Podcast
Questions and Answers
What initiates IgE-mediated degranulation?
What initiates IgE-mediated degranulation?
- Antigen cross-linkage (correct)
- Mast cell contraction
- Phosphatase rearrangement
- IgE binding to the Fc receptor
What is necessary for the movement of granules to the plasma membrane during degranulation?
What is necessary for the movement of granules to the plasma membrane during degranulation?
- Contraction of microfilaments
- Cooperation among protein and lipid kinases
- Increase in Ca2+
- A+C (correct)
Which drug is used to block the Ca++ influx as a treatment for allergies?
Which drug is used to block the Ca++ influx as a treatment for allergies?
- Cromolyn sodium
- Phosphatase inhibitor
- Disodium cromoglycate (correct)
- Cytoskeleton rearranger
What is the initial event that triggers IgE-mediated degranulation?
What is the initial event that triggers IgE-mediated degranulation?
What is the role of Ca++ influx in mast cell degranulation?
What is the role of Ca++ influx in mast cell degranulation?
What is the result of IgE cross-linkage?
What is the result of IgE cross-linkage?
Which intracellular signaling process is involved in initiating mast cell degranulation?
Which intracellular signaling process is involved in initiating mast cell degranulation?
Which process is rearranged during mast cell degranulation?
Which process is rearranged during mast cell degranulation?
What are the most significant primary mediators of Type I hypersensitivity?
What are the most significant primary mediators of Type I hypersensitivity?
Which agents are produced before degranulation and stored in the granules?
Which agents are produced before degranulation and stored in the granules?
When do the primary mediators of Type I hypersensitivity occur?
When do the primary mediators of Type I hypersensitivity occur?
What type of agents are synthesized after target-cell activation or released during the degranulation process?
What type of agents are synthesized after target-cell activation or released during the degranulation process?
What is the timing difference between the formation of leukotrienes and prostaglandins compared to histamine?
What is the timing difference between the formation of leukotrienes and prostaglandins compared to histamine?
Which biological effects of leukotrienes and prostaglandins are more pronounced and longer lasting than those of histamine?
Which biological effects of leukotrienes and prostaglandins are more pronounced and longer lasting than those of histamine?
Which cytokines are secreted by human mast cells to alter the local microenvironment and recruit inflammatory cells?
Which cytokines are secreted by human mast cells to alter the local microenvironment and recruit inflammatory cells?
How does systemic anaphylaxis typically start?
How does systemic anaphylaxis typically start?
What is the usual initiation point of systemic anaphylaxis?
What is the usual initiation point of systemic anaphylaxis?
Which of the following symptoms is associated with anaphylactic shock?
Which of the following symptoms is associated with anaphylactic shock?
What can cause the patient to die of suffocation in systemic anaphylaxis?
What can cause the patient to die of suffocation in systemic anaphylaxis?
What is the common name for Allergic Rhinitis?
What is the common name for Allergic Rhinitis?
Where does the reaction develop in allergic asthma (extrinsic asthma)?
Where does the reaction develop in allergic asthma (extrinsic asthma)?
What is the characteristic symptom of Allergic Rhinitis (hay fever)?
What is the characteristic symptom of Allergic Rhinitis (hay fever)?
Immunotherapy involves Desensitization: subcutaneous injections of allergens to cause a shift to IgG production instead of IgE.
Immunotherapy involves Desensitization: subcutaneous injections of allergens to cause a shift to IgG production instead of IgE.
How can antibody-bound cells be destroyed in Type II hypersensitivity reactions?
How can antibody-bound cells be destroyed in Type II hypersensitivity reactions?
What is the mechanism of cell destruction in antibody-dependent cell-mediated cytotoxicity (ADCC)?
What is the mechanism of cell destruction in antibody-dependent cell-mediated cytotoxicity (ADCC)?
What role does opsonization play in Type II hypersensitivity reactions?
What role does opsonization play in Type II hypersensitivity reactions?
RBCs have different antigen ,but the most important are A and B antigens(used for blood grouping ABO).
RBCs have different antigen ,but the most important are A and B antigens(used for blood grouping ABO).
Antibodies to the A, B, and O antigens, called isohemagglutinins, are usually of the IgM class
Antibodies to the A, B, and O antigens, called isohemagglutinins, are usually of the IgM class
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