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Questions and Answers
What is the typical duration of mesalamine therapy for induction of remission in active proctitis and distal ulcerative colitis?
What is the typical duration of mesalamine therapy for induction of remission in active proctitis and distal ulcerative colitis?
- 8-16 weeks (correct)
- 16-24 weeks
- 4-8 weeks
- 2-4 weeks
What is the typical response time to local therapy with mesalamine?
What is the typical response time to local therapy with mesalamine?
- Within 21-28 days
- Within 14-21 days
- Within 7-14 days (correct)
- Within 3-7 days
What percentage of orally administered sulfasalazine (a mesalamine prodrug) is absorbed in the small intestine?
What percentage of orally administered sulfasalazine (a mesalamine prodrug) is absorbed in the small intestine?
- 30-40%
- 20-30% (correct)
- 10-20%
- 40-50%
What happens to the remaining 70% of the orally administered sulfasalazine that reaches the colon?
What happens to the remaining 70% of the orally administered sulfasalazine that reaches the colon?
What is the recommended dosing regimen for mesalamine suppositories?
What is the recommended dosing regimen for mesalamine suppositories?
What is the recommended dosing regimen for mesalamine enemas?
What is the recommended dosing regimen for mesalamine enemas?
Which cells present the antigen(s) to CD4+ lymphocytes and secrete cytokines like IL-12 and IL-23?
Which cells present the antigen(s) to CD4+ lymphocytes and secrete cytokines like IL-12 and IL-23?
What is the role of regulatory TH17 and TReg cells in the GI tract?
What is the role of regulatory TH17 and TReg cells in the GI tract?
Which cytokines drive the expansion of regulatory T-cell subsets?
Which cytokines drive the expansion of regulatory T-cell subsets?
What is the characteristic array of cytokines produced by TH1 cells?
What is the characteristic array of cytokines produced by TH1 cells?
How do macrophages positively regulate TH1 cells?
How do macrophages positively regulate TH1 cells?
What is the role of cell adhesion molecules like integrins in the infiltration of leukocytes?
What is the role of cell adhesion molecules like integrins in the infiltration of leukocytes?
What are the common psychological manifestations associated with IBD?
What are the common psychological manifestations associated with IBD?
Which disease is a serious extraintestinal manifestation of IBD, usually associated with ulcerative colitis?
Which disease is a serious extraintestinal manifestation of IBD, usually associated with ulcerative colitis?
What condition is associated with an increased risk for colorectal cancer in individuals with chronic, severe IBD?
What condition is associated with an increased risk for colorectal cancer in individuals with chronic, severe IBD?
What is the common immune response abnormality in both Crohn’s disease and ulcerative colitis?
What is the common immune response abnormality in both Crohn’s disease and ulcerative colitis?
What type of lesions in Crohn’s disease exhibit marked infiltration of lymphocytes and macrophages, granuloma formation, and submucosal fibrosis?
What type of lesions in Crohn’s disease exhibit marked infiltration of lymphocytes and macrophages, granuloma formation, and submucosal fibrosis?
In ulcerative colitis, what type of infiltrates are commonly observed in the superficial lesions?
In ulcerative colitis, what type of infiltrates are commonly observed in the superficial lesions?
What is the main route of excretion for methotrexate?
What is the main route of excretion for methotrexate?
Which of the following medications may increase treatment-related toxicity of methotrexate by inhibiting its renal excretion?
Which of the following medications may increase treatment-related toxicity of methotrexate by inhibiting its renal excretion?
What are common manifestations of methotrexate toxicity?
What are common manifestations of methotrexate toxicity?
What is the role of cyclosporine in IBD treatment?
What is the role of cyclosporine in IBD treatment?
Why is careful monitoring necessary for cyclosporine levels during treatment?
Why is careful monitoring necessary for cyclosporine levels during treatment?
Which adverse effect limits the use of cyclosporine as a first-line medication in IBD?
Which adverse effect limits the use of cyclosporine as a first-line medication in IBD?
What is the mechanism of action of S1PR agonists?
What is the mechanism of action of S1PR agonists?
Which receptors does ozanimod act on?
Which receptors does ozanimod act on?
What is one of the therapeutic uses of ozanimod besides multiple sclerosis?
What is one of the therapeutic uses of ozanimod besides multiple sclerosis?
How is ozanimod supplied for administration?
How is ozanimod supplied for administration?
When do peak plasma levels of ozanimod occur?
When do peak plasma levels of ozanimod occur?
What is considered a key factor in the development of IBD according to recent research?
What is considered a key factor in the development of IBD according to recent research?
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