not crucial for T cell activation according to the text.
False
In the absence of costimulatory signals, T cell activation may occur normally.
False
CD28 is not a key costimulatory molecule involved in T cell activation according to the text.
False
CD28 interacts with CD86 (B7.2) on the surface of APCs to provide a crucial second signal for T cell activation.
True
The presence of costimulatory signals like CD28-B7 interactions does not impact whether a T cell becomes activated or tolerant to the antigen presented by the APC.
False
B7 molecules are not expressed on the surface of APCs in response to microbial products and various cytokines.
False
Manipulation of B7/CD28 interaction for therapeutic purposes is not discussed in the text.
False
Surrogate light chain transition is unrelated to the regulation of immune responses.
True
Allelic exclusion plays a critical role in modulating immune responses according to the text.
True
Activation of Light Chain Recombination is essential for the differentiation into regulatory T cells.
False
Learn about how IL-2 signaling through its receptor (IL-2R) promotes T cell survival, expansion, and differentiation into effector T cells, mediating immune responses against pathogens. Explore the role of costimulatory signals, proinflammatory cytokines, and IL-2 in T cell activation, proliferation, and differentiation in the adaptive immune response.
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