Idiopathic Pulmonary Fibrosis Pathology Quiz

ThriftyInspiration avatar
ThriftyInspiration
·
·
Download

Start Quiz

Study Flashcards

88 Questions

What is the main characteristic of idiopathic pulmonary fibrosis described in the text?

Fibrosis surrounding residual airspaces

Which process contributes to the severity of idiopathic pulmonary fibrosis?

Collagen deposition and fibroblast proliferation

What does a Trichrome stain help visualize in idiopathic pulmonary fibrosis?

Collagen fibrosis

What type of repair process is idiopathic pulmonary fibrosis an example of?

Maladaptive repair

Where are areas of fibrosis mainly located?

Peripheral zones of lobules

How does the extent of fibrosis impact the severity of idiopathic pulmonary fibrosis?

It reduces gas exchange efficiency

What does the subpleural fibroblastic focus consist of?

Fibroblasts and myofibroblasts

What does the honeycombing seen in idiopathic pulmonary fibrosis correspond to?

Usual interstitial pneumonia pattern

How is architectural destruction highlighted in the imaging of idiopathic pulmonary fibrosis?

Prominent bright interstitial markings

What is typically seen in smaller darker, round lucent areas on imaging of idiopathic pulmonary fibrosis?

Honeycomb change

What does the elastic stain highlight in idiopathic interstitial pneumonias?

Architectural destruction seen as thick fragmented elastic fibers

What are the learning objectives related to restrictive lung diseases and chronic interstitial diseases?

Understanding the radiologic features of idiopathic pulmonary fibrosis

Which term is commonly used to describe idiopathic pulmonary fibrosis?

Usual interstitial pneumonia

What is a characteristic feature of hypersensitivity pneumonitis?

Hypersensitivity reaction to inhaled allergens

Which condition is known for its association with smoking and presents with desquamation of alveolar macrophages?

Desquamative interstitial pneumonitis

What is a common feature of radiation-induced lung injury?

Damage due to exposure to ionizing radiation

Which pathology is associated with respiratory bronchiolitis and interstitial lung disease?

Respiratory bronchiolitis-associated interstitial lung disease(s)

What is the 2nd most common type of interstitial pneumonia mentioned in the text?

Nonspecific interstitial pneumonia

Which gender is more commonly affected by nonspecific interstitial pneumonia according to the text?

Female non-smokers

What type of fibrosis involves the alveolar septa uniformly and diffusely in nonspecific interstitial pneumonia?

Loose fibrosis

Which of the following is unlikely to be found in the histology of nonspecific interstitial pneumonia?

Fibrosing infiltrates

In what age range does nonspecific interstitial pneumonia most commonly affect patients?

50-60 years

What lung architecture changes may occur in later phases of nonspecific interstitial pneumonia?

Cystic changes

What is the histologic feature seen in cryptogenic organizing pneumonia?

Polypoid plugs of loose connective tissue

Which cell types are predominantly found in the polypoid plugs of cryptogenic organizing pneumonia?

Fibroblasts and myofibroblasts

Which lung disease is characterized by the histologic pattern of usual interstitial pneumonia (UIP)?

Idiopathic pulmonary fibrosis

What is the main difference between idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia?

Presence of interstitial fibrosis

Which autoimmune disease can lead to nonspecific interstitial pneumonia as a pulmonary manifestation?

Systemic lupus erythematosis (SLE)

What is a key feature of cryptogenic organizing pneumonia in terms of prognosis?

Good prognosis but may relapse

What is a potential treatment option for nonspecific interstitial pneumonia according to the text?

Glucocorticoids with/without other immunosuppressive drugs

Which pulmonary function test result is typically decreased in patients with nonspecific interstitial pneumonia?

Diffusing capacity of lung for carbon monoxide (DLCO)

What is a common symptom associated with nonspecific interstitial pneumonia as described in the text?

Fatigue

Which of the following is NOT a feature typically seen in the histology of nonspecific interstitial pneumonia?

Granulomas

In nonspecific interstitial pneumonia, what pattern is observed on imaging that corresponds to alveolar filling with exudates and fibroblastic foci?

Consolidation

Which cells play a key role in generating loose fibrosis in cryptogenic organizing pneumonia?

Fibroblasts

What is the main characteristic imaging finding in cryptogenic organizing pneumonia?

Ground-glass opacities

Which clinical feature is most commonly associated with cryptogenic organizing pneumonia?

Dyspnea

What is the histologic term used to describe the polypoid plugs of loose connective tissue seen in cryptogenic organizing pneumonia?

Masson bodies

Which underlying condition can potentially trigger cryptogenic organizing pneumonia?

Rheumatoid arthritis

What is the treatment of choice for cryptogenic organizing pneumonia with a good response rate?

Oral corticosteroids

What characterizes the pathophysiology of nonspecific interstitial pneumonia?

Uniform fibrosis involving the alveolar septa uniformly and diffusely

Which imaging feature differentiates nonspecific interstitial pneumonia from usual interstitial pneumonia?

Temporal and spatial homogeneity

In the later phase of nonspecific interstitial pneumonia, what can occur due to traction?

Cystic changes

Which age group is typically affected by nonspecific interstitial pneumonia?

50-60 years old

What distinguishes cryptogenic organizing pneumonia from idiopathic pulmonary fibrosis in terms of histology?

Balls of fibroblasts within alveoli

Which autoimmune disease can manifest as nonspecific interstitial pneumonia?

Systemic lupus erythematosus (SLE)

What is a histological difference between the cellular and fibrosing patterns of nonspecific interstitial pneumonia?

Looser fibrosis in cellular pattern

What type of cells are predominantly found in the histology of nonspecific interstitial pneumonia?

Lymphocytes and plasma cells

What is the main prognostic factor for cryptogenic organizing pneumonia?

Relapse potential

Which feature differentiates nonspecific interstitial pneumonia from idiopathic pulmonary fibrosis?

Younger patient population

In which lung structures are fibroblasts predominantly found in cryptogenic organizing pneumonia?

Airspaces (alveolar ducts, alveoli)

What differentiates the histologic pattern of usual interstitial pneumonia (UIP) from nonspecific interstitial pneumonia?

Absence of honeycombing

Which type of lung disease is associated with inhaled nitrogen gas from plant material?

Silo filler lung

What is a characteristic feature of pulmonary eosinophilia?

Eosinophils in alveolar and interstitial spaces

What proinflammatory cytokine release is associated with radiation-induced lung injury?

TNF-alpha

Which lung disease is uncommon and requires exclusion of various conditions like drug reactions and infections?

Pulmonary eosinophilia

What is the most common manifestation of radiation-induced lung injury after 6-12 months?

Fibrosis

Which lung disease involves interstitial disease with loosely formed granulomas and chronic inflammation centered around bronchioles?

Hypersensitivity pneumonitis

What is the primary mechanism for airway obstruction in emphysema?

Loss of elastic tissue in alveoli walls

Which cell type is chemotactically attracted to the alveoli in emphysema due to the presence of nicotine?

Neutrophils

What contributes to the collapse of respiratory bronchioles during expiration in emphysema?

Loss of radial traction

Which pattern of emphysema is most commonly associated with smoking?

Centrolobular (centriacinar) emphysema

What is a consequence of emphysema on pulmonary capillaries?

Decreased number

What histological feature is characteristic of emphysema?

Alveolar walls destruction

What is a characteristic clinical feature of emphysema that may lead to the appearance of callouses or swollen bursae on extensor forearm surfaces?

Pursed lips breathing

Which sign may indicate severe hypercapnia in emphysema patients?

Paradoxical retraction of lower interspaces during inspiration

What imaging finding is most supportive of a diagnosis of emphysema?

Hyperinflation especially in upper lobes

Which accessory muscles are commonly used by emphysema patients due to respiratory distress?

Neck and shoulder girdle muscles

In emphysema, what clinical feature is often seen in patients leaning forward with their arms outstretched and weight supported on palms or elbows?

Progressive dyspnea

Which condition is characterized by the presence of bullae and is often associated with 1-antitrypsin deficiency?

Emphysema

What is the underlying pathology associated with the term 'pink puffer' in emphysema?

Gradual destruction of pulmonary capillary bed

How do patients with ‘pink puffer’ emphysema compensate for diminished oxygen?

Hyperventilation

What is a potential consequence of progressively diminished oxygen levels in 'pink puffer' patients?

Muscle wasting and weight loss

What contributes to the 'pink' appearance of individuals with 'pink puffer' emphysema?

Work involving neck and chest muscles

Why do 'pink puffer' patients have relatively normal arterial blood gases (ABGs)?

Compensatory hyperventilation

How do patients with 'pink puffer' emphysema differ from 'blue bloaters' in terms of hypoxemia?

'Blue bloaters' have more severe hypoxemia

What is the main reason behind the 'blue bloater' appearance in patients with chronic bronchitis?

Hypercarbia with increased carbon dioxide retention

Which histopathologic finding is characteristic of chronic bronchitis?

Increased Reid index

How do patients with chronic bronchitis adapt to hypoventilation?

Use of accessory muscles decreasing caloric demand

In what way does chronic bronchitis differ from pure emphysema?

Increased carbon dioxide retention with compensatory elevations in plasma 'bicarbonate'

What is the primary pathology seen in chronic bronchitis?

Mucus gland hyperplasia

How can ventilation to perfusion mismatch lead to hypoxemia in chronic bronchitis?

Hypoxemia with decreased oxygenation

What is the most common cause of bronchiectasis in the United States?

Cystic fibrosis

Which lung disease presents with foul-smelling sputum and tube-like dilatations filled with pus?

Bronchiectasis

In bronchiectasis, what imaging feature might be seen that indicates abundant sputum in the airways?

Airbronchograms

Which lung disease is associated with recurrent infections, malabsorption, and an autosomal recessive genetic defect?

Cystic fibrosis

What is a key feature that distinguishes bronchiectasis from idiopathic pulmonary fibrosis?

Airbronchograms

Which lung disease is characterized by absent or deficient cystic fibrosis transmembrane conductance regulator (CFTR)?

Bronchiectasis

Test your knowledge on the pathology of idiopathic pulmonary fibrosis with this quiz. Explore key concepts and details related to collagen fibrosis, dense fibrous connective tissue, and other characteristics of this condition.

Make Your Own Quizzes and Flashcards

Convert your notes into interactive study material.

Get started for free

More Quizzes Like This

Use Quizgecko on...
Browser
Browser